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Protein

Cytochrome b-c1 complex subunit 6, mitochondrial

Gene

UQCRH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

GO - Molecular functioni

  1. ubiquinol-cytochrome-c reductase activity Source: InterPro

GO - Biological processi

  1. mitochondrial electron transport, ubiquinol to cytochrome c Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_281214. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 6, mitochondrial
Alternative name(s):
Complex III subunit 6
Complex III subunit VIII
Cytochrome c1 non-heme 11 kDa protein
Mitochondrial hinge protein
Ubiquinol-cytochrome c reductase complex 11 kDa protein
Gene namesi
Name:UQCRH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1313Mitochondrion1 PublicationAdd
BLAST
Chaini14 – 9178Cytochrome b-c1 complex subunit 6, mitochondrialPRO_0000193540Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 811 Publication
Modified residuei42 – 421N6-acetyllysineBy similarity
Disulfide bondi53 ↔ 671 Publication
Modified residuei85 – 851N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiP00126.
PRIDEiP00126.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

DIPiDIP-38973N.
IntActiP00126. 2 interactions.
STRINGi9913.ENSBTAP00000012635.

Structurei

Secondary structure

1
91
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi17 – 248Combined sources
Helixi29 – 379Combined sources
Beta strandi38 – 403Combined sources
Helixi41 – 5818Combined sources
Beta strandi61 – 633Combined sources
Helixi68 – 8518Combined sources
Helixi86 – 894Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16H14-91[»]
1BE3X-ray3.00H14-91[»]
1BGYX-ray3.00H/T14-91[»]
1L0LX-ray2.35H14-91[»]
1L0NX-ray2.60H14-91[»]
1NTKX-ray2.60H14-91[»]
1NTMX-ray2.40H14-91[»]
1NTZX-ray2.60H14-91[»]
1NU1X-ray3.20H14-91[»]
1PP9X-ray2.10H/U14-91[»]
1PPJX-ray2.10H/U14-91[»]
1QCRX-ray2.70H31-90[»]
1SQBX-ray2.69H14-91[»]
1SQPX-ray2.70H14-91[»]
1SQQX-ray3.00H14-91[»]
1SQVX-ray2.85H14-91[»]
1SQXX-ray2.60H14-91[»]
2A06X-ray2.10H/U14-91[»]
2BCCX-ray3.50H14-91[»]
2FYUX-ray2.26H14-91[»]
2YBBelectron microscopy19.00H/h14-91[»]
3BCCX-ray3.70H14-91[»]
4D6TX-ray3.57H/U1-91[»]
4D6UX-ray4.09H/U1-91[»]
SMRiP00126. Positions 14-91.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00126.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 258Poly-Glu

Sequence similaritiesi

Belongs to the UQCRH/QCR6 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG312125.
GeneTreeiENSGT00390000003860.
HOGENOMiHOG000243673.
HOVERGENiHBG001487.
InParanoidiP00126.
KOiK00416.
OMAiSQTEEDC.
OrthoDBiEOG7PK92F.
TreeFamiTF105036.

Family and domain databases

Gene3Di1.10.287.20. 1 hit.
InterProiIPR003422. Cyt_b-c1_6.
IPR023184. Ubol_cytC_Rdtase_hinge_dom.
[Graphical view]
PANTHERiPTHR15336. PTHR15336. 1 hit.
PfamiPF02320. UCR_hinge. 1 hit.
[Graphical view]
PIRSFiPIRSF000019. Bc1_11K. 1 hit.
SUPFAMiSSF81531. SSF81531. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLEDEQRML TGSGDPKEEE EEEEELVDPL TTVREQCEQL EKCVKARERL
60 70 80 90
ELCDERVSSR SQTEEDCTEE LLDFLHARDH CVAHKLFNSL K
Length:91
Mass (Da):10,624
Last modified:June 27, 2006 - v2
Checksum:iF444A2E7B6A147D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102729 mRNA. Translation: AAI02730.1.
PIRiA00119. CCBO11.
RefSeqiNP_001029917.1. NM_001034745.2.
UniGeneiBt.27327.

