Cytochrome c, testis-specific - Mus musculus (Mouse)

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Reviewed, UniProtKB/Swiss-Prot P00015 (CYC2_MOUSE)

Last modified June 16, 2009. Version 93. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Cytochrome c, testis-specific

Gene names

Name:

Cyct

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	105 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular location	Mitochondrion matrix.
Tissue specificity	This is one of two isocytochromes C found in the testis. The other is identical with the form found in other mouse tissues. These cytochromes are assumed to be located in the sperm.
Post-translational modification	Binds 1 heme group per subunit.
Sequence similarities	Belongs to the cytochrome c family.

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Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	Heme Iron Metal-binding
PTM	Acetylation
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	apoptosis Inferred from direct assay. Source: MGI electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW hydrogen peroxide metabolic process Inferred from direct assay. Source: MGI transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from direct assay. Source: MGI
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed Ref.3

Chain

2 – 105

104

Cytochrome c, testis-specific

PRO_0000108226

Sites

Metal binding

Iron (heme axial ligand)

Metal binding

Iron (heme axial ligand)

Binding site

Heme (covalent) Ref.3

Binding site

Heme (covalent) Ref.3

Amino acid modifications

Modified residue

N-acetylglycine Ref.3

Secondary structure

105

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P00015-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 00C275FC70B5AAF9
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FASTA

105

11,714

        10         20         30         40         50         60 
MGDAEAGKKI FVQKCAQCHT VEKGGKHKTG PNLWGLFGRK TGQAPGFSYT DANKNKGVIW 

        70         80         90        100 
SEETLMEYLE NPKKYIPGTK MIFAGIKKKS EREDLIKYLK QATSS

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and expression of rodent genes encoding the testis-specific cytochrome c. Differences in gene structure and evolution between somatic and testicular variants." Virbasius J.V., Scarpulla R.C. J. Biol. Chem. 263:6791-6796(1988) [PubMed: 2834389] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Testis.
[3]	"Change of cytochrome c structure during development of the mouse." Hennig B. Eur. J. Biochem. 55:167-183(1975) [PubMed: 240690] [Abstract] Cited for: PRELIMINARY PROTEIN SEQUENCE OF 2-105. Strain: BALB/c.
+	Additional computationally mapped references.

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Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

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Cross-references

Sequence databases

M20625 mRNA. Translation: AAA37501.1.
X55771 mRNA. Translation: CAA39293.1.
AK005582 mRNA. Translation: BAB24136.1.
AK018833 mRNA. Translation: BAB31455.1.
AK018851 mRNA. Translation: BAB31464.1.

IPI

IPI00230033.

PIR

CCMST. B28160.

RefSeq

NP_034119.1.

UniGene

Mm.4872

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2AIU	X-ray	1.60	A	2-104	[»]

ModBase

Search...

Proteomic databases

PRIDE

P00015.

Genome annotation databases

Ensembl

ENSMUSG00000056436. Mus musculus. [Contig view]

GeneID

13067.

KEGG

mmu:13067.

NMPDR

fig|10090.3.peg.6178.

Organism-specific databases

MGI

MGI:88579. Cyct.

Phylogenomic databases

HOGENOM

P00015.

HOVERGEN

P00015.

OMA

P00015. IFIQKCA.

Gene expression databases

ArrayExpress

P00015.

Bgee

P00015.

CleanEx

MM_CYCT.

GermOnline

ENSMUSG00000056436. Mus musculus.

Family and domain databases

InterPro

IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_I.
IPR009056. Cyt_c_monohaem.
[Graphical view]

Gene3D

G3DSA:1.10.760.10. Cytochrome_c_R. 1 hit.

PANTHER

PTHR11961. Cyt_CIAB. 1 hit.

Pfam

PF00034. Cytochrom_C. 1 hit.
[Graphical view]

PRINTS

PR00604. CYTCHRMECIAB.

ProDom

PD000375. Cyt_CIAB. 1 hit.
[Graphical view] [Entries sharing at least one domain]

PROSITE

PS51007. CYTC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

283000.

SOURCE

Search...

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Entry information

Entry name

CYC2_MOUSE

Accession

Primary (citable) accession number: P00015

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 93 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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