P00156 (CYB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome b

Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit

Gene names

Name:	MT-CYB
Synonyms:	COB, CYTB, MTCYB

Encoded on

Mitochondrion

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis By similarity.
Cofactor	Binds 2 heme groups non-covalently By similarity.
Subunit structure	The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Involvement in disease	Defects in MT-CYB are a rare cause of mitochondrial dysfunction underlying different myopathies. They include mitochondrial encephalomyopathy, hypertrophic cardiomyopathy (HCM), and sporadic mitochondrial myopathy (MM). In mitochondrial myopathy, exercise intolerance is the predominant symptom. Additional features include lactic acidosis, muscle weakness and/or myoglobinuria. Defects in MTCYB are also found in cases of exercise intolerance accompanied by deafness, mental retardation, retinitis pigmentosa, cataract, growth retardation, epilepsy (multisystem disorder). Ref.9 Ref.15 Cardiomyopathy, infantile histiocytoid (CMIH) [MIM:500000]: A heart disease characterized by the presence of pale granular foamy histiocyte-like cells within the myocardium. It usually affects children younger than 2 years of age, with a clear predominance of females over males. Infants present with dysrhythmia or cardiac arrest. The clinical course is usually fulminant, sometimes simulating sudden infant death syndrome. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.17 Leber hereditary optic neuropathy (LHON) [MIM:535000]: A maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. Note: The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Ref.9 Ref.11
Miscellaneous	Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm By similarity.
Sequence similarities	Belongs to the cytochrome b family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Polymorphism
Disease	Cardiomyopathy Cataract Deafness Disease mutation Leber hereditary optic neuropathy
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular metabolic process Traceable author statement. Source: Reactome hydrogen ion transmembrane transport Non-traceable author statement Ref.8. Source: GOC mitochondrial electron transport, ubiquinol to cytochrome c Non-traceable author statement Ref.8. Source: UniProtKB respiratory electron transport chain Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	mitochondrial inner membrane Traceable author statement. Source: Reactome mitochondrial respiratory chain complex III Non-traceable author statement Ref.8. Source: UniProtKB mitochondrion Inferred from direct assay PubMed 20833797. Source: UniProt
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquinol-cytochrome-c reductase activity Non-traceable author statement Ref.8. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	Cytochrome b		PRO_0000061045
Regions
	Transmembrane	33 – 53	21	Helical; Potential
	Transmembrane	76 – 98	23	Helical; Potential
	Transmembrane	115 – 135	21	Helical; Potential
	Transmembrane	138 – 158	21	Helical; Potential
	Transmembrane	178 – 198	21	Helical; Potential
	Transmembrane	230 – 250	21	Helical; Potential
	Transmembrane	288 – 308	21	Helical; Potential
	Transmembrane	323 – 343	21	Helical; Potential
	Transmembrane	349 – 369	21	Helical; Potential
Sites
	Metal binding	83	1	Iron 1 (heme b562 axial ligand)
