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P00129

- QCR7_BOVIN

UniProt

P00129 - QCR7_BOVIN

Protein

Cytochrome b-c1 complex subunit 7

Gene

UQCRB

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.

    GO - Biological processi

    1. mitochondrial electron transport, ubiquinol to cytochrome c Source: InterPro

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b-c1 complex subunit 7
    Alternative name(s):
    Complex III subunit 7
    Complex III subunit VII
    QP-C
    Ubiquinol-cytochrome c reductase complex 14 kDa protein
    Gene namesi
    Name:UQCRB
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 14

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial respiratory chain complex III Source: InterPro

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 111110Cytochrome b-c1 complex subunit 7PRO_0000193523Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei19 – 191N6-acetyllysineBy similarity
    Modified residuei78 – 781N6-acetyllysine; alternateBy similarity
    Modified residuei78 – 781N6-succinyllysine; alternateBy similarity
    Modified residuei83 – 831N6-acetyllysineBy similarity
    Modified residuei88 – 881N6-acetyllysine; alternateBy similarity
    Modified residuei88 – 881N6-succinyllysine; alternateBy similarity
    Modified residuei96 – 961N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiP00129.

    Interactioni

    Subunit structurei

    The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

    Protein-protein interaction databases

    DIPiDIP-1082N.
    IntActiP00129. 3 interactions.
    STRINGi9913.ENSBTAP00000001993.

    Structurei

    Secondary structure

    1
    111
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni9 – 135
    Helixi14 – 2512
    Helixi27 – 304
    Helixi34 – 374
    Helixi42 – 498
    Helixi53 – 7119
    Helixi78 – 803
    Helixi84 – 863
    Helixi92 – 11019

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BCCX-ray3.16F2-108[»]
    1BE3X-ray3.00F2-111[»]
    1BGYX-ray3.00F/R2-111[»]
    1L0LX-ray2.35F2-111[»]
    1L0NX-ray2.60F2-111[»]
    1NTKX-ray2.60F2-111[»]
    1NTMX-ray2.40F2-111[»]
    1NTZX-ray2.60F2-111[»]
    1NU1X-ray3.20F2-111[»]
    1PP9X-ray2.10F/S2-111[»]
    1PPJX-ray2.10F/S2-111[»]
    1QCRX-ray2.70F9-111[»]
    1SQBX-ray2.69F2-111[»]
    1SQPX-ray2.70F2-111[»]
    1SQQX-ray3.00F2-111[»]
    1SQVX-ray2.85F2-111[»]
    1SQXX-ray2.60F2-111[»]
    2A06X-ray2.10F/S2-111[»]
    2BCCX-ray3.50F2-108[»]
    2FYUX-ray2.26F2-111[»]
    2YBBelectron microscopy19.00F/f2-111[»]
    3BCCX-ray3.70F2-108[»]
    ProteinModelPortaliP00129.
    SMRiP00129. Positions 3-111.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP00129.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UQCRB/QCR7 family.Curated

    Phylogenomic databases

    eggNOGiNOG235867.
    GeneTreeiENSGT00390000012916.
    HOGENOMiHOG000188221.
    HOVERGENiHBG002984.
    InParanoidiP00129.
    KOiK00417.
    OMAiQWVKYEE.
    OrthoDBiEOG7VDXR7.
    TreeFamiTF105035.

    Family and domain databases

    Gene3Di1.10.1090.10. 1 hit.
    InterProiIPR003197. QCR7.
    [Graphical view]
    PANTHERiPTHR12022. PTHR12022. 1 hit.
    PfamiPF02271. UCR_14kD. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000022. Bc1_14K. 1 hit.
    ProDomiPD008153. Cyt_bd_ubiquinol_oxidase_14kDa. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF81524. SSF81524. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00129-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGRPAVSAS SRWLEGIRKW YYNAAGFNKL GLMRDDTIHE NDDVKEAIRR    50
    LPENLYNDRV FRIKRALDLS MRQQILPKEQ WTKYEEDKSY LEPYLKEVIR 100
    ERKEREEWAK K 111
    Length:111
    Mass (Da):13,476
    Last modified:January 23, 2007 - v3
    Checksum:i2D89B44D53DA494B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 571N → D AA sequence (PubMed:2981208)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC103057 mRNA. Translation: AAI03058.1.
    PIRiA00122. UYBO.
    RefSeqiNP_001029969.1. NM_001034797.2.
    UniGeneiBt.49002.

