Cytochrome b - MT-CYB - Homo sapiens (Human)

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P00156 (CYB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 163. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome b

Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit

Gene names

Name:	MT-CYB
Synonyms:	COB, CYTB, MTCYB

Encoded on

Mitochondrion

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis By similarity.
Cofactor	Binds 2 heme groups non-covalently By similarity.
Subunit structure	The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Involvement in disease	Defects in MT-CYB are a rare cause of mitochondrial dysfunction underlying different myopathies. They include mitochondrial encephalomyopathy, hypertrophic cardiomyopathy (HCM), and sporadic mitochondrial myopathy (MM). In mitochondrial myopathy, exercise intolerance is the predominant symptom. Additional features include lactic acidosis, muscle weakness and/or myoglobinuria. Defects in MTCYB are also found in cases of exercise intolerance accompanied by deafness, mental retardation, retinitis pigmentosa, cataract, growth retardation, epilepsy (multisystem disorder). Ref.9 Ref.15 Cardiomyopathy, infantile histiocytoid (CMIH) [MIM:500000]: A heart disease characterized by the presence of pale granular foamy histiocyte-like cells within the myocardium. It usually affects children younger than 2 years of age, with a clear predominance of females over males. Infants present with dysrhythmia or cardiac arrest. The clinical course is usually fulminant, sometimes simulating sudden infant death syndrome. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.17 Leber hereditary optic neuropathy (LHON) [MIM:535000]: A maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. Note: The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Ref.9 Ref.11
Miscellaneous	Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm By similarity.
Sequence similarities	Belongs to the cytochrome b family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Polymorphism
Disease	Cardiomyopathy Cataract Deafness Disease mutation Leber hereditary optic neuropathy
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular metabolic process Traceable author statement. Source: Reactome hydrogen ion transmembrane transport Non-traceable author statement Ref.8. Source: GOC mitochondrial electron transport, ubiquinol to cytochrome c Non-traceable author statement Ref.8. Source: UniProtKB respiratory electron transport chain Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	mitochondrial inner membrane Traceable author statement. Source: Reactome mitochondrial respiratory chain complex III Non-traceable author statement Ref.8. Source: UniProtKB mitochondrion Inferred from direct assay PubMed 20833797. Source: UniProt
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquinol-cytochrome-c reductase activity Non-traceable author statement Ref.8. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 380

380

Cytochrome b

PRO_0000061045

Regions

Transmembrane

33 – 53

Helical; Potential

Transmembrane

76 – 98

Helical; Potential

Transmembrane

115 – 135

Helical; Potential

Transmembrane

138 – 158

Helical; Potential

Transmembrane

178 – 198

Helical; Potential

Transmembrane

230 – 250

Helical; Potential

Transmembrane

288 – 308

Helical; Potential

Transmembrane

323 – 343

Helical; Potential

Transmembrane

349 – 369

Helical; Potential

Sites

Metal binding

Iron 1 (heme b562 axial ligand)

Metal binding

Iron 2 (heme b566 axial ligand)

Metal binding

182

Iron 1 (heme b562 axial ligand)

Metal binding

196

Iron 2 (heme b566 axial ligand)

Natural variations

Natural variant

T → I. Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.10 Ref.15 Ref.22
Corresponds to variant rs3135031 [ dbSNP | Ensembl ].

VAR_008585

Natural variant

N → S. Ref.5 Ref.6 Ref.15
Corresponds to variant rs28357679 [ dbSNP | Ensembl ].

VAR_013643

Natural variant

F → L. Ref.5 Ref.6 Ref.15
Corresponds to variant rs28357681 [ dbSNP | Ensembl ].

VAR_013644

Natural variant

G → S in mitochondrial myopathy; sporadic. Ref.16

VAR_013645

Natural variant

S → P in exercice intolerance; with cardiomyopathy and septo-optic dysplasia. Ref.20

VAR_033058

Natural variant

A → T. Ref.7

VAR_015571

Natural variant

A → V. Ref.5

VAR_013646

Natural variant

I → T. Ref.5

VAR_013647

Natural variant

I → V. Ref.7

VAR_015572

Natural variant

R → H in colorectal cancer. Ref.14

VAR_008388

Natural variant

A → P. Ref.10

VAR_008586

Natural variant

122

A → T. Ref.5 Ref.6
Corresponds to variant rs28357685 [ dbSNP | Ensembl ].

