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Protein

Cytochrome b-c1 complex subunit 6, mitochondrial

Gene

UQCRH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 6, mitochondrial
Alternative name(s):
Complex III subunit 6
Complex III subunit VIII
Cytochrome c1 non-heme 11 kDa protein
Mitochondrial hinge protein
Ubiquinol-cytochrome c reductase complex 11 kDa protein
Gene namesi
Name:UQCRH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

  • Mitochondrion inner membrane By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 13Mitochondrion1 PublicationAdd BLAST13
ChainiPRO_000019354014 – 91Cytochrome b-c1 complex subunit 6, mitochondrialAdd BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 811 Publication
Modified residuei42N6-acetyllysineBy similarity1
Disulfide bondi53 ↔ 671 Publication
Modified residuei85N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiP00126.
PeptideAtlasiP00126.
PRIDEiP00126.

Expressioni

Gene expression databases

BgeeiENSBTAG00000009603.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

DIPiDIP-38973N.
IntActiP00126. 2 interactors.
STRINGi9913.ENSBTAP00000012635.

Structurei

Secondary structure

191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 24Combined sources8
Helixi29 – 37Combined sources9
Beta strandi38 – 40Combined sources3
Helixi41 – 58Combined sources18
Beta strandi61 – 63Combined sources3
Helixi68 – 85Combined sources18
Helixi86 – 89Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16H14-91[»]
1BE3X-ray3.00H14-91[»]
1BGYX-ray3.00H/T14-91[»]
1L0LX-ray2.35H14-91[»]
1L0NX-ray2.60H14-91[»]
1NTKX-ray2.60H14-91[»]
1NTMX-ray2.40H14-91[»]
1NTZX-ray2.60H14-91[»]
1NU1X-ray3.20H14-91[»]
1PP9X-ray2.10H/U14-91[»]
1PPJX-ray2.10H/U14-91[»]
1QCRX-ray2.70H31-90[»]
1SQBX-ray2.69H14-91[»]
1SQPX-ray2.70H14-91[»]
1SQQX-ray3.00H14-91[»]
1SQVX-ray2.85H14-91[»]
1SQXX-ray2.60H14-91[»]
2A06X-ray2.10H/U14-91[»]
2BCCX-ray3.50H14-91[»]
2FYUX-ray2.26H14-91[»]
2YBBelectron microscopy19.00H/h14-91[»]
3BCCX-ray3.70H14-91[»]
4D6TX-ray3.57H/U1-91[»]
4D6UX-ray4.09H/U1-91[»]
5KLVX-ray2.65H14-91[»]
ProteinModelPortaliP00126.
SMRiP00126.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00126.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 25Poly-Glu8

Sequence similaritiesi

Belongs to the UQCRH/QCR6 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4763. Eukaryota.
ENOG411247S. LUCA.
GeneTreeiENSGT00390000003860.
HOGENOMiHOG000243673.
HOVERGENiHBG001487.
InParanoidiP00126.
KOiK00416.
OMAiSQTEEDC.
OrthoDBiEOG091G13DH.
TreeFamiTF105036.

Family and domain databases

Gene3Di1.10.287.20. 1 hit.
InterProiIPR003422. Cyt_b-c1_6.
IPR023184. Ubol_cytC_Rdtase_hinge_dom.
[Graphical view]
PANTHERiPTHR15336. PTHR15336. 1 hit.
PfamiPF02320. UCR_hinge. 1 hit.
[Graphical view]
PIRSFiPIRSF000019. Bc1_11K. 1 hit.
SUPFAMiSSF81531. SSF81531. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLEDEQRML TGSGDPKEEE EEEEELVDPL TTVREQCEQL EKCVKARERL
60 70 80 90
ELCDERVSSR SQTEEDCTEE LLDFLHARDH CVAHKLFNSL K
Length:91
Mass (Da):10,624
Last modified:June 27, 2006 - v2
Checksum:iF444A2E7B6A147D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102729 mRNA. Translation: AAI02730.1.
PIRiA00119. CCBO11.
RefSeqiNP_001029917.1. NM_001034745.2.
UniGeneiBt.27327.

Genome annotation databases

EnsembliENSBTAT00000012635; ENSBTAP00000012635; ENSBTAG00000009603.
GeneIDi613899.
KEGGibta:613899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102729 mRNA. Translation: AAI02730.1.
PIRiA00119. CCBO11.
RefSeqiNP_001029917.1. NM_001034745.2.
UniGeneiBt.27327.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16H14-91[»]
1BE3X-ray3.00H14-91[»]
1BGYX-ray3.00H/T14-91[»]
1L0LX-ray2.35H14-91[»]
1L0NX-ray2.60H14-91[»]
1NTKX-ray2.60H14-91[»]
1NTMX-ray2.40H14-91[»]
1NTZX-ray2.60H14-91[»]
1NU1X-ray3.20H14-91[»]
1PP9X-ray2.10H/U14-91[»]
1PPJX-ray2.10H/U14-91[»]
1QCRX-ray2.70H31-90[»]
1SQBX-ray2.69H14-91[»]
1SQPX-ray2.70H14-91[»]
1SQQX-ray3.00H14-91[»]
1SQVX-ray2.85H14-91[»]
1SQXX-ray2.60H14-91[»]
2A06X-ray2.10H/U14-91[»]
2BCCX-ray3.50H14-91[»]
2FYUX-ray2.26H14-91[»]
2YBBelectron microscopy19.00H/h14-91[»]
3BCCX-ray3.70H14-91[»]
4D6TX-ray3.57H/U1-91[»]
4D6UX-ray4.09H/U1-91[»]
5KLVX-ray2.65H14-91[»]
ProteinModelPortaliP00126.
SMRiP00126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-38973N.
IntActiP00126. 2 interactors.
STRINGi9913.ENSBTAP00000012635.

Proteomic databases

PaxDbiP00126.
PeptideAtlasiP00126.
PRIDEiP00126.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000012635; ENSBTAP00000012635; ENSBTAG00000009603.
GeneIDi613899.
KEGGibta:613899.

Organism-specific databases

CTDi7388.

Phylogenomic databases

eggNOGiKOG4763. Eukaryota.
ENOG411247S. LUCA.
GeneTreeiENSGT00390000003860.
HOGENOMiHOG000243673.
HOVERGENiHBG001487.
InParanoidiP00126.
KOiK00416.
OMAiSQTEEDC.
OrthoDBiEOG091G13DH.
TreeFamiTF105036.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.

Miscellaneous databases

EvolutionaryTraceiP00126.

Gene expression databases

BgeeiENSBTAG00000009603.

Family and domain databases

Gene3Di1.10.287.20. 1 hit.
InterProiIPR003422. Cyt_b-c1_6.
IPR023184. Ubol_cytC_Rdtase_hinge_dom.
[Graphical view]
PANTHERiPTHR15336. PTHR15336. 1 hit.
PfamiPF02320. UCR_hinge. 1 hit.
[Graphical view]
PIRSFiPIRSF000019. Bc1_11K. 1 hit.
SUPFAMiSSF81531. SSF81531. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQCR6_BOVIN
AccessioniPrimary (citable) accession number: P00126
Secondary accession number(s): Q3SZS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 27, 2006
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.