    Genome annotation databases

    EnsembliENSBTAT00000001993; ENSBTAP00000001993; ENSBTAG00000001521.
    GeneIDi616871.
    KEGGibta:616871.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC103057 mRNA. Translation: AAI03058.1 .
    PIRi A00122. UYBO.
    RefSeqi NP_001029969.1. NM_001034797.2.
    UniGenei Bt.49002.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BCC X-ray 3.16 F 2-108 [» ]
    1BE3 X-ray 3.00 F 2-111 [» ]
    1BGY X-ray 3.00 F/R 2-111 [» ]
    1L0L X-ray 2.35 F 2-111 [» ]
    1L0N X-ray 2.60 F 2-111 [» ]
    1NTK X-ray 2.60 F 2-111 [» ]
    1NTM X-ray 2.40 F 2-111 [» ]
    1NTZ X-ray 2.60 F 2-111 [» ]
    1NU1 X-ray 3.20 F 2-111 [» ]
    1PP9 X-ray 2.10 F/S 2-111 [» ]
    1PPJ X-ray 2.10 F/S 2-111 [» ]
    1QCR X-ray 2.70 F 9-111 [» ]
    1SQB X-ray 2.69 F 2-111 [» ]
    1SQP X-ray 2.70 F 2-111 [» ]
    1SQQ X-ray 3.00 F 2-111 [» ]
    1SQV X-ray 2.85 F 2-111 [» ]
    1SQX X-ray 2.60 F 2-111 [» ]
    2A06 X-ray 2.10 F/S 2-111 [» ]
    2BCC X-ray 3.50 F 2-108 [» ]
    2FYU X-ray 2.26 F 2-111 [» ]
    2YBB electron microscopy 19.00 F/f 2-111 [» ]
    3BCC X-ray 3.70 F 2-108 [» ]
    ProteinModelPortali P00129.
    SMRi P00129. Positions 3-111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-1082N.
    IntActi P00129. 3 interactions.
    STRINGi 9913.ENSBTAP00000001993.

    Proteomic databases

    PRIDEi P00129.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000001993 ; ENSBTAP00000001993 ; ENSBTAG00000001521 .
    GeneIDi 616871.
    KEGGi bta:616871.

    Organism-specific databases

    CTDi 7381.

    Phylogenomic databases

    eggNOGi NOG235867.
    GeneTreei ENSGT00390000012916.
    HOGENOMi HOG000188221.
    HOVERGENi HBG002984.
    InParanoidi P00129.
    KOi K00417.
    OMAi QWVKYEE.
    OrthoDBi EOG7VDXR7.
    TreeFami TF105035.

    Miscellaneous databases

    EvolutionaryTracei P00129.
    NextBioi 20900361.

    Family and domain databases

    Gene3Di 1.10.1090.10. 1 hit.
    InterProi IPR003197. QCR7.
    [Graphical view ]
    PANTHERi PTHR12022. PTHR12022. 1 hit.
    Pfami PF02271. UCR_14kD. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000022. Bc1_14K. 1 hit.
    ProDomi PD008153. Cyt_bd_ubiquinol_oxidase_14kDa. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF81524. SSF81524. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Heart ventricle.
    2. "Complete amino acid sequence of the ubiquinone binding protein (QP-C), a protein similar to the 14,000-dalton subunit of the yeast ubiquinol-cytochrome c reductase complex."
      Wakabayashi S., Takao T., Shimonishi Y., Kuramitsu S., Matsubara H., Wang T., Zhang Z., King T.E.
      J. Biol. Chem. 260:337-343(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-111.
    3. "Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria."
      Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
      Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
    4. Erratum
      Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
      Science 278:2037-2037(1997)
    5. "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
      Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K.
      Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
    6. "The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition."
      Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D.
      Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
    7. "Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex."
      Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D.
      J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
    8. "Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern."
      Huang L.S., Cobessi D., Tung E.Y., Berry E.A.
      J. Mol. Biol. 351:573-597(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
    9. "Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex."
      Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D.
      Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).

    Entry informationi

    Entry nameiQCR7_BOVIN
    AccessioniPrimary (citable) accession number: P00129
    Secondary accession number(s): Q3SZ83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 124 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally thought to be the ubiquinone-binding protein (QP-C).1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3