	Metal binding	97	1	Iron 2 (heme b566 axial ligand)
	Metal binding	182	1	Iron 1 (heme b562 axial ligand)
	Metal binding	196	1	Iron 2 (heme b566 axial ligand)
Natural variations
	Natural variant	7	1	T → I. Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.10 Ref.15 Ref.22 Corresponds to variant rs3135031 [ dbSNP | Ensembl ].		VAR_008585
	Natural variant	8	1	N → S. Ref.5 Ref.6 Ref.15 Corresponds to variant rs28357679 [ dbSNP | Ensembl ].		VAR_013643
	Natural variant	18	1	F → L. Ref.5 Ref.6 Ref.15 Corresponds to variant rs28357681 [ dbSNP | Ensembl ].		VAR_013644
	Natural variant	34	1	G → S in mitochondrial myopathy; sporadic. Ref.16		VAR_013645
	Natural variant	35	1	S → P in exercice intolerance; with cardiomyopathy and septo-optic dysplasia. Ref.20		VAR_033058
	Natural variant	39	1	A → T. Ref.7		VAR_015571
	Natural variant	39	1	A → V. Ref.5		VAR_013646
	Natural variant	78	1	I → T. Ref.5		VAR_013647
	Natural variant	78	1	I → V. Ref.7		VAR_015572
	Natural variant	80	1	R → H in colorectal cancer. Ref.14		VAR_008388
	Natural variant	87	1	A → P. Ref.10		VAR_008586
	Natural variant	122	1	A → T. Ref.5 Ref.6 Corresponds to variant rs28357685 [ dbSNP | Ensembl ].		VAR_013648
	Natural variant	123	1	T → A. Ref.5		VAR_013649
	Natural variant	151	1	S → P in exercise intolerance. Ref.19		VAR_013650
	Natural variant	153	1	I → T. Ref.5 Corresponds to variant rs28357687 [ dbSNP | Ensembl ].		VAR_013651
	Natural variant	164	1	I → V. Ref.6		VAR_013652
	Natural variant	166	1	G → E in hyperthrophic cardiomyopathy. Ref.15		VAR_013653
	Natural variant	171	1	D → N in LHON; secondary mutation; does not seem to directly cause the disease. Ref.11		VAR_002197
	Natural variant	189 – 190	2	IA → VT.		VAR_013654
	Natural variant	191	1	A → T. Ref.4 Ref.7		VAR_011339
	Natural variant	194	1	T → A. Ref.4 Ref.5 Ref.6 Ref.7 Ref.15 Corresponds to variant rs2853508 [ dbSNP | Ensembl ].		VAR_011340
	Natural variant	229	1	A → T. Ref.4 Ref.5 Ref.6 Corresponds to variant rs2853509 [ dbSNP | Ensembl ].		VAR_011341
	Natural variant	236	1	L → I. Ref.5 Ref.6 Ref.15 Corresponds to variant rs3088309 [ dbSNP | Ensembl ].		VAR_013655
	Natural variant	251 – 258	8	Missing in mitochondrial myopathy; sporadic.		VAR_013657
	Natural variant	251	1	G → D in CMIH. Ref.17		VAR_013656
	Natural variant	251	1	G → S Associated with susceptibility to obesity. Ref.21		VAR_033059
	Natural variant	255	1	N → H in cardiomyopathy; fatal; post-partum. Ref.3		VAR_013658
	Natural variant	260	1	N → D. Ref.7		VAR_015573
	Natural variant	276	1	F → L in colorectal cancer. Ref.14		VAR_008389
	Natural variant	278	1	Y → C in multisystem disorder. Ref.18		VAR_013659
	Natural variant	290	1	G → D in exercise intolerance. Ref.12		VAR_013660
	Natural variant	306	1	I → T. Ref.5		VAR_013661
	Natural variant	316	1	M → T. Ref.15		VAR_013662
	Natural variant	329	1	A → T. Ref.5		VAR_013663
	Natural variant	330	1	A → T. Ref.6		VAR_013664
	Natural variant	334	1	I → V. Ref.5		VAR_013665
	Natural variant	339	1	G → E in mitochondrial myopathy. Ref.13		VAR_002198
	Natural variant	353	1	V → M. Ref.5		VAR_013666
	Natural variant	356	1	V → M in LHON; secondary mutation; does not seem to directly cause the disease. Ref.5 Ref.11		VAR_002199
	Natural variant	360	1	T → A. Ref.6 Corresponds to variant rs28357376 [ dbSNP | Ensembl ].		VAR_013667
	Natural variant	368	1	T → I. Ref.5 Ref.6		VAR_013668

