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P00130 (QCR9_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome b-c1 complex subunit 9
Alternative name(s):
Complex III subunit 9
Complex III subunit X
Cytochrome c1 non-heme 7 kDa protein
Ubiquinol-cytochrome c reductase complex 7.2 kDa protein
Gene names
Name:UQCR10
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length64 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1.

Subunit structure

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the UQCR10/QCR9 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 6463Cytochrome b-c1 complex subunit 9
PRO_0000193552

Secondary structure

......... 64
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P00130 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: D48CDB1344504049

FASTA647,458
        10         20         30         40         50         60 
MVAPTLTARL YSLLFRRTST FALTIVVGAL FFERAFDQGA DAIYEHINEG KLWKHIKHKY 


ENKE 

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.
[2]"Amino-acid sequence of the smallest protein of the cytochrome c1 subcomplex from beef heart mitochondria."
Schaegger H., von Jagow G., Borchart U., Machleidt W.
Hoppe-Seyler's Z. Physiol. Chem. 364:307-311(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-63.
Tissue: Heart.
[3]"Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria."
Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
[4]Erratum
Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
Science 278:2037-2037(1997)
[5]"Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K.
Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
[6]"The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition."
Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D.
Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
[7]"Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex."
Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D.
J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
[8]"Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern."
Huang L.S., Cobessi D., Tung E.Y., Berry E.A.
J. Mol. Biol. 351:573-597(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
[9]"Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex."
Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D.
Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC102720 mRNA. Translation: AAI02721.1.
PIRCCBO17. A00123.
RefSeqNP_001107195.1. NM_001113723.2.
UniGeneBt.1819.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16J2-63[»]
1BE3X-ray3.00J2-63[»]
1BGYX-ray3.00J/V2-63[»]
1L0LX-ray2.35J2-63[»]
1L0NX-ray2.60J2-63[»]
1NTKX-ray2.60J2-62[»]
1NTMX-ray2.40J2-62[»]
1NTZX-ray2.60J2-62[»]
1NU1X-ray3.20J2-62[»]
1PP9X-ray2.10J/W2-63[»]
1PPJX-ray2.10J/W2-63[»]
1QCRX-ray2.70J5-63[»]
1SQBX-ray2.69J2-63[»]
1SQPX-ray2.70J2-63[»]
1SQQX-ray3.00J2-63[»]
1SQVX-ray2.85J2-63[»]
1SQXX-ray2.60J2-63[»]
2A06X-ray2.10J/W2-63[»]
2BCCX-ray3.50J2-63[»]
2FYUX-ray2.26J2-63[»]
2YBBelectron microscopy19.00J/j2-63[»]
3BCCX-ray3.70J2-62[»]
ProteinModelPortalP00130.
SMRP00130. Positions 2-63.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP00130. 3 interactions.
STRING9913.ENSBTAP00000001208.

Proteomic databases

PRIDEP00130.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000001208; ENSBTAP00000001208; ENSBTAG00000000913.
GeneID616109.
KEGGbta:616109.

Organism-specific databases

CTD29796.

Phylogenomic databases

eggNOGNOG274563.
GeneTreeENSGT00390000014052.
HOGENOMHOG000215187.
HOVERGENHBG056661.
InParanoidP00130.
KOK00419.
OMAGKLWKHI.
OrthoDBEOG7VMP8B.
TreeFamTF324385.

Family and domain databases

Gene3D1.20.5.260. 1 hit.
InterProIPR008027. QCR9.
[Graphical view]
PANTHERPTHR12980. PTHR12980. 1 hit.
PfamPF05365. UCR_UQCRX_QCR9. 1 hit.
[Graphical view]
SUPFAMSSF81514. SSF81514. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP00130.
NextBio20899962.

Entry information

Entry nameQCR9_BOVIN
AccessionPrimary (citable) accession number: P00130
Secondary accession number(s): Q3SZT3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references