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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

nad4

Organism
Porphyra purpurea (Red seaweed) (Ulva purpurea)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

NADUniRule annotation, UbiquinoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4UniRule annotation (EC:1.6.5.3UniRule annotation)
Gene namesi
Name:nad4Imported
Encoded oniMitochondrionImported
OrganismiPorphyra purpurea (Red seaweed) (Ulva purpurea)Imported
Taxonomic identifieri2787 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaBangiophyceaeBangialesBangiaceaePorphyra

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 28HelicalSequence analysisAdd BLAST23
Transmembranei48 – 70HelicalSequence analysisAdd BLAST23
Transmembranei76 – 104HelicalSequence analysisAdd BLAST29
Transmembranei111 – 129HelicalSequence analysisAdd BLAST19
Transmembranei135 – 156HelicalSequence analysisAdd BLAST22
Transmembranei168 – 189HelicalSequence analysisAdd BLAST22
Transmembranei209 – 232HelicalSequence analysisAdd BLAST24
Transmembranei239 – 260HelicalSequence analysisAdd BLAST22
Transmembranei272 – 291HelicalSequence analysisAdd BLAST20
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Transmembranei329 – 351HelicalSequence analysisAdd BLAST23
Transmembranei363 – 386HelicalSequence analysisAdd BLAST24
Transmembranei406 – 428HelicalSequence analysisAdd BLAST23
Transmembranei452 – 473HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MitochondrionUniRule annotationImported

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 416Proton_antipo_MInterPro annotationAdd BLAST284

Sequence similaritiesi

Belongs to the complex I subunit 4 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O99981-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSNNLLMWT SLIPLGGVIL LILIPGSYCN LIRNIAFGTA QLTFISSILL
60 70 80 90 100
WICFDPTISL FQFVCTINWF PSYNIYYTIG IDGISLFFII LTTWLVTTCV
110 120 130 140 150
LISWTMINTQ IKEYLICFLT LEFILIQVFC VLDVIFFYIF FESVLIPMFL
160 170 180 190 200
IIGIWGSRQR KIRAAYQFFI YTLAGSLLML LAILVIYFQQ GTTDIQILWN
210 220 230 240 250
VSFDTRTQIL LWLSFFSSLA VKIPMIPFHI WLPEAHAEAP TAGSVILAGV
260 270 280 290 300
LLKMGGYGFL RFSLPMLPEA SLYFSPLIYL LSIVAAVYAS LTTIRQVDLK
310 320 330 340 350
KIIAYSSVSH MGFVTLGLFS FNLQGLEGSI ILMLSHGLVS SALFLCVGIL
360 370 380 390 400
YDRHKTRILK YYGGLVQVMP IFSILLLFFT FSNIGFPGTS SFVGEFLVLT
410 420 430 440 450
GLFKVSSIST FLSAFSMILG AGYSIWLFNR ICFGSLKLQY VTNFQDISRR
460 470 480
EFYILLPLAV SILLMGVCPE IFLNEIHCSS YNLISYFN
Length:488
Mass (Da):55,215
Last modified:May 1, 1999 - v1
Checksum:i6ABA0414B8FE1409
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF114794 Genomic DNA. Translation: AAD03109.1.
PIRiT11230.
RefSeqiNP_049306.1. NC_002007.1.

Genome annotation databases

GeneIDi809778.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF114794 Genomic DNA. Translation: AAD03109.1.
PIRiT11230.
RefSeqiNP_049306.1. NC_002007.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi809778.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO99981_PORPU
AccessioniPrimary (citable) accession number: O99981
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: April 13, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.