Reviewed,
UniProtKB/Swiss-Prot P00015 (CYC2_MOUSE)
Last modified
June 16, 2009.
Version 93.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cytochrome c, testis-specific | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 105 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. |
| Subcellular location | |
| Tissue specificity | This is one of two isocytochromes C found in the testis. The other is identical with the form found in other mouse tissues. These cytochromes are assumed to be located in the sperm. |
| Post-translational modification | Binds 1 heme group per subunit. |
| Sequence similarities | Belongs to the cytochrome c family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Electron transport Respiratory chain Transport |
| Cellular component | Mitochondrion |
| Ligand | Heme Iron Metal-binding |
| PTM | Acetylation |
| Technical term | 3D-structure Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | apoptosis Inferred from direct assay. Source: MGI electron transport chainInferred from electronic annotation. Source: UniProtKB-KW hydrogen peroxide metabolic processInferred from direct assay. Source: MGI transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chainInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | electron carrier activity Inferred from electronic annotation. Source: InterPro heme bindingInferred from direct assay. Source: MGI |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||
Molecule processing | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.3 | |||||||||||||||||||
| Chain | 2 – 105 | 104 | Cytochrome c, testis-specific | PRO_0000108226 | ||||||||||||||||||
Sites | ||||||||||||||||||||||
| Metal binding | 19 | 1 | Iron (heme axial ligand) | |||||||||||||||||||
| Metal binding | 81 | 1 | Iron (heme axial ligand) | |||||||||||||||||||
| Binding site | 15 | 1 | Heme (covalent) Ref.3 | |||||||||||||||||||
| Binding site | 18 | 1 | Heme (covalent) Ref.3 | |||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||
| Modified residue | 2 | 1 | N-acetylglycine Ref.3 | |||||||||||||||||||
Secondary structure | ||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||
| Helix | 4 – 14 | 11 | ||||||||||||||||||||
| Turn | 15 – 18 | 4 | ||||||||||||||||||||
| Beta strand | 39 – 42 | 4 | ||||||||||||||||||||
| Helix | 51 – 55 | 5 | ||||||||||||||||||||
| Helix | 62 – 70 | 9 | ||||||||||||||||||||
| Helix | 72 – 75 | 4 | ||||||||||||||||||||
| Helix | 89 – 104 | 16 | ||||||||||||||||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Structure and expression of rodent genes encoding the testis-specific cytochrome c. Differences in gene structure and evolution between somatic and testicular variants." Virbasius J.V., Scarpulla R.C. J. Biol. Chem. 263:6791-6796(1988) [PubMed: 2834389] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Testis. |
| [3] | "Change of cytochrome c structure during development of the mouse." Hennig B. Eur. J. Biochem. 55:167-183(1975) [PubMed: 240690] [Abstract] Cited for: PRELIMINARY PROTEIN SEQUENCE OF 2-105. Strain: BALB/c. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M20625 mRNA. Translation: AAA37501.1. X55771 mRNA. Translation: CAA39293.1. AK005582 mRNA. Translation: BAB24136.1. AK018833 mRNA. Translation: BAB31455.1. AK018851 mRNA. Translation: BAB31464.1. | |||||||||||||
| IPI | IPI00230033. | ||||||||||||
| PIR | CCMST. B28160. | ||||||||||||
| RefSeq | NP_034119.1. | ||||||||||||
| UniGene | Mm.4872 | ||||||||||||
3D structure databases | |||||||||||||
| |||||||||||||
| ModBase | Search... | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | P00015. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSMUSG00000056436. Mus musculus. [Contig view] | ||||||||||||
| GeneID | 13067. | ||||||||||||
| KEGG | mmu:13067. | ||||||||||||
| NMPDR | fig|10090.3.peg.6178. | ||||||||||||
Organism-specific databases | |||||||||||||
| MGI | MGI:88579. Cyct. | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | P00015. | ||||||||||||
| HOVERGEN | P00015. | ||||||||||||
| OMA | P00015. IFIQKCA. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P00015. | ||||||||||||
| Bgee | P00015. | ||||||||||||
| CleanEx | MM_CYCT. | ||||||||||||
| GermOnline | ENSMUSG00000056436. Mus musculus. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR002327. Cyt_c_1A/1B. IPR003088. Cyt_c_I. IPR009056. Cyt_c_monohaem. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:1.10.760.10. Cytochrome_c_R. 1 hit. | ||||||||||||
| PANTHER | PTHR11961. Cyt_CIAB. 1 hit. | ||||||||||||
| Pfam | PF00034. Cytochrom_C. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00604. CYTCHRMECIAB. | ||||||||||||
| ProDom | PD000375. Cyt_CIAB. 1 hit. [Graphical view] [Entries sharing at least one domain] | ||||||||||||
| PROSITE | PS51007. CYTC. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 283000. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | CYC2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P00015 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| Protein Spotlight Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


