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P00046 (CYC_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length109 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Subcellular location

Mitochondrion intermembrane space. Note: Loosely associated with the inner membrane.

Post-translational modification

Binds 1 heme group per subunit.

Sequence similarities

Belongs to the cytochrome c family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.3
Chain2 – 109108Cytochrome c
PRO_0000108333

Sites

Metal binding231Iron (heme axial ligand)
Metal binding851Iron (heme axial ligand)
Binding site191Heme (covalent)
Binding site221Heme (covalent)

Amino acid modifications

Modified residue771N6,N6,N6-trimethyllysine

Experimental info

Sequence conflict581R → K AA sequence Ref.3
Sequence conflict601K → R AA sequence Ref.3

Sequences

Sequence LengthMass (Da)Tools
P00046 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 28F4BAA1E9B906F9

FASTA10912,022
        10         20         30         40         50         60 
MPYAPGDEKK GASLFKTRCA QCHTVEKGGA NKVGPNLHGV FGRKTGQAEG FSYTEANRDK 

        70         80         90        100 
GITWDEETLF AYLENPKKYI PGTKMAFAGF KKPADRNNVI TYLKKATSE 

« Hide

References

« Hide 'large scale' references
[1]"Structure of the Schizosaccharomyces pombe cytochrome c gene."
Russell P.R., Hall B.D.
Mol. Cell. Biol. 2:106-116(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Cytochrome c from Schizosaccharomyces pombe. 2. Amino-acid sequence."
Simon-Becam A.-M., Claisse M., Lederer F.
Eur. J. Biochem. 86:407-416(1978) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-109.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J01318 Genomic DNA. Translation: AAA35300.1.
CU329672 Genomic DNA. Translation: CAB41053.1.
PIRCCZP. T41220.
RefSeqNP_588296.1. NM_001023286.2.

3D structure databases

ProteinModelPortalP00046.
SMRP00046. Positions 3-106.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid275718. 1 interaction.
MINTMINT-4686677.
STRING4896.SPCC191.07-1.

Proteomic databases

PaxDbP00046.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC191.07.1; SPCC191.07.1:pep; SPCC191.07.
GeneID2539146.
KEGGspo:SPCC191.07.

Organism-specific databases

PomBaseSPCC191.07.

Phylogenomic databases

eggNOGCOG3474.
HOGENOMHOG000009762.
KOK08738.
OMARDYLHNP.
OrthoDBEOG71RXXT.
PhylomeDBP00046.

Family and domain databases

Gene3D1.10.760.10. 1 hit.
InterProIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERPTHR11961. PTHR11961. 1 hit.
PfamPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSPR00604. CYTCHRMECIAB.
SUPFAMSSF46626. SSF46626. 1 hit.
PROSITEPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20800318.
PROP00046.

Entry information

Entry nameCYC_SCHPO
AccessionPrimary (citable) accession number: P00046
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names