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Protein

Cytochrome c iso-2

Gene

CYC7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Miscellaneous

Present with 1310 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei24Heme (covalent)1
Binding sitei27Heme (covalent)1
Metal bindingi28Iron (heme axial ligand)1
Metal bindingi90Iron (heme axial ligand)1

GO - Molecular functioni

  • electron transfer activity Source: SGD
  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • mitochondrial electron transport, cytochrome c to oxygen Source: SGD
  • mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD

Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30160-MONOMER
ReactomeiR-SCE-111457 Release of apoptotic factors from the mitochondria
R-SCE-111458 Formation of apoptosome
R-SCE-2151201 Transcriptional activation of mitochondrial biogenesis
R-SCE-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c iso-2
Gene namesi
Name:CYC7
Synonyms:CYP3
Ordered Locus Names:YEL039C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YEL039C
SGDiS000000765 CYC7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001083381 – 113Cytochrome c iso-2Add BLAST113

Post-translational modificationi

Binds 1 heme group per subunit.

Proteomic databases

MaxQBiP00045
PaxDbiP00045
PRIDEiP00045

Expressioni

Developmental stagei

Iso-2 is the predominant cytochrome c in anaerobically grown or heme deficient cells.

Inductioni

By oxygen and low cAMP levels.

Interactioni

Protein-protein interaction databases

BioGridi36690, 22 interactors
DIPiDIP-7178N
IntActiP00045, 2 interactors
MINTiP00045
STRINGi4932.YEL039C

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 7Combined sources4
Helixi13 – 23Combined sources11
Turni24 – 27Combined sources4
Helixi45 – 47Combined sources3
Beta strandi48 – 51Combined sources4
Helixi60 – 65Combined sources6
Helixi71 – 79Combined sources9
Helixi81 – 84Combined sources4
Helixi98 – 111Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YEAX-ray1.90A2-113[»]
1YEBX-ray1.95A6-111[»]
1YTCX-ray1.80A2-113[»]
3CXHX-ray2.50W2-113[»]
ProteinModelPortaliP00045
SMRiP00045
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00045

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000009405
HOGENOMiHOG000009762
InParanoidiP00045
KOiK08738
OMAiRDYLHNP
OrthoDBiEOG092C56RQ

Family and domain databases

Gene3Di1.10.760.10, 1 hit
InterProiView protein in InterPro
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR002327 Cyt_c_1A/1B
PANTHERiPTHR11961 PTHR11961, 1 hit
PfamiView protein in Pfam
PF00034 Cytochrom_C, 1 hit
PRINTSiPR00604 CYTCHRMECIAB
SUPFAMiSSF46626 SSF46626, 1 hit
PROSITEiView protein in PROSITE
PS51007 CYTC, 1 hit

Sequencei

Sequence statusi: Complete.

P00045-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKESTGFKP GSAKKGATLF KTRCQQCHTI EEGGPNKVGP NLHGIFGRHS
60 70 80 90 100
GQVKGYSYTD ANINKNVKWD EDSMSEYLTN PKKYIPGTKM AFAGLKKEKD
110
RNDLITYMTK AAK
Length:113
Mass (Da):12,532
Last modified:July 21, 1986 - v1
Checksum:i50CBD0F95B480CB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65964 Genomic DNA Translation: AAD13974.1
V01299 Genomic DNA Translation: CAA24606.1
L22173 Genomic DNA Translation: AAA34940.1
J01320 Genomic DNA Translation: AAB59339.1
U18779 Genomic DNA Translation: AAB65003.1
AY693032 Genomic DNA Translation: AAT93051.1
BK006939 Genomic DNA Translation: DAA07614.1
PIRiA00038 CCBYBC
RefSeqiNP_010875.1, NM_001178854.1

Genome annotation databases

EnsemblFungiiYEL039C; YEL039C; YEL039C
GeneIDi856672
KEGGisce:YEL039C

Similar proteinsi

Entry informationi

Entry nameiCYC7_YEAST
AccessioniPrimary (citable) accession number: P00045
Secondary accession number(s): D3DLL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 187 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

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