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P00048 (CYC_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c
Gene names
Name:cyc-1
Synonyms:cyt-12
ORF Names:B1K11.020, NCU01808
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length108 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Subcellular location

Mitochondrion intermembrane space. Note: Loosely associated with the inner membrane.

Post-translational modification

Binds 1 heme group per subunit.

Sequence similarities

Belongs to the cytochrome c family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5 Ref.6
Chain2 – 108107Cytochrome c
PRO_0000108328

Sites

Metal binding231Iron (heme axial ligand)
Metal binding851Iron (heme axial ligand)
Binding site191Heme (covalent)
Binding site221Heme (covalent)

Amino acid modifications

Modified residue771N6,N6,N6-trimethyllysine Ref.7

Natural variations

Natural variant111G → D in cyt-12-12/cyc-1-1; characterized by slow growth and a deficiency of spectrophotometrically-detectable cytochromes aa3 and c. Ref.1 Ref.2

Experimental info

Sequence conflict211Q → E AA sequence Ref.5
Sequence conflict24 – 318TLEEGGGN → GEGGNLTQ AA sequence Ref.5

Sequences

Sequence LengthMass (Da)Tools
P00048 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 8150D1A1B92A6E85

FASTA10811,813
        10         20         30         40         50         60 
MGFSAGDSKK GANLFKTRCA QCHTLEEGGG NKIGPALHGL FGRKTGSVDG YAYTDANKQK 

        70         80         90        100 
GITWDENTLF EYLENPKKYI PGTKMAFGGL KKDKDRNDII TFMKEATA 

« Hide

References

« Hide 'large scale' references
[1]"Deficiency in mRNA splicing in a cytochrome c mutant of Neurospora crassa: importance of carboxy terminus for import of apocytochrome c into mitochondria."
Stuart R.A., Neupert W., Tropschug M.
EMBO J. 6:2131-2137(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT ASP-11.
Strain: 74A.
[2]"Mutations in the structural gene for cytochrome c result in deficiency of both cytochromes aa3 and c in Neurospora crassa."
Bottorff D.A., Parmaksizoglu S., Lemire E.G., Coffin J.W., Bertrand H., Nargang F.E.
Curr. Genet. 26:329-335(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-11.
[3]"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[4]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[5]"Neurospora crassa cytochrome c. II. Chymotryptic peptides, tryptic peptides, cyanogen bromide peptides, and the complete amino acid sequence."
Heller J., Smith E.L.
J. Biol. Chem. 241:3165-3180(1966) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-108.
[6]"Neurospora crassa and Humicola lanuginosa cytochromes c: more homology in the heme region."
Lederer F., Simon A.M.
Biochem. Biophys. Res. Commun. 56:317-323(1974) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-44.
[7]"Presence and location of an unusual amino acid, epsilon-N-trimethyllysine, in cytochrome c of wheat germ and Neurospora."
Delange R.J., Glazer A.N., Smith E.L.
J. Biol. Chem. 244:1385-1388(1969) [PubMed] [Europe PMC] [Abstract]
Cited for: METHYLATION AT LYS-77.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X05506 mRNA. Translation: CAA29050.1.
L19358 Genomic DNA. Translation: AAA92156.1.
X05507 Genomic DNA. Translation: CAA29051.1.
AL669998 Genomic DNA. Translation: CAD21169.1.
CM002237 Genomic DNA. Translation: EAA27250.2.
PIRCCNC. S48221.
RefSeqXP_956486.2. XM_951393.2.

3D structure databases

ProteinModelPortalP00048.
SMRP00048. Positions 3-106.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU01808.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000001740; EFNCRP00000001740; EFNCRG00000001738.
GeneID3872635.
KEGGncr:NCU01808.

Phylogenomic databases

eggNOGCOG3474.
HOGENOMHOG000009762.
KOK08738.
OrthoDBEOG71RXXT.

Family and domain databases

Gene3D1.10.760.10. 1 hit.
InterProIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERPTHR11961. PTHR11961. 1 hit.
PfamPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSPR00604. CYTCHRMECIAB.
SUPFAMSSF46626. SSF46626. 1 hit.
PROSITEPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYC_NEUCR
AccessionPrimary (citable) accession number: P00048
Secondary accession number(s): Q7RV53
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries