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Reviewed, UniProtKB/Swiss-Prot P00096 (CY550_PARDE)

Last modified January 19, 2010. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome c-550
Alternative name(s):
    Cytochrome c550
    Cytochrome C2
Gene names
Name: cycA
OrganismParacoccus denitrificans
Taxonomic identifier266 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Paracoccus

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Protein attributes

Sequence length155 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Post-translational modification

Binds 1 heme group per subunit.

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Ontologies

Keywords
   Biological processElectron transport
Transport
   DomainSignal
   LigandHeme
Iron
Metal-binding
   PTMPyrrolidone carboxylic acid
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Biological processelectron transport chain

Inferred from electronic annotation. Source: UniProtKB-KW

transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionelectron carrier activity

Inferred from electronic annotation. Source: InterPro

heme binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Ref.4
Chain21 – 149129Cytochrome c-550
PRO_0000006523
Propeptide150 – 1556
PRO_0000006524

Sites

Metal binding391Iron (heme axial ligand) Ref.5
Metal binding1201Iron (heme axial ligand) Ref.5
Binding site351Heme (covalent) Ref.5
Binding site381Heme (covalent) Ref.5

Amino acid modifications

Modified residue211Pyrrolidone carboxylic acid Ref.4

Natural variations

Natural variant1491Missing in 50% of the molecules.

Secondary structure

1 ................. 155
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P00096-1 [UniParc].

Last modified February 1, 1991. Version 2.
Checksum: CB003CA423879B03

FASTA15516,398
        10         20         30         40         50         60 
MKISIYATLA AITLALPAAA QDGDAAKGEK EFNKCKACHM IQAPDGTDII KGGKTGPNLY 

        70         80         90        100        110        120 
GVVGRKIASE EGFKYGEGIL EVAEKNPDLT WTEADLIEYV TDPKPWLVKM TDDKGAKTKM 

       130        140        150 
TFKMGKNQAD VVAFLAQNSP DAGGDGEAAA EGESN

« Hide

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References

[1]"Are there isoenzymes of cytochrome c oxidase in Paracoccus denitrificans?"
Raitio M., Pispa J.M., Metso T., Saraste M.
FEBS Lett. 261:431-435(1990) [PubMed: 2155830] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Pd 1222.
[2]"Mutagenesis of the gene encoding cytochrome c550 of Paracoccus denitrificans and analysis of the resultant physiological effects."
van Spanning R.J.M., Wansell C., Harms N., Oltmann L.F., Stouthamer A.H.
J. Bacteriol. 172:986-996(1990) [PubMed: 2153663] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Pd 1222.
[3]Erratum
van Spanning R.J.M., Wansell C., Harms N., Oltmann L.F., Stouthamer A.H.
J. Bacteriol. 172:3534-3534(1990) [PubMed: 2160949] [Abstract]
[4]"A reassessment of the structure of Paracoccus cytochrome c-550."
Ambler R.P., Meyer T.E., Kamen M.D., Schichman S.A., Sawyer L.
J. Mol. Biol. 147:351-356(1981) [PubMed: 6270339] [Abstract]
Cited for: PROTEIN SEQUENCE OF 21-149.
Strain: ATCC 13543 / NRRL B-3784.
[5]"The structure of Paracoccus denitrificans cytochrome c550."
Timkovich R., Dickerson R.E.
J. Biol. Chem. 251:4033-4046(1976) [PubMed: 180013] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS).
[6]"X-ray structure of the cytochrome c2 isolated from Paracoccus denitrificans refined to 1.7-A resolution."
Benning M.M., Meyer T.E., Holden H.M.
Arch. Biochem. Biophys. 310:460-466(1994) [PubMed: 8179333] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Y07533 Genomic DNA. Translation: CAA68820.1.
M27304 Genomic DNA. Translation: AAA88364.1.
PIRCCPC50. S08269.
RefSeqYP_915726.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
155CX-ray2.50A23-142[»]
1COTX-ray1.70A21-149[»]
ModBaseSearch...

Protein family/group databases

TCDB3.D.4.6.1. proton-translocating cytochrome oxidase (COX) superfamily.

Genome annotation databases

GeneID4581059.

Family and domain databases

InterProIPR002327. Cyt_c_1A/1B.
IPR009056. Cyt_c_monohaem.
[Graphical view]
Gene3DG3DSA:1.10.760.10. Cytochrome_c_R. 1 hit.
PANTHERPTHR11961. Cyt_CIAB. 1 hit.
PROSITEPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCY550_PARDE
AccessionPrimary (citable) accession number: P00096
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1991
Last modified: January 19, 2010
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents