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O99825

- NU4M_RHISA

UniProt

O99825 - NU4M_RHISA

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Protein
NADH-ubiquinone oxidoreductase chain 4
Gene
ND4
Organism
Rhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:ND4
Encoded oniMitochondrion
OrganismiRhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Taxonomic identifieri34632 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusRhipicephalus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021Helical; Reviewed prediction
Add
BLAST
Transmembranei45 – 6521Helical; Reviewed prediction
Add
BLAST
Transmembranei80 – 10021Helical; Reviewed prediction
Add
BLAST
Transmembranei101 – 12121Helical; Reviewed prediction
Add
BLAST
Transmembranei132 – 15221Helical; Reviewed prediction
Add
BLAST
Transmembranei169 – 18921Helical; Reviewed prediction
Add
BLAST
Transmembranei203 – 22321Helical; Reviewed prediction
Add
BLAST
Transmembranei234 – 25421Helical; Reviewed prediction
Add
BLAST
Transmembranei261 – 28121Helical; Reviewed prediction
Add
BLAST
Transmembranei286 – 30621Helical; Reviewed prediction
Add
BLAST
Transmembranei331 – 35323Helical; Reviewed prediction
Add
BLAST
Transmembranei366 – 38621Helical; Reviewed prediction
Add
BLAST
Transmembranei410 – 43021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433NADH-ubiquinone oxidoreductase chain 4
PRO_0000117982Add
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.

Sequencei

Sequence statusi: Complete.

O99825-1 [UniParc]FASTAAdd to Basket

« Hide

MLMSVSILCL FFLINPYQIM IYLMIMTLFL LAKGLINNAE SFINFFFFDL    50
MSLSMVILTV WISILMIMAS KSNNNYKNKI FNFYLLLMMN LLFICFMLEN 100
LLMFYLFFEA VLFPIILMIS GWGSQPERIQ AGFYMLMYTV FGSLPLLILM 150
LLKNQSLSII FNEWLFNEMG FIFFLMILGF LVKIPMFLFH LWLPKAHVEA 200
PRAGSMILAG VLLKLGFYGL YRFKSFFFLD LLKFSFVLIV ISMWGAVLIS 250
IFCLYQNDIK SLIAYSSVSH MGITLAGCVT FQLHTSFGML MMMIGHGLCS 300
SGLFCLKNMI YERLHTRSIM MIKGMINFPN LSMWWFLFSI INMSAPMTMN 350
LFGELFLGLG LMKYSLLLSL PVMMMIFLSA CYSMFMYSYI NHGQSWMIFS 400
NKMISMREYY LMLLHIIPMI MWFLKINFFM KWI 433
Length:433
Mass (Da):50,758
Last modified:May 1, 1999 - v1
Checksum:i93663B781633CD04
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF081829 Genomic DNA. Translation: AAD05526.1.
PIRiT11162.
RefSeqiNP_008519.1. NC_002074.1.

Genome annotation databases

GeneIDi808367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF081829 Genomic DNA. Translation: AAD05526.1 .
PIRi T11162.
RefSeqi NP_008519.1. NC_002074.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 808367.

Organism-specific databases

CTDi 4538.

Family and domain databases

InterProi IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view ]
PRINTSi PR01437. NUOXDRDTASE4.
ProtoNeti Search...

Publicationsi

  1. "Mitochondrial gene order is not conserved in arthropods: prostriate and metastriate tick mitochondrial genomes."
    Black W.C. IV, Roehrdanz R.L.
    Mol. Biol. Evol. 15:1772-1785(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiNU4M_RHISA
AccessioniPrimary (citable) accession number: O99825
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi