O99822 (COX3_RHISA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:

COIII

Encoded on

Mitochondrion

Organism

Rhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)

Taxonomic identifier

34632 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Acari › Parasitiformes › Ixodida › Ixodoidea › Ixodidae › Rhipicephalinae › Rhipicephalus › Rhipicephalus › Rhipicephalus sanguineus group

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Cytochrome c oxidase subunit 3		PRO_0000183845
Regions
	Transmembrane	13 – 33	21	Helical; Potential
	Transmembrane	36 – 56	21	Helical; Potential
	Transmembrane	80 – 100	21	Helical; Potential
	Transmembrane	154 – 174	21	Helical; Potential
	Transmembrane	195 – 215	21	Helical; Potential
	Transmembrane	237 – 257	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O99822 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: B9741FD84E0504EC	FASTA	257	29,936
	10 20 30 40 50 60 MMFHPFHLVE KSPWPITSSI SALSLTLGFV SYFQNLSMYL ILLAVLMITI SSFQWWRDIS 70 80 90 100 110 120 REGSFQGFHT HWVLNGLKMG MILFILSEVF FFVSFFWAFF HSSLSPNIEI GSQWPPKGIY 130 140 150 160 170 180 PFNPFEIPLL NSTILISSGI TVTWSHHAIM NKNYISALNS LLITILLGVA FTMFQGFEYF 190 200 210 220 230 240 QAQFKISDGI FGSTFFMTTG FHGLHVLIGS IFLLVSYFRI KNQLISSDHF FGFEASAWYW 250 HFVDVVWLFL FTFMYWW

References

[1]	"Mitochondrial gene order is not conserved in arthropods: prostriate and metastriate tick mitochondrial genomes." Black W.C. IV, Roehrdanz R.L. Mol. Biol. Evol. 15:1772-1785(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF081829 Genomic DNA. Translation: AAD05522.1.
PIR	T11158.
RefSeq	NP_008515.1. NC_002074.1.
3D structure databases
ProteinModelPortal	O99822.
SMR	O99822. Positions 3-257.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	808371.
Organism-specific databases
CTD	4514.
Phylogenomic databases
ProtClustDB	MTH00155.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_RHISA

Accession

Primary (citable) accession number: O99822

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)