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Protein

Cytochrome c

Gene

cyc

Organism
Lampetra tridentata (Pacific lamprey) (Entosphenus tridentatus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15Heme (covalent)PROSITE-ProRule annotation1 Publication1
Binding sitei18Heme (covalent)PROSITE-ProRule annotation1 Publication1
Metal bindingi19Iron (heme axial ligand)1
Metal bindingi81Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c
Gene namesi
Name:cyc
OrganismiLampetra tridentata (Pacific lamprey) (Entosphenus tridentatus)
Taxonomic identifieri245074 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperoartiaPetromyzontiformesPetromyzontidaeLampetra

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001082522 – 105Cytochrome cAdd BLAST104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine1 Publication1

Post-translational modificationi

Binds 1 heme group per subunit.

Keywords - PTMi

Acetylation

Structurei

3D structure databases

ProteinModelPortaliP00028.
SMRiP00028.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

HOVERGENiHBG003023.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiView protein in InterPro
IPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiView protein in Pfam
PF00034. Cytochrom_C. 1 hit.
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiView protein in PROSITE
PS51007. CYTC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDVEKGKKV FVQKCSQCHT VEKAGKHKTG PNLSGLFGRK TGQAPGFSYT
60 70 80 90 100
DANKSKGIVW NQETLFVYLE NPKKYIPGTK MIFAGIKKEG ERKDLIAYLK

KSTSE
Length:105
Mass (Da):11,672
Last modified:January 23, 2007 - v2
Checksum:iA56EDDDF30E33FC7
GO

Sequence databases

PIRiA00025. CCLM.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

PIRiA00025. CCLM.

3D structure databases

ProteinModelPortaliP00028.
SMRiP00028.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG003023.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiView protein in InterPro
IPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiView protein in Pfam
PF00034. Cytochrom_C. 1 hit.
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiView protein in PROSITE
PS51007. CYTC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCYC_LAMTR
AccessioniPrimary (citable) accession number: P00028
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.