UniProtKB - P00156 (CYB_HUMAN)
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Protein
Cytochrome b
Gene
MT-CYB
Organism
Homo sapiens (Human)
Status
Functioni
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.By similarity
Miscellaneous
Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.By similarity
Cofactori
hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 83 | Iron 1 (heme b562 axial ligand)By similarity | 1 | |
Metal bindingi | 97 | Iron 2 (heme b566 axial ligand)By similarity | 1 | |
Metal bindingi | 182 | Iron 1 (heme b562 axial ligand)By similarity | 1 | |
Metal bindingi | 196 | Iron 2 (heme b566 axial ligand)By similarity | 1 | |
Binding sitei | 201 | UbiquinoneBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- protein complex binding Source: Ensembl
- ubiquinol-cytochrome-c reductase activity Source: UniProtKB
GO - Biological processi
- animal organ regeneration Source: Ensembl
- hyperosmotic salinity response Source: Ensembl
- mitochondrial electron transport, ubiquinol to cytochrome c Source: Reactome
- proton transport Source: Ensembl
- response to cadmium ion Source: Ensembl
- response to calcium ion Source: Ensembl
- response to cobalamin Source: Ensembl
- response to copper ion Source: Ensembl
- response to ethanol Source: Ensembl
- response to glucagon Source: Ensembl
- response to heat Source: Ensembl
- response to hyperoxia Source: Ensembl
- response to hypoxia Source: Ensembl
- response to mercury ion Source: Ensembl
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Ligand | Heme, Iron, Metal-binding, Ubiquinone |
Enzyme and pathway databases
Reactomei | R-HSA-611105. Respiratory electron transport. |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome bAlternative name(s): Complex III subunit 3 Complex III subunit III Cytochrome b-c1 complex subunit 3 Ubiquinol-cytochrome-c reductase complex cytochrome b subunit |
Gene namesi | Name:MT-CYB Synonyms:COB, CYTB, MTCYB |
Encoded oni | Mitochondrion |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000198727.2. |
HGNCi | HGNC:7427. MT-CYB. |
MIMi | 516020. gene. |
neXtProti | NX_P00156. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 33 – 53 | HelicalBy similarityAdd BLAST | 21 | |
Transmembranei | 77 – 98 | HelicalBy similarityAdd BLAST | 22 | |
Transmembranei | 113 – 133 | HelicalBy similarityAdd BLAST | 21 | |
Transmembranei | 178 – 198 | HelicalBy similarityAdd BLAST | 21 | |
Transmembranei | 226 – 246 | HelicalBy similarityAdd BLAST | 21 | |
Transmembranei | 288 – 308 | HelicalBy similarityAdd BLAST | 21 | |
Transmembranei | 320 – 340 | HelicalBy similarityAdd BLAST | 21 | |
Transmembranei | 347 – 367 | HelicalBy similarityAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Involvement in diseasei
Defects in MT-CYB are a rare cause of mitochondrial dysfunction underlying different myopathies. They include mitochondrial encephalomyopathy, hypertrophic cardiomyopathy (HCM), and sporadic mitochondrial myopathy (MM). In mitochondrial myopathy, exercise intolerance is the predominant symptom. Additional features include lactic acidosis, muscle weakness and/or myoglobinuria. Defects in MTCYB are also found in cases of exercise intolerance accompanied by deafness, mental retardation, retinitis pigmentosa, cataract, growth retardation, epilepsy (multisystem disorder).2 Publications
Cardiomyopathy, infantile histiocytoid (CMIH)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA heart disease characterized by the presence of pale granular foamy histiocyte-like cells within the myocardium. It usually affects children younger than 2 years of age, with a clear predominance of females over males. Infants present with dysrhythmia or cardiac arrest. The clinical course is usually fulminant, sometimes simulating sudden infant death syndrome.
See also OMIM:500000Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013656 | 251 | G → D in CMIH. 1 PublicationCorresponds to variant dbSNP:rs207460003Ensembl. | 1 |
Leber hereditary optic neuropathy (LHON)1 Publication
The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry.
