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Protein

Cytochrome b-c1 complex subunit 6

Gene

QCR6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR6 may mediate formation of the complex between cytochromes c and c1.

Miscellaneous

Present with 4490 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • aerobic respiration Source: SGD
  • mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciYEAST:YFR033C-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 6
Alternative name(s):
Complex III subunit 6
Complex III subunit VI
Cytochrome c1 non-heme 17 kDa protein
Mitochondrial hinge protein
Ubiquinol-cytochrome c reductase complex 17 kDa protein
Gene namesi
Name:QCR6
Synonyms:UCR6
Ordered Locus Names:YFR033C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFR033C
SGDiS000001929 QCR6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001935421 – 147Cytochrome b-c1 complex subunit 6Add BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi101 ↔ 1236 Publications

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP00127
PaxDbiP00127
PRIDEiP00127

PTM databases

CarbonylDBiP00127

Interactioni

Subunit structurei

Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

Protein-protein interaction databases

BioGridi31190, 103 interactors
DIPiDIP-1621N
IntActiP00127, 4 interactors
MINTiP00127
STRINGi4932.YFR033C

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi77 – 86Combined sources10
Helixi89 – 110Combined sources22
Helixi114 – 116Combined sources3
Helixi124 – 142Combined sources19
Helixi143 – 145Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30H74-147[»]
1KB9X-ray2.30F74-147[»]
1KYOX-ray2.97F/Q75-147[»]
1P84X-ray2.50F74-147[»]
2IBZX-ray2.30H74-147[»]
3CX5X-ray1.90F/Q2-147[»]
3CXHX-ray2.50F/Q2-147[»]
4PD4X-ray3.04F74-147[»]
DisProtiDP00853
ProteinModelPortaliP00127
SMRiP00127
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00127

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi26 – 80Asp/Glu-rich (acidic)Add BLAST55

Sequence similaritiesi

Belongs to the UQCRH/QCR6 family.Curated

Phylogenomic databases

HOGENOMiHOG000001146
InParanoidiP00127
KOiK00416
OMAiAHCATAC
OrthoDBiEOG092C5WYB

Family and domain databases

Gene3Di1.10.287.20, 1 hit
InterProiView protein in InterPro
IPR003422 Cyt_b-c1_6
IPR023184 Ubol_cytC_Rdtase_hinge_dom
IPR036811 Ubol_cytC_Rdtase_hinge_dom_sf
PANTHERiPTHR15336 PTHR15336, 1 hit
PfamiView protein in Pfam
PF02320 UCR_hinge, 1 hit
SUPFAMiSSF81531 SSF81531, 1 hit

Sequencei

Sequence statusi: Complete.

P00127-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMLELVGEY WEQLKITVVP VVAAAEDDDN EQHEEKAAEG EEKEEENGDE
60 70 80 90 100
DEDEDEDEDD DDDDDEDEEE EEEVTDQLED LREHFKNTEE GKALVHHYEE
110 120 130 140
CAERVKIQQQ QPGYADLEHK EDCVEEFFHL QHYLDTATAP RLFDKLK
Length:147
Mass (Da):17,257
Last modified:November 1, 1995 - v2
Checksum:i1488B9C0EB57BE8F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2G → D in CAA25220 (PubMed:6329732).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00551 Genomic DNA Translation: CAA25220.1
D50617 Genomic DNA Translation: BAA09272.1
BK006940 Genomic DNA Translation: DAA12476.1
PIRiS56288 RDBYUC
RefSeqiNP_116691.3, NM_001179998.3

Genome annotation databases

EnsemblFungiiBAA09272; BAA09272; BAA09272
YFR033C; YFR033C; YFR033C
GeneIDi850593
KEGGisce:YFR033C

Similar proteinsi

Entry informationi

Entry nameiQCR6_YEAST
AccessioniPrimary (citable) accession number: P00127
Secondary accession number(s): D6VTR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health