Sequences

	Sequence		Length	Mass (Da)
	P00156 [UniParc]. Last modified October 3, 2012. Version 2. Checksum: 600E520C262E5498	FASTA	380	42,718
	10 20 30 40 50 60 MTPMRKTNPL MKLINHSFID LPTPSNISAW WNFGSLLGAC LILQITTGLF LAMHYSPDAS 70 80 90 100 110 120 TAFSSIAHIT RDVNYGWIIR YLHANGASMF FICLFLHIGR GLYYGSFLYS ETWNIGIILL 130 140 150 160 170 180 LATMATAFMG YVLPWGQMSF WGATVITNLL SAIPYIGTDL VQWIWGGYSV DSPTLTRFFT 190 200 210 220 230 240 FHFILPFIIA ALATLHLLFL HETGSNNPLG ITSHSDKITF HPYYTIKDAL GLLLFLLSLM 250 260 270 280 290 300 TLTLFSPDLL GDPDNYTLAN PLNTPPHIKP EWYFLFAYTI LRSVPNKLGG VLALLLSILI 310 320 330 340 350 360 LAMIPILHMS KQQSMMFRPL SQSLYWLLAA DLLILTWIGG QPVSYPFTII GQVASVLYFT 370 380 TILILMPTIS LIENKMLKWA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and organization of the human mitochondrial genome." Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L., Coulson A.R., Drouin J., Eperon I.C., Nierlich D.P., Roe B.A., Sanger F., Schreier P.H., Smith A.J.H., Staden R., Young I.G. Nature 290:457-465(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Tissue: Placenta.
[2]	"Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA." Andrews R.M., Kubacka I., Chinnery P.F., Lightowlers R.N., Turnbull D.M., Howell N. Nat. Genet. 23:147-147(1999) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION TO 7.
[3]	"Novel mutations in mitochondrial cytochrome b in fatal post partum cardiomyopathy." Marin-Garcia J., Ananthakrishnan R., Gonzalvo A., Goldenthal M.J. J. Inherit. Metab. Dis. 18:77-78(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-7 AND CARDIOMYOPATHY HIS-255. Tissue: Heart.
[4]	"Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs." Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N. Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-7; THR-191; ALA-194 AND THR-229. Tissue: Placenta.
[5]	"Mitochondrial genome variation and the origin of modern humans." Ingman M., Kaessmann H., Paeaebo S., Gyllensten U. Nature 408:708-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-378, VARIANTS ILE-7; SER-8; LEU-18; VAL-39; THR-78; THR-122; ALA-123; THR-153; ALA-194; THR-229; ILE-236; THR-306; THR-329; VAL-334; MET-353; MET-356 AND ILE-368.
[6]	"Major genomic mitochondrial lineages delineate early human expansions." Maca-Meyer N., Gonzalez A.M., Larruga J.M., Flores C., Cabrera V.M. BMC Genet. 2:13-13(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-378, VARIANTS ILE-7; SER-8; LEU-18; THR-122; VAL-164; 189-VAL-THR-190; ALA-194; THR-229; ILE-236; THR-330; ALA-360 AND ILE-368.
[7]	"Mitochondrial genome diversity of native Americans supports a single early entry of founder populations into America." Silva W.A. Jr., Bonatto S.L., Holanda A.J., Ribeiro-Dos-Santos A.K., Paixao B.M., Goldman G.H., Abe-Sandes K., Rodriguez-Delfin L., Barbosa M., Paco-Larson M.L., Petzl-Erler M.L., Valente V., Santos S.E., Zago M.A. Am. J. Hum. Genet. 71:187-192(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-378, VARIANTS ILE-7; THR-39; VAL-78; THR-191; ALA-194 AND ASP-260.
[8]	"Serendipitous cloning of a mitochondrial cDNA and its polymorphism." Spurr N.K., Bodmer W.F. Mol. Biol. Med. 2:239-249(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 269-380. Tissue: Lymphoblast.
[9]	"Mitochondrial encephalomyopathy and complex III deficiency associated with a stop-codon mutation in the cytochrome b gene." Keightley J.A., Anitori R., Burton M.D., Quan F., Buist N.R.M., Kennaway N.G. Am. J. Hum. Genet. 67:1400-1410(2000) [PubMed] [Europe PMC] [Abstract] Cited for: DISEASE.