Disease descriptionA maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.
See also OMIM:535000Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_002197 | 171 | D → N in LHON; secondary mutation; does not seem to directly cause the disease. 1 PublicationCorresponds to variant dbSNP:rs41518645Ensembl. | 1 | |
Natural variantiVAR_002199 | 356 | V → M in LHON; secondary mutation; does not seem to directly cause the disease. 2 PublicationsCorresponds to variant dbSNP:rs200336777Ensembl. | 1 |
Keywords - Diseasei
Cardiomyopathy, Cataract, Deafness, Disease mutation, Leber hereditary optic neuropathy, Primary mitochondrial diseaseOrganism-specific databases
DisGeNETi | 4519. |
GeneReviewsi | MT-CYB. |
MalaCardsi | MT-CYB. |
MIMi | 500000. phenotype. 535000. phenotype. |
OpenTargetsi | ENSG00000198727. |
Orphaneti | 137675. Histiocytoid cardiomyopathy. 1460. Isolated CoQ-cytochrome C reductase deficiency. 104. Leber hereditary optic neuropathy. |
PharmGKBi | PA31234. |
Chemistry databases
DrugBanki | DB08453. 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE. DB07778. FAMOXADONE. DB07401. METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE. DB08330. METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE. DB08690. UBIQUINONE-2. |
Polymorphism and mutation databases
DMDMi | 408360043. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000061045 | 1 – 380 | Cytochrome bAdd BLAST | 380 |
Proteomic databases
EPDi | P00156. |
PaxDbi | P00156. |
PeptideAtlasi | P00156. |
PRIDEi | P00156. |
TopDownProteomicsi | P00156. |
PTM databases
iPTMneti | P00156. |
PhosphoSitePlusi | P00156. |
Expressioni
Gene expression databases
Bgeei | ENSG00000198727. |
ExpressionAtlasi | P00156. baseline and differential. |
Organism-specific databases
HPAi | CAB032215. HPA068400. |
Interactioni
Subunit structurei
The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.By similarity
GO - Molecular functioni
- protein complex binding Source: Ensembl
Protein-protein interaction databases
BioGridi | 110619. 12 interactors. |
IntActi | P00156. 3 interactors. |
MINTi | P00156. |
STRINGi | 9606.ENSP00000354554. |
Chemistry databases
BindingDBi | P00156. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 4 – 7 | Combined sources | 4 | |
Helixi | 9 – 17 | Combined sources | 9 | |
Beta strandi | 22 – 24 | Combined sources | 3 | |
Helixi | 29 – 31 | Combined sources | 3 | |
Helixi | 32 – 52 | Combined sources | 21 | |
Helixi | 61 – 70 | Combined sources | 10 | |
Helixi | 76 – 103 | Combined sources | 28 | |
Helixi | 106 – 108 | Combined sources | 3 | |
Helixi | 110 – 131 | Combined sources | 22 | |
Turni | 132 – 134 | Combined sources | 3 | |
Helixi | 137 – 148 | Combined sources | 12 | |
Helixi | 149 – 152 | Combined sources | 4 | |
Turni | 154 – 156 | Combined sources | 3 | |
Helixi | 157 – 165 | Combined sources | 9 | |
Beta strandi | 167 – 170 | Combined sources | 4 | |
Helixi | 172 – 200 | Combined sources | 29 | |
Turni | 201 – 203 | Combined sources | 3 | |
Helixi | 214 – 216 | Combined sources | 3 | |
Beta strandi | 217 – 219 | Combined sources | 3 | |
Helixi | 220 – 244 | Combined sources | 25 | |