VAR_013648

Natural variant

123

T → A. Ref.5

VAR_013649

Natural variant

151

S → P in exercise intolerance. Ref.19

VAR_013650

Natural variant

153

I → T. Ref.5
Corresponds to variant rs28357687 [ dbSNP | Ensembl ].

VAR_013651

Natural variant

164

I → V. Ref.6

VAR_013652

Natural variant

166

G → E in hyperthrophic cardiomyopathy. Ref.15

VAR_013653

Natural variant

171

D → N in LHON; secondary mutation; does not seem to directly cause the disease. Ref.11

VAR_002197

Natural variant

189 – 190

IA → VT.

VAR_013654

Natural variant

191

A → T. Ref.4 Ref.7

VAR_011339

Natural variant

194

T → A. Ref.4 Ref.5 Ref.6 Ref.7 Ref.15
Corresponds to variant rs2853508 [ dbSNP | Ensembl ].

VAR_011340

Natural variant

229

A → T. Ref.4 Ref.5 Ref.6
Corresponds to variant rs2853509 [ dbSNP | Ensembl ].

VAR_011341

Natural variant

236

L → I. Ref.5 Ref.6 Ref.15
Corresponds to variant rs3088309 [ dbSNP | Ensembl ].

VAR_013655

Natural variant

251 – 258

Missing in mitochondrial myopathy; sporadic.

VAR_013657

Natural variant

251

G → D in CMIH. Ref.17

VAR_013656

Natural variant

251

G → S Associated with susceptibility to obesity. Ref.21

VAR_033059

Natural variant

255

N → H in cardiomyopathy; fatal; post-partum. Ref.3

VAR_013658

Natural variant

260

N → D. Ref.7

VAR_015573

Natural variant

276

F → L in colorectal cancer. Ref.14

VAR_008389

Natural variant

278

Y → C in multisystem disorder. Ref.18

VAR_013659

Natural variant

290

G → D in exercise intolerance. Ref.12

VAR_013660

Natural variant

306

I → T. Ref.5

VAR_013661

Natural variant

316

M → T. Ref.15

VAR_013662

Natural variant

329

A → T. Ref.5

VAR_013663

Natural variant

330

A → T. Ref.6

VAR_013664

Natural variant

334

I → V. Ref.5

VAR_013665

Natural variant

339

G → E in mitochondrial myopathy. Ref.13

VAR_002198

Natural variant

353

V → M. Ref.5

VAR_013666

Natural variant

356

V → M in LHON; secondary mutation; does not seem to directly cause the disease. Ref.5 Ref.11

VAR_002199

Natural variant

360

T → A. Ref.6
Corresponds to variant rs28357376 [ dbSNP | Ensembl ].

VAR_013667

Natural variant

368

T → I. Ref.5 Ref.6

VAR_013668

Sequences

Sequence

Length

Mass (Da)

Tools

P00156 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 600E520C262E5498
Show »

FASTA

380

42,718

        10         20         30         40         50         60 
MTPMRKTNPL MKLINHSFID LPTPSNISAW WNFGSLLGAC LILQITTGLF LAMHYSPDAS 

        70         80         90        100        110        120 
TAFSSIAHIT RDVNYGWIIR YLHANGASMF FICLFLHIGR GLYYGSFLYS ETWNIGIILL 

       130        140        150        160        170        180 
LATMATAFMG YVLPWGQMSF WGATVITNLL SAIPYIGTDL VQWIWGGYSV DSPTLTRFFT 

       190        200        210        220        230        240 
FHFILPFIIA ALATLHLLFL HETGSNNPLG ITSHSDKITF HPYYTIKDAL GLLLFLLSLM 

       250        260        270        280        290        300 
TLTLFSPDLL GDPDNYTLAN PLNTPPHIKP EWYFLFAYTI LRSVPNKLGG VLALLLSILI 

       310        320        330        340        350        360 
LAMIPILHMS KQQSMMFRPL SQSLYWLLAA DLLILTWIGG QPVSYPFTII GQVASVLYFT 

       370        380 
TILILMPTIS LIENKMLKWA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and organization of the human mitochondrial genome." Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L., Coulson A.R., Drouin J., Eperon I.C., Nierlich D.P., Roe B.A., Sanger F., Schreier P.H., Smith A.J.H., Staden R., Young I.G. Nature 290:457-465(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Tissue: Placenta.
[2]	"Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA." Andrews R.M., Kubacka I., Chinnery P.F., Lightowlers R.N., Turnbull D.M., Howell N. Nat. Genet. 23:147-147(1999) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION TO 7.
[3]	"Novel mutations in mitochondrial cytochrome b in fatal post partum cardiomyopathy." Marin-Garcia J., Ananthakrishnan R., Gonzalvo A., Goldenthal M.J. J. Inherit. Metab. Dis. 18:77-78(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-7 AND CARDIOMYOPATHY HIS-255. Tissue: Heart.
[4]	"Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs." Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N. Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-7; THR-191; ALA-194 AND THR-229. Tissue: Placenta.
[5]	"Mitochondrial genome variation and the origin of modern humans." Ingman M., Kaessmann H., Paeaebo S., Gyllensten U. Nature 408:708-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-378, VARIANTS ILE-7; SER-8; LEU-18; VAL-39; THR-78; THR-122; ALA-123; THR-153; ALA-194; THR-229; ILE-236; THR-306; THR-329; VAL-334; MET-353; MET-356 AND ILE-368.
[6]	"Major genomic mitochondrial lineages delineate early human expansions." Maca-Meyer N., Gonzalez A.M., Larruga J.M., Flores C., Cabrera V.M. BMC Genet. 2:13-13(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-378, VARIANTS ILE-7; SER-8; LEU-18; THR-122; VAL-164; 189-VAL-THR-190; ALA-194; THR-229; ILE-236; THR-330; ALA-360 AND ILE-368.
[7]	"Mitochondrial genome diversity of native Americans supports a single early entry of founder populations into America." Silva W.A. Jr., Bonatto S.L., Holanda A.J., Ribeiro-Dos-Santos A.K., Paixao B.M., Goldman G.H., Abe-Sandes K., Rodriguez-Delfin L., Barbosa M., Paco-Larson M.L., Petzl-Erler M.L., Valente V., Santos S.E., Zago M.A. Am. J. Hum. Genet. 71:187-192(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-378, VARIANTS ILE-7; THR-39; VAL-78; THR-191; ALA-194 AND ASP-260.
[8]	"Serendipitous cloning of a mitochondrial cDNA and its polymorphism." Spurr N.K., Bodmer W.F. Mol. Biol. Med. 2:239-249(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 269-380. Tissue: Lymphoblast.
[9]	"Mitochondrial encephalomyopathy and complex III deficiency associated with a stop-codon mutation in the cytochrome b gene." Keightley J.A., Anitori R., Burton M.D., Quan F., Buist N.R.M., Kennaway N.G. Am. J. Hum. Genet. 67:1400-1410(2000) [PubMed] [Europe PMC] [Abstract] Cited for: DISEASE.
[10]	"Normal variants of human mitochondrial DNA and translation products: the building of a reference data base." Marzuki S., Noer A.S., Lertrit P., Thyagarajan D., Kapsa R., Utthanaphol P., Byrne E. Hum. Genet. 88:139-145(1991) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS ILE-7 AND PRO-87.
[11]	"Mitochondrial DNA complex I and III mutations associated with Leber's hereditary optic neuropathy." Brown M.D., Voljavec A.S., Lott M.T., Torroni A., Yang C.C., Wallace D.C. Genetics 130:163-173(1992) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS LHON ASN-171 AND MET-356.
[12]	"A novel gly290asp mitochondrial cytochrome b mutation linked to a complex III deficiency in progressive exercise intolerance." Dumoulin R., Sagnol I., Ferlin T., Bozon D., Stepien G., Mousson B. Mol. Cell. Probes 10:389-391(1996) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT EXERCISE INTOLERANCE ASP-290.
[13]	"Missense mutation in the mtDNA cytochrome b gene in a patient with myopathy." Andreu A.L., Bruno C., Shanske S., Shtilbans A., Hirano M., Krishna S., Hayward L., Systrom D.S., Brown R.H. Jr., Dimauro S. Neurology 51:1444-1447(1998) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MM GLU-339.
[14]	"Somatic mutations of the mitochondrial genome in human colorectal tumours." Polyak K., Li Y., Zhu H., Lengauer C., Willson J.K.V., Markowitz S.D., Trush M.A., Kinzler K.W., Vogelstein B. Nat. Genet. 20:291-293(1998) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS COLORECTAL CANCER HIS-80 AND LEU-276.
[15]	"A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency." Valnot I., Kassis J., Chretien D., de Lonlay P., Parfait B., Munnich A., Kachaner J., Rustin P., Roetig A. Hum. Genet. 104:460-466(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HCM GLU-166, VARIANTS ILE-7; SER-8; LEU-18; ALA-194; ILE-236 AND THR-316.
[16]	"Exercise intolerance due to mutations in the cytochrome b gene of mitochondrial DNA." Andreu A.L., Hanna M.G., Reichmann H., Bruno C., Penn A.S., Tanji K., Pallotti F., Iwata S., Bonilla E., Lach B., Morgan-Hughes J., DiMauro S. N. Engl. J. Med. 341:1037-1044(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MM SER-34 AND 251-GLY--LEU-258 DEL.
[17]	"A missense mutation in the mitochondrial cytochrome b gene in a revisited case with histiocytoid cardiomyopathy." Andreu A.L., Checcarelli N., Iwata S., Shanske S., DiMauro S. Pediatr. Res. 48:311-314(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT CMIH ASP-251.
[18]	"Multisystem disorder associated with a missense mutation in the mitochondrial cytochrome b gene." Wibrand F., Ravn K., Schwartz M., Rosenberg T., Horn N., Vissing J. Ann. Neurol. 50:540-543(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MULTISYSTEM DISORDER CYS-278.
[19]	"Functional characterization of novel mutations in the human cytochrome b gene." Legros F., Chatzoglou E., Frachon P., de Baulny H.O., Laforet P., Jardel C., Godinot C., Lombes A. Eur. J. Hum. Genet. 9:510-518(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT EXERCISE INTOLERANCE PRO-151.
[20]	"Septo-optic dysplasia associated with a new mitochondrial cytochrome b mutation." Schuelke M., Krude H., Finckh B., Mayatepek E., Janssen A., Schmelz M., Trefz F., Trijbels F., Smeitink J. Ann. Neurol. 51:388-392(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT EXERCICE INTOLERANCE PRO-35.
[21]	"Association of the mitochondrial DNA 15497G/A polymorphism with obesity in a middle-aged and elderly Japanese population." Okura T., Koda M., Ando F., Niino N., Tanaka M., Shimokata H. Hum. Genet. 113:432-436(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT SER-251.
[22]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	V00662 Genomic DNA. Translation: CAA24038.1. J01415 Genomic DNA. Translation: AAB58955.3. U09500 Genomic DNA. Translation: AAA19775.1. D38112 Genomic DNA. Translation: BAA77674.1. AF346963 Genomic DNA. Translation: AAK17219.1. AF346964 Genomic DNA. Translation: AAK17232.2. AF346965 Genomic DNA. Translation: AAK17245.2. AF346966 Genomic DNA. Translation: AAK17258.1. AF346967 Genomic DNA. Translation: AAK17271.2. AF346968 Genomic DNA. Translation: AAK17284.2. AF346969 Genomic DNA. Translation: AAK17297.2. AF346970 Genomic DNA. Translation: AAK17310.2. AF346971 Genomic DNA. Translation: AAK17323.2. AF346972 Genomic DNA. Translation: AAK17336.2. AF346973 Genomic DNA. Translation: AAK17349.2. AF346974 Genomic DNA. Translation: AAK17362.2. AF346975 Genomic DNA. Translation: AAK17375.2. AF346976 Genomic DNA. Translation: AAK17388.1. AF346977 Genomic DNA. Translation: AAK17401.1. AF346978 Genomic DNA. Translation: AAK17414.1. AF346979 Genomic DNA. Translation: AAK17427.1. AF346980 Genomic DNA. Translation: AAK17440.2. AF346981 Genomic DNA. Translation: AAK17453.2. AF346982 Genomic DNA. Translation: AAK17466.1. AF346983 Genomic DNA. Translation: AAK17479.1. AF346984 Genomic DNA. Translation: AAK17492.2. AF346985 Genomic DNA. Translation: AAK17505.2. AF346986 Genomic DNA. Translation: AAK17518.2. AF346987 Genomic DNA. Translation: AAK17531.2. AF346988 Genomic DNA. Translation: AAK17544.1. AF346989 Genomic DNA. Translation: AAK17557.2. AF346990 Genomic DNA. Translation: AAK17570.1. AF346991 Genomic DNA. Translation: AAK17583.2. AF346992 Genomic DNA. Translation: AAK17596.2. AF346993 Genomic DNA. Translation: AAK17609.2. AF346994 Genomic DNA. Translation: AAK17622.2. AF346995 Genomic DNA. Translation: AAK17635.2. AF346996 Genomic DNA. Translation: AAK17648.2. AF346997 Genomic DNA. Translation: AAK17661.2. AF346998 Genomic DNA. Translation: AAK17674.2. AF346999 Genomic DNA. Translation: AAK17687.2. AF347000 Genomic DNA. Translation: AAK17700.1. AF347001 Genomic DNA. Translation: AAK17713.2. AF347002 Genomic DNA. Translation: AAK17726.2. AF347003 Genomic DNA. Translation: AAK17739.2. AF347004 Genomic DNA. Translation: AAK17752.2. AF347005 Genomic DNA. Translation: AAK17765.2. AF347006 Genomic DNA. Translation: AAK17778.2. AF347007 Genomic DNA. Translation: AAK17791.2. AF347008 Genomic DNA. Translation: AAK17804.2. AF347009 Genomic DNA. Translation: AAK17817.2. AF347010 Genomic DNA. Translation: AAK17830.2. AF347011 Genomic DNA. Translation: AAK17843.2. AF347012 Genomic DNA. Translation: AAK17856.2. AF347013 Genomic DNA. Translation: AAK17869.2. AF347014 Genomic DNA. Translation: AAK17882.2. AF347015 Genomic DNA. Translation: AAK17895.2. AF381981 Genomic DNA. Translation: AAL54394.1. AF381982 Genomic DNA. Translation: AAL54409.1. AF381983 Genomic DNA. Translation: AAL54422.1. AF381984 Genomic DNA. Translation: AAL54435.1. AF381985 Genomic DNA. Translation: AAL54448.1. AF381986 Genomic DNA. Translation: AAL54461.1. AF381987 Genomic DNA. Translation: AAL54474.1. AF381988 Genomic DNA. Translation: AAL54487.1. AF381989 Genomic DNA. Translation: AAL54500.1. AF381990 Genomic DNA. Translation: AAL54513.1. AF381991 Genomic DNA. Translation: AAL54526.1. AF381992 Genomic DNA. Translation: AAL54539.1. AF381993 Genomic DNA. Translation: AAL54552.1. AF381994 Genomic DNA. Translation: AAL54565.1. AF381995 Genomic DNA. Translation: AAL54578.1. AF381996 Genomic DNA. Translation: AAL54591.1. AF381997 Genomic DNA. Translation: AAL54604.1. AF381998 Genomic DNA. Translation: