Cytochrome b-c1 complex subunit 9

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P00130 (QCR9_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 115. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome b-c1 complex subunit 9

Alternative name(s):
Complex III subunit 9
Complex III subunit X
Cytochrome c1 non-heme 7 kDa protein
Ubiquinol-cytochrome c reductase complex 7.2 kDa protein

Gene names

Name:

UQCR10

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	64 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1.
Subunit structure	The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the UQCR10/QCR9 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrial electron transport, ubiquinol to cytochrome c Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial respiratory chain complex III Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed Ref.2

Chain

2 – 64

Cytochrome b-c1 complex subunit 9

PRO_0000193552

Secondary structure

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P00130 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: D48CDB1344504049
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FASTA

7,458

        10         20         30         40         50         60 
MVAPTLTARL YSLLFRRTST FALTIVVGAL FFERAFDQGA DAIYEHINEG KLWKHIKHKY 


ENKE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.
[2]	"Amino-acid sequence of the smallest protein of the cytochrome c1 subcomplex from beef heart mitochondria." Schaegger H., von Jagow G., Borchart U., Machleidt W. Hoppe-Seyler's Z. Physiol. Chem. 364:307-311(1983) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-63. Tissue: Heart.
[3]	"Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria." Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J. Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
[4]	Erratum Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J. Science 278:2037-2037(1997)
[5]	"Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex." Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K. Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
[6]	"The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition." Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D. Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
[7]	"Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex." Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D. J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
[8]	"Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern." Huang L.S., Cobessi D., Tung E.Y., Berry E.A. J. Mol. Biol. 351:573-597(2005) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
[9]	"Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex." Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D. Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BC102720 mRNA. Translation: AAI02721.1.

IPI

IPI00702743.

PIR

CCBO17. A00123.

RefSeq

NP_001107195.1. NM_001113723.2.

UniGene

Bt.1819.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BCC	X-ray	3.16	J	2-62	[»]
1BE3	X-ray	3.00	J	2-63	[»]
1BGY	X-ray	3.00	J/V	2-63	[»]
1L0L	X-ray	2.35	J	2-63	[»]
1L0N	X-ray	2.60	J	2-63	[»]
1NTK	X-ray	2.60	J	2-62	[»]
1NTM	X-ray	2.40	J	2-62	[»]
1NTZ	X-ray	2.60	J	2-62	[»]
1NU1	X-ray	3.20	J	2-62	[»]
1PP9	X-ray	2.10	J/W	2-63	[»]
1PPJ	X-ray	2.10	J/W	2-63	[»]
1QCR	X-ray	2.70	J	5-63	[»]
1SQB	X-ray	2.69	J	2-63	[»]
1SQP	X-ray	2.70	J	2-63	[»]
1SQQ	X-ray	3.00	J	2-63	[»]
1SQV	X-ray	2.85	J	2-63	[»]
1SQX	X-ray	2.60	J	2-63	[»]
2A06	X-ray	2.10	J/W	2-63	[»]
2BCC	X-ray	3.50	J	2-63	[»]
2FYU	X-ray	2.26	J	2-63	[»]
2YBB	electron microscopy	19.00	J/j	2-63	[»]
3BCC	X-ray	3.70	J	2-62	[»]

ProteinModelPortal

P00130.

SMR

P00130. Positions 2-63.

ModBase

Search...

Protein-protein interaction databases

IntAct

P00130. 3 interactions.

STRING

9913.ENSBTAP00000001208.

Proteomic databases

PRIDE

P00130.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSBTAT00000001208; ENSBTAP00000001208; ENSBTAG00000000913.

GeneID

616109.

KEGG

bta:616109.

Organism-specific databases

CTD

29796.

Phylogenomic databases

eggNOG

NOG274563.

GeneTree

ENSGT00390000014052.

HOGENOM

HOG000215187.

HOVERGEN

HBG056661.

InParanoid

P00130.

K00419.

OMA

GKLWKHI.

OrthoDB

EOG4NVZN3.

Family and domain databases

Gene3D

1.20.5.260. 1 hit.

InterPro

IPR008027. QCR9.
[Graphical view]

PANTHER

PTHR12980. PTHR12980. 1 hit.

Pfam

PF05365. UCR_UQCRX_QCR9. 1 hit.
[Graphical view]

SUPFAM

SSF81514. Ubiquinol_cytC_Reductase_QCR9. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P00130.

NextBio

20899962.

Entry information

Entry name

QCR9_BOVIN

Accession

Primary (citable) accession number: P00130
Secondary accession number(s): Q3SZT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 115 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents