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P00046

- CYC_SCHPO

UniProt

P00046 - CYC_SCHPO

Protein

Cytochrome c

Gene

cyc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei19 – 191Heme (covalent)
    Binding sitei22 – 221Heme (covalent)
    Metal bindingi23 – 231Iron (heme axial ligand)
    Metal bindingi85 – 851Iron (heme axial ligand)

    GO - Molecular functioni

    1. electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity Source: PomBase
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. mitochondrial ATP synthesis coupled electron transport Source: PomBase
    2. mitochondrial electron transport, cytochrome c to oxygen Source: PomBase
    3. mitochondrial electron transport, ubiquinol to cytochrome c Source: PomBase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_199379. Release of apoptotic factors from the mitochondria.
    REACT_219607. Detoxification of Reactive Oxygen Species.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c
    Gene namesi
    Name:cyc1
    ORF Names:SPCC191.07
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC191.07.

    Subcellular locationi

    Mitochondrion intermembrane space
    Note: Loosely associated with the inner membrane.

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. mitochondrial intermembrane space Source: UniProtKB-SubCell
    3. mitochondrial respiratory chain Source: PomBase
    4. nucleus Source: PomBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 109108Cytochrome cPRO_0000108333Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei77 – 771N6,N6,N6-trimethyllysine

    Post-translational modificationi

    Binds 1 heme group per subunit.

    Keywords - PTMi

    Methylation

    Proteomic databases

    MaxQBiP00046.
    PaxDbiP00046.

    Interactioni

    Protein-protein interaction databases

    BioGridi275718. 1 interaction.
    MINTiMINT-4686677.
    STRINGi4896.SPCC191.07-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP00046.
    SMRiP00046. Positions 3-106.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c family.Curated

    Phylogenomic databases

    eggNOGiCOG3474.
    HOGENOMiHOG000009762.
    KOiK08738.
    OMAiDDQEITD.
    OrthoDBiEOG71RXXT.
    PhylomeDBiP00046.

    Family and domain databases

    Gene3Di1.10.760.10. 1 hit.
    InterProiIPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view]
    PANTHERiPTHR11961. PTHR11961. 1 hit.
    PfamiPF00034. Cytochrom_C. 1 hit.
    [Graphical view]
    PRINTSiPR00604. CYTCHRMECIAB.
    SUPFAMiSSF46626. SSF46626. 1 hit.
    PROSITEiPS51007. CYTC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00046-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPYAPGDEKK GASLFKTRCA QCHTVEKGGA NKVGPNLHGV FGRKTGQAEG    50
    FSYTEANRDK GITWDEETLF AYLENPKKYI PGTKMAFAGF KKPADRNNVI 100
    TYLKKATSE 109
    Length:109
    Mass (Da):12,022
    Last modified:January 23, 2007 - v3
    Checksum:i28F4BAA1E9B906F9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581R → K AA sequence (PubMed:207525)Curated
    Sequence conflicti60 – 601K → R AA sequence (PubMed:207525)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01318 Genomic DNA. Translation: AAA35300.1.
    CU329672 Genomic DNA. Translation: CAB41053.1.
    PIRiT41220. CCZP.
    RefSeqiNP_588296.1. NM_001023286.2.

    Genome annotation databases

    EnsemblFungiiSPCC191.07.1; SPCC191.07.1:pep; SPCC191.07.
    GeneIDi2539146.
    KEGGispo:SPCC191.07.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Life shuttle - Issue 76 of November 2006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01318 Genomic DNA. Translation: AAA35300.1 .
    CU329672 Genomic DNA. Translation: CAB41053.1 .
    PIRi T41220. CCZP.
    RefSeqi NP_588296.1. NM_001023286.2.

    3D structure databases

    ProteinModelPortali P00046.
    SMRi P00046. Positions 3-106.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275718. 1 interaction.
    MINTi MINT-4686677.
    STRINGi 4896.SPCC191.07-1.

    Proteomic databases

    MaxQBi P00046.
    PaxDbi P00046.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC191.07.1 ; SPCC191.07.1:pep ; SPCC191.07 .
    GeneIDi 2539146.
    KEGGi spo:SPCC191.07.

    Organism-specific databases

    PomBasei SPCC191.07.

    Phylogenomic databases

    eggNOGi COG3474.
    HOGENOMi HOG000009762.
    KOi K08738.
    OMAi DDQEITD.
    OrthoDBi EOG71RXXT.
    PhylomeDBi P00046.

    Enzyme and pathway databases

    Reactomei REACT_199379. Release of apoptotic factors from the mitochondria.
    REACT_219607. Detoxification of Reactive Oxygen Species.

    Miscellaneous databases

    NextBioi 20800318.
    PROi P00046.

    Family and domain databases

    Gene3Di 1.10.760.10. 1 hit.
    InterProi IPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view ]
    PANTHERi PTHR11961. PTHR11961. 1 hit.
    Pfami PF00034. Cytochrom_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00604. CYTCHRMECIAB.
    SUPFAMi SSF46626. SSF46626. 1 hit.
    PROSITEi PS51007. CYTC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of the Schizosaccharomyces pombe cytochrome c gene."
      Russell P.R., Hall B.D.
      Mol. Cell. Biol. 2:106-116(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. "Cytochrome c from Schizosaccharomyces pombe. 2. Amino-acid sequence."
      Simon-Becam A.-M., Claisse M., Lederer F.
      Eur. J. Biochem. 86:407-416(1978) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-109.

    Entry informationi

    Entry nameiCYC_SCHPO
    AccessioniPrimary (citable) accession number: P00046
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 132 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3