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Protein

Cytochrome b-c1 complex subunit 7

Gene

QCR7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR7 is involved in redox-linked proton pumping.

Miscellaneous

Present with 10100 molecules/cell in log phase SD medium.1 Publication

Caution

Was originally thought to be the ubiquinone-binding protein (QP-C).Curated

GO - Biological processi

  • aerobic respiration Source: SGD
  • mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD
  • mitochondrial respiratory chain complex III assembly Source: SGD

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciYEAST:YDR529C-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 7
Alternative name(s):
Complex III subunit 7
Complex III subunit VII
Ubiquinol-cytochrome c reductase c reductase complex 14 kDa protein
Gene namesi
Name:QCR7
Synonyms:CRO1, UCR7
Ordered Locus Names:YDR529C
ORF Names:D9719.32
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR529C
SGDiS000002937 QCR7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001935391 – 127Cytochrome b-c1 complex subunit 7Add BLAST127

Proteomic databases

MaxQBiP00128
PaxDbiP00128
PRIDEiP00128

Interactioni

Subunit structurei

Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

Protein-protein interaction databases

BioGridi32578, 138 interactors
DIPiDIP-2061N
IntActiP00128, 8 interactors
STRINGi4932.YDR529C

Structurei

Secondary structure

1127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 17Combined sources13
Helixi19 – 36Combined sources18
Helixi38 – 41Combined sources4
Helixi45 – 48Combined sources4
Helixi54 – 62Combined sources9
Helixi65 – 83Combined sources19
Helixi90 – 92Combined sources3
Helixi96 – 98Combined sources3
Helixi104 – 121Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30F3-127[»]
1KB9X-ray2.30G3-127[»]
1KYOX-ray2.97G/R2-127[»]
1P84X-ray2.50G3-127[»]
2IBZX-ray2.30F1-127[»]
3CX5X-ray1.90G/R2-127[»]
3CXHX-ray2.50G/R2-127[»]
4PD4X-ray3.04G2-127[»]
ProteinModelPortaliP00128
SMRiP00128
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00128

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCRB/QCR7 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000012916
HOGENOMiHOG000188221
InParanoidiP00128
KOiK00417
OMAiFRKWYYN
OrthoDBiEOG092C5M0U

Family and domain databases

Gene3Di1.10.1090.10, 1 hit
InterProiView protein in InterPro
IPR003197 QCR7
IPR036544 QCR7_sf
PANTHERiPTHR12022 PTHR12022, 1 hit
PfamiView protein in Pfam
PF02271 UCR_14kD, 1 hit
PIRSFiPIRSF000022 Bc1_14K, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD008153 Cyt_bd_ubiquinol_oxidase_14kDa, 1 hit
SUPFAMiSSF81524 SSF81524, 1 hit

Sequencei

Sequence statusi: Complete.

P00128-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQSFTSIAR IGDYILKSPV LSKLCVPVAN QFINLAGYKK LGLKFDDLIA
60 70 80 90 100
EENPIMQTAL RRLPEDESYA RAYRIIRAHQ TELTHHLLPR NEWIKAQEDV
110 120
PYLLPYILEA EAAAKEKDEL DNIEVSK
Length:127
Mass (Da):14,565
Last modified:October 1, 1996 - v2
Checksum:i1F1BA3DB6C4067B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92E → Q in CAA25064 (PubMed:6319130).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00256 Genomic DNA Translation: CAA25064.1
U33057 Genomic DNA Translation: AAB64968.1
BK006938 Genomic DNA Translation: DAA12360.1
PIRiS69584 RDBYUN
RefSeqiNP_010818.1, NM_001180837.1

Genome annotation databases

EnsemblFungiiYDR529C; YDR529C; YDR529C
GeneIDi852142
KEGGisce:YDR529C

Similar proteinsi

Entry informationi

Entry nameiQCR7_YEAST
AccessioniPrimary (citable) accession number: P00128
Secondary accession number(s): D6VTF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health