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Protein

Cytochrome c

Gene
N/A
Organism
Wickerhamomyces anomalus (Yeast) (Hansenula anomala)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20Heme (covalent)PROSITE-ProRule annotation1 Publication1
Binding sitei23Heme (covalent)PROSITE-ProRule annotation1 Publication1
Metal bindingi24Iron (heme axial ligand)1
Metal bindingi86Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c
OrganismiWickerhamomyces anomalus (Yeast) (Hansenula anomala)
Taxonomic identifieri4927 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeWickerhamomyces

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001083251 – 109Cytochrome cAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei61N6-methyllysine; alternate1 Publication1
Modified residuei78N6,N6,N6-trimethyllysine1 Publication1
Modified residuei79N6,N6,N6-trimethyllysine1 Publication1

Post-translational modificationi

Binds 1 heme group per subunit.

Keywords - PTMi

Methylation

Structurei

3D structure databases

ProteinModelPortaliP00042.
SMRiP00042.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiView protein in InterPro
IPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiView protein in Pfam
PF00034. Cytochrom_C. 1 hit.
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiView protein in PROSITE
PS51007. CYTC. 1 hit.

Sequencei

Sequence statusi: Complete.

P00042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PAPFKKGSEK KGATLFKTRC LQCHTVEKGG PHKVGPNLHG IFGRQSGKAE
60 70 80 90 100
GYSYTDANIK KAVEWSEQTM SDYLENPKKY IPGTKMAFGG LKKEKDRNDL

VTYLANATK
Length:109
Mass (Da):12,064
Last modified:July 21, 1986 - v1
Checksum:i49CDCB05D9EDBCBB
GO

Sequence databases

PIRiA00035. CCHQ.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCYC_WICAO
AccessioniPrimary (citable) accession number: P00042
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 15, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families