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Protein

Cytochrome c3

Gene

DVU_3171

Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Participates in sulfate respiration coupled with phosphorylation by transferring electrons from the enzyme dehydrogenase to ferredoxin.

Miscellaneous

The second and fourth heme binding sites have unusual CXXXXCH motifs.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Iron (heme 1 axial ligand)1
Metal bindingi47Iron (heme 3 axial ligand)1
Binding sitei52Heme 1 (covalent)1
Binding sitei55Heme 1 (covalent)1
Metal bindingi56Iron (heme 1 axial ligand)1
Metal bindingi57Iron (heme 2 axial ligand)1
Binding sitei68Heme 2 (covalent); atypical1
Binding sitei73Heme 2 (covalent); atypical1
Metal bindingi74Iron (heme 2 axial ligand)1
Metal bindingi92Iron (heme 4 axial ligand)1
Binding sitei101Heme 3 (covalent)1
Binding sitei104Heme 3 (covalent)1
Metal bindingi105Iron (heme 3 axial ligand)1
Binding sitei122Heme 4 (covalent); atypical1
Binding sitei127Heme 4 (covalent); atypical1
Metal bindingi128Iron (heme 4 axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Sulfate respiration, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c3
Gene namesi
Ordered Locus Names:DVU_3171
OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
Taxonomic identifieri882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002194 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 222 PublicationsAdd BLAST22
ChainiPRO_000000650423 – 129Cytochrome c31 PublicationAdd BLAST107

Post-translational modificationi

Binds 4 heme groups per subunit.

Proteomic databases

PaxDbiP00131.

Interactioni

Protein-protein interaction databases

STRINGi882.DVU3171.

Structurei

Secondary structure

1129
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 33Combined sources3
Beta strandi35 – 38Combined sources4
Beta strandi40 – 42Combined sources3
Helixi45 – 47Combined sources3
Beta strandi48 – 50Combined sources3
Helixi52 – 54Combined sources3
Beta strandi60 – 63Combined sources4
Turni70 – 72Combined sources3
Beta strandi83 – 85Combined sources3
Helixi87 – 92Combined sources6
Beta strandi95 – 98Combined sources4
Helixi101 – 109Combined sources9
Helixi113 – 120Combined sources8
Beta strandi122 – 127Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A2INMR-A23-129[»]
1GX7NMR-E23-129[»]
1MDVX-ray2.30A/B23-129[»]
2BPNNMR-A23-129[»]
2CTHX-ray1.67A/B23-129[»]
2CYMX-ray2.00A23-129[»]
ProteinModelPortaliP00131.
SMRiP00131.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00131.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106BES. Bacteria.
ENOG410XXW1. LUCA.
OMAiFNHSSHE.
OrthoDBiPOG091H32QK.

Family and domain databases

InterProiView protein in InterPro
IPR002322. Cyt_c_III.
IPR020942. Cyt_c_III_dom.
IPR011031. Multihaem_cyt.
PfamiView protein in Pfam
PF02085. Cytochrom_CIII. 1 hit.
PRINTSiPR00609. CYTOCHROMEC3.
SUPFAMiSSF48695. SSF48695. 1 hit.
PROSITEiView protein in PROSITE
PS51008. MULTIHEME_CYTC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00131-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKLFFCGVL ALAVAFALPV VAAPKAPADG LKMEATKQPV VFNHSTHKSV
60 70 80 90 100
KCGDCHHPVN GKEDYRKCGT AGCHDSMDKK DKSAKGYYHV MHDKNTKFKS
110 120
CVGCHVEVAG ADAAKKKDLT GCKKSKCHE
Length:129
Mass (Da):13,976
Last modified:August 13, 1987 - v1
Checksum:i78C2A85F33B18441
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04304 Genomic DNA. Translation: CAA27847.1.
AE017285 Genomic DNA. Translation: AAS97641.1.
PIRiA24799. CCDV3.
RefSeqiWP_010940429.1. NC_002937.3.
YP_012381.1. NC_002937.3.

Genome annotation databases

EnsemblBacteriaiAAS97641; AAS97641; DVU_3171.
GeneIDi2795876.
KEGGidvu:DVU3171.
PATRICifig|882.5.peg.2876.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCYC3_DESVH
AccessioniPrimary (citable) accession number: P00131
Secondary accession number(s): P81150
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: June 7, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references