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Protein

Cytochrome c iso-2

Gene

CYC7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei24 – 241Heme (covalent)
Binding sitei27 – 271Heme (covalent)
Metal bindingi28 – 281Iron (heme axial ligand)
Metal bindingi90 – 901Iron (heme axial ligand)

GO - Molecular functioni

  1. electron carrier activity Source: SGD
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. mitochondrial electron transport, cytochrome c to oxygen Source: SGD
  2. mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30160-MONOMER.
ReactomeiREACT_188673. Release of apoptotic factors from the mitochondria.
REACT_191152. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c iso-2
Gene namesi
Name:CYC7
Synonyms:CYP3
Ordered Locus Names:YEL039C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYEL039c.
SGDiS000000765. CYC7.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial intermembrane space Source: SGD
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 113113Cytochrome c iso-2PRO_0000108338Add
BLAST

Post-translational modificationi

Binds 1 heme group per subunit.

Proteomic databases

MaxQBiP00045.
PaxDbiP00045.
PeptideAtlasiP00045.

Expressioni

Developmental stagei

Iso-2 is the predominant cytochrome c in anaerobically grown or heme deficient cells.

Inductioni

By oxygen and low cAMP levels.

Gene expression databases

GenevestigatoriP00045.

Interactioni

Protein-protein interaction databases

BioGridi36690. 22 interactions.
DIPiDIP-7178N.
IntActiP00045. 2 interactions.
MINTiMINT-2783902.
STRINGi4932.YEL039C.

Structurei

Secondary structure

1
113
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 74Combined sources
Helixi13 – 2311Combined sources
Turni24 – 274Combined sources
Helixi45 – 473Combined sources
Beta strandi48 – 514Combined sources
Helixi60 – 656Combined sources
Helixi71 – 799Combined sources
Helixi81 – 844Combined sources
Helixi98 – 11114Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YEAX-ray1.90A2-113[»]
1YEBX-ray1.95A6-111[»]
1YTCX-ray1.80A2-113[»]
3CXHX-ray2.50W2-113[»]
ProteinModelPortaliP00045.
SMRiP00045. Positions 2-113.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00045.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiCOG3474.
GeneTreeiENSGT00390000009405.
HOGENOMiHOG000009762.
InParanoidiP00045.
KOiK08738.
OMAiNGALIYQ.
OrthoDBiEOG71RXXT.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00045-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKESTGFKP GSAKKGATLF KTRCQQCHTI EEGGPNKVGP NLHGIFGRHS
60 70 80 90 100
GQVKGYSYTD ANINKNVKWD EDSMSEYLTN PKKYIPGTKM AFAGLKKEKD
110
RNDLITYMTK AAK
Length:113
Mass (Da):12,532
Last modified:July 21, 1986 - v1
Checksum:i50CBD0F95B480CB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65964 Genomic DNA. Translation: AAD13974.1.
V01299 Genomic DNA. Translation: CAA24606.1.
L22173 Genomic DNA. Translation: AAA34940.1.
J01320 Genomic DNA. Translation: AAB59339.1.
U18779 Genomic DNA. Translation: AAB65003.1.
AY693032 Genomic DNA. Translation: AAT93051.1.
BK006939 Genomic DNA. Translation: DAA07614.1.
PIRiA00038. CCBYBC.
RefSeqiNP_010875.1. NM_001178854.1.

Genome annotation databases

EnsemblFungiiYEL039C; YEL039C; YEL039C.
GeneIDi856672.
KEGGisce:YEL039C.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65964 Genomic DNA. Translation: AAD13974.1.
V01299 Genomic DNA. Translation: CAA24606.1.
L22173 Genomic DNA. Translation: AAA34940.1.
J01320 Genomic DNA. Translation: AAB59339.1.
U18779 Genomic DNA. Translation: AAB65003.1.
AY693032 Genomic DNA. Translation: AAT93051.1.
BK006939 Genomic DNA. Translation: DAA07614.1.
PIRiA00038. CCBYBC.
RefSeqiNP_010875.1. NM_001178854.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YEAX-ray1.90A2-113[»]
1YEBX-ray1.95A6-111[»]
1YTCX-ray1.80A2-113[»]
3CXHX-ray2.50W2-113[»]
ProteinModelPortaliP00045.
SMRiP00045. Positions 2-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36690. 22 interactions.
DIPiDIP-7178N.
IntActiP00045. 2 interactions.
MINTiMINT-2783902.
STRINGi4932.YEL039C.

Proteomic databases

MaxQBiP00045.
PaxDbiP00045.
PeptideAtlasiP00045.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYEL039C; YEL039C; YEL039C.
GeneIDi856672.
KEGGisce:YEL039C.

Organism-specific databases

CYGDiYEL039c.
SGDiS000000765. CYC7.

Phylogenomic databases

eggNOGiCOG3474.
GeneTreeiENSGT00390000009405.
HOGENOMiHOG000009762.
InParanoidiP00045.
KOiK08738.
OMAiNGALIYQ.
OrthoDBiEOG71RXXT.

Enzyme and pathway databases

BioCyciYEAST:G3O-30160-MONOMER.
ReactomeiREACT_188673. Release of apoptotic factors from the mitochondria.
REACT_191152. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

EvolutionaryTraceiP00045.
NextBioi982687.

Gene expression databases

GenevestigatoriP00045.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and sequence of the gene for iso-2-cytochrome c in Saccharomyces cerevisiae."
    Montgomery D.L., Leung D.W., Smith M., Shalit P., Faye G., Hall B.D.
    Proc. Natl. Acad. Sci. U.S.A. 77:541-545(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The gene clusters ARC and COR on chromosomes 5 and 10, respectively, of Saccharomyces cerevisiae share a common ancestry."
    Melnick L., Sherman F.
    J. Mol. Biol. 233:372-388(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: B-6441.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Structure determination and analysis of yeast iso-2-cytochrome c and a composite mutant protein."
    Murphy M.E.P., Nall B.T., Brayer G.D.
    J. Mol. Biol. 227:160-176(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).

Entry informationi

Entry nameiCYC7_YEAST
AccessioniPrimary (citable) accession number: P00045
Secondary accession number(s): D3DLL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: January 7, 2015
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1310 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.