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Protein

Cytochrome c3, 13 kDa

Gene
N/A
Organism
Desulfomicrobium norvegicum (strain DSM 1741 / NCIMB 8310) (Desulfovibrio baculatus (strain Norway 4)) (Desulfovibrio desulfuricans (strain Norway 4))
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Participates in sulfate respiration coupled with phosphorylation by transferring electrons from the enzyme dehydrogenase to ferredoxin.

Miscellaneous

The second heme binding site has an unusual CXXXXCH motif.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi36Iron (heme 1 axial ligand)1
Metal bindingi39Iron (heme 3 axial ligand)1
Binding sitei44Heme 1 (covalent)1
Binding sitei47Heme 1 (covalent)1
Metal bindingi48Iron (heme 1 axial ligand)1
Metal bindingi49Iron (heme 2 axial ligand)1
Binding sitei61Heme 2 (covalent); atypical1
Binding sitei66Heme 2 (covalent); atypical1
Metal bindingi67Iron (heme 2 axial ligand)1
Metal bindingi89Iron (heme 4 axial ligand)1
Binding sitei92Heme 3 (covalent)1
Binding sitei95Heme 3 (covalent)1
Metal bindingi96Iron (heme 3 axial ligand)1
Binding sitei111Heme 4 (covalent)1
Binding sitei114Heme 4 (covalent)1
Metal bindingi115Iron (heme 4 axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Sulfate respiration, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c3, 13 kDa
OrganismiDesulfomicrobium norvegicum (strain DSM 1741 / NCIMB 8310) (Desulfovibrio baculatus (strain Norway 4)) (Desulfovibrio desulfuricans (strain Norway 4))
Taxonomic identifieri52561 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfomicrobiaceaeDesulfomicrobium

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

Pathology & Biotechi

Chemistry databases

DrugBankiDB03317. Heme C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001083581 – 118Cytochrome c3, 13 kDaAdd BLAST118

Post-translational modificationi

Binds 4 heme groups per subunit.

Proteomic databases

PRIDEiP00136.

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 33Combined sources3
Helixi36 – 39Combined sources4
Helixi44 – 47Combined sources4
Turni49 – 56Combined sources8
Turni76 – 79Combined sources4
Helixi84 – 101Combined sources18
Helixi111 – 114Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CY3X-ray1.70A1-118[»]
ProteinModelPortaliP00136.
SMRiP00136.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00136.

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR002322. Cyt_c_III.
IPR020942. Cyt_c_III_dom.
IPR011031. Multihaem_cyt.
PfamiView protein in Pfam
PF02085. Cytochrom_CIII. 1 hit.
PRINTSiPR00609. CYTOCHROMEC3.
SUPFAMiSSF48695. SSF48695. 1 hit.

Sequencei

Sequence statusi: Complete.

P00136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ADAPGDDYVI SAPEGMKAKP KGDKPGALQK TVPFPHTKHA TVECVQCHHT
60 70 80 90 100
LEADGGAVKK CTTSGCHDSL EFRDKANAKD IKLVENAFHT QCIDCHKALK
110
KDKKPTGPTA CGKCHTTN
Length:118
Mass (Da):12,622
Last modified:September 27, 2004 - v2
Checksum:iB9C3E8E14EC85728
GO

Sequence databases

PIRiA00129. CCDV3N.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCYC31_DESNO
AccessioniPrimary (citable) accession number: P00136
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 27, 2004
Last modified: March 15, 2017
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references