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P00130

- QCR9_BOVIN

UniProt

P00130 - QCR9_BOVIN

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Protein

Cytochrome b-c1 complex subunit 9

Gene

UQCR10

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1.

GO - Biological processi

  1. mitochondrial electron transport, ubiquinol to cytochrome c Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 9
Alternative name(s):
Complex III subunit 9
Complex III subunit X
Cytochrome c1 non-heme 7 kDa protein
Ubiquinol-cytochrome c reductase complex 7.2 kDa protein
Gene namesi
Name:UQCR10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 17

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. mitochondrial respiratory chain complex III Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 6463Cytochrome b-c1 complex subunit 9PRO_0000193552Add
BLAST

Proteomic databases

PRIDEiP00130.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

IntActiP00130. 3 interactions.
STRINGi9913.ENSBTAP00000001208.

Structurei

Secondary structure

1
64
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 138
Helixi18 – 4730
Turni48 – 514
Helixi53 – 564
Helixi57 – 593

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16J2-63[»]
1BE3X-ray3.00J2-63[»]
1BGYX-ray3.00J/V2-63[»]
1L0LX-ray2.35J2-63[»]
1L0NX-ray2.60J2-63[»]
1NTKX-ray2.60J2-63[»]
1NTMX-ray2.40J2-63[»]
1NTZX-ray2.60J2-63[»]
1NU1X-ray3.20J2-63[»]
1PP9X-ray2.10J/W2-63[»]
1PPJX-ray2.10J/W2-63[»]
1QCRX-ray2.70J5-63[»]
1SQBX-ray2.69J2-63[»]
1SQPX-ray2.70J2-63[»]
1SQQX-ray3.00J2-63[»]
1SQVX-ray2.85J2-63[»]
1SQXX-ray2.60J2-63[»]
2A06X-ray2.10J/W2-63[»]
2BCCX-ray3.50J2-63[»]
2FYUX-ray2.26J2-63[»]
2YBBelectron microscopy19.00J/j2-63[»]
3BCCX-ray3.70J2-63[»]
ProteinModelPortaliP00130.
SMRiP00130. Positions 2-63.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00130.

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCR10/QCR9 family.Curated

Phylogenomic databases

eggNOGiNOG274563.
GeneTreeiENSGT00390000014052.
HOGENOMiHOG000215187.
HOVERGENiHBG056661.
InParanoidiP00130.
KOiK00419.
OMAiNRGKLWK.
OrthoDBiEOG7VMP8B.
TreeFamiTF324385.

Family and domain databases

Gene3Di1.20.5.260. 1 hit.
InterProiIPR008027. QCR9.
[Graphical view]
PANTHERiPTHR12980. PTHR12980. 1 hit.
PfamiPF05365. UCR_UQCRX_QCR9. 1 hit.
[Graphical view]
SUPFAMiSSF81514. SSF81514. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00130-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAPTLTARL YSLLFRRTST FALTIVVGAL FFERAFDQGA DAIYEHINEG
60
KLWKHIKHKY ENKE
Length:64
Mass (Da):7,458
Last modified:January 23, 2007 - v3
Checksum:iD48CDB1344504049
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102720 mRNA. Translation: AAI02721.1.
PIRiA00123. CCBO17.
RefSeqiNP_001107195.1. NM_001113723.2.
UniGeneiBt.1819.

Genome annotation databases

EnsembliENSBTAT00000001208; ENSBTAP00000001208; ENSBTAG00000000913.
GeneIDi616109.
KEGGibta:616109.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102720 mRNA. Translation: AAI02721.1 .
PIRi A00123. CCBO17.
RefSeqi NP_001107195.1. NM_001113723.2.
UniGenei Bt.1819.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BCC X-ray 3.16 J 2-63 [» ]
1BE3 X-ray 3.00 J 2-63 [» ]
1BGY X-ray 3.00 J/V 2-63 [» ]
1L0L X-ray 2.35 J 2-63 [» ]
1L0N X-ray 2.60 J 2-63 [» ]
1NTK X-ray 2.60 J 2-63 [» ]
1NTM X-ray 2.40 J 2-63 [» ]
1NTZ X-ray 2.60 J 2-63 [» ]
1NU1 X-ray 3.20 J 2-63 [» ]
1PP9 X-ray 2.10 J/W 2-63 [» ]
1PPJ X-ray 2.10 J/W 2-63 [» ]
1QCR X-ray 2.70 J 5-63 [» ]
1SQB X-ray 2.69 J 2-63 [» ]
1SQP X-ray 2.70 J 2-63 [» ]
1SQQ X-ray 3.00 J 2-63 [» ]
1SQV X-ray 2.85 J 2-63 [» ]
1SQX X-ray 2.60 J 2-63 [» ]
2A06 X-ray 2.10 J/W 2-63 [» ]
2BCC X-ray 3.50 J 2-63 [» ]
2FYU X-ray 2.26 J 2-63 [» ]
2YBB electron microscopy 19.00 J/j 2-63 [» ]
3BCC X-ray 3.70 J 2-63 [» ]
ProteinModelPortali P00130.
SMRi P00130. Positions 2-63.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P00130. 3 interactions.
STRINGi 9913.ENSBTAP00000001208.

Proteomic databases

PRIDEi P00130.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000001208 ; ENSBTAP00000001208 ; ENSBTAG00000000913 .
GeneIDi 616109.
KEGGi bta:616109.

Organism-specific databases

CTDi 29796.

Phylogenomic databases

eggNOGi NOG274563.
GeneTreei ENSGT00390000014052.
HOGENOMi HOG000215187.
HOVERGENi HBG056661.
InParanoidi P00130.
KOi K00419.
OMAi NRGKLWK.
OrthoDBi EOG7VMP8B.
TreeFami TF324385.

Miscellaneous databases

EvolutionaryTracei P00130.
NextBioi 20899962.

Family and domain databases

Gene3Di 1.20.5.260. 1 hit.
InterProi IPR008027. QCR9.
[Graphical view ]
PANTHERi PTHR12980. PTHR12980. 1 hit.
Pfami PF05365. UCR_UQCRX_QCR9. 1 hit.
[Graphical view ]
SUPFAMi SSF81514. SSF81514. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.
  2. "Amino-acid sequence of the smallest protein of the cytochrome c1 subcomplex from beef heart mitochondria."
    Schaegger H., von Jagow G., Borchart U., Machleidt W.
    Hoppe-Seyler's Z. Physiol. Chem. 364:307-311(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-63.
    Tissue: Heart.
  3. "Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria."
    Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
    Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
  4. Erratum
    Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
    Science 278:2037-2037(1997)
  5. "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
    Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K.
    Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
  6. "The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition."
    Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D.
    Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
  7. "Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex."
    Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D.
    J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
  8. "Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern."
    Huang L.S., Cobessi D., Tung E.Y., Berry E.A.
    J. Mol. Biol. 351:573-597(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
  9. "Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex."
    Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D.
    Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).

Entry informationi

Entry nameiQCR9_BOVIN
AccessioniPrimary (citable) accession number: P00130
Secondary accession number(s): Q3SZT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3