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P00125

- CY1_BOVIN

UniProt

P00125 - CY1_BOVIN

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Protein

Cytochrome c1, heme protein, mitochondrial

Gene

CYC1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei121 – 1211Heme (covalent)
Binding sitei124 – 1241Heme (covalent)
Metal bindingi125 – 1251Iron (heme axial ligand)
Metal bindingi244 – 2441Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_223064. Respiratory electron transport.

Protein family/group databases

TCDBi3.D.3.2.1. the proton-translocating quinol:cytochrome c reductase (qcr) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c1, heme protein, mitochondrial
Alternative name(s):
Complex III subunit 4
Complex III subunit IV
Cytochrome b-c1 complex subunit 4
Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
Short name:
Cytochrome c-1
Gene namesi
Name:CYC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 14

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei292 – 30615Helical; Note=Anchors to the membraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: AgBase
  3. mitochondrion Source: AgBase
  4. nucleus Source: Ensembl
  5. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 8484Mitochondrion1 PublicationAdd
BLAST
Chaini85 – 325241Cytochrome c1, heme protein, mitochondrialPRO_0000108416Add
BLAST

Post-translational modificationi

Binds 1 heme group per subunit.

Proteomic databases

PaxDbiP00125.
PRIDEiP00125.

Expressioni

Gene expression databases

ExpressionAtlasiP00125. baseline.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

IntActiP00125. 9 interactions.

Structurei

Secondary structure

1
325
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi100 – 1023Combined sources
Helixi107 – 11913Combined sources
Helixi121 – 1233Combined sources
Beta strandi127 – 1315Combined sources
Helixi132 – 1354Combined sources
Turni136 – 1383Combined sources
Helixi142 – 1509Combined sources
Beta strandi152 – 1565Combined sources
Turni160 – 1623Combined sources
Beta strandi165 – 1684Combined sources
Beta strandi171 – 1744Combined sources
Beta strandi178 – 1814Combined sources
Helixi182 – 1887Combined sources
Turni189 – 1913Combined sources
Beta strandi197 – 1993Combined sources
Turni200 – 2023Combined sources
Beta strandi203 – 2064Combined sources
Helixi207 – 2159Combined sources
Beta strandi229 – 2335Combined sources
Beta strandi235 – 2373Combined sources
Beta strandi240 – 2445Combined sources
Beta strandi248 – 2503Combined sources
Turni256 – 2583Combined sources
Helixi263 – 27816Combined sources
Helixi282 – 31534Combined sources
Beta strandi318 – 3214Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16D85-325[»]
1BE3X-ray3.00D85-325[»]
1BGYX-ray3.00D/P85-325[»]
1L0LX-ray2.35D85-325[»]
1L0NX-ray2.60D85-325[»]
1NTKX-ray2.60D85-325[»]
1NTMX-ray2.40D85-325[»]
1NTZX-ray2.60D85-325[»]
1NU1X-ray3.20D85-325[»]
1PP9X-ray2.10D/Q85-325[»]
1PPJX-ray2.10D/Q85-325[»]
1QCRX-ray2.70D251-325[»]
1SQBX-ray2.69D85-325[»]
1SQPX-ray2.70D85-325[»]
1SQQX-ray3.00D85-325[»]
1SQVX-ray2.85D85-325[»]
1SQXX-ray2.60D85-325[»]
2A06X-ray2.10D/Q85-325[»]
2BCCX-ray3.50D85-325[»]
2FYUX-ray2.26D85-325[»]
2YBBelectron microscopy19.00D/d85-325[»]
3BCCX-ray3.70D85-325[»]
ProteinModelPortaliP00125.
SMRiP00125. Positions 85-325.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00125.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 209102Cytochrome cPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cytochrome c family.Curated
Contains 1 cytochrome c domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2857.
GeneTreeiENSGT00390000012445.
HOGENOMiHOG000003867.
HOVERGENiHBG001239.
InParanoidiP00125.
KOiK00413.
OMAiGLHPPAY.
OrthoDBiEOG7GBFX7.
TreeFamiTF314799.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002326. Cyt_c1.
IPR021157. Cyt_c1_TM_anchor_C.
[Graphical view]
PANTHERiPTHR10266. PTHR10266. 1 hit.
PfamiPF02167. Cytochrom_C1. 1 hit.
[Graphical view]
PRINTSiPR00603. CYTOCHROMEC1.
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF81496. SSF81496. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00125-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAAATLRG AMVGPRGAGL PGARARGLLC GARPGQLPLR TPQAVSLSSK
60 70 80 90 100
SGLSRGRKVI LSALGMLAAG GAGLAVALHS AVSASDLELH PPSYPWSHRG
110 120 130 140 150
LLSSLDHTSI RRGFQVYKQV CSSCHSMDYV AYRHLVGVCY TEDEAKALAE
160 170 180 190 200
EVEVQDGPNE DGEMFMRPGK LSDYFPKPYP NPEAARAANN GALPPDLSYI
210 220 230 240 250
VRARHGGEDY VFSLLTGYCE PPTGVSLREG LYFNPYFPGQ AIGMAPPIYN
260 270 280 290 300
EVLEFDDGTP ATMSQVAKDV CTFLRWAAEP EHDHRKRMGL KMLLMMGLLL
310 320
PLVYAMKRHK WSVLKSRKLA YRPPK
Length:325
Mass (Da):35,297
Last modified:June 27, 2006 - v2
Checksum:i588ED1DEFEAABD6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109917 mRNA. Translation: AAI09918.1.
U97172 Genomic DNA. Translation: AAB57834.1.
PIRiA00118. CCBO1.
RefSeqiNP_001033179.1. NM_001038090.2.
UniGeneiBt.1808.

Genome annotation databases

EnsembliENSBTAT00000016224; ENSBTAP00000016224; ENSBTAG00000012232.
GeneIDi512500.
KEGGibta:512500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109917 mRNA. Translation: AAI09918.1 .
U97172 Genomic DNA. Translation: AAB57834.1 .
PIRi A00118. CCBO1.
RefSeqi NP_001033179.1. NM_001038090.2.
UniGenei Bt.1808.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BCC X-ray 3.16 D 85-325 [» ]
1BE3 X-ray 3.00 D 85-325 [» ]
1BGY X-ray 3.00 D/P 85-325 [» ]
1L0L X-ray 2.35 D 85-325 [» ]
1L0N X-ray 2.60 D 85-325 [» ]
1NTK X-ray 2.60 D 85-325 [» ]
1NTM X-ray 2.40 D 85-325 [» ]
1NTZ X-ray 2.60 D 85-325 [» ]
1NU1 X-ray 3.20 D 85-325 [» ]
1PP9 X-ray 2.10 D/Q 85-325 [» ]
1PPJ X-ray 2.10 D/Q 85-325 [» ]
1QCR X-ray 2.70 D 251-325 [» ]
1SQB X-ray 2.69 D 85-325 [» ]
1SQP X-ray 2.70 D 85-325 [» ]
1SQQ X-ray 3.00 D 85-325 [» ]
1SQV X-ray 2.85 D 85-325 [» ]
1SQX X-ray 2.60 D 85-325 [» ]
2A06 X-ray 2.10 D/Q 85-325 [» ]
2BCC X-ray 3.50 D 85-325 [» ]
2FYU X-ray 2.26 D 85-325 [» ]
2YBB electron microscopy 19.00 D/d 85-325 [» ]
3BCC X-ray 3.70 D 85-325 [» ]
ProteinModelPortali P00125.
SMRi P00125. Positions 85-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P00125. 9 interactions.

Protein family/group databases

TCDBi 3.D.3.2.1. the proton-translocating quinol:cytochrome c reductase (qcr) superfamily.

Proteomic databases

PaxDbi P00125.
PRIDEi P00125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000016224 ; ENSBTAP00000016224 ; ENSBTAG00000012232 .
GeneIDi 512500.
KEGGi bta:512500.

Organism-specific databases

CTDi 1537.

Phylogenomic databases

eggNOGi COG2857.
GeneTreei ENSGT00390000012445.
HOGENOMi HOG000003867.
HOVERGENi HBG001239.
InParanoidi P00125.
KOi K00413.
OMAi GLHPPAY.
OrthoDBi EOG7GBFX7.
TreeFami TF314799.

Enzyme and pathway databases

Reactomei REACT_223064. Respiratory electron transport.

Miscellaneous databases

EvolutionaryTracei P00125.
NextBioi 20870422.

Gene expression databases

ExpressionAtlasi P00125. baseline.

Family and domain databases

Gene3Di 1.10.760.10. 1 hit.
InterProi IPR009056. Cyt_c-like_dom.
IPR002326. Cyt_c1.
IPR021157. Cyt_c1_TM_anchor_C.
[Graphical view ]
PANTHERi PTHR10266. PTHR10266. 1 hit.
Pfami PF02167. Cytochrom_C1. 1 hit.
[Graphical view ]
PRINTSi PR00603. CYTOCHROMEC1.
SUPFAMi SSF46626. SSF46626. 1 hit.
SSF81496. SSF81496. 1 hit.
PROSITEi PS51007. CYTC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.
  2. "Structural studies of bovine heart cytochrome c1."
    Wakabayashi S., Matsubara H., Kim C.H., King T.E.
    J. Biol. Chem. 257:9335-9344(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 85-325.
    Tissue: Heart.
  3. "Partial genomic sequence of the bovine cytochrome c1 gene."
    Band M., Ron M.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 120-194.
    Strain: Holstein-Friesian.
  4. "Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria."
    Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
    Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 85-321.
  5. "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
    Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K.
    Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 85-321.
  6. "The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition."
    Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D.
    Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
  7. "Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex."
    Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D.
    J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
  8. "Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern."
    Huang L.S., Cobessi D., Tung E.Y., Berry E.A.
    J. Mol. Biol. 351:573-597(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
  9. "Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex."
    Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D.
    Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).

Entry informationi

Entry nameiCY1_BOVIN
AccessioniPrimary (citable) accession number: P00125
Secondary accession number(s): Q2TBM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 27, 2006
Last modified: November 26, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3