Beta strandi | 249 – 251 | Combined sources | 3 | |
Beta strandi | 255 – 258 | Combined sources | 4 | |
Helixi | 272 – 283 | Combined sources | 12 | |
Beta strandi | 284 – 286 | Combined sources | 3 | |
Helixi | 289 – 303 | Combined sources | 15 | |
Helixi | 304 – 307 | Combined sources | 4 | |
Helixi | 315 – 317 | Combined sources | 3 | |
Helixi | 319 – 339 | Combined sources | 21 | |
Helixi | 345 – 363 | Combined sources | 19 | |
Helixi | 365 – 376 | Combined sources | 12 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5XTE | electron microscopy | 3.40 | J/V | 2-379 | [»] | |
5XTH | electron microscopy | 3.90 | AJ/AV | 2-379 | [»] | |
5XTI | electron microscopy | 17.40 | AJ/AV | 2-379 | [»] | |
ProteinModelPortali | P00156. | |||||
SMRi | P00156. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome b family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4663. Eukaryota. COG1290. LUCA. |
GeneTreei | ENSGT00390000017948. |
HOVERGENi | HBG017694. |
InParanoidi | P00156. |
KOi | K00412. |
OMAi | HETGSNN. |
OrthoDBi | EOG091G0DW4. |
PhylomeDBi | P00156. |
TreeFami | TF353088. |
Family and domain databases
CDDi | cd00290. cytochrome_b_C. 1 hit. cd00284. Cytochrome_b_N. 1 hit. |
Gene3Di | 1.20.810.10. 1 hit. |
InterProi | View protein in InterPro IPR005798. Cyt_b/b6_C. IPR036150. Cyt_b/b6_C_sf. IPR005797. Cyt_b/b6_N. IPR027387. Cytb/b6-like_sf. IPR030689. Cytochrome_b. IPR016174. Di-haem_cyt_TM. |
Pfami | View protein in Pfam PF00032. Cytochrom_B_C. 1 hit. PF00033. Cytochrome_B. 1 hit. |
PIRSFi | PIRSF038885. COB. 1 hit. |
SUPFAMi | SSF81342. SSF81342. 1 hit. SSF81648. SSF81648. 1 hit. |
PROSITEi | View protein in PROSITE PS51003. CYTB_CTER. 1 hit. PS51002. CYTB_NTER. 1 hit. |
i Sequence
Sequence statusi: Complete.
P00156-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPMRKTNPL MKLINHSFID LPTPSNISAW WNFGSLLGAC LILQITTGLF
60 70 80 90 100
LAMHYSPDAS TAFSSIAHIT RDVNYGWIIR YLHANGASMF FICLFLHIGR
110 120 130 140 150
GLYYGSFLYS ETWNIGIILL LATMATAFMG YVLPWGQMSF WGATVITNLL
160 170 180 190 200
SAIPYIGTDL VQWIWGGYSV DSPTLTRFFT FHFILPFIIA ALATLHLLFL
210 220 230 240 250
HETGSNNPLG ITSHSDKITF HPYYTIKDAL GLLLFLLSLM TLTLFSPDLL
260 270 280 290 300
GDPDNYTLAN PLNTPPHIKP EWYFLFAYTI LRSVPNKLGG VLALLLSILI
310 320 330 340 350
LAMIPILHMS KQQSMMFRPL SQSLYWLLAA DLLILTWIGG QPVSYPFTII
360 370 380
GQVASVLYFT TILILMPTIS LIENKMLKWA
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_008585 | 7 | T → ICombined sources7 PublicationsCorresponds to variant dbSNP:rs193302980Ensembl. | 1 | |
Natural variantiVAR_013643 | 8 | N → S3 PublicationsCorresponds to variant dbSNP:rs28357679Ensembl. | 1 | |
Natural variantiVAR_013644 | 18 | F → L3 PublicationsCorresponds to variant dbSNP:rs28357681Ensembl. | 1 | |
Natural variantiVAR_013645 | 34 | G → S in mitochondrial myopathy; sporadic. 1 PublicationCorresponds to variant dbSNP:rs207459998Ensembl. | 1 | |
Natural variantiVAR_033058 | 35 | S → P in exercice intolerance; with cardiomyopathy and septo-optic dysplasia. 1 PublicationCorresponds to variant dbSNP:rs207460004Ensembl. | 1 | |
Natural variantiVAR_015571 | 39 | A → T1 PublicationCorresponds to variant dbSNP:rs2853505Ensembl. | 1 | |
Natural variantiVAR_013646 | 39 | A → V1 Publication | 1 | |
Natural variantiVAR_013647 | 78 | I → T1 PublicationCorresponds to variant dbSNP:rs200786872Ensembl. | 1 | |
Natural variantiVAR_015572 | 78 | I → V1 PublicationCorresponds to variant dbSNP:rs199997767Ensembl. | 1 | |
Natural variantiVAR_008388 | 80 | R → H in colorectal cancer. 1 PublicationCorresponds to variant dbSNP:rs207459995Ensembl. | 1 | |
Natural variantiVAR_008586 | 87 | A → P1 Publication | 1 | |
Natural variantiVAR_013648 | 122 | A → T2 PublicationsCorresponds to variant dbSNP:rs28357685Ensembl. | 1 | |
Natural variantiVAR_013649 | 123 | T → A1 Publication | 1 | |
Natural variantiVAR_013650 | 151 | S → P in exercise intolerance. 1 PublicationCorresponds to variant dbSNP:rs207460001Ensembl. | 1 | |
Natural variantiVAR_013651 | 153 | I → T1 PublicationCorresponds to variant dbSNP:rs28357687Ensembl. | 1 | |
Natural variantiVAR_013652 | 164 | I → V1 PublicationCorresponds to variant dbSNP:rs201250154Ensembl. | 1 | |
Natural variantiVAR_013653 | 166 | G → E in hyperthrophic cardiomyopathy. 1 Publication | 1 | |
Natural variantiVAR_002197 | 171 | D → N in LHON; secondary mutation; does not seem to directly cause the disease. 1 PublicationCorresponds to variant dbSNP:rs41518645Ensembl. | 1 | |
Natural variantiVAR_013654 | 189 – 190 | IA → VT. | 2 | |
Natural variantiVAR_011339 | 191 | A → T2 PublicationsCorresponds to variant dbSNP:rs2853507Ensembl. | 1 | |
Natural variantiVAR_011340 | 194 | T → A5 PublicationsCorresponds to variant dbSNP:rs2853508Ensembl. | 1 | |
Natural variantiVAR_011341 | 229 | A → T3 PublicationsCorresponds to variant dbSNP:rs193302993Ensembl. | 1 | |
Natural variantiVAR_013655 | 236 | L → I3 PublicationsCorresponds to variant dbSNP:rs193302994Ensembl. | 1 | |
Natural variantiVAR_013657 | 251 – 258 | Missing in mitochondrial myopathy; sporadic. 1 Publication | 8 | |
Natural variantiVAR_013656 | 251 | G → D in CMIH. 1 PublicationCorresponds to variant dbSNP:rs207460003Ensembl. | 1 | |
Natural variantiVAR_033059 | 251 | G → S Associated with susceptibility to obesity. 1 PublicationCorresponds to variant dbSNP:rs199951903Ensembl. | 1 | |
Natural variantiVAR_013658 | 255 | N → H in cardiomyopathy; fatal; post-partum. 1 Publication | 1 | |
Natural variantiVAR_015573 | 260 | N → D1 Publication | 1 | |
Natural variantiVAR_008389 | 276 | F → L in colorectal cancer. 1 PublicationCorresponds to variant dbSNP:rs207459996Ensembl. | 1 | |
Natural variantiVAR_013659 | 278 | Y → C in multisystem disorder. 1 PublicationCorresponds to variant dbSNP:rs207460002Ensembl. | 1 | |
Natural variantiVAR_013660 | 290 | G → D in exercise intolerance. 1 PublicationCorresponds to variant dbSNP:rs207459997Ensembl. | 1 | |
Natural variantiVAR_013661 | 306 | I → T1 PublicationCorresponds to variant dbSNP:rs369851331Ensembl. | 1 | |
Natural variantiVAR_013662 | 316 | M → T1 PublicationCorresponds to variant dbSNP:rs200975632Ensembl. | 1 | |
Natural variantiVAR_013663 | 329 | A → T1 Publication | 1 | |
Natural variantiVAR_013664 | 330 | A → T1 PublicationCorresponds to variant dbSNP:rs386829259Ensembl. | 1 | |
