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P00045

- CYC7_YEAST

UniProt

P00045 - CYC7_YEAST

Protein

Cytochrome c iso-2

Gene

CYC7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei24 – 241Heme (covalent)
    Binding sitei27 – 271Heme (covalent)
    Metal bindingi28 – 281Iron (heme axial ligand)
    Metal bindingi90 – 901Iron (heme axial ligand)

    GO - Molecular functioni

    1. electron carrier activity Source: SGD
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. mitochondrial electron transport, cytochrome c to oxygen Source: SGD
    2. mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30160-MONOMER.
    ReactomeiREACT_188673. Release of apoptotic factors from the mitochondria.
    REACT_191152. Detoxification of Reactive Oxygen Species.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c iso-2
    Gene namesi
    Name:CYC7
    Synonyms:CYP3
    Ordered Locus Names:YEL039C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYEL039c.
    SGDiS000000765. CYC7.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial intermembrane space Source: SGD
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 113113Cytochrome c iso-2PRO_0000108338Add
    BLAST

    Post-translational modificationi

    Binds 1 heme group per subunit.

    Proteomic databases

    MaxQBiP00045.
    PaxDbiP00045.
    PeptideAtlasiP00045.

    Expressioni

    Developmental stagei

    Iso-2 is the predominant cytochrome c in anaerobically grown or heme deficient cells.

    Inductioni

    By oxygen and low cAMP levels.

    Gene expression databases

    GenevestigatoriP00045.

    Interactioni

    Protein-protein interaction databases

    BioGridi36690. 22 interactions.
    DIPiDIP-7178N.
    IntActiP00045. 2 interactions.
    MINTiMINT-2783902.
    STRINGi4932.YEL039C.

    Structurei

    Secondary structure

    1
    113
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 74
    Helixi13 – 2311
    Turni24 – 274
    Helixi45 – 473
    Beta strandi48 – 514
    Helixi60 – 656
    Helixi71 – 799
    Helixi81 – 844
    Helixi98 – 11114

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1YEAX-ray1.90A2-113[»]
    1YEBX-ray1.95A6-111[»]
    1YTCX-ray1.80A2-113[»]
    3CXHX-ray2.50W2-113[»]
    ProteinModelPortaliP00045.
    SMRiP00045. Positions 2-113.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP00045.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c family.Curated

    Phylogenomic databases

    eggNOGiCOG3474.
    GeneTreeiENSGT00390000009405.
    HOGENOMiHOG000009762.
    KOiK08738.
    OMAiKMIYAGL.
    OrthoDBiEOG71RXXT.

    Family and domain databases

    Gene3Di1.10.760.10. 1 hit.
    InterProiIPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view]
    PANTHERiPTHR11961. PTHR11961. 1 hit.
    PfamiPF00034. Cytochrom_C. 1 hit.
    [Graphical view]
    PRINTSiPR00604. CYTCHRMECIAB.
    SUPFAMiSSF46626. SSF46626. 1 hit.
    PROSITEiPS51007. CYTC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00045-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKESTGFKP GSAKKGATLF KTRCQQCHTI EEGGPNKVGP NLHGIFGRHS    50
    GQVKGYSYTD ANINKNVKWD EDSMSEYLTN PKKYIPGTKM AFAGLKKEKD 100
    RNDLITYMTK AAK 113
    Length:113
    Mass (Da):12,532
    Last modified:July 21, 1986 - v1
    Checksum:i50CBD0F95B480CB7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S65964 Genomic DNA. Translation: AAD13974.1.
    V01299 Genomic DNA. Translation: CAA24606.1.
    L22173 Genomic DNA. Translation: AAA34940.1.
    J01320 Genomic DNA. Translation: AAB59339.1.
    U18779 Genomic DNA. Translation: AAB65003.1.
    AY693032 Genomic DNA. Translation: AAT93051.1.
    BK006939 Genomic DNA. Translation: DAA07614.1.
    PIRiA00038. CCBYBC.
    RefSeqiNP_010875.1. NM_001178854.1.

    Genome annotation databases

    EnsemblFungiiYEL039C; YEL039C; YEL039C.
    GeneIDi856672.
    KEGGisce:YEL039C.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Life shuttle - Issue 76 of November 2006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S65964 Genomic DNA. Translation: AAD13974.1 .
    V01299 Genomic DNA. Translation: CAA24606.1 .
    L22173 Genomic DNA. Translation: AAA34940.1 .
    J01320 Genomic DNA. Translation: AAB59339.1 .
    U18779 Genomic DNA. Translation: AAB65003.1 .
    AY693032 Genomic DNA. Translation: AAT93051.1 .
    BK006939 Genomic DNA. Translation: DAA07614.1 .
    PIRi A00038. CCBYBC.
    RefSeqi NP_010875.1. NM_001178854.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1YEA X-ray 1.90 A 2-113 [» ]
    1YEB X-ray 1.95 A 6-111 [» ]
    1YTC X-ray 1.80 A 2-113 [» ]
    3CXH X-ray 2.50 W 2-113 [» ]
    ProteinModelPortali P00045.
    SMRi P00045. Positions 2-113.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36690. 22 interactions.
    DIPi DIP-7178N.
    IntActi P00045. 2 interactions.
    MINTi MINT-2783902.
    STRINGi 4932.YEL039C.

    Proteomic databases

    MaxQBi P00045.
    PaxDbi P00045.
    PeptideAtlasi P00045.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YEL039C ; YEL039C ; YEL039C .
    GeneIDi 856672.
    KEGGi sce:YEL039C.

    Organism-specific databases

    CYGDi YEL039c.
    SGDi S000000765. CYC7.

    Phylogenomic databases

    eggNOGi COG3474.
    GeneTreei ENSGT00390000009405.
    HOGENOMi HOG000009762.
    KOi K08738.
    OMAi KMIYAGL.
    OrthoDBi EOG71RXXT.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30160-MONOMER.
    Reactomei REACT_188673. Release of apoptotic factors from the mitochondria.
    REACT_191152. Detoxification of Reactive Oxygen Species.

    Miscellaneous databases

    EvolutionaryTracei P00045.
    NextBioi 982687.

    Gene expression databases

    Genevestigatori P00045.

    Family and domain databases

    Gene3Di 1.10.760.10. 1 hit.
    InterProi IPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view ]
    PANTHERi PTHR11961. PTHR11961. 1 hit.
    Pfami PF00034. Cytochrom_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00604. CYTCHRMECIAB.
    SUPFAMi SSF46626. SSF46626. 1 hit.
    PROSITEi PS51007. CYTC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and sequence of the gene for iso-2-cytochrome c in Saccharomyces cerevisiae."
      Montgomery D.L., Leung D.W., Smith M., Shalit P., Faye G., Hall B.D.
      Proc. Natl. Acad. Sci. U.S.A. 77:541-545(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The gene clusters ARC and COR on chromosomes 5 and 10, respectively, of Saccharomyces cerevisiae share a common ancestry."
      Melnick L., Sherman F.
      J. Mol. Biol. 233:372-388(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: B-6441.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Structure determination and analysis of yeast iso-2-cytochrome c and a composite mutant protein."
      Murphy M.E.P., Nall B.T., Brayer G.D.
      J. Mol. Biol. 227:160-176(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).

    Entry informationi

    Entry nameiCYC7_YEAST
    AccessioniPrimary (citable) accession number: P00045
    Secondary accession number(s): D3DLL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 156 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1310 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3