AAL54617.1. AF381999 Genomic DNA. Translation: AAL54630.1. AF382000 Genomic DNA. Translation: AAL54643.1. AF382001 Genomic DNA. Translation: AAL54656.1. AF382002 Genomic DNA. Translation: AAL54669.1. AF382003 Genomic DNA. Translation: AAL54682.1. AF382004 Genomic DNA. Translation: AAL54695.1. AF382005 Genomic DNA. Translation: AAL54708.1. AF382006 Genomic DNA. Translation: AAL54721.1. AF382007 Genomic DNA. Translation: AAL54734.1. AF382008 Genomic DNA. Translation: AAL54747.1. AF382009 Genomic DNA. Translation: AAL54760.1. AF382010 Genomic DNA. Translation: AAL54773.1. AF382011 Genomic DNA. Translation: AAL54786.1. AF382012 Genomic DNA. Translation: AAL54799.1. AF382013 Genomic DNA. Translation: AAL54812.1. AF465942 Genomic DNA. Translation: AAN14559.1. AF465945 Genomic DNA. Translation: AAN14592.1. AF465946 Genomic DNA. Translation: AAN14603.1. AF465947 Genomic DNA. Translation: AAN14614.1. AF465948 Genomic DNA. Translation: AAN14625.1. AF465949 Genomic DNA. Translation: AAN14636.1. AF465953 Genomic DNA. Translation: AAN14680.1. AF465956 Genomic DNA. Translation: AAN14713.1. AF465968 Genomic DNA. Translation: AAN14845.1. AF465971 Genomic DNA. Translation: AAN14878.1. AF465972 Genomic DNA. Translation: AAN14889.1. AF465973 Genomic DNA. Translation: AAN14900.1. AF465974 Genomic DNA. Translation: AAN14911.1. AF465975 Genomic DNA. Translation: AAN14922.1. AF465977 Genomic DNA. Translation: AAN14944.1. M28016 mRNA. Translation: AAA31851.1.
PIR	CBHU. A00151.
RefSeq	YP_003024038.1. NC_012920.1.
3D structure databases
ProteinModelPortal	P00156.
SMR	P00156. Positions 15-379.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	110619. 1 interaction.
IntAct	P00156. 1 interaction.
Chemistry
DrugBank	DB01117. Atovaquone.
PTM databases
PhosphoSite	P00156.
Polymorphism databases
DMDM	408360043.
Proteomic databases
MaxQB	P00156.
PaxDb	P00156.
PRIDE	P00156.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361789; ENSP00000354554; ENSG00000198727.
GeneID	4519.
KEGG	hsa:4519.
Organism-specific databases
CTD	4519.
GeneCards	GCMTP014749.
GeneReviews	MT-CYB.
HGNC	HGNC:7427. MT-CYB.
HPA	CAB032215.
MIM	500000. phenotype. 516020. gene. 535000. phenotype.
neXtProt	NX_P00156.
Orphanet	137675. Histiocytoid cardiomyopathy. 1460. Isolated CoQ-cytochrome C reductase deficiency. 104. Leber hereditary optic neuropathy.
PharmGKB	PA31234.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1290.
HOVERGEN	HBG017694.
InParanoid	P00156.
KO	K00412.
OMA	NTINQIF.
OrthoDB	EOG7BGHKX.
PhylomeDB	P00156.
TreeFam	TF353088.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
Genevestigator	P00156.
Family and domain databases
Gene3D	1.20.810.10. 1 hit.
InterPro	IPR005798. Cyt_b/b6_C. IPR005797. Cyt_b/b6_N. IPR027387. Cytb/b6-like. IPR016174. Di-haem_cyt_TM. [Graphical view]
Pfam	PF00032. Cytochrom_B_C. 1 hit. PF13631. Cytochrom_B_N_2. 1 hit. [Graphical view]
SUPFAM	SSF81342. SSF81342. 1 hit. SSF81648. SSF81648. 1 hit.
PROSITE	PS51003. CYTB_CTER. 1 hit. PS51002. CYTB_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GeneWiki	MT-CYB.
NextBio	17445.
PRO	P00156.
SOURCE	Search...

Entry information

Entry name

CYB_HUMAN

Accession

Primary (citable) accession number: P00156
Secondary accession number(s): Q34786

Q9TEH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	October 3, 2012
Last modified:	July 9, 2014
This is version 163 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents