P00038 (CYC_APIME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c

Gene names

Name:

cytC

Organism

Apis mellifera (Honeybee)

Taxonomic identifier

7460 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Hymenoptera › Apocrita › Aculeata › Apoidea › Apidae › Apis

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular location	Mitochondrion matrix.
Post-translational modification	Binds 1 heme group per subunit.
Sequence similarities	Belongs to the cytochrome c family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	Heme Iron Metal-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 108	107	Cytochrome c		PRO_0000108258
Sites
	Metal binding	23	1	Iron (heme axial ligand)
	Metal binding	85	1	Iron (heme axial ligand)
	Binding site	19	1	Heme (covalent) Ref.2
	Binding site	22	1	Heme (covalent) Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P00038 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 17C298A8B7092AB1	FASTA	108	11,910
	10 20 30 40 50 60 MGIPAGDPEK GKKIFVQKCA QCHTIESGGK HKVGPNLYGV YGRKTGQAPG YSYTDANKGK 70 80 90 100 GITWNKETLF EYLENPKKYI PGTKMVFAGL KKPQERADLI AYIEQASK

References

[1]	"Molecular mechanisms of honey bee queen longevity." Corona M., Hughes K.A., Weaver D.B., Robinson G.E. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete amino acid sequence of cytochrome c from the honeybee, Apis mellifera, and evolutionary relationship of the honeybee to other insects on the basis of the amino acid sequence." Inoue S., Matsubara H., Yamanaka T. J. Biochem. 97:947-954(1985) [PubMed: 2991212] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-108.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY601642 mRNA. Translation: AAT12410.1.
PIR	CCHB. A00031.
RefSeq	NP_001170961.1. NM_001177490.1.
UniGene	Ame.4918.
3D structure databases
ProteinModelPortal	P00038.
SMR	P00038. Positions 6-107.
ModBase	Search...
Protein-protein interaction databases
STRING	P00038.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	GB19293-RA; GB19293-PA; GB19293.
GeneID	408270.
KEGG	ame:408270.
Organism-specific databases
CTD	408270.
Phylogenomic databases
InParanoid	P00038.
OMA	KMIYAGL.
OrthoDB	EOG43FFDF.
PhylomeDB	P00038.
Family and domain databases
InterPro	IPR002327. Cyt_c_1A/1B. IPR009056. Cyt_c_dom. IPR003088. Cyt_c_I. [Graphical view]
Gene3D	G3DSA:1.10.760.10. Cytochrome_c_R. 1 hit.
KO	K08738.
PANTHER	PTHR11961. Cyt_CIAB. 1 hit.
Pfam	PF00034. Cytochrom_C. 1 hit. [Graphical view]
PRINTS	PR00604. CYTCHRMECIAB.
SUPFAM	SSF46626. Cytochrome_c. 1 hit.
PROSITE	PS51007. CYTC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYC_APIME

Accession

Primary (citable) accession number: P00038
Secondary accession number(s): Q6J4P9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)