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O99819 (COX2_RHISA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COII
Encoded onMitochondrion
OrganismRhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Taxonomic identifier34632 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusRhipicephalus

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 225225Cytochrome c oxidase subunit 2
PRO_0000183680

Regions

Topological domain1 – 2626Mitochondrial intermembrane Potential
Transmembrane27 – 4822Helical; Potential
Topological domain49 – 6214Mitochondrial matrix Potential
Transmembrane63 – 8220Helical; Potential
Topological domain83 – 225143Mitochondrial intermembrane Potential

Sites

Metal binding1601Copper A Probable
Metal binding1951Copper A Probable
Metal binding1991Copper A Probable
Metal binding2031Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
O99819 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 4CD3A9BBA31C7DBE

FASTA22526,011
        10         20         30         40         50         60 
MMTWSQMSFS DMNSPIMEQM VFFHDHSMMI ILMITILTIY MITNIMMNNL LSRSMMEGQE 

        70         80         90        100        110        120 
IEIIWTIIPA ITLIFIAIPS LHLLYLTDET FNSQISIKVL GHQWYWSYEY SDFNKEFDSF 

       130        140        150        160        170        180 
MIPEPEMMKN SFRLLDTDNN LVIPINTNIK YLISSMDVIH SWTIPSLGIK MDAVPGRLNQ 

       190        200        210        220 
SFSISSRPGL YYGQCSEICG ANHSFMPISL GVTSMKNFIN FINSS 

« Hide

References

[1]"Mitochondrial gene order is not conserved in arthropods: prostriate and metastriate tick mitochondrial genomes."
Black W.C. IV, Roehrdanz R.L.
Mol. Biol. Evol. 15:1772-1785(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF081829 Genomic DNA. Translation: AAD05519.1.
PIRT11155.
RefSeqNP_008512.1. NC_002074.1.

3D structure databases

ProteinModelPortalO99819.
SMRO99819. Positions 1-224.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID808373.

Organism-specific databases

CTD4513.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_RHISA
AccessionPrimary (citable) accession number: O99819
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families