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P00047 (CYC_THELA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c
OrganismThermomyces lanuginosus (Humicola lanuginosa)
Taxonomic identifier5541 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeThermomyces

Protein attributes

Sequence length111 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Subcellular location

Mitochondrion intermembrane space. Note: Loosely associated with the inner membrane.

Post-translational modification

Binds 1 heme group per subunit.

Lys-94 was found to be 95% trimethylated.

Sequence similarities

Belongs to the cytochrome c family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 111111Cytochrome c
PRO_0000108334

Sites

Metal binding261Iron (heme axial ligand)
Metal binding881Iron (heme axial ligand)
Binding site221Heme (covalent) Ref.1
Binding site251Heme (covalent) Ref.1

Amino acid modifications

Modified residue801N6,N6-dimethyllysine Ref.1
Modified residue941N6,N6,N6-trimethyllysine; partial Ref.1

Experimental info

Sequence conflict11 – 122AS → SA AA sequence Ref.1
Sequence conflict241Q → E AA sequence Ref.1
Sequence conflict27 – 348SVEQGGAN → GEGANVSQ AA sequence Ref.1

Sequences

Sequence LengthMass (Da)Tools
P00047 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 123501124E3CF317

FASTA11112,076
        10         20         30         40         50         60 
AKGGSFEPGD ASKGANLFKT RCAQCHSVEQ GGANKIGPNL HGLFGRKTGS VEGYSYTDAN 

        70         80         90        100        110 
KQAGITWNED TLFEYLENPK KFIPGTKMAF GGLKKNKDRN DLITYLKEAT K 

« Hide

References

[1]"Proteins of the thermophilic fungus Humicola lanuginosa. I. Isolation and amino acid sequence of a cytochrome C."
Morgan W.T., Hensley C.P. Jr., Riehm J.P.
J. Biol. Chem. 247:6555-6565(1972) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Strain: ATCC 16455 / CBS 632.91.
[2]"Neurospora crassa and Humicola lanuginosa cytochromes c: more homology in the heme region."
Lederer F., Simon A.M.
Biochem. Biophys. Res. Commun. 56:317-323(1974) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-37.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases

PIRCCHL. A92114.

3D structure databases

ProteinModelPortalP00047.
SMRP00047. Positions 6-109.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.760.10. 1 hit.
InterProIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERPTHR11961. PTHR11961. 1 hit.
PfamPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSPR00604. CYTCHRMECIAB.
SUPFAMSSF46626. SSF46626. 1 hit.
PROSITEPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYC_THELA
AccessionPrimary (citable) accession number: P00047
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries