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P00129

- QCR7_BOVIN

UniProt

P00129 - QCR7_BOVIN

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Protein

Cytochrome b-c1 complex subunit 7

Gene

UQCRB

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.

GO - Biological processi

  1. mitochondrial electron transport, ubiquinol to cytochrome c Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_223064. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 7
Alternative name(s):
Complex III subunit 7
Complex III subunit VII
QP-C
Ubiquinol-cytochrome c reductase complex 14 kDa protein
Gene namesi
Name:UQCRB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 14

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial respiratory chain complex III Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 111110Cytochrome b-c1 complex subunit 7PRO_0000193523Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei19 – 191N6-acetyllysineBy similarity
Modified residuei78 – 781N6-acetyllysine; alternateBy similarity
Modified residuei78 – 781N6-succinyllysine; alternateBy similarity
Modified residuei83 – 831N6-acetyllysineBy similarity
Modified residuei88 – 881N6-acetyllysine; alternateBy similarity
Modified residuei88 – 881N6-succinyllysine; alternateBy similarity
Modified residuei96 – 961N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP00129.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

DIPiDIP-1082N.
IntActiP00129. 3 interactions.
STRINGi9913.ENSBTAP00000001993.

Structurei

Secondary structure

1
111
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni9 – 135Combined sources
Helixi14 – 2512Combined sources
Helixi27 – 304Combined sources
Helixi34 – 374Combined sources
Helixi42 – 498Combined sources
Helixi53 – 7119Combined sources
Helixi78 – 803Combined sources
Helixi84 – 863Combined sources
Helixi92 – 11019Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16F2-108[»]
1BE3X-ray3.00F2-111[»]
1BGYX-ray3.00F/R2-111[»]
1L0LX-ray2.35F2-111[»]
1L0NX-ray2.60F2-111[»]
1NTKX-ray2.60F2-111[»]
1NTMX-ray2.40F2-111[»]
1NTZX-ray2.60F2-111[»]
1NU1X-ray3.20F2-111[»]
1PP9X-ray2.10F/S2-111[»]
1PPJX-ray2.10F/S2-111[»]
1QCRX-ray2.70F9-111[»]
1SQBX-ray2.69F2-111[»]
1SQPX-ray2.70F2-111[»]
1SQQX-ray3.00F2-111[»]
1SQVX-ray2.85F2-111[»]
1SQXX-ray2.60F2-111[»]
2A06X-ray2.10F/S2-111[»]
2BCCX-ray3.50F2-108[»]
2FYUX-ray2.26F2-111[»]
2YBBelectron microscopy19.00F/f2-111[»]
3BCCX-ray3.70F2-108[»]
ProteinModelPortaliP00129.
SMRiP00129. Positions 3-111.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00129.

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCRB/QCR7 family.Curated

Phylogenomic databases

eggNOGiNOG235867.
GeneTreeiENSGT00390000012916.
HOGENOMiHOG000188221.
HOVERGENiHBG002984.
InParanoidiP00129.
KOiK00417.
OMAiQWVKYEE.
OrthoDBiEOG7VDXR7.
TreeFamiTF105035.

Family and domain databases

Gene3Di1.10.1090.10. 1 hit.
InterProiIPR003197. QCR7.
[Graphical view]
PANTHERiPTHR12022. PTHR12022. 1 hit.
PfamiPF02271. UCR_14kD. 1 hit.
[Graphical view]
PIRSFiPIRSF000022. Bc1_14K. 1 hit.
ProDomiPD008153. Cyt_bd_ubiquinol_oxidase_14kDa. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81524. SSF81524. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00129-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGRPAVSAS SRWLEGIRKW YYNAAGFNKL GLMRDDTIHE NDDVKEAIRR
60 70 80 90 100
LPENLYNDRV FRIKRALDLS MRQQILPKEQ WTKYEEDKSY LEPYLKEVIR
110
ERKEREEWAK K
Length:111
Mass (Da):13,476
Last modified:January 23, 2007 - v3
Checksum:i2D89B44D53DA494B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571N → D AA sequence (PubMed:2981208)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103057 mRNA. Translation: AAI03058.1.
PIRiA00122. UYBO.
RefSeqiNP_001029969.1. NM_001034797.2.
UniGeneiBt.49002.

Genome annotation databases

EnsembliENSBTAT00000001993; ENSBTAP00000001993; ENSBTAG00000001521.
GeneIDi616871.
KEGGibta:616871.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103057 mRNA. Translation: AAI03058.1 .
PIRi A00122. UYBO.
RefSeqi NP_001029969.1. NM_001034797.2.
UniGenei Bt.49002.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BCC X-ray 3.16 F 2-108 [» ]
1BE3 X-ray 3.00 F 2-111 [» ]
1BGY X-ray 3.00 F/R 2-111 [» ]
1L0L X-ray 2.35 F 2-111 [» ]
1L0N X-ray 2.60 F 2-111 [» ]
1NTK X-ray 2.60 F 2-111 [» ]
1NTM X-ray 2.40 F 2-111 [» ]
1NTZ X-ray 2.60 F 2-111 [» ]
1NU1 X-ray 3.20 F 2-111 [» ]
1PP9 X-ray 2.10 F/S 2-111 [» ]
1PPJ X-ray 2.10 F/S 2-111 [» ]
1QCR X-ray 2.70 F 9-111 [» ]
1SQB X-ray 2.69 F 2-111 [» ]
1SQP X-ray 2.70 F 2-111 [» ]
1SQQ X-ray 3.00 F 2-111 [» ]
1SQV X-ray 2.85 F 2-111 [» ]
1SQX X-ray 2.60 F 2-111 [» ]
2A06 X-ray 2.10 F/S 2-111 [» ]
2BCC X-ray 3.50 F 2-108 [» ]
2FYU X-ray 2.26 F 2-111 [» ]
2YBB electron microscopy 19.00 F/f 2-111 [» ]
3BCC X-ray 3.70 F 2-108 [» ]
ProteinModelPortali P00129.
SMRi P00129. Positions 3-111.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-1082N.
IntActi P00129. 3 interactions.
STRINGi 9913.ENSBTAP00000001993.

Proteomic databases

PRIDEi P00129.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000001993 ; ENSBTAP00000001993 ; ENSBTAG00000001521 .
GeneIDi 616871.
KEGGi bta:616871.

Organism-specific databases

CTDi 7381.

Phylogenomic databases

eggNOGi NOG235867.
GeneTreei ENSGT00390000012916.
HOGENOMi HOG000188221.
HOVERGENi HBG002984.
InParanoidi P00129.
KOi K00417.
OMAi QWVKYEE.
OrthoDBi EOG7VDXR7.
TreeFami TF105035.

Enzyme and pathway databases

Reactomei REACT_223064. Respiratory electron transport.

Miscellaneous databases

EvolutionaryTracei P00129.
NextBioi 20900361.

Family and domain databases

Gene3Di 1.10.1090.10. 1 hit.
InterProi IPR003197. QCR7.
[Graphical view ]
PANTHERi PTHR12022. PTHR12022. 1 hit.
Pfami PF02271. UCR_14kD. 1 hit.
[Graphical view ]
PIRSFi PIRSF000022. Bc1_14K. 1 hit.
ProDomi PD008153. Cyt_bd_ubiquinol_oxidase_14kDa. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF81524. SSF81524. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.
  2. "Complete amino acid sequence of the ubiquinone binding protein (QP-C), a protein similar to the 14,000-dalton subunit of the yeast ubiquinol-cytochrome c reductase complex."
    Wakabayashi S., Takao T., Shimonishi Y., Kuramitsu S., Matsubara H., Wang T., Zhang Z., King T.E.
    J. Biol. Chem. 260:337-343(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-111.
  3. "Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria."
    Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
    Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
  4. Erratum
    Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
    Science 278:2037-2037(1997)
  5. "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
    Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K.
    Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
  6. "The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition."
    Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D.
    Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
  7. "Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex."
    Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D.
    J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
  8. "Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern."
    Huang L.S., Cobessi D., Tung E.Y., Berry E.A.
    J. Mol. Biol. 351:573-597(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
  9. "Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex."
    Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D.
    Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).

Entry informationi

Entry nameiQCR7_BOVIN
AccessioniPrimary (citable) accession number: P00129
Secondary accession number(s): Q3SZ83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be the ubiquinone-binding protein (QP-C).1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3