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Protein

Cytochrome c iso-1

Gene

CYC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Miscellaneous

Present with 7330 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20Heme (covalent)1
Binding sitei23Heme (covalent)1
Metal bindingi24Iron (heme axial ligand)1
Metal bindingi86Iron (heme axial ligand)1

GO - Molecular functioni

  • electron transfer activity Source: SGD
  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • mitochondrial electron transport, cytochrome c to oxygen Source: SGD
  • mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD

Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31683-MONOMER
ReactomeiR-SCE-111457 Release of apoptotic factors from the mitochondria
R-SCE-111458 Formation of apoptosome
R-SCE-2151201 Transcriptional activation of mitochondrial biogenesis
R-SCE-3299685 Detoxification of Reactive Oxygen Species

Protein family/group databases

MoonProtiP00044

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c iso-1
Gene namesi
Name:CYC1
Ordered Locus Names:YJR048W
ORF Names:J1653
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR048W
SGDiS000003809 CYC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi78K → R: Loss of methylation by CTM1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001083372 – 109Cytochrome c iso-1Add BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78N6,N6,N6-trimethyllysine; by CTM11 Publication1
Modified residuei79N6,N6,N6-trimethyllysine2 Publications1

Post-translational modificationi

Binds 1 heme group per subunit.
Methylation may enhance its transport into mitochondria. Methylation occurs in fungi, plants, and some protozoa, but not in animals. The precise role of methylation at Lys-79 is unknown, but it seems to preclude pro-apoptotic activity, possibly by lowering affinity for APAF1.4 Publications

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiP00044
PaxDbiP00044
PRIDEiP00044

Expressioni

Developmental stagei

Iso-1 is the predominant cytochrome c in aerobically grown cells.

Inductioni

By oxygen.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCP1P004314EBI-5393,EBI-4389

Protein-protein interaction databases

BioGridi33801, 127 interactors
DIPiDIP-4265N
IntActiP00044, 4 interactors
MINTiP00044
STRINGi4932.YJR048W

Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 19Combined sources11
Turni20 – 23Combined sources4
Beta strandi27 – 29Combined sources3
Beta strandi33 – 35Combined sources3
Helixi41 – 43Combined sources3
Beta strandi44 – 47Combined sources4
Beta strandi49 – 52Combined sources4
Helixi56 – 61Combined sources6
Beta strandi64 – 66Combined sources3
Helixi67 – 75Combined sources9
Helixi77 – 80Combined sources4
Beta strandi81 – 83Combined sources3
Helixi84 – 87Combined sources4
Helixi94 – 107Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CHHX-ray1.97A2-107[»]
1CHIX-ray2.00A2-107[»]
1CHJX-ray1.90A2-107[»]
1CIEX-ray1.80A2-107[»]
1CIFX-ray1.90A2-107[»]
1CIGX-ray1.80A2-107[»]
1CIHX-ray1.80A2-107[»]
1CRGX-ray2.00A2-107[»]
1CRHX-ray1.90A2-109[»]
1CRIX-ray2.00A2-107[»]
1CRJX-ray2.05A2-107[»]
1CSUX-ray1.81A2-107[»]
1CSVX-ray1.90A2-107[»]
1CSWX-ray1.90A2-107[»]
1CSXX-ray1.90A2-107[»]
1CTYX-ray2.20A2-107[»]
1CTZX-ray1.90A2-107[»]
1FHBNMR-A2-107[»]
1IRVX-ray1.90A2-107[»]
1IRWX-ray2.00A2-107[»]
1KYOX-ray2.97W2-109[»]
1LMSNMR-A2-107[»]
1NMINMR-A2-107[»]
1RAPX-ray2.25A2-109[»]
1RAQX-ray1.90A2-109[»]
1S6VX-ray1.88B/D2-107[»]
1U74X-ray2.40B/D2-107[»]
1YCCX-ray1.23A2-109[»]
1YFCNMR-A2-107[»]
1YICNMR-A2-107[»]
2B0ZX-ray2.70B2-109[»]
2B10X-ray2.80B/D2-109[»]
2B11X-ray2.30B/D2-109[»]
2B12X-ray3.02B2-109[»]
2BCNX-ray1.70B2-107[»]
2GB8NMR-B2-109[»]
2HV4NMR-A2-107[»]
2JQRNMR-A2-107[»]
2JTINMR-B2-109[»]
2LIRNMR-A2-107[»]
2LITNMR-A2-107[»]
2MHMNMR-A2-107[»]
2N18NMR-B3-107[»]
C2-109[»]
2ORLNMR-A2-107[»]
2PCCX-ray2.30B/D2-109[»]
2YCCX-ray1.90A2-107[»]
3CX5X-ray1.90W2-109[»]
3TYIX-ray1.40A/B2-107[»]
4MU8X-ray1.45A/B2-107[»]
4N0KX-ray1.05A/B2-107[»]
4P4QX-ray2.01B/D7-109[»]
4Q5PX-ray1.87A/B/C4-107[»]
4QAOX-ray2.10A/B/C4-107[»]
4YE1X-ray1.39A/B2-109[»]
5CIBX-ray3.01B/D2-109[»]
5CICX-ray2.10B/D2-109[»]
5CIDX-ray2.76B/D2-109[»]
5CIEX-ray2.60B/D2-109[»]
5CIFX-ray2.01B/D7-109[»]
5CIGX-ray2.06B/D2-109[»]
5CIHX-ray2.60B/D7-109[»]
5KKEX-ray1.70A2-107[»]
5KLUX-ray1.99A/B4-107[»]
5KPFX-ray1.70A/B3-109[»]
5LFTX-ray1.25A3-109[»]
5LYCX-ray1.80A/B3-109[»]
5NCVX-ray1.50A/B3-109[»]
5T7HX-ray2.00A/B/C/D1-107[»]
5T8WX-ray1.60A/B2-109[»]
ProteinModelPortaliP00044
SMRiP00044
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00044

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000009405
HOGENOMiHOG000009762
InParanoidiP00044
KOiK08738
OMAiGLFKTRC
OrthoDBiEOG092C56RQ

Family and domain databases

Gene3Di1.10.760.10, 1 hit
InterProiView protein in InterPro
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR002327 Cyt_c_1A/1B
PANTHERiPTHR11961 PTHR11961, 1 hit
PfamiView protein in Pfam
PF00034 Cytochrom_C, 1 hit
PRINTSiPR00604 CYTCHRMECIAB
SUPFAMiSSF46626 SSF46626, 1 hit
PROSITEiView protein in PROSITE
PS51007 CYTC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00044-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEFKAGSAK KGATLFKTRC LQCHTVEKGG PHKVGPNLHG IFGRHSGQAE
60 70 80 90 100
GYSYTDANIK KNVLWDENNM SEYLTNPKKY IPGTKMAFGG LKKEKDRNDL

ITYLKKACE
Length:109
Mass (Da):12,182
Last modified:January 23, 2007 - v2
Checksum:i1F8B6CB3B60C0BE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37696 Genomic DNA Translation: AAB59344.1
V01298 Genomic DNA Translation: CAA24605.1
L26347 Genomic DNA Translation: AAA62856.1
L36344 Genomic DNA Translation: AAA88751.1
Z49548 Genomic DNA Translation: CAA89576.1
X03472 Genomic DNA Translation: CAA27189.1
BK006943 Genomic DNA Translation: DAA08835.1
PIRiA00037 CCBY
RefSeqiNP_012582.1, NM_001181706.1

Genome annotation databases

EnsemblFungiiYJR048W; YJR048W; YJR048W
GeneIDi853507
KEGGisce:YJR048W

Similar proteinsi

Entry informationi

Entry nameiCYC1_YEAST
AccessioniPrimary (citable) accession number: P00044
Secondary accession number(s): D6VWL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 203 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health