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P00156 (CYB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 163. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome b
Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Gene names
Name:MT-CYB
Synonyms:COB, CYTB, MTCYB
Encoded onMitochondrion
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis By similarity.

Cofactor

Binds 2 heme groups non-covalently By similarity.

Subunit structure

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Involvement in disease

Defects in MT-CYB are a rare cause of mitochondrial dysfunction underlying different myopathies. They include mitochondrial encephalomyopathy, hypertrophic cardiomyopathy (HCM), and sporadic mitochondrial myopathy (MM). In mitochondrial myopathy, exercise intolerance is the predominant symptom. Additional features include lactic acidosis, muscle weakness and/or myoglobinuria. Defects in MTCYB are also found in cases of exercise intolerance accompanied by deafness, mental retardation, retinitis pigmentosa, cataract, growth retardation, epilepsy (multisystem disorder). Ref.9 Ref.15

Cardiomyopathy, infantile histiocytoid (CMIH) [MIM:500000]: A heart disease characterized by the presence of pale granular foamy histiocyte-like cells within the myocardium. It usually affects children younger than 2 years of age, with a clear predominance of females over males. Infants present with dysrhythmia or cardiac arrest. The clinical course is usually fulminant, sometimes simulating sudden infant death syndrome.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.17

Leber hereditary optic neuropathy (LHON) [MIM:535000]: A maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.
Note: The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Ref.9 Ref.11

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm By similarity.

Sequence similarities

Belongs to the cytochrome b family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Cytochrome b
PRO_0000061045

Regions

Transmembrane33 – 5321Helical; Potential
Transmembrane76 – 9823Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane138 – 15821Helical; Potential
Transmembrane178 – 19821Helical; Potential
Transmembrane230 – 25021Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane323 – 34321Helical; Potential
Transmembrane349 – 36921Helical; Potential

Sites

Metal binding831Iron 1 (heme b562 axial ligand)
Metal binding971Iron 2 (heme b566 axial ligand)
Metal binding1821Iron 1 (heme b562 axial ligand)
Metal binding1961Iron 2 (heme b566 axial ligand)

