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Protein

Cytochrome c1, heme protein, mitochondrial

Gene

CYC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei121Heme (covalent)1
Binding sitei124Heme (covalent)1
Metal bindingi125Iron (heme axial ligand)1
Metal bindingi244Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.

Protein family/group databases

TCDBi3.D.3.2.1. the proton-translocating quinol:cytochrome c reductase (qcr) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c1, heme protein, mitochondrial
Alternative name(s):
Complex III subunit 4
Complex III subunit IV
Cytochrome b-c1 complex subunit 4
Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
Short name:
Cytochrome c-1
Gene namesi
Name:CYC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei292 – 306Helical; Note=Anchors to the membraneSequence analysisAdd BLAST15

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 84Mitochondrion1 PublicationAdd BLAST84
ChainiPRO_000010841685 – 325Cytochrome c1, heme protein, mitochondrialAdd BLAST241

Post-translational modificationi

Binds 1 heme group per subunit.

Proteomic databases

PaxDbiP00125.
PeptideAtlasiP00125.
PRIDEiP00125.

Expressioni

Gene expression databases

BgeeiENSBTAG00000012232.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

DIPiDIP-38976N.
IntActiP00125. 9 interactors.
STRINGi9913.ENSBTAP00000016224.

Structurei

Secondary structure

1325
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi100 – 102Combined sources3
Helixi107 – 119Combined sources13
Helixi121 – 123Combined sources3
Beta strandi127 – 131Combined sources5
Helixi132 – 135Combined sources4
Turni136 – 138Combined sources3
Helixi142 – 150Combined sources9
Beta strandi152 – 156Combined sources5
Turni160 – 162Combined sources3
Beta strandi165 – 168Combined sources4
Beta strandi171 – 174Combined sources4
Beta strandi178 – 181Combined sources4
Helixi182 – 188Combined sources7
Turni189 – 191Combined sources3
Beta strandi197 – 199Combined sources3
Turni200 – 202Combined sources3
Beta strandi203 – 206Combined sources4
Helixi207 – 215Combined sources9
Beta strandi229 – 233Combined sources5
Beta strandi235 – 237Combined sources3
Beta strandi240 – 244Combined sources5
Beta strandi248 – 250Combined sources3
Turni256 – 258Combined sources3
Helixi263 – 278Combined sources16
Helixi282 – 315Combined sources34
Beta strandi318 – 321Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16D85-325[»]
1BE3X-ray3.00D85-325[»]
1BGYX-ray3.00D/P85-325[»]
1L0LX-ray2.35D85-325[»]
1L0NX-ray2.60D85-325[»]
1NTKX-ray2.60D85-325[»]
1NTMX-ray2.40D85-325[»]
1NTZX-ray2.60D85-325[»]
1NU1X-ray3.20D85-325[»]
1PP9X-ray2.10D/Q85-325[»]
1PPJX-ray2.10D/Q85-325[»]
1QCRX-ray2.70D251-325[»]
1SQBX-ray2.69D85-325[»]
1SQPX-ray2.70D85-325[»]
1SQQX-ray3.00D85-325[»]
1SQVX-ray2.85D85-325[»]
1SQXX-ray2.60D85-325[»]
2A06X-ray2.10D/Q85-325[»]
2BCCX-ray3.50D85-325[»]
2FYUX-ray2.26D85-325[»]
2YBBelectron microscopy19.00D/d85-325[»]
3BCCX-ray3.70D85-325[»]
4D6TX-ray3.57D/Q61-325[»]
4D6UX-ray4.09D/Q1-325[»]
5KLVX-ray2.65D85-325[»]
ProteinModelPortaliP00125.
SMRiP00125.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00125.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 209Cytochrome cPROSITE-ProRule annotationAdd BLAST102

Sequence similaritiesi

Belongs to the cytochrome c family.Curated
Contains 1 cytochrome c domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3052. Eukaryota.
COG2857. LUCA.
GeneTreeiENSGT00390000012445.
HOGENOMiHOG000003867.
HOVERGENiHBG001239.
InParanoidiP00125.
KOiK00413.
OMAiKMLLMMG.
OrthoDBiEOG091G0FT2.
TreeFamiTF314799.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002326. Cyt_c1.
IPR021157. Cyt_c1_TM_anchor_C.
[Graphical view]
PANTHERiPTHR10266. PTHR10266. 1 hit.
PfamiPF02167. Cytochrom_C1. 1 hit.
[Graphical view]
PRINTSiPR00603. CYTOCHROMEC1.
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF81496. SSF81496. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAATLRG AMVGPRGAGL PGARARGLLC GARPGQLPLR TPQAVSLSSK
60 70 80 90 100
SGLSRGRKVI LSALGMLAAG GAGLAVALHS AVSASDLELH PPSYPWSHRG
110 120 130 140 150
LLSSLDHTSI RRGFQVYKQV CSSCHSMDYV AYRHLVGVCY TEDEAKALAE
160 170 180 190 200
EVEVQDGPNE DGEMFMRPGK LSDYFPKPYP NPEAARAANN GALPPDLSYI
210 220 230 240 250
VRARHGGEDY VFSLLTGYCE PPTGVSLREG LYFNPYFPGQ AIGMAPPIYN
260 270 280 290 300
EVLEFDDGTP ATMSQVAKDV CTFLRWAAEP EHDHRKRMGL KMLLMMGLLL
310 320
PLVYAMKRHK WSVLKSRKLA YRPPK
Length:325
Mass (Da):35,297
Last modified:June 27, 2006 - v2
Checksum:i588ED1DEFEAABD6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109917 mRNA. Translation: AAI09918.1.
U97172 Genomic DNA. Translation: AAB57834.1.
PIRiA00118. CCBO1.
RefSeqiNP_001033179.1. NM_001038090.2.
UniGeneiBt.1808.

Genome annotation databases

EnsembliENSBTAT00000016224; ENSBTAP00000016224; ENSBTAG00000012232.
GeneIDi512500.
KEGGibta:512500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109917 mRNA. Translation: AAI09918.1.
U97172 Genomic DNA. Translation: AAB57834.1.
PIRiA00118. CCBO1.
RefSeqiNP_001033179.1. NM_001038090.2.
UniGeneiBt.1808.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16D85-325[»]
1BE3X-ray3.00D85-325[»]
1BGYX-ray3.00D/P85-325[»]
1L0LX-ray2.35D85-325[»]
1L0NX-ray2.60D85-325[»]
1NTKX-ray2.60D85-325[»]
1NTMX-ray2.40D85-325[»]
1NTZX-ray2.60D85-325[»]
1NU1X-ray3.20D85-325[»]
1PP9X-ray2.10D/Q85-325[»]
1PPJX-ray2.10D/Q85-325[»]
1QCRX-ray2.70D251-325[»]
1SQBX-ray2.69D85-325[»]
1SQPX-ray2.70D85-325[»]
1SQQX-ray3.00D85-325[»]
1SQVX-ray2.85D85-325[»]
1SQXX-ray2.60D85-325[»]
2A06X-ray2.10D/Q85-325[»]
2BCCX-ray3.50D85-325[»]
2FYUX-ray2.26D85-325[»]
2YBBelectron microscopy19.00D/d85-325[»]
3BCCX-ray3.70D85-325[»]
4D6TX-ray3.57D/Q61-325[»]
4D6UX-ray4.09D/Q1-325[»]
5KLVX-ray2.65D85-325[»]
ProteinModelPortaliP00125.
SMRiP00125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-38976N.
IntActiP00125. 9 interactors.
STRINGi9913.ENSBTAP00000016224.

Protein family/group databases

TCDBi3.D.3.2.1. the proton-translocating quinol:cytochrome c reductase (qcr) superfamily.

Proteomic databases

PaxDbiP00125.
PeptideAtlasiP00125.
PRIDEiP00125.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016224; ENSBTAP00000016224; ENSBTAG00000012232.
GeneIDi512500.
KEGGibta:512500.

Organism-specific databases

CTDi1537.

Phylogenomic databases

eggNOGiKOG3052. Eukaryota.
COG2857. LUCA.
GeneTreeiENSGT00390000012445.
HOGENOMiHOG000003867.
HOVERGENiHBG001239.
InParanoidiP00125.
KOiK00413.
OMAiKMLLMMG.
OrthoDBiEOG091G0FT2.
TreeFamiTF314799.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.

Miscellaneous databases

EvolutionaryTraceiP00125.

Gene expression databases

BgeeiENSBTAG00000012232.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002326. Cyt_c1.
IPR021157. Cyt_c1_TM_anchor_C.
[Graphical view]
PANTHERiPTHR10266. PTHR10266. 1 hit.
PfamiPF02167. Cytochrom_C1. 1 hit.
[Graphical view]
PRINTSiPR00603. CYTOCHROMEC1.
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF81496. SSF81496. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCY1_BOVIN
AccessioniPrimary (citable) accession number: P00125
Secondary accession number(s): Q2TBM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 27, 2006
Last modified: November 30, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.