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P00130

- QCR9_BOVIN

UniProt

P00130 - QCR9_BOVIN

Protein

Cytochrome b-c1 complex subunit 9

Gene

UQCR10

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1.

    GO - Biological processi

    1. mitochondrial electron transport, ubiquinol to cytochrome c Source: InterPro

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b-c1 complex subunit 9
    Alternative name(s):
    Complex III subunit 9
    Complex III subunit X
    Cytochrome c1 non-heme 7 kDa protein
    Ubiquinol-cytochrome c reductase complex 7.2 kDa protein
    Gene namesi
    Name:UQCR10
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 17

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial respiratory chain complex III Source: InterPro

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 6463Cytochrome b-c1 complex subunit 9PRO_0000193552Add
    BLAST

    Proteomic databases

    PRIDEiP00130.

    Interactioni

    Subunit structurei

    The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

    Protein-protein interaction databases

    IntActiP00130. 3 interactions.
    STRINGi9913.ENSBTAP00000001208.

    Structurei

    Secondary structure

    1
    64
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 138
    Helixi18 – 4730
    Turni48 – 514
    Helixi53 – 564
    Helixi57 – 593

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BCCX-ray3.16J2-63[»]
    1BE3X-ray3.00J2-63[»]
    1BGYX-ray3.00J/V2-63[»]
    1L0LX-ray2.35J2-63[»]
    1L0NX-ray2.60J2-63[»]
    1NTKX-ray2.60J2-63[»]
    1NTMX-ray2.40J2-63[»]
    1NTZX-ray2.60J2-63[»]
    1NU1X-ray3.20J2-63[»]
    1PP9X-ray2.10J/W2-63[»]
    1PPJX-ray2.10J/W2-63[»]
    1QCRX-ray2.70J5-63[»]
    1SQBX-ray2.69J2-63[»]
    1SQPX-ray2.70J2-63[»]
    1SQQX-ray3.00J2-63[»]
    1SQVX-ray2.85J2-63[»]
    1SQXX-ray2.60J2-63[»]
    2A06X-ray2.10J/W2-63[»]
    2BCCX-ray3.50J2-63[»]
    2FYUX-ray2.26J2-63[»]
    2YBBelectron microscopy19.00J/j2-63[»]
    3BCCX-ray3.70J2-63[»]
    ProteinModelPortaliP00130.
    SMRiP00130. Positions 2-63.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP00130.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UQCR10/QCR9 family.Curated

    Phylogenomic databases

    eggNOGiNOG274563.
    GeneTreeiENSGT00390000014052.
    HOGENOMiHOG000215187.
    HOVERGENiHBG056661.
    InParanoidiP00130.
    KOiK00419.
    OMAiNRGKLWK.
    OrthoDBiEOG7VMP8B.
    TreeFamiTF324385.

    Family and domain databases

    Gene3Di1.20.5.260. 1 hit.
    InterProiIPR008027. QCR9.
    [Graphical view]
    PANTHERiPTHR12980. PTHR12980. 1 hit.
    PfamiPF05365. UCR_UQCRX_QCR9. 1 hit.
    [Graphical view]
    SUPFAMiSSF81514. SSF81514. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00130-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVAPTLTARL YSLLFRRTST FALTIVVGAL FFERAFDQGA DAIYEHINEG   50
    KLWKHIKHKY ENKE 64
    Length:64
    Mass (Da):7,458
    Last modified:January 23, 2007 - v3
    Checksum:iD48CDB1344504049
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102720 mRNA. Translation: AAI02721.1.
    PIRiA00123. CCBO17.
    RefSeqiNP_001107195.1. NM_001113723.2.
    UniGeneiBt.1819.

    Genome annotation databases

    EnsembliENSBTAT00000001208; ENSBTAP00000001208; ENSBTAG00000000913.
    GeneIDi616109.
    KEGGibta:616109.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102720 mRNA. Translation: AAI02721.1 .
    PIRi A00123. CCBO17.
    RefSeqi NP_001107195.1. NM_001113723.2.
    UniGenei Bt.1819.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BCC X-ray 3.16 J 2-63 [» ]
    1BE3 X-ray 3.00 J 2-63 [» ]
    1BGY X-ray 3.00 J/V 2-63 [» ]
    1L0L X-ray 2.35 J 2-63 [» ]
    1L0N X-ray 2.60 J 2-63 [» ]
    1NTK X-ray 2.60 J 2-63 [» ]
    1NTM X-ray 2.40 J 2-63 [» ]
    1NTZ X-ray 2.60 J 2-63 [» ]
    1NU1 X-ray 3.20 J 2-63 [» ]
    1PP9 X-ray 2.10 J/W 2-63 [» ]
    1PPJ X-ray 2.10 J/W 2-63 [» ]
    1QCR X-ray 2.70 J 5-63 [» ]
    1SQB X-ray 2.69 J 2-63 [» ]
    1SQP X-ray 2.70 J 2-63 [» ]
    1SQQ X-ray 3.00 J 2-63 [» ]
    1SQV X-ray 2.85 J 2-63 [» ]
    1SQX X-ray 2.60 J 2-63 [» ]
    2A06 X-ray 2.10 J/W 2-63 [» ]
    2BCC X-ray 3.50 J 2-63 [» ]
    2FYU X-ray 2.26 J 2-63 [» ]
    2YBB electron microscopy 19.00 J/j 2-63 [» ]
    3BCC X-ray 3.70 J 2-63 [» ]
    ProteinModelPortali P00130.
    SMRi P00130. Positions 2-63.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P00130. 3 interactions.
    STRINGi 9913.ENSBTAP00000001208.

    Proteomic databases

    PRIDEi P00130.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000001208 ; ENSBTAP00000001208 ; ENSBTAG00000000913 .
    GeneIDi 616109.
    KEGGi bta:616109.

    Organism-specific databases

    CTDi 29796.

    Phylogenomic databases

    eggNOGi NOG274563.
    GeneTreei ENSGT00390000014052.
    HOGENOMi HOG000215187.
    HOVERGENi HBG056661.
    InParanoidi P00130.
    KOi K00419.
    OMAi NRGKLWK.
    OrthoDBi EOG7VMP8B.
    TreeFami TF324385.

    Miscellaneous databases

    EvolutionaryTracei P00130.
    NextBioi 20899962.

    Family and domain databases

    Gene3Di 1.20.5.260. 1 hit.
    InterProi IPR008027. QCR9.
    [Graphical view ]
    PANTHERi PTHR12980. PTHR12980. 1 hit.
    Pfami PF05365. UCR_UQCRX_QCR9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81514. SSF81514. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.
    2. "Amino-acid sequence of the smallest protein of the cytochrome c1 subcomplex from beef heart mitochondria."
      Schaegger H., von Jagow G., Borchart U., Machleidt W.
      Hoppe-Seyler's Z. Physiol. Chem. 364:307-311(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-63.
      Tissue: Heart.
    3. "Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria."
      Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
      Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
    4. Erratum
      Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
      Science 278:2037-2037(1997)
    5. "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
      Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K.
      Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
    6. "The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition."
      Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D.
      Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
    7. "Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex."
      Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D.
      J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
    8. "Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern."
      Huang L.S., Cobessi D., Tung E.Y., Berry E.A.
      J. Mol. Biol. 351:573-597(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
    9. "Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex."
      Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D.
      Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).

    Entry informationi

    Entry nameiQCR9_BOVIN
    AccessioniPrimary (citable) accession number: P00130
    Secondary accession number(s): Q3SZT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 125 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3