Natural variations

Natural variant71T → I. Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.10 Ref.15 Ref.22
Corresponds to variant rs3135031 [ dbSNP | Ensembl ].
VAR_008585
Natural variant81N → S. Ref.5 Ref.6 Ref.15
Corresponds to variant rs28357679 [ dbSNP | Ensembl ].
VAR_013643
Natural variant181F → L. Ref.5 Ref.6 Ref.15
Corresponds to variant rs28357681 [ dbSNP | Ensembl ].
VAR_013644
Natural variant341G → S in mitochondrial myopathy; sporadic. Ref.16
VAR_013645
Natural variant351S → P in exercice intolerance; with cardiomyopathy and septo-optic dysplasia. Ref.20
VAR_033058
Natural variant391A → T. Ref.7
VAR_015571
Natural variant391A → V. Ref.5
VAR_013646
Natural variant781I → T. Ref.5
VAR_013647
Natural variant781I → V. Ref.7
VAR_015572
Natural variant801R → H in colorectal cancer. Ref.14
VAR_008388
Natural variant871A → P. Ref.10
VAR_008586
Natural variant1221A → T. Ref.5 Ref.6
Corresponds to variant rs28357685 [ dbSNP | Ensembl ].
VAR_013648
Natural variant1231T → A. Ref.5
VAR_013649
Natural variant1511S → P in exercise intolerance. Ref.19
VAR_013650
Natural variant1531I → T. Ref.5
Corresponds to variant rs28357687 [ dbSNP | Ensembl ].
VAR_013651
Natural variant1641I → V. Ref.6
VAR_013652
Natural variant1661G → E in hyperthrophic cardiomyopathy. Ref.15
VAR_013653
Natural variant1711D → N in LHON; secondary mutation; does not seem to directly cause the disease. Ref.11
VAR_002197
Natural variant189 – 1902IA → VT.
VAR_013654
Natural variant1911A → T. Ref.4 Ref.7
VAR_011339
Natural variant1941T → A. Ref.4 Ref.5 Ref.6 Ref.7 Ref.15
Corresponds to variant rs2853508 [ dbSNP | Ensembl ].
VAR_011340
Natural variant2291A → T. Ref.4 Ref.5 Ref.6
Corresponds to variant rs2853509 [ dbSNP | Ensembl ].
VAR_011341
Natural variant2361L → I. Ref.5 Ref.6 Ref.15
Corresponds to variant rs3088309 [ dbSNP | Ensembl ].
VAR_013655
Natural variant251 – 2588Missing in mitochondrial myopathy; sporadic.
VAR_013657
Natural variant2511G → D in CMIH. Ref.17
VAR_013656
Natural variant2511G → S Associated with susceptibility to obesity. Ref.21
VAR_033059
Natural variant2551N → H in cardiomyopathy; fatal; post-partum. Ref.3
VAR_013658
Natural variant2601N → D. Ref.7
VAR_015573
Natural variant2761F → L in colorectal cancer. Ref.14
VAR_008389
Natural variant2781Y → C in multisystem disorder. Ref.18
VAR_013659
Natural variant2901G → D in exercise intolerance. Ref.12
VAR_013660
Natural variant3061I → T. Ref.5
VAR_013661
Natural variant3161M → T. Ref.15
VAR_013662
Natural variant3291A → T. Ref.5
VAR_013663
Natural variant3301A → T. Ref.6
VAR_013664
Natural variant3341I → V. Ref.5
VAR_013665
Natural variant3391G → E in mitochondrial myopathy. Ref.13
VAR_002198
Natural variant3531V → M. Ref.5
VAR_013666
Natural variant3561V → M in LHON; secondary mutation; does not seem to directly cause the disease. Ref.5 Ref.11
VAR_002199
Natural variant3601T → A. Ref.6
Corresponds to variant rs28357376 [ dbSNP | Ensembl ].
VAR_013667
Natural variant3681T → I. Ref.5 Ref.6
VAR_013668

Sequences

Sequence LengthMass (Da)Tools
P00156 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 600E520C262E5498

FASTA38042,718
        10         20         30         40         50         60 
MTPMRKTNPL MKLINHSFID LPTPSNISAW WNFGSLLGAC LILQITTGLF LAMHYSPDAS 

        70         80         90        100        110        120 
TAFSSIAHIT RDVNYGWIIR YLHANGASMF FICLFLHIGR GLYYGSFLYS ETWNIGIILL 

       130        140        150        160        170        180 
LATMATAFMG YVLPWGQMSF WGATVITNLL SAIPYIGTDL VQWIWGGYSV DSPTLTRFFT 

       190        200        210        220        230        240 
FHFILPFIIA ALATLHLLFL HETGSNNPLG ITSHSDKITF HPYYTIKDAL GLLLFLLSLM 

       250        260        270        280        290        300 
TLTLFSPDLL GDPDNYTLAN PLNTPPHIKP EWYFLFAYTI LRSVPNKLGG VLALLLSILI 

       310        320        330        340        350        360 
LAMIPILHMS KQQSMMFRPL SQSLYWLLAA DLLILTWIGG QPVSYPFTII GQVASVLYFT 

       370        380 
TILILMPTIS LIENKMLKWA 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and organization of the human mitochondrial genome."
Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L., Coulson A.R., Drouin J., Eperon I.C., Nierlich D.P., Roe B.A., Sanger F., Schreier P.H., Smith A.J.H., Staden R., Young I.G.
Nature 290:457-465(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Tissue: Placenta.
[2]"Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA."
Andrews R.M., Kubacka I., Chinnery P.F., Lightowlers R.N., Turnbull D.M., Howell N.
Nat. Genet. 23:147-147(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO 7.
[3]"Novel mutations in mitochondrial cytochrome b in fatal post partum cardiomyopathy."
Marin-Garcia J., Ananthakrishnan R., Gonzalvo A., Goldenthal M.J.
J. Inherit. Metab. Dis. 18:77-78(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-7 AND CARDIOMYOPATHY HIS-255.
Tissue: Heart.
[4]"Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs."
Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.
Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-7; THR-191; ALA-194 AND THR-229.
Tissue: Placenta.
[5]"Mitochondrial genome variation and the origin of modern humans."
Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.
Nature 408:708-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-378, VARIANTS ILE-7; SER-8; LEU-18; VAL-39; THR-78; THR-122; ALA-123; THR-153; ALA-194; THR-229; ILE-236; THR-306; THR-329; VAL-334; MET-353; MET-356 AND ILE-368.
[6]"Major genomic mitochondrial lineages delineate early human expansions."
Maca-Meyer N., Gonzalez A.M., Larruga J.M., Flores C., Cabrera V.M.
BMC Genet. 2:13-13(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-378, VARIANTS ILE-7; SER-8; LEU-18; THR-122; VAL-164; 189-VAL-THR-190; ALA-194; THR-229; ILE-236; THR-330; ALA-360 AND ILE-368.
[7]"Mitochondrial genome diversity of native Americans supports a single early entry of founder populations into America."
Silva W.A. Jr., Bonatto S.L., Holanda A.J., Ribeiro-Dos-Santos A.K., Paixao B.M., Goldman G.H., Abe-Sandes K., Rodriguez-Delfin L., Barbosa M., Paco-Larson M.L., Petzl-Erler M.L., Valente V., Santos S.E., Zago M.A.
Am. J. Hum. Genet. 71:187-192(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-378, VARIANTS ILE-7; THR-39; VAL-78; THR-191; ALA-194 AND ASP-260.
[8]"Serendipitous cloning of a mitochondrial cDNA and its polymorphism."
Spurr N.K., Bodmer W.F.
Mol. Biol. Med. 2:239-249(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 269-380.
Tissue: Lymphoblast.
[9]"Mitochondrial encephalomyopathy and complex III deficiency associated with a stop-codon mutation in the cytochrome b gene."
Keightley J.A., Anitori R., Burton M.D., Quan F., Buist N.R.M., Kennaway N.G.
Am. J. Hum. Genet. 67:1400-1410(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: DISEASE.
[10]"Normal variants of human mitochondrial DNA and translation products: the building of a reference data base."
Marzuki S., Noer A.S., Lertrit P., Thyagarajan D., Kapsa R., Utthanaphol P., Byrne E.
Hum. Genet. 88:139-145(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ILE-7 AND PRO-87.
[11]"Mitochondrial DNA complex I and III mutations associated with Leber's hereditary optic neuropathy."
Brown M.D., Voljavec A.S., Lott M.T., Torroni A., Yang C.C., Wallace D.C.
Genetics 130:163-173(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS LHON ASN-171 AND MET-356.
[12]"A novel gly290asp mitochondrial cytochrome b mutation linked to a complex III deficiency in progressive exercise intolerance."
Dumoulin R., Sagnol I., Ferlin T., Bozon D., Stepien G., Mousson B.
Mol. Cell. Probes 10:389-391(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT EXERCISE INTOLERANCE ASP-290.
[13]"Missense mutation in the mtDNA cytochrome b gene in a patient with myopathy."
Andreu A.L., Bruno C., Shanske S., Shtilbans A., Hirano M., Krishna S., Hayward L., Systrom D.S., Brown R.H. Jr., Dimauro S.
Neurology 51:1444-1447(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT MM GLU-339.
[14]"Somatic mutations of the mitochondrial genome in human colorectal tumours."
Polyak K., Li Y., Zhu H., Lengauer C., Willson J.K.V., Markowitz S.D., Trush M.A., Kinzler K.W., Vogelstein B.
Nat. Genet. 20:291-293(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS COLORECTAL CANCER HIS-80 AND LEU-276.
[15]"A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency."
Valnot I., Kassis J., Chretien D., de Lonlay P., Parfait B., Munnich A., Kachaner J., Rustin P., Roetig A.
Hum. Genet. 104:460-466(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT HCM GLU-166, VARIANTS ILE-7; SER-8; LEU-18; ALA-194; ILE-236 AND THR-316.
[16]"Exercise intolerance due to mutations in the cytochrome b gene of mitochondrial DNA."
Andreu A.L., Hanna M.G., Reichmann H., Bruno C., Penn A.S., Tanji K., Pallotti F., Iwata S., Bonilla E., Lach B., Morgan-Hughes J., DiMauro S.
N. Engl. J. Med. 341:1037-1044(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS MM SER-34 AND 251-GLY--LEU-258 DEL.
[17]"A missense mutation in the mitochondrial cytochrome b gene in a revisited case with histiocytoid cardiomyopathy."
Andreu A.L., Checcarelli N., Iwata S., Shanske S., DiMauro S.
Pediatr. Res. 48:311-314(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT CMIH ASP-251.
[18]"Multisystem disorder associated with a missense mutation in the mitochondrial cytochrome b gene."
Wibrand F., Ravn K., Schwartz M., Rosenberg T., Horn N., Vissing J.
Ann. Neurol. 50:540-543(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT MULTISYSTEM DISORDER CYS-278.
[19]"Functional characterization of novel mutations in the human cytochrome b gene."
Legros F., Chatzoglou E., Frachon P., de Baulny H.O., Laforet P., Jardel C., Godinot C., Lombes A.
Eur. J. Hum. Genet. 9:510-518(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT EXERCISE INTOLERANCE PRO-151.
[20]"Septo-optic dysplasia associated with a new mitochondrial cytochrome b mutation."
Schuelke M., Krude H., Finckh B., Mayatepek E., Janssen A., Schmelz M., Trefz F., Trijbels F., Smeitink J.
Ann. Neurol. 51:388-392(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT EXERCICE INTOLERANCE PRO-35.
[21]"Association of the mitochondrial DNA 15497G/A polymorphism with obesity in a middle-aged and elderly Japanese population."
Okura T., Koda M., Ando F., Niino N., Tanaka M., Shimokata H.
Hum. Genet. 113:432-436(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT SER-251.
[22]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V00662 Genomic DNA. Translation: CAA24038.1.
J01415 Genomic DNA. Translation: AAB58955.3.
U09500 Genomic DNA. Translation: AAA19775.1.
D38112 Genomic DNA. Translation: BAA77674.1.
AF346963 Genomic DNA. Translation: AAK17219.1.
AF346964 Genomic DNA. Translation: AAK17232.2.
AF346965 Genomic DNA. Translation: AAK17245.2.
AF346966 Genomic DNA. Translation: AAK17258.1.
AF346967 Genomic DNA. Translation: AAK17271.2.
AF346968 Genomic DNA. Translation: AAK17284.2.
AF346969 Genomic DNA. Translation: AAK17297.2.
AF346970 Genomic DNA. Translation: AAK17310.2.
AF346971 Genomic DNA. Translation: AAK17323.2.
AF346972 Genomic DNA. Translation: AAK17336.2.
AF346973 Genomic DNA. Translation: AAK17349.2.
AF346974 Genomic DNA. Translation: AAK17362.2.
AF346975 Genomic DNA. Translation: AAK17375.2.
AF346976 Genomic DNA. Translation: AAK17388.1.
AF346977 Genomic DNA. Translation: AAK17401.1.
AF346978 Genomic DNA. Translation: AAK17414.1.
AF346979 Genomic DNA. Translation: AAK17427.1.
AF346980 Genomic DNA. Translation: AAK17440.2.
AF346981 Genomic DNA. Translation: AAK17453.2.
AF346982 Genomic DNA. Translation: AAK17466.1.
AF346983 Genomic DNA. Translation: AAK17479.1.
AF346984 Genomic DNA. Translation: AAK17492.2.
AF346985 Genomic DNA. Translation: AAK17505.2.
AF346986 Genomic DNA. Translation: AAK17518.2.
AF346987 Genomic DNA. Translation: AAK17531.2.
AF346988 Genomic DNA. Translation: AAK17544.1.
AF346989 Genomic DNA. Translation: AAK17557.2.
AF346990 Genomic DNA. Translation: AAK17570.1.
AF346991 Genomic DNA. Translation: AAK17583.2.
AF346992 Genomic DNA. Translation: AAK17596.2.
AF346993 Genomic DNA. Translation: AAK17609.2.
AF346994 Genomic DNA. Translation: AAK17622.2.
AF346995 Genomic DNA. Translation: AAK17635.2.
AF346996 Genomic DNA. Translation: AAK17648.2.
AF346997 Genomic DNA. Translation: AAK17661.2.
AF346998 Genomic DNA. Translation: AAK17674.2.
AF346999 Genomic DNA. Translation: AAK17687.2.
AF347000 Genomic DNA. Translation: AAK17700.1.
AF347001 Genomic DNA. Translation: AAK17713.2.
AF347002 Genomic DNA. Translation: AAK17726.2.
AF347003 Genomic DNA. Translation: AAK17739.2.
AF347004 Genomic DNA. Translation: AAK17752.2.
AF347005 Genomic DNA. Translation: AAK17765.2.
AF347006 Genomic DNA. Translation: AAK17778.2.
AF347007 Genomic DNA. Translation: AAK17791.2.
AF347008 Genomic DNA. Translation: AAK17804.2.
AF347009 Genomic DNA. Translation: AAK17817.2.
AF347010 Genomic DNA. Translation: AAK17830.2.
AF347011 Genomic DNA. Translation: AAK17843.2.
AF347012 Genomic DNA. Translation: AAK17856.2.
AF347013 Genomic DNA. Translation: AAK17869.2.
AF347014 Genomic DNA. Translation: AAK17882.2.
AF347015 Genomic DNA. Translation: AAK17895.2.
AF381981 Genomic DNA. Translation: AAL54394.1.
AF381982 Genomic DNA. Translation: AAL54409.1.
AF381983 Genomic DNA. Translation: AAL54422.1.
AF381984 Genomic DNA. Translation: AAL54435.1.
AF381985 Genomic DNA. Translation: AAL54448.1.
AF381986 Genomic DNA. Translation: AAL54461.1.
AF381987 Genomic DNA. Translation: AAL54474.1.
AF381988 Genomic DNA. Translation: AAL54487.1.
AF381989 Genomic DNA. Translation: AAL54500.1.
AF381990 Genomic DNA. Translation: AAL54513.1.
AF381991 Genomic DNA. Translation: AAL54526.1.
AF381992 Genomic DNA. Translation: AAL54539.1.
AF381993 Genomic DNA. Translation: AAL54552.1.
AF381994 Genomic DNA. Translation: AAL54565.1.
AF381995 Genomic DNA. Translation: AAL54578.1.
AF381996 Genomic DNA. Translation: AAL54591.1.
AF381997 Genomic DNA. Translation: AAL54604.1.
AF381998 Genomic DNA. Translation: AAL54617.1.
AF381999 Genomic DNA. Translation: AAL54630.1.
AF382000 Genomic DNA. Translation: AAL54643.1.
AF382001 Genomic DNA. Translation: AAL54656.1.
AF382002 Genomic DNA. Translation: AAL54669.1.
AF382003 Genomic DNA. Translation: AAL54682.1.
AF382004 Genomic DNA. Translation: AAL54695.1.
AF382005 Genomic DNA. Translation: AAL54708.1.
AF382006 Genomic DNA. Translation: AAL54721.1.
AF382007 Genomic DNA. Translation: AAL54734.1.
AF382008 Genomic DNA. Translation: AAL54747.1.
AF382009 Genomic DNA. Translation: AAL54760.1.
AF382010 Genomic DNA. Translation: AAL54773.1.
AF382011 Genomic DNA. Translation: AAL54786.1.
AF382012 Genomic DNA. Translation: AAL54799.1.
AF382013 Genomic DNA. Translation: AAL54812.1.
AF465942 Genomic DNA. Translation: AAN14559.1.
AF465945 Genomic DNA. Translation: AAN14592.1.
AF465946 Genomic DNA. Translation: AAN14603.1.
AF465947 Genomic DNA. Translation: AAN14614.1.
AF465948 Genomic DNA. Translation: AAN14625.1.
AF465949 Genomic DNA. Translation: AAN14636.1.
AF465953 Genomic DNA. Translation: AAN14680.1.
AF465956 Genomic DNA. Translation: AAN14713.1.
AF465968 Genomic DNA. Translation: AAN14845.1.
AF465971 Genomic DNA. Translation: AAN14878.1.
AF465972 Genomic DNA. Translation: AAN14889.1.
AF465973 Genomic DNA. Translation: AAN14900.1.
AF465974 Genomic DNA. Translation: AAN14911.1.
AF465975 Genomic DNA. Translation: AAN14922.1.
AF465977 Genomic DNA. Translation: AAN14944.1.
M28016 mRNA. Translation: AAA31851.1.
PIRCBHU. A00151.
RefSeqYP_003024038.1. NC_012920.1.