Natural variantiVAR_013665 | 334 | I → V1 PublicationCorresponds to variant dbSNP:rs386829260Ensembl. | 1 | |
Natural variantiVAR_002198 | 339 | G → E in mitochondrial myopathy. 1 Publication | 1 | |
Natural variantiVAR_013666 | 353 | V → M1 Publication | 1 | |
Natural variantiVAR_002199 | 356 | V → M in LHON; secondary mutation; does not seem to directly cause the disease. 2 PublicationsCorresponds to variant dbSNP:rs200336777Ensembl. | 1 | |
Natural variantiVAR_013667 | 360 | T → A1 PublicationCorresponds to variant dbSNP:rs28357376Ensembl. | 1 | |
Natural variantiVAR_013668 | 368 | T → I2 PublicationsCorresponds to variant dbSNP:rs202225494Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00662 Genomic DNA. Translation: CAA24038.1. J01415 Genomic DNA. Translation: AAB58955.3. U09500 Genomic DNA. Translation: AAA19775.1. D38112 Genomic DNA. Translation: BAA77674.1. AF346963 Genomic DNA. Translation: AAK17219.1. AF346964 Genomic DNA. Translation: AAK17232.2. AF346965 Genomic DNA. Translation: AAK17245.2. AF346966 Genomic DNA. Translation: AAK17258.1. AF346967 Genomic DNA. Translation: AAK17271.2. AF346968 Genomic DNA. Translation: AAK17284.2. AF346969 Genomic DNA. Translation: AAK17297.2. AF346970 Genomic DNA. Translation: AAK17310.2. AF346971 Genomic DNA. Translation: AAK17323.2. AF346972 Genomic DNA. Translation: AAK17336.2. AF346973 Genomic DNA. Translation: AAK17349.2. AF346974 Genomic DNA. Translation: AAK17362.2. AF346975 Genomic DNA. Translation: AAK17375.2. AF346976 Genomic DNA. Translation: AAK17388.1. AF346977 Genomic DNA. Translation: AAK17401.1. AF346978 Genomic DNA. Translation: AAK17414.1. AF346979 Genomic DNA. Translation: AAK17427.1. AF346980 Genomic DNA. Translation: AAK17440.2. AF346981 Genomic DNA. Translation: AAK17453.2. AF346982 Genomic DNA. Translation: AAK17466.1. AF346983 Genomic DNA. Translation: AAK17479.1. AF346984 Genomic DNA. Translation: AAK17492.2. AF346985 Genomic DNA. Translation: AAK17505.2. AF346986 Genomic DNA. Translation: AAK17518.2. AF346987 Genomic DNA. Translation: AAK17531.2. AF346988 Genomic DNA. Translation: AAK17544.1. AF346989 Genomic DNA. Translation: AAK17557.2. AF346990 Genomic DNA. Translation: AAK17570.1. AF346991 Genomic DNA. Translation: AAK17583.2. AF346992 Genomic DNA. Translation: AAK17596.2. AF346993 Genomic DNA. Translation: AAK17609.2. AF346994 Genomic DNA. Translation: AAK17622.2. AF346995 Genomic DNA. Translation: AAK17635.2. AF346996 Genomic DNA. Translation: AAK17648.2. AF346997 Genomic DNA. Translation: AAK17661.2. AF346998 Genomic DNA. Translation: AAK17674.2. AF346999 Genomic DNA. Translation: AAK17687.2. AF347000 Genomic DNA. Translation: AAK17700.1. AF347001 Genomic DNA. Translation: AAK17713.2. AF347002 Genomic DNA. Translation: AAK17726.2. AF347003 Genomic DNA. Translation: AAK17739.2. AF347004 Genomic DNA. Translation: AAK17752.2. AF347005 Genomic DNA. Translation: AAK17765.2. AF347006 Genomic DNA. Translation: AAK17778.2. AF347007 Genomic DNA. Translation: AAK17791.2. AF347008 Genomic DNA. Translation: AAK17804.2. AF347009 Genomic DNA. Translation: AAK17817.2. AF347010 Genomic DNA. Translation: AAK17830.2. AF347011 Genomic