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Protein

Cytochrome c

Gene

cyc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei19 – 191Heme (covalent)
Binding sitei22 – 221Heme (covalent)
Metal bindingi23 – 231Iron (heme axial ligand)
Metal bindingi85 – 851Iron (heme axial ligand)

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_273375. Detoxification of Reactive Oxygen Species.
REACT_302202. Release of apoptotic factors from the mitochondria.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c
Gene namesi
Name:cyc1
ORF Names:SPCC191.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC191.07.
PomBaseiSPCC191.07. cyc1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • mitochondrial intermembrane space Source: GO_Central
  • mitochondrial respiratory chain Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 109108Cytochrome cPRO_0000108333Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771N6,N6,N6-trimethyllysine1 Publication

Post-translational modificationi

Binds 1 heme group per subunit.

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiP00046.
PaxDbiP00046.

Interactioni

Protein-protein interaction databases

BioGridi275718. 1 interaction.
MINTiMINT-4686677.

Structurei

3D structure databases

ProteinModelPortaliP00046.
SMRiP00046. Positions 3-106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiCOG3474.
HOGENOMiHOG000009762.
InParanoidiP00046.
KOiK08738.
OMAiRDYLHNP.
OrthoDBiEOG71RXXT.
PhylomeDBiP00046.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYAPGDEKK GASLFKTRCA QCHTVEKGGA NKVGPNLHGV FGRKTGQAEG
60 70 80 90 100
FSYTEANRDK GITWDEETLF AYLENPKKYI PGTKMAFAGF KKPADRNNVI

TYLKKATSE
Length:109
Mass (Da):12,022
Last modified:January 23, 2007 - v3
Checksum:i28F4BAA1E9B906F9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581R → K AA sequence (PubMed:207525).Curated
Sequence conflicti60 – 601K → R AA sequence (PubMed:207525).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01318 Genomic DNA. Translation: AAA35300.1.
CU329672 Genomic DNA. Translation: CAB41053.1.
PIRiT41220. CCZP.
RefSeqiNP_588296.1. NM_001023286.2.

Genome annotation databases

EnsemblFungiiSPCC191.07.1; SPCC191.07.1:pep; SPCC191.07.
GeneIDi2539146.
KEGGispo:SPCC191.07.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01318 Genomic DNA. Translation: AAA35300.1.
CU329672 Genomic DNA. Translation: CAB41053.1.
PIRiT41220. CCZP.
RefSeqiNP_588296.1. NM_001023286.2.

3D structure databases

ProteinModelPortaliP00046.
SMRiP00046. Positions 3-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275718. 1 interaction.
MINTiMINT-4686677.

Proteomic databases

MaxQBiP00046.
PaxDbiP00046.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC191.07.1; SPCC191.07.1:pep; SPCC191.07.
GeneIDi2539146.
KEGGispo:SPCC191.07.

Organism-specific databases

EuPathDBiFungiDB:SPCC191.07.
PomBaseiSPCC191.07. cyc1.

Phylogenomic databases

eggNOGiCOG3474.
HOGENOMiHOG000009762.
InParanoidiP00046.
KOiK08738.
OMAiRDYLHNP.
OrthoDBiEOG71RXXT.
PhylomeDBiP00046.

Enzyme and pathway databases

ReactomeiREACT_273375. Detoxification of Reactive Oxygen Species.
REACT_302202. Release of apoptotic factors from the mitochondria.

Miscellaneous databases

NextBioi20800318.
PROiP00046.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the Schizosaccharomyces pombe cytochrome c gene."
    Russell P.R., Hall B.D.
    Mol. Cell. Biol. 2:106-116(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Cytochrome c from Schizosaccharomyces pombe. 2. Amino-acid sequence."
    Simon-Becam A.-M., Claisse M., Lederer F.
    Eur. J. Biochem. 86:407-416(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-109, METHYLATION AT LYS-77.

Entry informationi

Entry nameiCYC_SCHPO
AccessioniPrimary (citable) accession number: P00046
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.