Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O99825 (NU4M_RHISA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4
Gene names
Name:ND4
Encoded onMitochondrion
OrganismRhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Taxonomic identifier34632 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusRhipicephalus

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433NADH-ubiquinone oxidoreductase chain 4
PRO_0000117982

Regions

Transmembrane10 – 3021Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane101 – 12121Helical; Potential
Transmembrane132 – 15221Helical; Potential
Transmembrane169 – 18921Helical; Potential
Transmembrane203 – 22321Helical; Potential
Transmembrane234 – 25421Helical; Potential
Transmembrane261 – 28121Helical; Potential
Transmembrane286 – 30621Helical; Potential
Transmembrane331 – 35323Helical; Potential
Transmembrane366 – 38621Helical; Potential
Transmembrane410 – 43021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O99825 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 93663B781633CD04

FASTA43350,758
        10         20         30         40         50         60 
MLMSVSILCL FFLINPYQIM IYLMIMTLFL LAKGLINNAE SFINFFFFDL MSLSMVILTV 

        70         80         90        100        110        120 
WISILMIMAS KSNNNYKNKI FNFYLLLMMN LLFICFMLEN LLMFYLFFEA VLFPIILMIS 

       130        140        150        160        170        180 
GWGSQPERIQ AGFYMLMYTV FGSLPLLILM LLKNQSLSII FNEWLFNEMG FIFFLMILGF 

       190        200        210        220        230        240 
LVKIPMFLFH LWLPKAHVEA PRAGSMILAG VLLKLGFYGL YRFKSFFFLD LLKFSFVLIV 

       250        260        270        280        290        300 
ISMWGAVLIS IFCLYQNDIK SLIAYSSVSH MGITLAGCVT FQLHTSFGML MMMIGHGLCS 

       310        320        330        340        350        360 
SGLFCLKNMI YERLHTRSIM MIKGMINFPN LSMWWFLFSI INMSAPMTMN LFGELFLGLG 

       370        380        390        400        410        420 
LMKYSLLLSL PVMMMIFLSA CYSMFMYSYI NHGQSWMIFS NKMISMREYY LMLLHIIPMI 

       430 
MWFLKINFFM KWI 

« Hide

References

[1]"Mitochondrial gene order is not conserved in arthropods: prostriate and metastriate tick mitochondrial genomes."
Black W.C. IV, Roehrdanz R.L.
Mol. Biol. Evol. 15:1772-1785(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF081829 Genomic DNA. Translation: AAD05526.1.
PIRT11162.
RefSeqNP_008519.1. NC_002074.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID808367.

Organism-specific databases

CTD4538.

Phylogenomic databases

ProtClustDBMTH00163.

Family and domain databases

InterProIPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
ProtoNetSearch...

Entry information

Entry nameNU4M_RHISA
AccessionPrimary (citable) accession number: O99825
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families