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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

ND4

Organism
Rhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:ND4
Encoded oniMitochondrion
OrganismiRhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Taxonomic identifieri34632 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusRhipicephalus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Transmembranei331 – 353HelicalSequence analysisAdd BLAST23
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001179821 – 433NADH-ubiquinone oxidoreductase chain 4Add BLAST433

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.

Sequencei

Sequence statusi: Complete.

O99825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMSVSILCL FFLINPYQIM IYLMIMTLFL LAKGLINNAE SFINFFFFDL
60 70 80 90 100
MSLSMVILTV WISILMIMAS KSNNNYKNKI FNFYLLLMMN LLFICFMLEN
110 120 130 140 150
LLMFYLFFEA VLFPIILMIS GWGSQPERIQ AGFYMLMYTV FGSLPLLILM
160 170 180 190 200
LLKNQSLSII FNEWLFNEMG FIFFLMILGF LVKIPMFLFH LWLPKAHVEA
210 220 230 240 250
PRAGSMILAG VLLKLGFYGL YRFKSFFFLD LLKFSFVLIV ISMWGAVLIS
260 270 280 290 300
IFCLYQNDIK SLIAYSSVSH MGITLAGCVT FQLHTSFGML MMMIGHGLCS
310 320 330 340 350
SGLFCLKNMI YERLHTRSIM MIKGMINFPN LSMWWFLFSI INMSAPMTMN
360 370 380 390 400
LFGELFLGLG LMKYSLLLSL PVMMMIFLSA CYSMFMYSYI NHGQSWMIFS
410 420 430
NKMISMREYY LMLLHIIPMI MWFLKINFFM KWI
Length:433
Mass (Da):50,758
Last modified:May 1, 1999 - v1
Checksum:i93663B781633CD04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081829 Genomic DNA. Translation: AAD05526.1.
PIRiT11162.
RefSeqiNP_008519.1. NC_002074.1.

Genome annotation databases

GeneIDi808367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081829 Genomic DNA. Translation: AAD05526.1.
PIRiT11162.
RefSeqiNP_008519.1. NC_002074.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808367.

Organism-specific databases

CTDi4538.

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
ProtoNetiSearch...

Entry informationi

Entry nameiNU4M_RHISA
AccessioniPrimary (citable) accession number: O99825
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 16, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.