DNA. Translation: AAK17843.2. AF347012 Genomic DNA. Translation: AAK17856.2. AF347013 Genomic DNA. Translation: AAK17869.2. AF347014 Genomic DNA. Translation: AAK17882.2. AF347015 Genomic DNA. Translation: AAK17895.2. AF381981 Genomic DNA. Translation: AAL54394.1. AF381982 Genomic DNA. Translation: AAL54409.1. AF381983 Genomic DNA. Translation: AAL54422.1. AF381984 Genomic DNA. Translation: AAL54435.1. AF381985 Genomic DNA. Translation: AAL54448.1. AF381986 Genomic DNA. Translation: AAL54461.1. AF381987 Genomic DNA. Translation: AAL54474.1. AF381988 Genomic DNA. Translation: AAL54487.1. AF381989 Genomic DNA. Translation: AAL54500.1. AF381990 Genomic DNA. Translation: AAL54513.1. AF381991 Genomic DNA. Translation: AAL54526.1. AF381992 Genomic DNA. Translation: AAL54539.1. AF381993 Genomic DNA. Translation: AAL54552.1. AF381994 Genomic DNA. Translation: AAL54565.1. AF381995 Genomic DNA. Translation: AAL54578.1. AF381996 Genomic DNA. Translation: AAL54591.1. AF381997 Genomic DNA. Translation: AAL54604.1. AF381998 Genomic DNA. Translation: AAL54617.1. AF381999 Genomic DNA. Translation: AAL54630.1. AF382000 Genomic DNA. Translation: AAL54643.1. AF382001 Genomic DNA. Translation: AAL54656.1. AF382002 Genomic DNA. Translation: AAL54669.1. AF382003 Genomic DNA. Translation: AAL54682.1. AF382004 Genomic DNA. Translation: AAL54695.1. AF382005 Genomic DNA. Translation: AAL54708.1. AF382006 Genomic DNA. Translation: AAL54721.1. AF382007 Genomic DNA. Translation: AAL54734.1. AF382008 Genomic DNA. Translation: AAL54747.1. AF382009 Genomic DNA. Translation: AAL54760.1. AF382010 Genomic DNA. Translation: AAL54773.1. AF382011 Genomic DNA. Translation: AAL54786.1. AF382012 Genomic DNA. Translation: AAL54799.1. AF382013 Genomic DNA. Translation: AAL54812.1. AF465942 Genomic DNA. Translation: AAN14559.1. AF465945 Genomic DNA. Translation: AAN14592.1. AF465946 Genomic DNA. Translation: AAN14603.1. AF465947 Genomic DNA. Translation: AAN14614.1. AF465948 Genomic DNA. Translation: AAN14625.1. AF465949 Genomic DNA. Translation: AAN14636.1. AF465953 Genomic DNA. Translation: AAN14680.1. AF465956 Genomic DNA. Translation: AAN14713.1. AF465968 Genomic DNA. Translation: AAN14845.1. AF465971 Genomic DNA. Translation: AAN14878.1. AF465972 Genomic DNA. Translation: AAN14889.1. AF465973 Genomic DNA. Translation: AAN14900.1. AF465974 Genomic DNA. Translation: AAN14911.1. AF465975 Genomic DNA. Translation: AAN14922.1. AF465977 Genomic DNA. Translation: AAN14944.1. M28016 mRNA. Translation: AAA31851.1. |
PIRi | A00151. CBHU. |
RefSeqi | YP_003024038.1. NC_012920.1. |
Genome annotation databases
Ensembli | ENST00000361789; ENSP00000354554; ENSG00000198727. |
GeneIDi | 4519. |
KEGGi | hsa:4519. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | CYB_HUMAN | |
Accessioni | P00156Primary (citable) accession number: P00156 Secondary accession number(s): Q34786 Q9TEH4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | October 3, 2012 | |
Last modified: | February 28, 2018 | |
This is version 198 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Caution
The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.By similarity