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P00126

- QCR6_BOVIN

UniProt

P00126 - QCR6_BOVIN

Protein

Cytochrome b-c1 complex subunit 6, mitochondrial

Gene

UQCRH

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

    GO - Molecular functioni

    1. ubiquinol-cytochrome-c reductase activity Source: InterPro

    GO - Biological processi

    1. mitochondrial electron transport, ubiquinol to cytochrome c Source: InterPro

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b-c1 complex subunit 6, mitochondrial
    Alternative name(s):
    Complex III subunit 6
    Complex III subunit VIII
    Cytochrome c1 non-heme 11 kDa protein
    Mitochondrial hinge protein
    Ubiquinol-cytochrome c reductase complex 11 kDa protein
    Gene namesi
    Name:UQCRH
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 3

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1313Mitochondrion1 PublicationAdd
    BLAST
    Chaini14 – 9178Cytochrome b-c1 complex subunit 6, mitochondrialPRO_0000193540Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi37 ↔ 811 Publication
    Modified residuei42 – 421N6-acetyllysineBy similarity
    Disulfide bondi53 ↔ 671 Publication
    Modified residuei85 – 851N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Disulfide bond

    Proteomic databases

    PaxDbiP00126.
    PRIDEiP00126.

    Interactioni

    Subunit structurei

    The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

    Protein-protein interaction databases

    IntActiP00126. 2 interactions.
    STRINGi9913.ENSBTAP00000012635.

    Structurei

    Secondary structure

    1
    91
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi17 – 248
    Helixi29 – 379
    Beta strandi38 – 403
    Helixi41 – 5818
    Beta strandi61 – 633
    Helixi68 – 8518
    Helixi86 – 894

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BCCX-ray3.16H14-91[»]
    1BE3X-ray3.00H14-91[»]
    1BGYX-ray3.00H/T14-91[»]
    1L0LX-ray2.35H14-91[»]
    1L0NX-ray2.60H14-91[»]
    1NTKX-ray2.60H14-91[»]
    1NTMX-ray2.40H14-91[»]
    1NTZX-ray2.60H14-91[»]
    1NU1X-ray3.20H14-91[»]
    1PP9X-ray2.10H/U14-91[»]
    1PPJX-ray2.10H/U14-91[»]
    1QCRX-ray2.70H31-90[»]
    1SQBX-ray2.69H14-91[»]
    1SQPX-ray2.70H14-91[»]
    1SQQX-ray3.00H14-91[»]
    1SQVX-ray2.85H14-91[»]
    1SQXX-ray2.60H14-91[»]
    2A06X-ray2.10H/U14-91[»]
    2BCCX-ray3.50H14-91[»]
    2FYUX-ray2.26H14-91[»]
    2YBBelectron microscopy19.00H/h14-91[»]
    3BCCX-ray3.70H14-91[»]
    ProteinModelPortaliP00126.
    SMRiP00126. Positions 14-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP00126.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi18 – 258Poly-Glu

    Sequence similaritiesi

    Belongs to the UQCRH/QCR6 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG312125.
    GeneTreeiENSGT00390000003860.
    HOGENOMiHOG000243673.
    HOVERGENiHBG001487.
    InParanoidiP00126.
    KOiK00416.
    OMAiADAIPMV.
    OrthoDBiEOG7PK92F.
    TreeFamiTF105036.

    Family and domain databases

    Gene3Di1.10.287.20. 1 hit.
    InterProiIPR003422. Cyt_b-c1_6.
    IPR023184. Ubol_cytC_Rdtase_hinge_dom.
    [Graphical view]
    PANTHERiPTHR15336. PTHR15336. 1 hit.
    PfamiPF02320. UCR_hinge. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000019. Bc1_11K. 1 hit.
    SUPFAMiSSF81531. SSF81531. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00126-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLEDEQRML TGSGDPKEEE EEEEELVDPL TTVREQCEQL EKCVKARERL   50
    ELCDERVSSR SQTEEDCTEE LLDFLHARDH CVAHKLFNSL K 91
    Length:91
    Mass (Da):10,624
    Last modified:June 27, 2006 - v2
    Checksum:iF444A2E7B6A147D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102729 mRNA. Translation: AAI02730.1.
    PIRiA00119. CCBO11.
    RefSeqiNP_001029917.1. NM_001034745.2.
    UniGeneiBt.27327.

    Genome annotation databases

    EnsembliENSBTAT00000012635; ENSBTAP00000012635; ENSBTAG00000009603.
    GeneIDi613899.
    KEGGibta:613899.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102729 mRNA. Translation: AAI02730.1 .
    PIRi A00119. CCBO11.
    RefSeqi NP_001029917.1. NM_001034745.2.
    UniGenei Bt.27327.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BCC X-ray 3.16 H 14-91 [» ]
    1BE3 X-ray 3.00 H 14-91 [» ]
    1BGY X-ray 3.00 H/T 14-91 [» ]
    1L0L X-ray 2.35 H 14-91 [» ]
    1L0N X-ray 2.60 H 14-91 [» ]
    1NTK X-ray 2.60 H 14-91 [» ]
    1NTM X-ray 2.40 H 14-91 [» ]
    1NTZ X-ray 2.60 H 14-91 [» ]
    1NU1 X-ray 3.20 H 14-91 [» ]
    1PP9 X-ray 2.10 H/U 14-91 [» ]
    1PPJ X-ray 2.10 H/U 14-91 [» ]
    1QCR X-ray 2.70 H 31-90 [» ]
    1SQB X-ray 2.69 H 14-91 [» ]
    1SQP X-ray 2.70 H 14-91 [» ]
    1SQQ X-ray 3.00 H 14-91 [» ]
    1SQV X-ray 2.85 H 14-91 [» ]
    1SQX X-ray 2.60 H 14-91 [» ]
    2A06 X-ray 2.10 H/U 14-91 [» ]
    2BCC X-ray 3.50 H 14-91 [» ]
    2FYU X-ray 2.26 H 14-91 [» ]
    2YBB electron microscopy 19.00 H/h 14-91 [» ]
    3BCC X-ray 3.70 H 14-91 [» ]
    ProteinModelPortali P00126.
    SMRi P00126. Positions 14-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P00126. 2 interactions.
    STRINGi 9913.ENSBTAP00000012635.

    Proteomic databases

    PaxDbi P00126.
    PRIDEi P00126.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000012635 ; ENSBTAP00000012635 ; ENSBTAG00000009603 .
    GeneIDi 613899.
    KEGGi bta:613899.

    Organism-specific databases

    CTDi 7388.

    Phylogenomic databases

    eggNOGi NOG312125.
    GeneTreei ENSGT00390000003860.
    HOGENOMi HOG000243673.
    HOVERGENi HBG001487.
    InParanoidi P00126.
    KOi K00416.
    OMAi ADAIPMV.
    OrthoDBi EOG7PK92F.
    TreeFami TF105036.

    Miscellaneous databases

    EvolutionaryTracei P00126.
    NextBioi 20898827.

    Family and domain databases

    Gene3Di 1.10.287.20. 1 hit.
    InterProi IPR003422. Cyt_b-c1_6.
    IPR023184. Ubol_cytC_Rdtase_hinge_dom.
    [Graphical view ]
    PANTHERi PTHR15336. PTHR15336. 1 hit.
    Pfami PF02320. UCR_hinge. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000019. Bc1_11K. 1 hit.
    SUPFAMi SSF81531. SSF81531. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.
    2. "Identity of the heme-not-containing protein in bovine heart cytochrome c1 preparation with the protein mediating c1-c complex formation -- a protein with high glutamic acid content."
      Wakabayashi S., Takeda H., Matsubara H., Kim C.H., King T.E.
      J. Biochem. 91:2077-2085(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 14-91.
    3. "Dissociation of bovine cytochrome c1 subcomplex and the status of cysteine residues in the subunits."
      Mukai K., Miyazaki T., Wakabayashi S., Kuramitsu S., Matsubara H.
      J. Biochem. 98:1417-1425(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS.
    4. "Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria."
      Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
      Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 14-91.
    5. Erratum
      Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
      Science 278:2037-2037(1997)
    6. "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
      Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K.
      Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 14-91.
    7. "The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition."
      Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D.
      Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
    8. "Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex."
      Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D.
      J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
    9. "Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern."
      Huang L.S., Cobessi D., Tung E.Y., Berry E.A.
      J. Mol. Biol. 351:573-597(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
    10. "Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex."
      Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D.
      Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).

    Entry informationi

    Entry nameiQCR6_BOVIN
    AccessioniPrimary (citable) accession number: P00126
    Secondary accession number(s): Q3SZS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3