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P00047

- CYC_THELA

UniProt

P00047 - CYC_THELA

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Protein

Cytochrome c

Gene
N/A
Organism
Thermomyces lanuginosus (Humicola lanuginosa)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei22 – 221Heme (covalent)1 PublicationPROSITE-ProRule annotation
Binding sitei25 – 251Heme (covalent)1 PublicationPROSITE-ProRule annotation
Metal bindingi26 – 261Iron (heme axial ligand)
Metal bindingi88 – 881Iron (heme axial ligand)

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c
OrganismiThermomyces lanuginosus (Humicola lanuginosa)
Taxonomic identifieri5541 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeThermomyces

Subcellular locationi

Mitochondrion intermembrane space
Note: Loosely associated with the inner membrane.

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 111111Cytochrome cPRO_0000108334Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei80 – 801N6,N6-dimethyllysine1 Publication
Modified residuei94 – 941N6,N6,N6-trimethyllysine; partial1 Publication

Post-translational modificationi

Binds 1 heme group per subunit.
Lys-94 was found to be 95% trimethylated.

Keywords - PTMi

Methylation

Structurei

3D structure databases

ProteinModelPortaliP00047.
SMRiP00047. Positions 6-109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00047-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
AKGGSFEPGD ASKGANLFKT RCAQCHSVEQ GGANKIGPNL HGLFGRKTGS
60 70 80 90 100
VEGYSYTDAN KQAGITWNED TLFEYLENPK KFIPGTKMAF GGLKKNKDRN
110
DLITYLKEAT K
Length:111
Mass (Da):12,076
Last modified:July 21, 1986 - v1
Checksum:i123501124E3CF317
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 122AS → SA AA sequence (PubMed:4342602)Curated
Sequence conflicti24 – 241Q → E AA sequence (PubMed:4342602)Curated
Sequence conflicti27 – 348SVEQGGAN → GEGANVSQ AA sequence (PubMed:4342602)Curated

Sequence databases

PIRiA92114. CCHL.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

PIRi A92114. CCHL.

3D structure databases

ProteinModelPortali P00047.
SMRi P00047. Positions 6-109.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.760.10. 1 hit.
InterProi IPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view ]
PANTHERi PTHR11961. PTHR11961. 1 hit.
Pfami PF00034. Cytochrom_C. 1 hit.
[Graphical view ]
PRINTSi PR00604. CYTCHRMECIAB.
SUPFAMi SSF46626. SSF46626. 1 hit.
PROSITEi PS51007. CYTC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Proteins of the thermophilic fungus Humicola lanuginosa. I. Isolation and amino acid sequence of a cytochrome C."
    Morgan W.T., Hensley C.P. Jr., Riehm J.P.
    J. Biol. Chem. 247:6555-6565(1972) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, METHYLATION AT LYS-80 AND LYS-94.
    Strain: ATCC 16455 / CBS 632.91.
  2. "Neurospora crassa and Humicola lanuginosa cytochromes c: more homology in the heme region."
    Lederer F., Simon A.M.
    Biochem. Biophys. Res. Commun. 56:317-323(1974) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-37.

Entry informationi

Entry nameiCYC_THELA
AccessioniPrimary (citable) accession number: P00047
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3