[10]	"Normal variants of human mitochondrial DNA and translation products: the building of a reference data base." Marzuki S., Noer A.S., Lertrit P., Thyagarajan D., Kapsa R., Utthanaphol P., Byrne E. Hum. Genet. 88:139-145(1991) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS ILE-7 AND PRO-87.
[11]	"Mitochondrial DNA complex I and III mutations associated with Leber's hereditary optic neuropathy." Brown M.D., Voljavec A.S., Lott M.T., Torroni A., Yang C.C., Wallace D.C. Genetics 130:163-173(1992) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS LHON ASN-171 AND MET-356.
[12]	"A novel gly290asp mitochondrial cytochrome b mutation linked to a complex III deficiency in progressive exercise intolerance." Dumoulin R., Sagnol I., Ferlin T., Bozon D., Stepien G., Mousson B. Mol. Cell. Probes 10:389-391(1996) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT EXERCISE INTOLERANCE ASP-290.
[13]	"Missense mutation in the mtDNA cytochrome b gene in a patient with myopathy." Andreu A.L., Bruno C., Shanske S., Shtilbans A., Hirano M., Krishna S., Hayward L., Systrom D.S., Brown R.H. Jr., Dimauro S. Neurology 51:1444-1447(1998) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MM GLU-339.
[14]	"Somatic mutations of the mitochondrial genome in human colorectal tumours." Polyak K., Li Y., Zhu H., Lengauer C., Willson J.K.V., Markowitz S.D., Trush M.A., Kinzler K.W., Vogelstein B. Nat. Genet. 20:291-293(1998) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS COLORECTAL CANCER HIS-80 AND LEU-276.
[15]	"A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency." Valnot I., Kassis J., Chretien D., de Lonlay P., Parfait B., Munnich A., Kachaner J., Rustin P., Roetig A. Hum. Genet. 104:460-466(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HCM GLU-166, VARIANTS ILE-7; SER-8; LEU-18; ALA-194; ILE-236 AND THR-316.
[16]	"Exercise intolerance due to mutations in the cytochrome b gene of mitochondrial DNA." Andreu A.L., Hanna M.G., Reichmann H., Bruno C., Penn A.S., Tanji K., Pallotti F., Iwata S., Bonilla E., Lach B., Morgan-Hughes J., DiMauro S. N. Engl. J. Med. 341:1037-1044(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MM SER-34 AND 251-GLY--LEU-258 DEL.
[17]	"A missense mutation in the mitochondrial cytochrome b gene in a revisited case with histiocytoid cardiomyopathy." Andreu A.L., Checcarelli N., Iwata S., Shanske S., DiMauro S. Pediatr. Res. 48:311-314(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT CMIH ASP-251.
[18]	"Multisystem disorder associated with a missense mutation in the mitochondrial cytochrome b gene." Wibrand F., Ravn K., Schwartz M., Rosenberg T., Horn N., Vissing J. Ann. Neurol. 50:540-543(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MULTISYSTEM DISORDER CYS-278.
[19]	"Functional characterization of novel mutations in the human cytochrome b gene." Legros F., Chatzoglou E., Frachon P., de Baulny H.O., Laforet P., Jardel C., Godinot C., Lombes A. Eur. J. Hum. Genet. 9:510-518(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT EXERCISE INTOLERANCE PRO-151.
[20]	"Septo-optic dysplasia associated with a new mitochondrial cytochrome b mutation." Schuelke M., Krude H., Finckh B., Mayatepek E., Janssen A., Schmelz M., Trefz F., Trijbels F., Smeitink J. Ann. Neurol. 51:388-392(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT EXERCICE INTOLERANCE PRO-35.
[21]	"Association of the mitochondrial DNA 15497G/A polymorphism with obesity in a middle-aged and elderly Japanese population." Okura T., Koda M., Ando F., Niino N., Tanaka M., Shimokata H. Hum. Genet. 113:432-436(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT SER-251.
[22]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	V00662 Genomic DNA. Translation: CAA24038.1. J01415 Genomic DNA. Translation: AAB58955.3. U09500 Genomic DNA. Translation: AAA19775.1. D38112 Genomic DNA. Translation: BAA77674.1. AF346963 Genomic DNA. Translation: AAK17219.1. AF346964 Genomic DNA. Translation: AAK17232.2. AF346965 Genomic DNA. Translation: AAK17245.2. AF346966 Genomic DNA. Translation: AAK17258.1. AF346967 Genomic DNA. Translation: AAK17271.2. AF346968 Genomic DNA. Translation: AAK17284.2. AF346969 Genomic DNA. Translation: AAK17297.2. AF346970 Genomic DNA. Translation: AAK17310.2. AF346971 Genomic DNA. Translation: AAK17323.2. AF346972 Genomic DNA. Translation: AAK17336.2. AF346973 Genomic DNA. Translation: AAK17349.2. AF346974 Genomic DNA. Translation: AAK17362.2. AF346975 Genomic DNA. Translation: AAK17375.2. AF346976 Genomic DNA. Translation: AAK17388.1. AF346977 Genomic DNA. Translation: AAK17401.1. AF346978 Genomic DNA. Translation: AAK17414.1. AF346979 Genomic DNA. Translation: AAK17427.1. AF346980 Genomic DNA. Translation: AAK17440.2. AF346981 Genomic DNA. Translation: AAK17453.2. AF346982 Genomic DNA. Translation: AAK17466.1. AF346983 Genomic DNA. Translation: AAK17479.1. AF346984 Genomic DNA. Translation: AAK17492.2. AF346985 Genomic DNA. Translation: AAK17505.2. AF346986 Genomic DNA. Translation: AAK17518.2. AF346987 Genomic DNA. Translation: AAK17531.2. AF346988 Genomic DNA. Translation: AAK17544.1. AF346989 Genomic DNA. Translation: AAK17557.2. AF346990 Genomic DNA. Translation: AAK17570.1. AF346991 Genomic DNA. Translation: AAK17583.2. AF346992 Genomic DNA. Translation: AAK17596.2. AF346993 Genomic DNA. Translation: AAK17609.2. AF346994 Genomic DNA. Translation: AAK17622.2. AF346995 Genomic DNA. Translation: AAK17635.2. AF346996 Genomic DNA. Translation: AAK17648.2. AF346997 Genomic DNA. Translation: AAK17661.2. AF346998 Genomic DNA. Translation: AAK17674.2. AF346999 Genomic DNA. Translation: AAK17687.2. AF347000 Genomic DNA. Translation: AAK17700.1. AF347001 Genomic DNA. Translation: AAK17713.2. AF347002 Genomic DNA. Translation: AAK17726.2. AF347003 Genomic DNA. Translation: AAK17739.2. AF347004 Genomic DNA. Translation: AAK17752.2. AF347005 Genomic DNA. Translation: AAK17765.2. AF347006 Genomic DNA. Translation: AAK17778.2. AF347007 Genomic DNA. Translation: AAK17791.2. AF347008 Genomic DNA. Translation: AAK17804.2. AF347009 Genomic DNA. Translation: AAK17817.2. AF347010 Genomic DNA. Translation: AAK17830.2. AF347011 Genomic DNA. Translation: AAK17843.2. AF347012 Genomic DNA. Translation: AAK17856.2. AF347013 Genomic DNA. Translation: AAK17869.2. AF347014 Genomic DNA. Translation: AAK17882.2. AF347015 Genomic DNA. Translation: AAK17895.2. AF381981 Genomic DNA. Translation: AAL54394.1. AF381982 Genomic DNA. Translation: AAL54409.1. AF381983 Genomic DNA. Translation: AAL54422.1. AF381984 Genomic DNA. Translation: AAL54435.1. AF381985 Genomic DNA. Translation: AAL54448.1. AF381986 Genomic DNA. Translation: AAL54461.1. AF381987 Genomic DNA. Translation: AAL54474.1. AF381988 Genomic DNA. Translation: AAL54487.1. AF381989 Genomic DNA. Translation: AAL54500.1. AF381990 Genomic DNA. Translation: AAL54513.1. AF381991 Genomic DNA. Translation: AAL54526.1. AF381992 Genomic DNA. Translation: AAL54539.1. AF381993 Genomic DNA. Translation: AAL54552.1. AF381994 Genomic DNA. Translation: AAL54565.1. AF381995 Genomic DNA. Translation: AAL54578.1. AF381996 Genomic DNA. Translation: AAL54591.1. AF381997 Genomic DNA. Translation: AAL54604.1. AF381998 Genomic DNA. Translation: AAL54617.1. AF381999 Genomic DNA. Translation: AAL54630.1. AF382000 Genomic DNA. Translation: AAL54643.1. AF382001 Genomic DNA. Translation: AAL54656.1. AF382002 Genomic DNA. Translation: AAL54669.1. AF382003 Genomic DNA. Translation: AAL54682.1. AF382004 Genomic DNA. Translation: AAL54695.1. AF382005 Genomic DNA. Translation: AAL54708.1. AF382006 Genomic DNA. Translation: AAL54721.1. AF382007 Genomic DNA. Translation: AAL54734.1. AF382008 Genomic DNA. Translation: AAL54747.1. AF382009 Genomic DNA. Translation: AAL54760.1. AF382010 Genomic DNA. Translation: AAL54773.1. AF382011 Genomic DNA. Translation: AAL54786.1. AF382012 Genomic DNA. Translation: AAL54799.1. AF382013 Genomic DNA. Translation: AAL54812.1. AF465942 Genomic DNA. Translation: AAN14559.1. AF465945 Genomic DNA. Translation: AAN14592.1. AF465946 Genomic DNA. Translation: AAN14603.1. AF465947 Genomic DNA. Translation: AAN14614.1. AF465948 Genomic DNA. Translation: AAN14625.1. AF465949 Genomic DNA. Translation: AAN14636.1. AF465953 Genomic DNA. Translation: AAN14680.1. AF465956 Genomic DNA. Translation: AAN14713.1. AF465968 Genomic DNA. Translation: AAN14845.1. AF465971 Genomic DNA. Translation: AAN14878.1. AF465972 Genomic DNA. Translation: AAN14889.1. AF465973 Genomic DNA. Translation: AAN14900.1. AF465974 Genomic DNA. Translation: AAN14911.1. AF465975 Genomic DNA. Translation: AAN14922.1. AF465977 Genomic DNA. Translation: AAN14944.1. M28016 mRNA. Translation: AAA31851.1.
PIR	CBHU. A00151.
RefSeq	YP_003024038.1. NC_012920.1.
3D structure databases
ProteinModelPortal	P00156.
SMR	P00156. Positions 15-379.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	110619. 1 interaction.
IntAct	P00156. 1 interaction.
Chemistry
DrugBank	DB01117. Atovaquone.
PTM databases
PhosphoSite	P00156.
Polymorphism databases
DMDM	408360043.
Proteomic databases
PaxDb	P00156.
PRIDE	P00156.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361789; ENSP00000354554; ENSG00000198727.
GeneID	4519.
KEGG	hsa:4519.
Organism-specific databases
CTD	4519.
GeneCards	GCMTP014749.
HGNC	HGNC:7427. MT-CYB.
HPA	CAB032215.
MIM	500000. phenotype. 516020. gene. 535000. phenotype.
neXtProt	NX_P00156.
Orphanet	137675. Histiocytoid cardiomyopathy. 1460. Isolated CoQ-cytochrome C reductase deficiency. 104. Leber hereditary optic neuropathy.
PharmGKB	PA31234.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1290.
HOVERGEN	HBG017694.
InParanoid	P00156.
KO	K00412.
OMA	FFFVAVY.
OrthoDB	EOG7BGHKX.
ProtClustDB	MTH00100.
TreeFam	TF353088.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
Genevestigator	P00156.
Family and domain databases
Gene3D	1.20.810.10. 1 hit.
InterPro	IPR016175. Cyt_b/b6. IPR005798. Cyt_b/b6_C. IPR005797. Cyt_b/b6_N. IPR027387. Cytb/b6-like. IPR016174. Di-haem_cyt_TM. [Graphical view]
PANTHER	PTHR19271:SF0. PTHR19271:SF0. 1 hit.
Pfam	PF00032. Cytochrom_B_C. 1 hit. PF13631. Cytochrom_B_N_2. 1 hit. [Graphical view]
SUPFAM	SSF81342. SSF81342. 1 hit. SSF81648. SSF81648. 1 hit.
PROSITE	PS51003. CYTB_CTER. 1 hit. PS51002. CYTB_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GeneWiki	MT-CYB.
NextBio	17445.
PRO	P00156.
SOURCE	Search...

Entry information

Entry name

CYB_HUMAN

Accession

Primary (citable) accession number: P00156
Secondary accession number(s): Q34786 , Q8HBR6, Q8HNQ0, Q8HNQ1, Q8HNQ9, Q8HNR4, Q8HNR7, Q8W7V8, Q8WCV9, Q8WCY2, Q8WCY7, Q8WCY8, Q9B1A6, Q9B1B6, Q9B1B8, Q9B1D4, Q9B1X6, Q9B2V0, Q9B2V8, Q9B2W0, Q9B2W3, Q9B2W8, Q9B2X1, Q9B2X7, Q9B2X9, Q9B2Y3, Q9B2Z0, Q9B2Z4, Q9T6H6, Q9T9Y0, Q9TEH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	October 3, 2012
Last modified:	April 16, 2014
This is version 160 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.