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P00125 (CY1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c1, heme protein, mitochondrial
Alternative name(s):
Complex III subunit 4
Complex III subunit IV
Cytochrome b-c1 complex subunit 4
Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
Short name=Cytochrome c-1
Gene names
Name:CYC1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.

Subunit structure

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Subcellular location

Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.

Post-translational modification

Binds 1 heme group per subunit.

Sequence similarities

Belongs to the cytochrome c family.

Contains 1 cytochrome c domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 8484Mitochondrion Ref.2
Chain85 – 325241Cytochrome c1, heme protein, mitochondrial
PRO_0000108416

Regions

Transmembrane292 – 30615Helical; Note=Anchors to the membrane; Potential
Domain108 – 209102Cytochrome c

Sites

Metal binding1251Iron (heme axial ligand)
Metal binding2441Iron (heme axial ligand) By similarity
Binding site1211Heme (covalent)
Binding site1241Heme (covalent)

Secondary structure

.............................................. 325
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P00125 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: 588ED1DEFEAABD6D

FASTA32535,297
        10         20         30         40         50         60 
MAAAAATLRG AMVGPRGAGL PGARARGLLC GARPGQLPLR TPQAVSLSSK SGLSRGRKVI 

        70         80         90        100        110        120 
LSALGMLAAG GAGLAVALHS AVSASDLELH PPSYPWSHRG LLSSLDHTSI RRGFQVYKQV 

       130        140        150        160        170        180 
CSSCHSMDYV AYRHLVGVCY TEDEAKALAE EVEVQDGPNE DGEMFMRPGK LSDYFPKPYP 

       190        200        210        220        230        240 
NPEAARAANN GALPPDLSYI VRARHGGEDY VFSLLTGYCE PPTGVSLREG LYFNPYFPGQ 

       250        260        270        280        290        300 
AIGMAPPIYN EVLEFDDGTP ATMSQVAKDV CTFLRWAAEP EHDHRKRMGL KMLLMMGLLL 

       310        320 
PLVYAMKRHK WSVLKSRKLA YRPPK 

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.
[2]"Structural studies of bovine heart cytochrome c1."
Wakabayashi S., Matsubara H., Kim C.H., King T.E.
J. Biol. Chem. 257:9335-9344(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 85-325.
Tissue: Heart.
[3]"Partial genomic sequence of the bovine cytochrome c1 gene."
Band M., Ron M.
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 120-194.
Strain: Holstein-Friesian.
[4]"Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria."
Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 85-321.
[5]"Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K.
Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 85-321.
[6]"The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition."
Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D.
Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
[7]"Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex."
Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D.
J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
[8]"Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern."
Huang L.S., Cobessi D., Tung E.Y., Berry E.A.
J. Mol. Biol. 351:573-597(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
[9]"Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex."
Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D.
Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC109917 mRNA. Translation: AAI09918.1.
U97172 Genomic DNA. Translation: AAB57834.1.
PIRCCBO1. A00118.
RefSeqNP_001033179.1. NM_001038090.2.
UniGeneBt.1808.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16D85-325[»]
1BE3X-ray3.00D85-325[»]
1BGYX-ray3.00D/P85-325[»]
1L0LX-ray2.35D85-325[»]
1L0NX-ray2.60D85-325[»]
1NTKX-ray2.60D85-325[»]
1NTMX-ray2.40D85-325[»]
1NTZX-ray2.60D85-325[»]
1NU1X-ray3.20D85-325[»]
1PP9X-ray2.10D/Q85-325[»]
1PPJX-ray2.10D/Q85-325[»]
1QCRX-ray2.70D251-325[»]
1SQBX-ray2.69D85-325[»]
1SQPX-ray2.70D85-325[»]
1SQQX-ray3.00D85-325[»]
1SQVX-ray2.85D85-325[»]
1SQXX-ray2.60D85-325[»]
2A06X-ray2.10D/Q85-325[»]
2BCCX-ray3.50D85-325[»]
2FYUX-ray2.26D85-325[»]
2YBBelectron microscopy19.00D/d85-325[»]
3BCCX-ray3.70D85-325[»]
ProteinModelPortalP00125.
SMRP00125. Positions 85-325.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP00125. 9 interactions.

Proteomic databases

PaxDbP00125.
PRIDEP00125.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000016224; ENSBTAP00000016224; ENSBTAG00000012232.
GeneID512500.
KEGGbta:512500.

Organism-specific databases

CTD1537.

Phylogenomic databases

eggNOGCOG2857.
GeneTreeENSGT00390000012445.
HOGENOMHOG000003867.
HOVERGENHBG001239.
KOK00413.
OMAMAPPIYT.
OrthoDBEOG7GBFX7.
TreeFamTF314799.

Family and domain databases

Gene3D1.10.760.10. 1 hit.
InterProIPR009056. Cyt_c-like_dom.
IPR002326. Cyt_c1.
IPR021157. Cyt_c1_TM_anchor_C.
[Graphical view]
PANTHERPTHR10266. PTHR10266. 1 hit.
PfamPF02167. Cytochrom_C1. 1 hit.
[Graphical view]
PRINTSPR00603. CYTOCHROMEC1.
SUPFAMSSF46626. SSF46626. 1 hit.
SSF81496. SSF81496. 1 hit.
PROSITEPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP00125.
NextBio20870422.

Entry information

Entry nameCY1_BOVIN
AccessionPrimary (citable) accession number: P00125
Secondary accession number(s): Q2TBM2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 27, 2006
Last modified: April 16, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references