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Protein

Cytochrome b-c1 complex subunit 7

Gene

UQCRB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 7
Alternative name(s):
Complex III subunit 7
Complex III subunit VII
QP-C
Ubiquinol-cytochrome c reductase complex 14 kDa protein
Gene namesi
Name:UQCRB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001935232 – 111Cytochrome b-c1 complex subunit 7Add BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei19N6-acetyllysineBy similarity1
Modified residuei78N6-acetyllysine; alternateBy similarity1
Modified residuei78N6-succinyllysine; alternateBy similarity1
Modified residuei83N6-acetyllysineBy similarity1
Modified residuei88N6-acetyllysine; alternateBy similarity1
Modified residuei88N6-succinyllysine; alternateBy similarity1
Modified residuei96N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP00129.
PRIDEiP00129.

Expressioni

Gene expression databases

BgeeiENSBTAG00000001521.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

DIPiDIP-1082N.
IntActiP00129. 3 interactors.
STRINGi9913.ENSBTAP00000001993.

Structurei

Secondary structure

1111
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni9 – 13Combined sources5
Helixi14 – 25Combined sources12
Helixi27 – 30Combined sources4
Helixi34 – 37Combined sources4
Helixi42 – 49Combined sources8
Helixi53 – 71Combined sources19
Helixi78 – 80Combined sources3
Helixi84 – 86Combined sources3
Helixi92 – 110Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16F2-108[»]
1BE3X-ray3.00F2-111[»]
1BGYX-ray3.00F/R2-111[»]
1L0LX-ray2.35F2-111[»]
1L0NX-ray2.60F2-111[»]
1NTKX-ray2.60F2-111[»]
1NTMX-ray2.40F2-111[»]
1NTZX-ray2.60F2-111[»]
1NU1X-ray3.20F2-111[»]
1PP9X-ray2.10F/S2-111[»]
1PPJX-ray2.10F/S2-111[»]
1QCRX-ray2.70F9-111[»]
1SQBX-ray2.69F2-111[»]
1SQPX-ray2.70F2-111[»]
1SQQX-ray3.00F2-111[»]
1SQVX-ray2.85F2-111[»]
1SQXX-ray2.60F2-111[»]
2A06X-ray2.10F/S2-111[»]
2BCCX-ray3.50F2-108[»]
2FYUX-ray2.26F2-111[»]
2YBBelectron microscopy19.00F/f2-111[»]
3BCCX-ray3.70F2-108[»]
4D6TX-ray3.57F/S1-111[»]
4D6UX-ray4.09F/S1-111[»]
5KLVX-ray2.65F2-111[»]
ProteinModelPortaliP00129.
SMRiP00129.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00129.

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCRB/QCR7 family.Curated

Phylogenomic databases

eggNOGiKOG3440. Eukaryota.
ENOG4111V1G. LUCA.
GeneTreeiENSGT00390000012916.
HOGENOMiHOG000188221.
HOVERGENiHBG002984.
InParanoidiP00129.
KOiK00417.
OMAiPENVYND.
OrthoDBiEOG091G0RM5.
TreeFamiTF105035.

Family and domain databases

Gene3Di1.10.1090.10. 1 hit.
InterProiIPR003197. QCR7.
[Graphical view]
PANTHERiPTHR12022. PTHR12022. 1 hit.
PfamiPF02271. UCR_14kD. 1 hit.
[Graphical view]
PIRSFiPIRSF000022. Bc1_14K. 1 hit.
ProDomiPD008153. Cyt_bd_ubiquinol_oxidase_14kDa. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81524. SSF81524. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00129-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRPAVSAS SRWLEGIRKW YYNAAGFNKL GLMRDDTIHE NDDVKEAIRR
60 70 80 90 100
LPENLYNDRV FRIKRALDLS MRQQILPKEQ WTKYEEDKSY LEPYLKEVIR
110
ERKEREEWAK K
Length:111
Mass (Da):13,476
Last modified:January 23, 2007 - v3
Checksum:i2D89B44D53DA494B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57N → D AA sequence (PubMed:2981208).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103057 mRNA. Translation: AAI03058.1.
PIRiA00122. UYBO.
RefSeqiNP_001029969.1. NM_001034797.2.
UniGeneiBt.49002.

Genome annotation databases

EnsembliENSBTAT00000001993; ENSBTAP00000001993; ENSBTAG00000001521.
GeneIDi616871.
KEGGibta:616871.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103057 mRNA. Translation: AAI03058.1.
PIRiA00122. UYBO.
RefSeqiNP_001029969.1. NM_001034797.2.
UniGeneiBt.49002.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16F2-108[»]
1BE3X-ray3.00F2-111[»]
1BGYX-ray3.00F/R2-111[»]
1L0LX-ray2.35F2-111[»]
1L0NX-ray2.60F2-111[»]
1NTKX-ray2.60F2-111[»]
1NTMX-ray2.40F2-111[»]
1NTZX-ray2.60F2-111[»]
1NU1X-ray3.20F2-111[»]
1PP9X-ray2.10F/S2-111[»]
1PPJX-ray2.10F/S2-111[»]
1QCRX-ray2.70F9-111[»]
1SQBX-ray2.69F2-111[»]
1SQPX-ray2.70F2-111[»]
1SQQX-ray3.00F2-111[»]
1SQVX-ray2.85F2-111[»]
1SQXX-ray2.60F2-111[»]
2A06X-ray2.10F/S2-111[»]
2BCCX-ray3.50F2-108[»]
2FYUX-ray2.26F2-111[»]
2YBBelectron microscopy19.00F/f2-111[»]
3BCCX-ray3.70F2-108[»]
4D6TX-ray3.57F/S1-111[»]
4D6UX-ray4.09F/S1-111[»]
5KLVX-ray2.65F2-111[»]
ProteinModelPortaliP00129.
SMRiP00129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-1082N.
IntActiP00129. 3 interactors.
STRINGi9913.ENSBTAP00000001993.

Proteomic databases

PaxDbiP00129.
PRIDEiP00129.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001993; ENSBTAP00000001993; ENSBTAG00000001521.
GeneIDi616871.
KEGGibta:616871.

Organism-specific databases

CTDi7381.

Phylogenomic databases

eggNOGiKOG3440. Eukaryota.
ENOG4111V1G. LUCA.
GeneTreeiENSGT00390000012916.
HOGENOMiHOG000188221.
HOVERGENiHBG002984.
InParanoidiP00129.
KOiK00417.
OMAiPENVYND.
OrthoDBiEOG091G0RM5.
TreeFamiTF105035.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.

Miscellaneous databases

EvolutionaryTraceiP00129.

Gene expression databases

BgeeiENSBTAG00000001521.

Family and domain databases

Gene3Di1.10.1090.10. 1 hit.
InterProiIPR003197. QCR7.
[Graphical view]
PANTHERiPTHR12022. PTHR12022. 1 hit.
PfamiPF02271. UCR_14kD. 1 hit.
[Graphical view]
PIRSFiPIRSF000022. Bc1_14K. 1 hit.
ProDomiPD008153. Cyt_bd_ubiquinol_oxidase_14kDa. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81524. SSF81524. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQCR7_BOVIN
AccessioniPrimary (citable) accession number: P00129
Secondary accession number(s): Q3SZ83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be the ubiquinone-binding protein (QP-C).1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.