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P00047

- CYC_THELA

UniProt

P00047 - CYC_THELA

Protein

Cytochrome c

Gene
N/A
Organism
Thermomyces lanuginosus (Humicola lanuginosa)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei22 – 221Heme (covalent)1 PublicationPROSITE-ProRule annotation
    Binding sitei25 – 251Heme (covalent)1 PublicationPROSITE-ProRule annotation
    Metal bindingi26 – 261Iron (heme axial ligand)
    Metal bindingi88 – 881Iron (heme axial ligand)

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. oxidation-reduction process Source: UniProtKB-KW

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c
    OrganismiThermomyces lanuginosus (Humicola lanuginosa)
    Taxonomic identifieri5541 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeThermomyces

    Subcellular locationi

    Mitochondrion intermembrane space
    Note: Loosely associated with the inner membrane.

    GO - Cellular componenti

    1. mitochondrial intermembrane space Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 111111Cytochrome cPRO_0000108334Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei80 – 801N6,N6-dimethyllysine1 Publication
    Modified residuei94 – 941N6,N6,N6-trimethyllysine; partial1 Publication

    Post-translational modificationi

    Binds 1 heme group per subunit.
    Lys-94 was found to be 95% trimethylated.

    Keywords - PTMi

    Methylation

    Structurei

    3D structure databases

    ProteinModelPortaliP00047.
    SMRiP00047. Positions 6-109.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c family.Curated

    Family and domain databases

    Gene3Di1.10.760.10. 1 hit.
    InterProiIPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view]
    PANTHERiPTHR11961. PTHR11961. 1 hit.
    PfamiPF00034. Cytochrom_C. 1 hit.
    [Graphical view]
    PRINTSiPR00604. CYTCHRMECIAB.
    SUPFAMiSSF46626. SSF46626. 1 hit.
    PROSITEiPS51007. CYTC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00047-1 [UniParc]FASTAAdd to Basket

    « Hide

    AKGGSFEPGD ASKGANLFKT RCAQCHSVEQ GGANKIGPNL HGLFGRKTGS    50
    VEGYSYTDAN KQAGITWNED TLFEYLENPK KFIPGTKMAF GGLKKNKDRN 100
    DLITYLKEAT K 111
    Length:111
    Mass (Da):12,076
    Last modified:July 21, 1986 - v1
    Checksum:i123501124E3CF317
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 122AS → SA AA sequence (PubMed:4342602)Curated
    Sequence conflicti24 – 241Q → E AA sequence (PubMed:4342602)Curated
    Sequence conflicti27 – 348SVEQGGAN → GEGANVSQ AA sequence (PubMed:4342602)Curated

    Sequence databases

    PIRiA92114. CCHL.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Life shuttle - Issue 76 of November 2006

    Sequence databases

    PIRi A92114. CCHL.

    3D structure databases

    ProteinModelPortali P00047.
    SMRi P00047. Positions 6-109.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.760.10. 1 hit.
    InterProi IPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view ]
    PANTHERi PTHR11961. PTHR11961. 1 hit.
    Pfami PF00034. Cytochrom_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00604. CYTCHRMECIAB.
    SUPFAMi SSF46626. SSF46626. 1 hit.
    PROSITEi PS51007. CYTC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Proteins of the thermophilic fungus Humicola lanuginosa. I. Isolation and amino acid sequence of a cytochrome C."
      Morgan W.T., Hensley C.P. Jr., Riehm J.P.
      J. Biol. Chem. 247:6555-6565(1972) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Strain: ATCC 16455 / CBS 632.91.
    2. "Neurospora crassa and Humicola lanuginosa cytochromes c: more homology in the heme region."
      Lederer F., Simon A.M.
      Biochem. Biophys. Res. Commun. 56:317-323(1974) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-37.

    Entry informationi

    Entry nameiCYC_THELA
    AccessioniPrimary (citable) accession number: P00047
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3