Cytochrome b-c1 complex subunit 6, mitochondrial precursor

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P00126 (QCR6_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 114. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome b-c1 complex subunit 6, mitochondrial

Alternative name(s):
Complex III subunit 6
Complex III subunit VIII
Cytochrome c1 non-heme 11 kDa protein
Mitochondrial hinge protein
Ubiquinol-cytochrome c reductase complex 11 kDa protein

Gene names

Name:

UQCRH

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	91 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
Subunit structure	The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the UQCRH/QCR6 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
PTM	Acetylation Disulfide bond Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrial electron transport, ubiquinol to cytochrome c Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ubiquinol-cytochrome-c reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 13

Mitochondrion Ref.2

Chain

14 – 91

Cytochrome b-c1 complex subunit 6, mitochondrial

PRO_0000193540

Regions

Compositional bias

18 – 25

Poly-Glu

Amino acid modifications

Modified residue

N6-acetyllysine By similarity

Modified residue

Phosphothreonine By similarity

Modified residue

N6-acetyllysine By similarity

Disulfide bond

Disulfide bond

Secondary structure

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P00126 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: F444A2E7B6A147D4
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FASTA

10,624

        10         20         30         40         50         60 
MGLEDEQRML TGSGDPKEEE EEEEELVDPL TTVREQCEQL EKCVKARERL ELCDERVSSR 

        70         80         90 
SQTEEDCTEE LLDFLHARDH CVAHKLFNSL K

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.
[2]	"Identity of the heme-not-containing protein in bovine heart cytochrome c1 preparation with the protein mediating c1-c complex formation -- a protein with high glutamic acid content." Wakabayashi S., Takeda H., Matsubara H., Kim C.H., King T.E. J. Biochem. 91:2077-2085(1982) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 14-91.
[3]	"Dissociation of bovine cytochrome c1 subcomplex and the status of cysteine residues in the subunits." Mukai K., Miyazaki T., Wakabayashi S., Kuramitsu S., Matsubara H. J. Biochem. 98:1417-1425(1985) [PubMed] [Europe PMC] [Abstract] Cited for: DISULFIDE BONDS.
[4]	"Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria." Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J. Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 14-91.
[5]	Erratum Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J. Science 278:2037-2037(1997)
[6]	"Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex." Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K. Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 14-91.
[7]	"The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition." Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D. Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
[8]	"Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex." Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D. J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
[9]	"Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern." Huang L.S., Cobessi D., Tung E.Y., Berry E.A. J. Mol. Biol. 351:573-597(2005) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
[10]	"Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex." Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D. Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BC102729 mRNA. Translation: AAI02730.1.

IPI

IPI00697651.

PIR

CCBO11. A00119.

RefSeq

NP_001029917.1. NM_001034745.2.

UniGene

Bt.27327.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BCC	X-ray	3.16	H	14-91	[»]
1BE3	X-ray	3.00	H	14-91	[»]
1BGY	X-ray	3.00	H/T	14-91	[»]
1L0L	X-ray	2.35	H	14-91	[»]
1L0N	X-ray	2.60	H	14-91	[»]
1NTK	X-ray	2.60	H	14-91	[»]
1NTM	X-ray	2.40	H	14-91	[»]
1NTZ	X-ray	2.60	H	14-91	[»]
1NU1	X-ray	3.20	H	14-91	[»]
1PP9	X-ray	2.10	H/U	14-91	[»]
1PPJ	X-ray	2.10	H/U	14-91	[»]
1QCR	X-ray	2.70	H	31-90	[»]
1SQB	X-ray	2.69	H	14-91	[»]
1SQP	X-ray	2.70	H	14-91	[»]
1SQQ	X-ray	3.00	H	14-91	[»]
1SQV	X-ray	2.85	H	14-91	[»]
1SQX	X-ray	2.60	H	14-91	[»]
2A06	X-ray	2.10	H/U	14-91	[»]
2BCC	X-ray	3.50	H	14-91	[»]
2FYU	X-ray	2.26	H	14-91	[»]
2YBB	electron microscopy	19.00	H/h	14-91	[»]
3BCC	X-ray	3.70	H	14-91	[»]

ProteinModelPortal

P00126.

SMR

P00126. Positions 14-91.

ModBase

Search...

Protein-protein interaction databases

IntAct

P00126. 2 interactions.

STRING

9913.ENSBTAP00000012635.

Proteomic databases

PaxDb

P00126.

PRIDE

P00126.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSBTAT00000012635; ENSBTAP00000012635; ENSBTAG00000009603.

GeneID

613899.

KEGG

bta:613899.

Organism-specific databases

CTD

7388.

Phylogenomic databases

eggNOG

NOG312125.

GeneTree

ENSGT00390000003860.

HOGENOM

HOG000243673.

HOVERGEN

HBG001487.

InParanoid

P00126.

K00416.

OMA

HKLFNSL.

OrthoDB

EOG405S2P.

Family and domain databases

Gene3D

1.10.287.20. 1 hit.

InterPro

IPR003422. Cyt_b-c1_6.
IPR023184. Ubol_cytC_Rdtase_hinge_dom.
[Graphical view]

PANTHER

PTHR15336. PTHR15336. 1 hit.

Pfam

PF02320. UCR_hinge. 1 hit.
[Graphical view]

PIRSF

PIRSF000019. Bc1_11K. 1 hit.

SUPFAM

SSF81531. Ubol_cytC_Rdtase_hinge_dom. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P00126.

NextBio

20898827.

Entry information

Entry name

QCR6_BOVIN

Accession

Primary (citable) accession number: P00126
Secondary accession number(s): Q3SZS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	June 27, 2006
Last modified:	April 3, 2013
This is version 114 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents