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P00130

- QCR9_BOVIN

UniProt

P00130 - QCR9_BOVIN

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Protein

Cytochrome b-c1 complex subunit 9

Gene

UQCR10

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1.

GO - Biological processi

  1. mitochondrial electron transport, ubiquinol to cytochrome c Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_223064. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 9
Alternative name(s):
Complex III subunit 9
Complex III subunit X
Cytochrome c1 non-heme 7 kDa protein
Ubiquinol-cytochrome c reductase complex 7.2 kDa protein
Gene namesi
Name:UQCR10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 17

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. mitochondrial respiratory chain complex III Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 6463Cytochrome b-c1 complex subunit 9PRO_0000193552Add
BLAST

Proteomic databases

PRIDEiP00130.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

IntActiP00130. 3 interactions.
STRINGi9913.ENSBTAP00000001208.

Structurei

Secondary structure

1
64
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 138Combined sources
Helixi18 – 4730Combined sources
Turni48 – 514Combined sources
Helixi53 – 564Combined sources
Helixi57 – 593Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16J2-63[»]
1BE3X-ray3.00J2-63[»]
1BGYX-ray3.00J/V2-63[»]
1L0LX-ray2.35J2-63[»]
1L0NX-ray2.60J2-63[»]
1NTKX-ray2.60J2-63[»]
1NTMX-ray2.40J2-63[»]
1NTZX-ray2.60J2-63[»]
1NU1X-ray3.20J2-63[»]
1PP9X-ray2.10J/W2-63[»]
1PPJX-ray2.10J/W2-63[»]
1QCRX-ray2.70J5-63[»]
1SQBX-ray2.69J2-63[»]
1SQPX-ray2.70J2-63[»]
1SQQX-ray3.00J2-63[»]
1SQVX-ray2.85J2-63[»]
1SQXX-ray2.60J2-63[»]
2A06X-ray2.10J/W2-63[»]
2BCCX-ray3.50J2-63[»]
2FYUX-ray2.26J2-63[»]
2YBBelectron microscopy19.00J/j2-63[»]
3BCCX-ray3.70J2-63[»]
ProteinModelPortaliP00130.
SMRiP00130. Positions 2-63.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00130.

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCR10/QCR9 family.Curated

Phylogenomic databases

eggNOGiNOG274563.
GeneTreeiENSGT00390000014052.
HOGENOMiHOG000215187.
HOVERGENiHBG056661.
InParanoidiP00130.
KOiK00419.
OMAiNRGKLWK.
OrthoDBiEOG7VMP8B.
TreeFamiTF324385.

Family and domain databases

Gene3Di1.20.5.260. 1 hit.
InterProiIPR008027. QCR9.
[Graphical view]
PANTHERiPTHR12980. PTHR12980. 1 hit.
PfamiPF05365. UCR_UQCRX_QCR9. 1 hit.
[Graphical view]
SUPFAMiSSF81514. SSF81514. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00130-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAPTLTARL YSLLFRRTST FALTIVVGAL FFERAFDQGA DAIYEHINEG
60
KLWKHIKHKY ENKE
Length:64
Mass (Da):7,458
Last modified:January 23, 2007 - v3
Checksum:iD48CDB1344504049
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102720 mRNA. Translation: AAI02721.1.
PIRiA00123. CCBO17.
RefSeqiNP_001107195.1. NM_001113723.2.
UniGeneiBt.1819.

Genome annotation databases

EnsembliENSBTAT00000001208; ENSBTAP00000001208; ENSBTAG00000000913.
GeneIDi616109.
KEGGibta:616109.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102720 mRNA. Translation: AAI02721.1 .
PIRi A00123. CCBO17.
RefSeqi NP_001107195.1. NM_001113723.2.
UniGenei Bt.1819.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BCC X-ray 3.16 J 2-63 [» ]
1BE3 X-ray 3.00 J 2-63 [» ]
1BGY X-ray 3.00 J/V 2-63 [» ]
1L0L X-ray 2.35 J 2-63 [» ]
1L0N X-ray 2.60 J 2-63 [» ]
1NTK X-ray 2.60 J 2-63 [» ]
1NTM X-ray 2.40 J 2-63 [» ]
1NTZ X-ray 2.60 J 2-63 [» ]
1NU1 X-ray 3.20 J 2-63 [» ]
1PP9 X-ray 2.10 J/W 2-63 [» ]
1PPJ X-ray 2.10 J/W 2-63 [» ]
1QCR X-ray 2.70 J 5-63 [» ]
1SQB X-ray 2.69 J 2-63 [» ]
1SQP X-ray 2.70 J 2-63 [» ]
1SQQ X-ray 3.00 J 2-63 [» ]
1SQV X-ray 2.85 J 2-63 [» ]
1SQX X-ray 2.60 J 2-63 [» ]
2A06 X-ray 2.10 J/W 2-63 [» ]
2BCC X-ray 3.50 J 2-63 [» ]
2FYU X-ray 2.26 J 2-63 [» ]
2YBB electron microscopy 19.00 J/j 2-63 [» ]
3BCC X-ray 3.70 J 2-63 [» ]
ProteinModelPortali P00130.
SMRi P00130. Positions 2-63.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P00130. 3 interactions.
STRINGi 9913.ENSBTAP00000001208.

Proteomic databases

PRIDEi P00130.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000001208 ; ENSBTAP00000001208 ; ENSBTAG00000000913 .
GeneIDi 616109.
KEGGi bta:616109.

Organism-specific databases

CTDi 29796.

Phylogenomic databases

eggNOGi NOG274563.
GeneTreei ENSGT00390000014052.
HOGENOMi HOG000215187.
HOVERGENi HBG056661.
InParanoidi P00130.
KOi K00419.
OMAi NRGKLWK.
OrthoDBi EOG7VMP8B.
TreeFami TF324385.

Enzyme and pathway databases

Reactomei REACT_223064. Respiratory electron transport.

Miscellaneous databases

EvolutionaryTracei P00130.
NextBioi 20899962.

Family and domain databases

Gene3Di 1.20.5.260. 1 hit.
InterProi IPR008027. QCR9.
[Graphical view ]
PANTHERi PTHR12980. PTHR12980. 1 hit.
Pfami PF05365. UCR_UQCRX_QCR9. 1 hit.
[Graphical view ]
SUPFAMi SSF81514. SSF81514. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.
  2. "Amino-acid sequence of the smallest protein of the cytochrome c1 subcomplex from beef heart mitochondria."
    Schaegger H., von Jagow G., Borchart U., Machleidt W.
    Hoppe-Seyler's Z. Physiol. Chem. 364:307-311(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-63.
    Tissue: Heart.
  3. "Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria."
    Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
    Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
  4. Erratum
    Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
    Science 278:2037-2037(1997)
  5. "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
    Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K.
    Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
  6. "The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition."
    Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D.
    Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
  7. "Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex."
    Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D.
    J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
  8. "Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern."
    Huang L.S., Cobessi D., Tung E.Y., Berry E.A.
    J. Mol. Biol. 351:573-597(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
  9. "Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex."
    Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D.
    Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).

Entry informationi

Entry nameiQCR9_BOVIN
AccessioniPrimary (citable) accession number: P00130
Secondary accession number(s): Q3SZT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3