P00036 (CYC_LUCCU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Cytochrome c
Organism	Lucilia cuprina (Green bottle fly) (Australian sheep blowfly)
Taxonomic identifier	7375 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Calyptratae › Oestroidea › Calliphoridae › Luciliinae › Lucilia

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular location	Mitochondrion intermembrane space. Note: Loosely associated with the inner membrane.
Post-translational modification	Binds 1 heme group per subunit.
Sequence similarities	Belongs to the cytochrome c family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	Heme Iron Metal-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 108	107	Cytochrome c		PRO_0000108263
Sites
	Metal binding	23	1	Iron (heme axial ligand)
	Metal binding	85	1	Iron (heme axial ligand)
	Binding site	19	1	Heme (covalent)
	Binding site	22	1	Heme (covalent)

Sequences

	Sequence		Length	Mass (Da)
	P00036 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 6D528A88CD771567	FASTA	108	11,794
	10 20 30 40 50 60 MGVPAGDVEK GKKIFVQRCA QCHTVEAGGK HKVGPNLHGL FGRKTGQAPG FAYTNANKAK 70 80 90 100 GITWQDDTLF EYLENPKKYI PGTKMIFAGL KKPNERGDLI AYLKSATK

References

[1]	"The amino acid sequence of cytochrome c from the blowfly Lucilia cuprina." Shaw D.C., Williams K.L., Smith E., Birt L.M. Biochim. Biophys. Acta 532:179-184(1978) [PubMed] [Europe PMC] [Abstract] Cited for: PRELIMINARY PROTEIN SEQUENCE, PROTEIN SEQUENCE OF 45-50.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases
PIR	CCHFGB. A38041.
3D structure databases
ProteinModelPortal	P00036.
SMR	P00036. Positions 6-107.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002327. Cyt_c_1A/1B. IPR009056. Cyt_c_dom. IPR003088. Cyt_c_I. [Graphical view]
PANTHER	PTHR11961. PTHR11961. 1 hit.
Pfam	PF00034. Cytochrom_C. 1 hit. [Graphical view]
PRINTS	PR00604. CYTCHRMECIAB.
SUPFAM	SSF46626. Cytochrome_c. 1 hit.
PROSITE	PS51007. CYTC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYC_LUCCU

Accession

Primary (citable) accession number: P00036

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)