Genome annotation databases

EnsembliENSBTAT00000012635; ENSBTAP00000012635; ENSBTAG00000009603.
GeneIDi613899.
KEGGibta:613899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102729 mRNA. Translation: AAI02730.1.
PIRiA00119. CCBO11.
RefSeqiNP_001029917.1. NM_001034745.2.
UniGeneiBt.27327.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16H14-91[»]
1BE3X-ray3.00H14-91[»]
1BGYX-ray3.00H/T14-91[»]
1L0LX-ray2.35H14-91[»]
1L0NX-ray2.60H14-91[»]
1NTKX-ray2.60H14-91[»]
1NTMX-ray2.40H14-91[»]
1NTZX-ray2.60H14-91[»]
1NU1X-ray3.20H14-91[»]
1PP9X-ray2.10H/U14-91[»]
1PPJX-ray2.10H/U14-91[»]
1QCRX-ray2.70H31-90[»]
1SQBX-ray2.69H14-91[»]
1SQPX-ray2.70H14-91[»]
1SQQX-ray3.00H14-91[»]
1SQVX-ray2.85H14-91[»]
1SQXX-ray2.60H14-91[»]
2A06X-ray2.10H/U14-91[»]
2BCCX-ray3.50H14-91[»]
2FYUX-ray2.26H14-91[»]
2YBBelectron microscopy19.00H/h14-91[»]
3BCCX-ray3.70H14-91[»]
4D6TX-ray3.57H/U1-91[»]
4D6UX-ray4.09H/U1-91[»]
SMRiP00126. Positions 14-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-38973N.
IntActiP00126. 2 interactions.
STRINGi9913.ENSBTAP00000012635.

Proteomic databases

PaxDbiP00126.
PRIDEiP00126.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000012635; ENSBTAP00000012635; ENSBTAG00000009603.
GeneIDi613899.
KEGGibta:613899.

Organism-specific databases

CTDi7388.

Phylogenomic databases

eggNOGiNOG312125.
GeneTreeiENSGT00390000003860.
HOGENOMiHOG000243673.
HOVERGENiHBG001487.
InParanoidiP00126.
KOiK00416.
OMAiSQTEEDC.
OrthoDBiEOG7PK92F.
TreeFamiTF105036.

Enzyme and pathway databases

ReactomeiREACT_281214. Respiratory electron transport.

Miscellaneous databases

EvolutionaryTraceiP00126.
NextBioi20898827.

Family and domain databases

Gene3Di1.10.287.20. 1 hit.
InterProiIPR003422. Cyt_b-c1_6.
IPR023184. Ubol_cytC_Rdtase_hinge_dom.
[Graphical view]
PANTHERiPTHR15336. PTHR15336. 1 hit.
PfamiPF02320. UCR_hinge. 1 hit.
[Graphical view]
PIRSFiPIRSF000019. Bc1_11K. 1 hit.
SUPFAMiSSF81531. SSF81531. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.
  2. "Identity of the heme-not-containing protein in bovine heart cytochrome c1 preparation with the protein mediating c1-c complex formation -- a protein with high glutamic acid content."
    Wakabayashi S., Takeda H., Matsubara H., Kim C.H., King T.E.
    J. Biochem. 91:2077-2085(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 14-91.
  3. "Dissociation of bovine cytochrome c1 subcomplex and the status of cysteine residues in the subunits."
    Mukai K., Miyazaki T., Wakabayashi S., Kuramitsu S., Matsubara H.
    J. Biochem. 98:1417-1425(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.
  4. "Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria."
    Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
    Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 14-91.
  5. Erratum
    Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
    Science 278:2037-2037(1997)
  6. "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
    Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K.
    Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 14-91.
  7. "The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition."
    Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D.
    Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
  8. "Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex."
    Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D.
    J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
  9. "Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern."
    Huang L.S., Cobessi D., Tung E.Y., Berry E.A.
    J. Mol. Biol. 351:573-597(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
  10. "Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex."
    Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D.
    Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).

Entry informationi

Entry nameiQCR6_BOVIN
AccessioniPrimary (citable) accession number: P00126
Secondary accession number(s): Q3SZS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 27, 2006
Last modified: April 29, 2015
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.