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P00129

- QCR7_BOVIN

UniProt

P00129 - QCR7_BOVIN

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Protein
Cytochrome b-c1 complex subunit 7
Gene
UQCRB
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.

GO - Biological processi

  1. mitochondrial electron transport, ubiquinol to cytochrome c Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 7
Alternative name(s):
Complex III subunit 7
Complex III subunit VII
QP-C
Ubiquinol-cytochrome c reductase complex 14 kDa protein
Gene namesi
Name:UQCRB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 14

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial respiratory chain complex III Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 111110Cytochrome b-c1 complex subunit 7
PRO_0000193523Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei19 – 191N6-acetyllysine By similarity
Modified residuei78 – 781N6-acetyllysine; alternate By similarity
Modified residuei78 – 781N6-succinyllysine; alternate By similarity
Modified residuei83 – 831N6-acetyllysine By similarity
Modified residuei88 – 881N6-acetyllysine; alternate By similarity
Modified residuei88 – 881N6-succinyllysine; alternate By similarity
Modified residuei96 – 961N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP00129.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

DIPiDIP-1082N.
IntActiP00129. 3 interactions.
STRINGi9913.ENSBTAP00000001993.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni9 – 135
Helixi14 – 2512
Helixi27 – 304
Helixi34 – 374
Helixi42 – 498
Helixi53 – 7119
Helixi78 – 803
Helixi84 – 863
Helixi92 – 11019

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16F2-108[»]
1BE3X-ray3.00F2-111[»]
1BGYX-ray3.00F/R2-111[»]
1L0LX-ray2.35F2-111[»]
1L0NX-ray2.60F2-111[»]
1NTKX-ray2.60F2-111[»]
1NTMX-ray2.40F2-111[»]
1NTZX-ray2.60F2-111[»]
1NU1X-ray3.20F2-111[»]
1PP9X-ray2.10F/S2-111[»]
1PPJX-ray2.10F/S2-111[»]
1QCRX-ray2.70F9-111[»]
1SQBX-ray2.69F2-111[»]
1SQPX-ray2.70F2-111[»]
1SQQX-ray3.00F2-111[»]
1SQVX-ray2.85F2-111[»]
1SQXX-ray2.60F2-111[»]
2A06X-ray2.10F/S2-111[»]
2BCCX-ray3.50F2-108[»]
2FYUX-ray2.26F2-111[»]
2YBBelectron microscopy19.00F/f2-111[»]
3BCCX-ray3.70F2-108[»]
ProteinModelPortaliP00129.
SMRiP00129. Positions 3-111.

Miscellaneous databases

EvolutionaryTraceiP00129.

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCRB/QCR7 family.

Phylogenomic databases

eggNOGiNOG235867.
GeneTreeiENSGT00390000012916.
HOGENOMiHOG000188221.
HOVERGENiHBG002984.
InParanoidiP00129.
KOiK00417.
OMAiQWVKYEE.
OrthoDBiEOG7VDXR7.
TreeFamiTF105035.

Family and domain databases

Gene3Di1.10.1090.10. 1 hit.
InterProiIPR003197. QCR7.
[Graphical view]
PANTHERiPTHR12022. PTHR12022. 1 hit.
PfamiPF02271. UCR_14kD. 1 hit.
[Graphical view]
PIRSFiPIRSF000022. Bc1_14K. 1 hit.
ProDomiPD008153. Cyt_bd_ubiquinol_oxidase_14kDa. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81524. SSF81524. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00129-1 [UniParc]FASTAAdd to Basket

« Hide

MAGRPAVSAS SRWLEGIRKW YYNAAGFNKL GLMRDDTIHE NDDVKEAIRR    50
LPENLYNDRV FRIKRALDLS MRQQILPKEQ WTKYEEDKSY LEPYLKEVIR 100
ERKEREEWAK K 111
Length:111
Mass (Da):13,476
Last modified:January 23, 2007 - v3
Checksum:i2D89B44D53DA494B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571N → D AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103057 mRNA. Translation: AAI03058.1.
PIRiA00122. UYBO.
RefSeqiNP_001029969.1. NM_001034797.2.
UniGeneiBt.49002.

Genome annotation databases

EnsembliENSBTAT00000001993; ENSBTAP00000001993; ENSBTAG00000001521.
GeneIDi616871.
KEGGibta:616871.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103057 mRNA. Translation: AAI03058.1 .
PIRi A00122. UYBO.
RefSeqi NP_001029969.1. NM_001034797.2.
UniGenei Bt.49002.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BCC X-ray 3.16 F 2-108 [» ]
1BE3 X-ray 3.00 F 2-111 [» ]
1BGY X-ray 3.00 F/R 2-111 [» ]
1L0L X-ray 2.35 F 2-111 [» ]
1L0N X-ray 2.60 F 2-111 [» ]
1NTK X-ray 2.60 F 2-111 [» ]
1NTM X-ray 2.40 F 2-111 [» ]
1NTZ X-ray 2.60 F 2-111 [» ]
1NU1 X-ray 3.20 F 2-111 [» ]
1PP9 X-ray 2.10 F/S 2-111 [» ]
1PPJ X-ray 2.10 F/S 2-111 [» ]
1QCR X-ray 2.70 F 9-111 [» ]
1SQB X-ray 2.69 F 2-111 [» ]
1SQP X-ray 2.70 F 2-111 [» ]
1SQQ X-ray 3.00 F 2-111 [» ]
1SQV X-ray 2.85 F 2-111 [» ]
1SQX X-ray 2.60 F 2-111 [» ]
2A06 X-ray 2.10 F/S 2-111 [» ]
2BCC X-ray 3.50 F 2-108 [» ]
2FYU X-ray 2.26 F 2-111 [» ]
2YBB electron microscopy 19.00 F/f 2-111 [» ]
3BCC X-ray 3.70 F 2-108 [» ]
ProteinModelPortali P00129.
SMRi P00129. Positions 3-111.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-1082N.
IntActi P00129. 3 interactions.
STRINGi 9913.ENSBTAP00000001993.

Proteomic databases

PRIDEi P00129.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000001993 ; ENSBTAP00000001993 ; ENSBTAG00000001521 .
GeneIDi 616871.
KEGGi bta:616871.

Organism-specific databases

CTDi 7381.

Phylogenomic databases

eggNOGi NOG235867.
GeneTreei ENSGT00390000012916.
HOGENOMi HOG000188221.
HOVERGENi HBG002984.
InParanoidi P00129.
KOi K00417.
OMAi QWVKYEE.
OrthoDBi EOG7VDXR7.
TreeFami TF105035.

Miscellaneous databases

EvolutionaryTracei P00129.
NextBioi 20900361.

Family and domain databases

Gene3Di 1.10.1090.10. 1 hit.
InterProi IPR003197. QCR7.
[Graphical view ]
PANTHERi PTHR12022. PTHR12022. 1 hit.
Pfami PF02271. UCR_14kD. 1 hit.
[Graphical view ]
PIRSFi PIRSF000022. Bc1_14K. 1 hit.
ProDomi PD008153. Cyt_bd_ubiquinol_oxidase_14kDa. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF81524. SSF81524. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.
  2. "Complete amino acid sequence of the ubiquinone binding protein (QP-C), a protein similar to the 14,000-dalton subunit of the yeast ubiquinol-cytochrome c reductase complex."
    Wakabayashi S., Takao T., Shimonishi Y., Kuramitsu S., Matsubara H., Wang T., Zhang Z., King T.E.
    J. Biol. Chem. 260:337-343(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-111.
  3. "Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria."
    Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
    Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
  4. Erratum
    Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
    Science 278:2037-2037(1997)
  5. "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
    Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K.
    Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
  6. "The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition."
    Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D.
    Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
  7. "Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex."
    Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D.
    J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
  8. "Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern."
    Huang L.S., Cobessi D., Tung E.Y., Berry E.A.
    J. Mol. Biol. 351:573-597(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
  9. "Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex."
    Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D.
    Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).

Entry informationi

Entry nameiQCR7_BOVIN
AccessioniPrimary (citable) accession number: P00129
Secondary accession number(s): Q3SZ83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally (1 Publication) thought to be the ubiquinone-binding protein (QP-C).

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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