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P00046

- CYC_SCHPO

UniProt

P00046 - CYC_SCHPO

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Protein

Cytochrome c

Gene

cyc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei19 – 191Heme (covalent)
Binding sitei22 – 221Heme (covalent)
Metal bindingi23 – 231Iron (heme axial ligand)
Metal bindingi85 – 851Iron (heme axial ligand)

GO - Molecular functioni

  1. electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity Source: PomBase
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. mitochondrial ATP synthesis coupled electron transport Source: PomBase
  2. mitochondrial electron transport, cytochrome c to oxygen Source: PomBase
  3. mitochondrial electron transport, ubiquinol to cytochrome c Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_199379. Release of apoptotic factors from the mitochondria.
REACT_219607. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c
Gene namesi
Name:cyc1
ORF Names:SPCC191.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC191.07.

Subcellular locationi

Mitochondrion intermembrane space
Note: Loosely associated with the inner membrane.

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. mitochondrial respiratory chain Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 109108Cytochrome cPRO_0000108333Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771N6,N6,N6-trimethyllysine1 Publication

Post-translational modificationi

Binds 1 heme group per subunit.

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiP00046.
PaxDbiP00046.

Interactioni

Protein-protein interaction databases

BioGridi275718. 1 interaction.
MINTiMINT-4686677.
STRINGi4896.SPCC191.07-1.

Structurei

3D structure databases

ProteinModelPortaliP00046.
SMRiP00046. Positions 3-106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiCOG3474.
HOGENOMiHOG000009762.
InParanoidiP00046.
KOiK08738.
OMAiDDQEITD.
OrthoDBiEOG71RXXT.
PhylomeDBiP00046.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00046-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPYAPGDEKK GASLFKTRCA QCHTVEKGGA NKVGPNLHGV FGRKTGQAEG
60 70 80 90 100
FSYTEANRDK GITWDEETLF AYLENPKKYI PGTKMAFAGF KKPADRNNVI

TYLKKATSE
Length:109
Mass (Da):12,022
Last modified:January 23, 2007 - v3
Checksum:i28F4BAA1E9B906F9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581R → K AA sequence (PubMed:207525)Curated
Sequence conflicti60 – 601K → R AA sequence (PubMed:207525)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J01318 Genomic DNA. Translation: AAA35300.1.
CU329672 Genomic DNA. Translation: CAB41053.1.
PIRiT41220. CCZP.
RefSeqiNP_588296.1. NM_001023286.2.

Genome annotation databases

EnsemblFungiiSPCC191.07.1; SPCC191.07.1:pep; SPCC191.07.
GeneIDi2539146.
KEGGispo:SPCC191.07.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J01318 Genomic DNA. Translation: AAA35300.1 .
CU329672 Genomic DNA. Translation: CAB41053.1 .
PIRi T41220. CCZP.
RefSeqi NP_588296.1. NM_001023286.2.

3D structure databases

ProteinModelPortali P00046.
SMRi P00046. Positions 3-106.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275718. 1 interaction.
MINTi MINT-4686677.
STRINGi 4896.SPCC191.07-1.

Proteomic databases

MaxQBi P00046.
PaxDbi P00046.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC191.07.1 ; SPCC191.07.1:pep ; SPCC191.07 .
GeneIDi 2539146.
KEGGi spo:SPCC191.07.

Organism-specific databases

PomBasei SPCC191.07.

Phylogenomic databases

eggNOGi COG3474.
HOGENOMi HOG000009762.
InParanoidi P00046.
KOi K08738.
OMAi DDQEITD.
OrthoDBi EOG71RXXT.
PhylomeDBi P00046.

Enzyme and pathway databases

Reactomei REACT_199379. Release of apoptotic factors from the mitochondria.
REACT_219607. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

NextBioi 20800318.
PROi P00046.

Family and domain databases

Gene3Di 1.10.760.10. 1 hit.
InterProi IPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view ]
PANTHERi PTHR11961. PTHR11961. 1 hit.
Pfami PF00034. Cytochrom_C. 1 hit.
[Graphical view ]
PRINTSi PR00604. CYTCHRMECIAB.
SUPFAMi SSF46626. SSF46626. 1 hit.
PROSITEi PS51007. CYTC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the Schizosaccharomyces pombe cytochrome c gene."
    Russell P.R., Hall B.D.
    Mol. Cell. Biol. 2:106-116(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Cytochrome c from Schizosaccharomyces pombe. 2. Amino-acid sequence."
    Simon-Becam A.-M., Claisse M., Lederer F.
    Eur. J. Biochem. 86:407-416(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-109, METHYLATION AT LYS-77.

Entry informationi

Entry nameiCYC_SCHPO
AccessioniPrimary (citable) accession number: P00046
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3