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P00011

- CYC_CANFA

UniProt

P00011 - CYC_CANFA

Protein

Cytochrome c

Gene

CYCS

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
    Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei15 – 151Heme (covalent)
    Binding sitei18 – 181Heme (covalent)
    Metal bindingi19 – 191Iron (heme axial ligand)
    Metal bindingi81 – 811Iron (heme axial ligand)

    GO - Molecular functioni

    1. electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity Source: UniProtKB
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. apoptotic DNA fragmentation Source: UniProtKB
    2. oxidation-reduction process Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c
    Gene namesi
    Name:CYCS
    Synonyms:CYC
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 14

    Subcellular locationi

    Mitochondrion intermembrane space
    Note: Loosely associated with the inner membrane.

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. mitochondrial intermembrane space Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 105104Cytochrome cPRO_0000108211Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycine1 Publication
    Modified residuei49 – 491PhosphotyrosineBy similarity
    Modified residuei98 – 981PhosphotyrosineBy similarity

    Post-translational modificationi

    Binds 1 heme group per subunit.
    Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiP00011.
    PRIDEiP00011.

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000004225.

    Structurei

    3D structure databases

    ProteinModelPortaliP00011.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c family.Curated

    Phylogenomic databases

    eggNOGiCOG3474.
    GeneTreeiENSGT00390000009405.
    HOGENOMiHOG000009762.
    HOVERGENiHBG003023.
    InParanoidiP00011.
    KOiK08738.
    OMAiCHNLKEG.
    OrthoDBiEOG761BWX.
    TreeFamiTF300226.

    Family and domain databases

    Gene3Di1.10.760.10. 1 hit.
    InterProiIPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view]
    PANTHERiPTHR11961. PTHR11961. 1 hit.
    PfamiPF00034. Cytochrom_C. 1 hit.
    [Graphical view]
    PRINTSiPR00604. CYTCHRMECIAB.
    SUPFAMiSSF46626. SSF46626. 1 hit.
    PROSITEiPS51007. CYTC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00011-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDVEKGKKI FVQKCAQCHT VEKGGKHKTG PNLHGLFGRK TGQAPGFSYT    50
    DANKNKGITW GEETLMEYLE NPKKYIPGTK MIFAGIKKTG ERADLIAYLK 100
    KATKE 105
    Length:105
    Mass (Da):11,633
    Last modified:January 23, 2007 - v2
    Checksum:iB9670628E8E00483
    GO

    Sequence databases

    PIRiA00010. CCDG.
    RefSeqiNP_001183974.1. NM_001197045.1.
    UniGeneiCfa.379.

    Genome annotation databases

    EnsembliENSCAFT00000004569; ENSCAFP00000004225; ENSCAFG00000002856.
    GeneIDi475258.
    KEGGicfa:475258.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Life shuttle - Issue 76 of November 2006

    Sequence databases

    PIRi A00010. CCDG.
    RefSeqi NP_001183974.1. NM_001197045.1.
    UniGenei Cfa.379.

    3D structure databases

    ProteinModelPortali P00011.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000004225.

    Proteomic databases

    PaxDbi P00011.
    PRIDEi P00011.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000004569 ; ENSCAFP00000004225 ; ENSCAFG00000002856 .
    GeneIDi 475258.
    KEGGi cfa:475258.

    Organism-specific databases

    CTDi 54205.

    Phylogenomic databases

    eggNOGi COG3474.
    GeneTreei ENSGT00390000009405.
    HOGENOMi HOG000009762.
    HOVERGENi HBG003023.
    InParanoidi P00011.
    KOi K08738.
    OMAi CHNLKEG.
    OrthoDBi EOG761BWX.
    TreeFami TF300226.

    Miscellaneous databases

    NextBioi 20851130.

    Family and domain databases

    Gene3Di 1.10.760.10. 1 hit.
    InterProi IPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view ]
    PANTHERi PTHR11961. PTHR11961. 1 hit.
    Pfami PF00034. Cytochrom_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00604. CYTCHRMECIAB.
    SUPFAMi SSF46626. SSF46626. 1 hit.
    PROSITEi PS51007. CYTC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amino acid sequence of dog heart cytochrome c."
      McDowall M.A., Smith E.L.
      J. Biol. Chem. 240:4635-4647(1965) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-105, ACETYLATION AT GLY-2.

    Entry informationi

    Entry nameiCYC_CANFA
    AccessioniPrimary (citable) accession number: P00011
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3