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Protein

Cytochrome c

Gene

cyc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei19Heme (covalent)1
Binding sitei22Heme (covalent)1
Metal bindingi23Iron (heme axial ligand)1
Metal bindingi85Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-111457. Release of apoptotic factors from the mitochondria.
R-SPO-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c
Gene namesi
Name:cyc1
ORF Names:SPCC191.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC191.07.
PomBaseiSPCC191.07. cyc1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001083332 – 109Cytochrome cAdd BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77N6,N6,N6-trimethyllysine1 Publication1

Post-translational modificationi

Binds 1 heme group per subunit.

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiP00046.
PRIDEiP00046.

Interactioni

Protein-protein interaction databases

BioGridi275718. 1 interactor.
MINTiMINT-4686677.

Structurei

3D structure databases

ProteinModelPortaliP00046.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

HOGENOMiHOG000009762.
InParanoidiP00046.
KOiK08738.
OMAiRDYLHNP.
OrthoDBiEOG092C56RQ.
PhylomeDBiP00046.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYAPGDEKK GASLFKTRCA QCHTVEKGGA NKVGPNLHGV FGRKTGQAEG
60 70 80 90 100
FSYTEANRDK GITWDEETLF AYLENPKKYI PGTKMAFAGF KKPADRNNVI

TYLKKATSE
Length:109
Mass (Da):12,022
Last modified:January 23, 2007 - v3
Checksum:i28F4BAA1E9B906F9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58R → K AA sequence (PubMed:207525).Curated1
Sequence conflicti60K → R AA sequence (PubMed:207525).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01318 Genomic DNA. Translation: AAA35300.1.
CU329672 Genomic DNA. Translation: CAB41053.1.
PIRiT41220. CCZP.
RefSeqiNP_588296.1. NM_001023286.2.

Genome annotation databases

EnsemblFungiiSPCC191.07.1; SPCC191.07.1:pep; SPCC191.07.
GeneIDi2539146.
KEGGispo:SPCC191.07.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01318 Genomic DNA. Translation: AAA35300.1.
CU329672 Genomic DNA. Translation: CAB41053.1.
PIRiT41220. CCZP.
RefSeqiNP_588296.1. NM_001023286.2.

3D structure databases

ProteinModelPortaliP00046.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275718. 1 interactor.
MINTiMINT-4686677.

Proteomic databases

MaxQBiP00046.
PRIDEiP00046.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC191.07.1; SPCC191.07.1:pep; SPCC191.07.
GeneIDi2539146.
KEGGispo:SPCC191.07.

Organism-specific databases

EuPathDBiFungiDB:SPCC191.07.
PomBaseiSPCC191.07. cyc1.

Phylogenomic databases

HOGENOMiHOG000009762.
InParanoidiP00046.
KOiK08738.
OMAiRDYLHNP.
OrthoDBiEOG092C56RQ.
PhylomeDBiP00046.

Enzyme and pathway databases

ReactomeiR-SPO-111457. Release of apoptotic factors from the mitochondria.
R-SPO-3299685. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

PROiP00046.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYC_SCHPO
AccessioniPrimary (citable) accession number: P00046
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.