Reviewed, UniProtKB/Swiss-Prot P00003 (CYC_ATESP)

Names and origin

Protein names

Recommended name:
    Cytochrome c

Gene names

Name:	CYCS
Synonyms:	CYC

Organism

Ateles sp. (Spider monkey)

Taxonomic identifier

9511 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Atelidae › Atelinae › Ateles

Protein attributes

Sequence length	105 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular location	Mitochondrion matrix.
Post-translational modification	Binds 1 heme group per subunit.
Sequence similarities	Belongs to the cytochrome c family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	Heme Iron Metal-binding
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	DNA fragmentation involved in apoptosis Inferred from sequence or structural similarity. Source: UniProtKB electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity Inferred from sequence or structural similarity. Source: UniProtKB heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 105	104	Cytochrome c		PRO_0000108208
Sites
	Metal binding	19	1	Iron (heme axial ligand)
	Metal binding	81	1	Iron (heme axial ligand)
	Binding site	15	1	Heme (covalent)
	Binding site	18	1	Heme (covalent)
Amino acid modifications
	Modified residue	2	1	N-acetylglycine Probable

Sequences

	Sequence		Length	Mass (Da)
	P00003-1 [UniParc]. Last modified January 20, 2009. Version 3. Checksum: CA6E52C3613F1C43	FASTA	105	11,823
	10 20 30 40 50 60 MGDVEKGKRI FIMKCSQCHT VEKGGKHKTG PNLHGLFGRK TGQASGFTYT EANKNKGIIW 70 80 90 100 GEDTLMEYLE NPKKYIPGTK MIFVGIKKKE ERADLIAYLK KATNE

References

[1]	"Protein influences on porphyrin structure in cytochrome c: evidence from Raman difference spectroscopy." Shelnutt J.A., Rousseau D.L., Dethmers J.K., Margoliash E. Biochemistry 20:6485-6497(1981) [PubMed: 6272840] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-105.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases
PIR	CCMKP. A00004.
3D structure databases
HSSP	HSSP built from PDB template 2PCB based on UniProtKB P00004.
SMR	P00003. Positions 2-105.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P00003.
Family and domain databases
InterPro	IPR002327. Cyt_c_1A/1B. IPR003088. Cyt_c_I. IPR009056. Cyt_c_monohaem. [Graphical view]
Gene3D	G3DSA:1.10.760.10. Cytochrome_c_R. 1 hit.
PANTHER	PTHR11961. Cyt_CIAB. 1 hit.
Pfam	PF00034. Cytochrom_C. 1 hit. [Graphical view]
PRINTS	PR00604. CYTCHRMECIAB.
ProDom	PD000375. Cyt_CIAB. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS51007. CYTC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYC_ATESP

Accession

Primary (citable) accession number: P00003

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 20, 2009
Last modified:	June 16, 2009
This is version 72 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)