Reviewed, UniProtKB/Swiss-Prot P00038 (CYC_APIME)

Names and origin

Protein names

Recommended name:
    Cytochrome c

Gene names

Name:

cytC

Organism

Apis mellifera (Honeybee)

Taxonomic identifier

7460 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Hymenoptera › Apocrita › Aculeata › Apoidea › Apidae › Apis

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular location	Mitochondrion matrix.
Post-translational modification	Binds 1 heme group per subunit.
Sequence similarities	Belongs to the cytochrome c family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	Heme Iron Metal-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 108	107	Cytochrome c
Sites
	Metal binding	23	1	Iron (heme axial ligand)
	Metal binding	85	1	Iron (heme axial ligand)
	Binding site	19	1	Heme (covalent)
	Binding site	22	1	Heme (covalent)

Sequences

	Sequence		Length	Mass (Da)
	P00038-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 17C298A8B7092AB1	FASTA	108	11,910
	10 20 30 40 50 60 MGIPAGDPEK GKKIFVQKCA QCHTIESGGK HKVGPNLYGV YGRKTGQAPG YSYTDANKGK 70 80 90 100 GITWNKETLF EYLENPKKYI PGTKMVFAGL KKPQERADLI AYIEQASK

References

[1]	"Molecular mechanisms of honey bee queen longevity." Corona M., Hughes K.A., Weaver D.B., Robinson G.E. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete amino acid sequence of cytochrome c from the honeybee, Apis mellifera, and evolutionary relationship of the honeybee to other insects on the basis of the amino acid sequence." Inoue S., Matsubara H., Yamanaka T. J. Biochem. 97:947-954(1985) [PubMed: 2991212] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-108.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY601642 mRNA. Translation: AAT12410.1.
PIR	CCHB. A00031.
RefSeq	XP_391823.1.
UniGene	Ame.4918
3D structure databases
HSSP	HSSP built from PDB template 2PCB based on UniProtKB P00004.
SMR	P00038. Positions 6-107.
ModBase	Search...
Genome annotation databases
Ensembl	ENSAPMG00000003281. Apis mellifera. [Contig view]
GeneID	408270.
Family and domain databases
InterPro	IPR009056. Cyt_c_monohaem. IPR003088. Cyt_CI. IPR002327. Cyt_CIAB. [Graphical view]
Gene3D	G3DSA:1.10.760.10. Cytochrome_c_R. 1 hit.
PANTHER	PTHR11961. Cyt_CIAB. 1 hit.
Pfam	PF00034. Cytochrom_C. 1 hit. [Graphical view]
PRINTS	PR00604. CYTCHRMECIAB.
ProDom	PD000375. Cyt_CIAB. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS51007. CYTC. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CYC_APIME

Accession

Primary (citable) accession number: P00038
Secondary accession number(s): Q6J4P9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	July 22, 2008
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)