Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P00126 (QCR6_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome b-c1 complex subunit 6, mitochondrial
Alternative name(s):
Complex III subunit 6
Complex III subunit VIII
Cytochrome c1 non-heme 11 kDa protein
Mitochondrial hinge protein
Ubiquinol-cytochrome c reductase complex 11 kDa protein
Gene names
Name:UQCRH
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length91 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

Subunit structure

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the UQCRH/QCR6 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1313Mitochondrion Ref.2
Chain14 – 9178Cytochrome b-c1 complex subunit 6, mitochondrial
PRO_0000193540

Regions

Compositional bias18 – 258Poly-Glu

Amino acid modifications

Modified residue421N6-acetyllysine By similarity
Modified residue851N6-acetyllysine By similarity
Disulfide bond37 ↔ 81 Ref.3
Disulfide bond53 ↔ 67 Ref.3

Secondary structure

............ 91
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P00126 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: F444A2E7B6A147D4

FASTA9110,624
        10         20         30         40         50         60 
MGLEDEQRML TGSGDPKEEE EEEEELVDPL TTVREQCEQL EKCVKARERL ELCDERVSSR 

        70         80         90 
SQTEEDCTEE LLDFLHARDH CVAHKLFNSL K 

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.
[2]"Identity of the heme-not-containing protein in bovine heart cytochrome c1 preparation with the protein mediating c1-c complex formation -- a protein with high glutamic acid content."
Wakabayashi S., Takeda H., Matsubara H., Kim C.H., King T.E.
J. Biochem. 91:2077-2085(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 14-91.
[3]"Dissociation of bovine cytochrome c1 subcomplex and the status of cysteine residues in the subunits."
Mukai K., Miyazaki T., Wakabayashi S., Kuramitsu S., Matsubara H.
J. Biochem. 98:1417-1425(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: DISULFIDE BONDS.
[4]"Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria."
Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 14-91.
[5]Erratum
Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
Science 278:2037-2037(1997)
[6]"Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K.
Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 14-91.
[7]"The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition."
Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D.
Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
[8]"Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex."
Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D.
J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
[9]"Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern."
Huang L.S., Cobessi D., Tung E.Y., Berry E.A.
J. Mol. Biol. 351:573-597(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
[10]"Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex."
Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D.
Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC102729 mRNA. Translation: AAI02730.1.
PIRCCBO11. A00119.
RefSeqNP_001029917.1. NM_001034745.2.
UniGeneBt.27327.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16H14-91[»]
1BE3X-ray3.00H14-91[»]
1BGYX-ray3.00H/T14-91[»]
1L0LX-ray2.35H14-91[»]
1L0NX-ray2.60H14-91[»]
1NTKX-ray2.60H14-91[»]
1NTMX-ray2.40H14-91[»]
1NTZX-ray2.60H14-91[»]
1NU1X-ray3.20H14-91[»]
1PP9X-ray2.10H/U14-91[»]
1PPJX-ray2.10H/U14-91[»]
1QCRX-ray2.70H31-90[»]
1SQBX-ray2.69H14-91[»]
1SQPX-ray2.70H14-91[»]
1SQQX-ray3.00H14-91[»]
1SQVX-ray2.85H14-91[»]
1SQXX-ray2.60H14-91[»]
2A06X-ray2.10H/U14-91[»]
2BCCX-ray3.50H14-91[»]
2FYUX-ray2.26H14-91[»]
2YBBelectron microscopy19.00H/h14-91[»]
3BCCX-ray3.70H14-91[»]
ProteinModelPortalP00126.
SMRP00126. Positions 14-91.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP00126. 2 interactions.
STRING9913.ENSBTAP00000012635.

Proteomic databases

PaxDbP00126.
PRIDEP00126.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000012635; ENSBTAP00000012635; ENSBTAG00000009603.
GeneID613899.
KEGGbta:613899.

Organism-specific databases

CTD7388.

Phylogenomic databases

eggNOGNOG312125.
GeneTreeENSGT00390000003860.
HOGENOMHOG000243673.
HOVERGENHBG001487.
InParanoidP00126.
KOK00416.
OMAHKLFNSL.
OrthoDBEOG7PK92F.
TreeFamTF105036.

Family and domain databases

Gene3D1.10.287.20. 1 hit.
InterProIPR003422. Cyt_b-c1_6.
IPR023184. Ubol_cytC_Rdtase_hinge_dom.
[Graphical view]
PANTHERPTHR15336. PTHR15336. 1 hit.
PfamPF02320. UCR_hinge. 1 hit.
[Graphical view]
PIRSFPIRSF000019. Bc1_11K. 1 hit.
SUPFAMSSF81531. SSF81531. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP00126.
NextBio20898827.

Entry information

Entry nameQCR6_BOVIN
AccessionPrimary (citable) accession number: P00126
Secondary accession number(s): Q3SZS4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 27, 2006
Last modified: April 16, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references