3D structure databases

ProteinModelPortalP00156.
SMRP00156. Positions 15-379.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110619. 1 interaction.
IntActP00156. 1 interaction.

Chemistry

DrugBankDB01117. Atovaquone.

PTM databases

PhosphoSiteP00156.

Polymorphism databases

DMDM408360043.

Proteomic databases

MaxQBP00156.
PaxDbP00156.
PRIDEP00156.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361789; ENSP00000354554; ENSG00000198727.
GeneID4519.
KEGGhsa:4519.

Organism-specific databases

CTD4519.
GeneCardsGCMTP014749.
GeneReviewsMT-CYB.
HGNCHGNC:7427. MT-CYB.
HPACAB032215.
MIM500000. phenotype.
516020. gene.
535000. phenotype.
neXtProtNX_P00156.
Orphanet137675. Histiocytoid cardiomyopathy.
1460. Isolated CoQ-cytochrome C reductase deficiency.
104. Leber hereditary optic neuropathy.
PharmGKBPA31234.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1290.
HOVERGENHBG017694.
InParanoidP00156.
KOK00412.
OMANTINQIF.
OrthoDBEOG7BGHKX.
PhylomeDBP00156.
TreeFamTF353088.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

GenevestigatorP00156.

Family and domain databases

Gene3D1.20.810.10. 1 hit.
InterProIPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PfamPF00032. Cytochrom_B_C. 1 hit.
PF13631. Cytochrom_B_N_2. 1 hit.
[Graphical view]
SUPFAMSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMT-CYB.
NextBio17445.
PROP00156.
SOURCESearch...

Entry information

Entry nameCYB_HUMAN
AccessionPrimary (citable) accession number: P00156
Secondary accession number(s): Q34786 expand/collapse secondary AC list , Q8HBR6, Q8HNQ0, Q8HNQ1, Q8HNQ9, Q8HNR4, Q8HNR7, Q8W7V8, Q8WCV9, Q8WCY2, Q8WCY7, Q8WCY8, Q9B1A6, Q9B1B6, Q9B1B8, Q9B1D4, Q9B1X6, Q9B2V0, Q9B2V8, Q9B2W0, Q9B2W3, Q9B2W8, Q9B2X1, Q9B2X7, Q9B2X9, Q9B2Y3, Q9B2Z0, Q9B2Z4, Q9T6H6, Q9T9Y0, Q9TEH4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 163 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations