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P00028 (CYC_LAMTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c
Gene names
Name:cyc
OrganismLampetra tridentata (Pacific lamprey) (Entosphenus tridentatus)
Taxonomic identifier245074 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataHyperoartiaPetromyzontiformesPetromyzontidaeLampetra

Protein attributes

Sequence length105 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Subcellular location

Mitochondrion intermembrane space. Note: Loosely associated with the inner membrane.

Post-translational modification

Binds 1 heme group per subunit.

Sequence similarities

Belongs to the cytochrome c family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 105104Cytochrome c
PRO_0000108252

Sites

Metal binding191Iron (heme axial ligand)
Metal binding811Iron (heme axial ligand)
Binding site151Heme (covalent) Ref.1
Binding site181Heme (covalent) Ref.1

Amino acid modifications

Modified residue21N-acetylglycine Ref.1

Sequences

Sequence LengthMass (Da)Tools
P00028 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: A56EDDDF30E33FC7

FASTA10511,672
        10         20         30         40         50         60 
MGDVEKGKKV FVQKCSQCHT VEKAGKHKTG PNLSGLFGRK TGQAPGFSYT DANKSKGIVW 

        70         80         90        100 
NQETLFVYLE NPKKYIPGTK MIFAGIKKEG ERKDLIAYLK KSTSE 

« Hide

References

[1]"Amino acid sequence of a cytochrome c from the common Pacific lamprey, Entosphenus tridentatus."
Nolan C., Fitch W.M., Uzzell T., Weiss L.J., Margoliash E.
Biochemistry 12:4052-4060(1973) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-105, ACETYLATION AT GLY-2.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases

PIRCCLM. A00025.

3D structure databases

ProteinModelPortalP00028.
SMRP00028. Positions 2-105.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG003023.

Family and domain databases

Gene3D1.10.760.10. 1 hit.
InterProIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERPTHR11961. PTHR11961. 1 hit.
PfamPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSPR00604. CYTCHRMECIAB.
SUPFAMSSF46626. SSF46626. 1 hit.
PROSITEPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYC_LAMTR
AccessionPrimary (citable) accession number: P00028
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries