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Protein

Cytochrome c3

Gene

DVU_3171

Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Participates in sulfate respiration coupled with phosphorylation by transferring electrons from the enzyme dehydrogenase to ferredoxin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Iron (heme 1 axial ligand)1
Metal bindingi47Iron (heme 3 axial ligand)1
Binding sitei52Heme 1 (covalent)1
Binding sitei55Heme 1 (covalent)1
Metal bindingi56Iron (heme 1 axial ligand)1
Metal bindingi57Iron (heme 2 axial ligand)1
Binding sitei68Heme 2 (covalent); atypical1
Binding sitei73Heme 2 (covalent); atypical1
Metal bindingi74Iron (heme 2 axial ligand)1
Metal bindingi92Iron (heme 4 axial ligand)1
Binding sitei101Heme 3 (covalent)1
Binding sitei104Heme 3 (covalent)1
Metal bindingi105Iron (heme 3 axial ligand)1
Binding sitei122Heme 4 (covalent); atypical1
Binding sitei127Heme 4 (covalent); atypical1
Metal bindingi128Iron (heme 4 axial ligand)1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Sulfate respiration, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c3
Gene namesi
Ordered Locus Names:DVU_3171
OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
Taxonomic identifieri882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002194 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 222 PublicationsAdd BLAST22
ChainiPRO_000000650423 – 129Cytochrome c31 PublicationAdd BLAST107

Post-translational modificationi

Binds 4 heme groups per subunit.

Proteomic databases

PaxDbiP00131.

Interactioni

Protein-protein interaction databases

STRINGi882.DVU3171.

Structurei

Secondary structure

1129
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 33Combined sources3
Beta strandi35 – 38Combined sources4
Beta strandi40 – 42Combined sources3
Helixi45 – 47Combined sources3
Beta strandi48 – 50Combined sources3
Helixi52 – 54Combined sources3
Beta strandi60 – 63Combined sources4
Turni70 – 72Combined sources3
Beta strandi83 – 85Combined sources3
Helixi87 – 92Combined sources6
Beta strandi95 – 98Combined sources4
Helixi101 – 109Combined sources9
Helixi113 – 120Combined sources8
Beta strandi122 – 127Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A2INMR-A23-129[»]
1GX7NMR-E23-129[»]
1MDVX-ray2.30A/B23-129[»]
2BPNNMR-A23-129[»]
2CTHX-ray1.67A/B23-129[»]
2CYMX-ray2.00A23-129[»]
ProteinModelPortaliP00131.
SMRiP00131.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00131.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106BES. Bacteria.
ENOG410XXW1. LUCA.
OMAiLMICLMV.
OrthoDBiPOG091H32QK.

Family and domain databases

InterProiIPR002322. Cyt_c_III.
IPR020942. Cyt_c_III_dom.
IPR011031. Multihaem_cyt.
[Graphical view]
PfamiPF02085. Cytochrom_CIII. 1 hit.
[Graphical view]
PRINTSiPR00609. CYTOCHROMEC3.
SUPFAMiSSF48695. SSF48695. 1 hit.
PROSITEiPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00131-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKLFFCGVL ALAVAFALPV VAAPKAPADG LKMEATKQPV VFNHSTHKSV
60 70 80 90 100
KCGDCHHPVN GKEDYRKCGT AGCHDSMDKK DKSAKGYYHV MHDKNTKFKS
110 120
CVGCHVEVAG ADAAKKKDLT GCKKSKCHE
Length:129
Mass (Da):13,976
Last modified:August 13, 1987 - v1
Checksum:i78C2A85F33B18441
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04304 Genomic DNA. Translation: CAA27847.1.
AE017285 Genomic DNA. Translation: AAS97641.1.
PIRiA24799. CCDV3.
RefSeqiWP_010940429.1. NC_002937.3.
YP_012381.1. NC_002937.3.

Genome annotation databases

EnsemblBacteriaiAAS97641; AAS97641; DVU_3171.
GeneIDi2795876.
KEGGidvu:DVU3171.
PATRICi32065884. VBIDesVul119526_2876.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04304 Genomic DNA. Translation: CAA27847.1.
AE017285 Genomic DNA. Translation: AAS97641.1.
PIRiA24799. CCDV3.
RefSeqiWP_010940429.1. NC_002937.3.
YP_012381.1. NC_002937.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A2INMR-A23-129[»]
1GX7NMR-E23-129[»]
1MDVX-ray2.30A/B23-129[»]
2BPNNMR-A23-129[»]
2CTHX-ray1.67A/B23-129[»]
2CYMX-ray2.00A23-129[»]
ProteinModelPortaliP00131.
SMRiP00131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi882.DVU3171.

Proteomic databases

PaxDbiP00131.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS97641; AAS97641; DVU_3171.
GeneIDi2795876.
KEGGidvu:DVU3171.
PATRICi32065884. VBIDesVul119526_2876.

Phylogenomic databases

eggNOGiENOG4106BES. Bacteria.
ENOG410XXW1. LUCA.
OMAiLMICLMV.
OrthoDBiPOG091H32QK.

Miscellaneous databases

EvolutionaryTraceiP00131.

Family and domain databases

InterProiIPR002322. Cyt_c_III.
IPR020942. Cyt_c_III_dom.
IPR011031. Multihaem_cyt.
[Graphical view]
PfamiPF02085. Cytochrom_CIII. 1 hit.
[Graphical view]
PRINTSiPR00609. CYTOCHROMEC3.
SUPFAMiSSF48695. SSF48695. 1 hit.
PROSITEiPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYC3_DESVH
AccessioniPrimary (citable) accession number: P00131
Secondary accession number(s): P81150
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The second and fourth heme binding sites have unusual CXXXXCH motifs.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.