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P00045 (CYC7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 152. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c iso-2
Gene names
Name:CYC7
Synonyms:CYP3
Ordered Locus Names:YEL039C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length113 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Subcellular location

Mitochondrion intermembrane space.

Developmental stage

Iso-2 is the predominant cytochrome c in anaerobically grown or heme deficient cells.

Induction

By oxygen and low cAMP levels.

Post-translational modification

Binds 1 heme group per subunit.

Miscellaneous

Present with 1310 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the cytochrome c family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 113113Cytochrome c iso-2
PRO_0000108338

Sites

Metal binding281Iron (heme axial ligand)
Metal binding901Iron (heme axial ligand)
Binding site241Heme (covalent)
Binding site271Heme (covalent)

Secondary structure

................. 113
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P00045 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 50CBD0F95B480CB7

FASTA11312,532
        10         20         30         40         50         60 
MAKESTGFKP GSAKKGATLF KTRCQQCHTI EEGGPNKVGP NLHGIFGRHS GQVKGYSYTD 

        70         80         90        100        110 
ANINKNVKWD EDSMSEYLTN PKKYIPGTKM AFAGLKKEKD RNDLITYMTK AAK 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and sequence of the gene for iso-2-cytochrome c in Saccharomyces cerevisiae."
Montgomery D.L., Leung D.W., Smith M., Shalit P., Faye G., Hall B.D.
Proc. Natl. Acad. Sci. U.S.A. 77:541-545(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The gene clusters ARC and COR on chromosomes 5 and 10, respectively, of Saccharomyces cerevisiae share a common ancestry."
Melnick L., Sherman F.
J. Mol. Biol. 233:372-388(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: B-6441.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Structure determination and analysis of yeast iso-2-cytochrome c and a composite mutant protein."
Murphy M.E.P., Nall B.T., Brayer G.D.
J. Mol. Biol. 227:160-176(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
+Additional computationally mapped references.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S65964 Genomic DNA. Translation: AAD13974.1.
V01299 Genomic DNA. Translation: CAA24606.1.
L22173 Genomic DNA. Translation: AAA34940.1.
J01320 Genomic DNA. Translation: AAB59339.1.
U18779 Genomic DNA. Translation: AAB65003.1.
AY693032 Genomic DNA. Translation: AAT93051.1.
BK006939 Genomic DNA. Translation: DAA07614.1.
PIRCCBYBC. A00038.
RefSeqNP_010875.1. NM_001178854.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1YEAX-ray1.90A2-113[»]
1YEBX-ray1.95A8-107[»]
1YTCX-ray1.80A2-113[»]
3CXHX-ray2.50W2-113[»]
ProteinModelPortalP00045.
SMRP00045. Positions 2-113.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36690. 22 interactions.
DIPDIP-7178N.
IntActP00045. 2 interactions.
MINTMINT-2783902.
STRING4932.YEL039C.

Proteomic databases

PaxDbP00045.
PeptideAtlasP00045.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYEL039C; YEL039C; YEL039C.
GeneID856672.
KEGGsce:YEL039C.

Organism-specific databases

CYGDYEL039c.
SGDS000000765. CYC7.

Phylogenomic databases

eggNOGCOG3474.
GeneTreeENSGT00390000009405.
HOGENOMHOG000009762.
KOK08738.
OMAGHYSEAM.
OrthoDBEOG71RXXT.

Enzyme and pathway databases

BioCycYEAST:G3O-30160-MONOMER.

Gene expression databases

GenevestigatorP00045.

Family and domain databases

Gene3D1.10.760.10. 1 hit.
InterProIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERPTHR11961. PTHR11961. 1 hit.
PfamPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSPR00604. CYTCHRMECIAB.
SUPFAMSSF46626. SSF46626. 1 hit.
PROSITEPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP00045.
NextBio982687.

Entry information

Entry nameCYC7_YEAST
AccessionPrimary (citable) accession number: P00045
Secondary accession number(s): D3DLL0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references