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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

nad4

Organism
Porphyra purpurea (Red seaweed) (Ulva purpurea)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

NADUniRule annotation, UbiquinoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4UniRule annotation (EC:1.6.5.3UniRule annotation)
Gene namesi
Name:nad4Imported
Encoded oniMitochondrionImported
OrganismiPorphyra purpurea (Red seaweed) (Ulva purpurea)Imported
Taxonomic identifieri2787 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaBangiophyceaeBangialesBangiaceaePorphyra

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2823HelicalSequence analysisAdd
BLAST
Transmembranei48 – 7023HelicalSequence analysisAdd
BLAST
Transmembranei76 – 10429HelicalSequence analysisAdd
BLAST
Transmembranei111 – 12919HelicalSequence analysisAdd
BLAST
Transmembranei135 – 15622HelicalSequence analysisAdd
BLAST
Transmembranei168 – 18922HelicalSequence analysisAdd
BLAST
Transmembranei209 – 23224HelicalSequence analysisAdd
BLAST
Transmembranei239 – 26022HelicalSequence analysisAdd
BLAST
Transmembranei272 – 29120HelicalSequence analysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence analysisAdd
BLAST
Transmembranei329 – 35123HelicalSequence analysisAdd
BLAST
Transmembranei363 – 38624HelicalSequence analysisAdd
BLAST
Transmembranei406 – 42823HelicalSequence analysisAdd
BLAST
Transmembranei452 – 47322HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MitochondrionUniRule annotationImported

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 416284Proton_antipo_MInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the complex I subunit 4 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O99981-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSNNLLMWT SLIPLGGVIL LILIPGSYCN LIRNIAFGTA QLTFISSILL
60 70 80 90 100
WICFDPTISL FQFVCTINWF PSYNIYYTIG IDGISLFFII LTTWLVTTCV
110 120 130 140 150
LISWTMINTQ IKEYLICFLT LEFILIQVFC VLDVIFFYIF FESVLIPMFL
160 170 180 190 200
IIGIWGSRQR KIRAAYQFFI YTLAGSLLML LAILVIYFQQ GTTDIQILWN
210 220 230 240 250
VSFDTRTQIL LWLSFFSSLA VKIPMIPFHI WLPEAHAEAP TAGSVILAGV
260 270 280 290 300
LLKMGGYGFL RFSLPMLPEA SLYFSPLIYL LSIVAAVYAS LTTIRQVDLK
310 320 330 340 350
KIIAYSSVSH MGFVTLGLFS FNLQGLEGSI ILMLSHGLVS SALFLCVGIL
360 370 380 390 400
YDRHKTRILK YYGGLVQVMP IFSILLLFFT FSNIGFPGTS SFVGEFLVLT
410 420 430 440 450
GLFKVSSIST FLSAFSMILG AGYSIWLFNR ICFGSLKLQY VTNFQDISRR
460 470 480
EFYILLPLAV SILLMGVCPE IFLNEIHCSS YNLISYFN
Length:488
Mass (Da):55,215
Last modified:May 1, 1999 - v1
Checksum:i6ABA0414B8FE1409
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF114794 Genomic DNA. Translation: AAD03109.1.
PIRiT11230.
RefSeqiNP_049306.1. NC_002007.1.

Genome annotation databases

GeneIDi809778.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF114794 Genomic DNA. Translation: AAD03109.1.
PIRiT11230.
RefSeqiNP_049306.1. NC_002007.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi809778.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO99981_PORPU
AccessioniPrimary (citable) accession number: O99981
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: April 13, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.