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Protein

Cytochrome c

Gene

cyc-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei19Heme (covalent)1
Binding sitei22Heme (covalent)1
Metal bindingi23Iron (heme axial ligand)1
Metal bindingi85Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c
Gene namesi
Name:cyc-1
Synonyms:cyt-12
ORF Names:B1K11.020, NCU01808
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 6, Linkage Group II

Organism-specific databases

EuPathDBiFungiDB:NCU01808.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001083282 – 108Cytochrome cAdd BLAST107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77N6,N6,N6-trimethyllysine1 Publication1

Post-translational modificationi

Binds 1 heme group per subunit.

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiP00048.

Structurei

3D structure databases

ProteinModelPortaliP00048.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

HOGENOMiHOG000009762.
InParanoidiP00048.
KOiK08738.
OrthoDBiEOG092C56RQ.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00048-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFSAGDSKK GANLFKTRCA QCHTLEEGGG NKIGPALHGL FGRKTGSVDG
60 70 80 90 100
YAYTDANKQK GITWDENTLF EYLENPKKYI PGTKMAFGGL KKDKDRNDII

TFMKEATA
Length:108
Mass (Da):11,813
Last modified:January 23, 2007 - v2
Checksum:i8150D1A1B92A6E85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21Q → E AA sequence (PubMed:5950080).Curated1
Sequence conflicti24 – 31TLEEGGGN → GEGGNLTQ AA sequence (PubMed:5950080).Curated8

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti11G → D in cyt-12-12/cyc-1-1; characterized by slow growth and a deficiency of spectrophotometrically-detectable cytochromes aa3 and c. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05506 mRNA. Translation: CAA29050.1.
L19358 Genomic DNA. Translation: AAA92156.1.
X05507 Genomic DNA. Translation: CAA29051.1.
AL669998 Genomic DNA. Translation: CAD21169.1.
CM002237 Genomic DNA. Translation: EAA27250.2.
PIRiS48221. CCNC.
RefSeqiXP_956486.2. XM_951393.3.

Genome annotation databases

EnsemblFungiiEAA27250; EAA27250; NCU01808.
GeneIDi3872635.
KEGGincr:NCU01808.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05506 mRNA. Translation: CAA29050.1.
L19358 Genomic DNA. Translation: AAA92156.1.
X05507 Genomic DNA. Translation: CAA29051.1.
AL669998 Genomic DNA. Translation: CAD21169.1.
CM002237 Genomic DNA. Translation: EAA27250.2.
PIRiS48221. CCNC.
RefSeqiXP_956486.2. XM_951393.3.

3D structure databases

ProteinModelPortaliP00048.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP00048.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA27250; EAA27250; NCU01808.
GeneIDi3872635.
KEGGincr:NCU01808.

Organism-specific databases

EuPathDBiFungiDB:NCU01808.

Phylogenomic databases

HOGENOMiHOG000009762.
InParanoidiP00048.
KOiK08738.
OrthoDBiEOG092C56RQ.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYC_NEUCR
AccessioniPrimary (citable) accession number: P00048
Secondary accession number(s): Q7RV53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.