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P00011

- CYC_CANFA

UniProt

P00011 - CYC_CANFA

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Protein

Cytochrome c

Gene

CYCS

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151Heme (covalent)
Binding sitei18 – 181Heme (covalent)
Metal bindingi19 – 191Iron (heme axial ligand)
Metal bindingi81 – 811Iron (heme axial ligand)

GO - Molecular functioni

  1. electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity Source: UniProtKB
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. apoptotic DNA fragmentation Source: UniProtKB
  2. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_174045. Detoxification of Reactive Oxygen Species.
REACT_209134. Transcriptional activation of mitochondrial biogenesis.
REACT_233170. Formation of apoptosome.
REACT_238631. Activation of caspases through apoptosome-mediated cleavage.
REACT_239907. Respiratory electron transport.
REACT_240737. Release of apoptotic factors from the mitochondria.
REACT_270528. Orphan transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c
Gene namesi
Name:CYCS
Synonyms:CYC
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 14

Subcellular locationi

Mitochondrion intermembrane space
Note: Loosely associated with the inner membrane.

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. mitochondrion Source: UniProtKB-KW
  3. nucleus Source: Ensembl
  4. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 105104Cytochrome cPRO_0000108211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine1 Publication
Modified residuei49 – 491PhosphotyrosineBy similarity
Modified residuei98 – 981PhosphotyrosineBy similarity

Post-translational modificationi

Binds 1 heme group per subunit.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP00011.
PRIDEiP00011.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000004225.

Structurei

3D structure databases

ProteinModelPortaliP00011.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiCOG3474.
GeneTreeiENSGT00390000009405.
HOGENOMiHOG000009762.
HOVERGENiHBG003023.
InParanoidiP00011.
KOiK08738.
OMAiCHNLKEG.
OrthoDBiEOG761BWX.
TreeFamiTF300226.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00011-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDVEKGKKI FVQKCAQCHT VEKGGKHKTG PNLHGLFGRK TGQAPGFSYT
60 70 80 90 100
DANKNKGITW GEETLMEYLE NPKKYIPGTK MIFAGIKKTG ERADLIAYLK

KATKE
Length:105
Mass (Da):11,633
Last modified:January 23, 2007 - v2
Checksum:iB9670628E8E00483
GO

Sequence databases

PIRiA00010. CCDG.
RefSeqiNP_001183974.1. NM_001197045.1.
UniGeneiCfa.379.

Genome annotation databases

EnsembliENSCAFT00000004569; ENSCAFP00000004225; ENSCAFG00000002856.
GeneIDi475258.
KEGGicfa:475258.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

PIRi A00010. CCDG.
RefSeqi NP_001183974.1. NM_001197045.1.
UniGenei Cfa.379.

3D structure databases

ProteinModelPortali P00011.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000004225.

Proteomic databases

PaxDbi P00011.
PRIDEi P00011.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000004569 ; ENSCAFP00000004225 ; ENSCAFG00000002856 .
GeneIDi 475258.
KEGGi cfa:475258.

Organism-specific databases

CTDi 54205.

Phylogenomic databases

eggNOGi COG3474.
GeneTreei ENSGT00390000009405.
HOGENOMi HOG000009762.
HOVERGENi HBG003023.
InParanoidi P00011.
KOi K08738.
OMAi CHNLKEG.
OrthoDBi EOG761BWX.
TreeFami TF300226.

Enzyme and pathway databases

Reactomei REACT_174045. Detoxification of Reactive Oxygen Species.
REACT_209134. Transcriptional activation of mitochondrial biogenesis.
REACT_233170. Formation of apoptosome.
REACT_238631. Activation of caspases through apoptosome-mediated cleavage.
REACT_239907. Respiratory electron transport.
REACT_240737. Release of apoptotic factors from the mitochondria.
REACT_270528. Orphan transporters.

Miscellaneous databases

NextBioi 20851130.

Family and domain databases

Gene3Di 1.10.760.10. 1 hit.
InterProi IPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view ]
PANTHERi PTHR11961. PTHR11961. 1 hit.
Pfami PF00034. Cytochrom_C. 1 hit.
[Graphical view ]
PRINTSi PR00604. CYTCHRMECIAB.
SUPFAMi SSF46626. SSF46626. 1 hit.
PROSITEi PS51007. CYTC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amino acid sequence of dog heart cytochrome c."
    McDowall M.A., Smith E.L.
    J. Biol. Chem. 240:4635-4647(1965) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-105, ACETYLATION AT GLY-2.

Entry informationi

Entry nameiCYC_CANFA
AccessioniPrimary (citable) accession number: P00011
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3