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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

nad5

Organism
Porphyra purpurea (Red seaweed) (Ulva purpurea)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.SAAS annotation

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotationImported

Keywords - Biological processi

Electron transport, Respiratory chainSAAS annotation, Transport

Keywords - Ligandi

NADUniRule annotationSAAS annotation, UbiquinoneUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5UniRule annotationSAAS annotation (EC:1.6.5.3UniRule annotation)
Gene namesi
Name:nad5Imported
Encoded oniMitochondrionImported
OrganismiPorphyra purpurea (Red seaweed) (Ulva purpurea)Imported
Taxonomic identifieri2787 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaBangiophyceaeBangialesBangiaceaePorphyra

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotationSAAS annotation; Multi-pass membrane protein UniRule annotationSAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 4819HelicalSequence analysisAdd
BLAST
Transmembranei83 – 10119HelicalSequence analysisAdd
BLAST
Transmembranei113 – 13018HelicalSequence analysisAdd
BLAST
Transmembranei136 – 15520HelicalSequence analysisAdd
BLAST
Transmembranei167 – 18923HelicalSequence analysisAdd
BLAST
Transmembranei209 – 23224HelicalSequence analysisAdd
BLAST
Transmembranei253 – 27119HelicalSequence analysisAdd
BLAST
Transmembranei283 – 30422HelicalSequence analysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence analysisAdd
BLAST
Transmembranei343 – 36018HelicalSequence analysisAdd
BLAST
Transmembranei372 – 40130HelicalSequence analysisAdd
BLAST
Transmembranei421 – 44525HelicalSequence analysisAdd
BLAST
Transmembranei466 – 48621HelicalSequence analysisAdd
BLAST
Transmembranei524 – 54522HelicalSequence analysisAdd
BLAST
Transmembranei629 – 65022HelicalSequence analysisAdd
BLAST
Transmembranei656 – 67621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 11755Proton_antipo_NInterPro annotationAdd
BLAST
Domaini130 – 409280Proton_antipo_MInterPro annotationAdd
BLAST
Domaini439 – 643205NADH5_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the complex I subunit 5 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR018393. NADHpl_OxRdtase_5_subgr.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
PRINTSiPR01435. NPOXDRDTASE5.
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

O99982-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLLIIALPL LGTLITGLGG RWLGREGSNI FSTTCVILCL FLSLVSFYEV
60 70 80 90 100
GLCGVPCYIS ISPWISSGAL NISWGFLFDS LTTTMLVVIT SISSLVHIYS
110 120 130 140 150
IQYMEYDPHC PRFMSFLEIF TFFMLLLVTA DNFVQMFLGW EGVGLASYLL
160 170 180 190 200
INFWYTRLCA NQAAVKALIV NRVGDFGLSL GIFTIFFLFG SVDYEVVFSL
210 220 230 240 250
ADVYSNHSIY IFGNYINTLT LIGVFLLIGA VGKSAQLGLH TWLPDAMEGP
260 270 280 290 300
TPVSALIHAA TMVTAGVFLI VRCSPLINLS PNVLFLITIL GSSTAFFASI
310 320 330 340 350
VGVFQNDIKR VIAYSTCSQL GYMVFVCGLS YYNVGMFHLV NHAFFKALLF
360 370 380 390 400
LSAGSVIHAL SNEQDMRRMG SLVYNLPITY TAMLIGSLSL AGFPFLTGFY
410 420 430 440 450
SKDLIIEITQ ISYYSNLYTT YGIFACWLAN ISVFFTAFYT FRLVFLTFIK
460 470 480 490 500
NNNSYKSSMD NIHESPLFIV IPLILLAIAS ILIGFISKDI FVGVGSSFWG
510 520 530 540 550
NSIHIMPTAY NLLEVEFMDT YIKWLPFVLS TSGAFFAYSI NIGLFKSNIT
560 570 580 590 600
FAYSNRFQKL AFSLSKKLYW DKLYNALVVS SLLNFGYNIS FKNIDRGFIE
610 620 630 640 650
LLGPYGISKT VSNLSFKITK IQTGQITHYA FFVATGLCLL LLFVPSFTFL
660 670
DNLIDVRLMT FCFFALFTAW SSKIALI
Length:677
Mass (Da):75,583
Last modified:May 1, 1999 - v1
Checksum:iF7258A465E69687A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF114794 Genomic DNA. Translation: AAD03110.1.
PIRiT11231.
RefSeqiNP_049307.1. NC_002007.1.

Genome annotation databases

GeneIDi809779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF114794 Genomic DNA. Translation: AAD03110.1.
PIRiT11231.
RefSeqiNP_049307.1. NC_002007.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi809779.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR018393. NADHpl_OxRdtase_5_subgr.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
PRINTSiPR01435. NPOXDRDTASE5.
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO99982_PORPU
AccessioniPrimary (citable) accession number: O99982
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.