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O99818

- COX1_RHISA

UniProt

O99818 - COX1_RHISA

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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Rhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron (heme A axial ligand)Curated
Metal bindingi239 – 2391Copper BCurated
Metal bindingi243 – 2431Copper BCurated
Metal bindingi289 – 2891Copper BCurated
Metal bindingi290 – 2901Copper BCurated
Metal bindingi375 – 3751Iron (heme A3 axial ligand)Curated
Metal bindingi377 – 3771Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiRhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Taxonomic identifieri34632 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusRhipicephalus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Transmembranei55 – 7521HelicalSequence AnalysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence AnalysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence AnalysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence AnalysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence AnalysisAdd
BLAST
Transmembranei267 – 28721HelicalSequence AnalysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence AnalysisAdd
BLAST
Transmembranei337 – 35721HelicalSequence AnalysisAdd
BLAST
Transmembranei382 – 40221HelicalSequence AnalysisAdd
BLAST
Transmembranei413 – 43321HelicalSequence AnalysisAdd
BLAST
Transmembranei456 – 47621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Cytochrome c oxidase subunit 1PRO_0000183408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki239 ↔ 2431'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliO99818.
SMRiO99818. Positions 4-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O99818-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPRWMYSTN HKDIGTMYLI FGAWSGMLGL SMSMLIRMEL GQPGTLIGND
60 70 80 90 100
QIYNVIVTAH AFIMIFFMVM PIMIGGFGNW LVPIMLGAPD MAFPRMNNMS
110 120 130 140 150
FWLLPPSLFL LINSSLIESG AGTGWTVYPP LSSNLSHYGP SVDLAIFSLH
160 170 180 190 200
LAGASSILGA INFITTIVNM RSIGMTMERM PLFVWSVLIT AILLLLSLPV
210 220 230 240 250
LAGAITMLLT DRNFNTSFFD PSGGGDPILY QHLFWFFGHP EVYILILPGF
260 270 280 290 300
GMISQIICYN TGKKEPFGNL GMIYAMAAIG LLGFIVWAHH MFTVGMDVDT
310 320 330 340 350
RAYFTSATMI IAVPTGIKIF SWLATLHGSH IKFNTSILWA LGFVFLFTVG
360 370 380 390 400
GLTGIMLANS SIDIVLHDTY YVVAHFHYVL SMGAVFGIMG AIIHWFPMFL
410 420 430 440 450
GLNLNSMLTK VQFMITFIGV NLTFFPQHFL GLAGMPRRYS DYPDFFTKWN
460 470 480 490 500
FISSLGSLIS LMGVIMLIII IWTSIIEKKM INFSSFTNSS IEWMLNFPPS
510
EHSFNQNNII LK
Length:512
Mass (Da):57,126
Last modified:May 1, 1999 - v1
Checksum:i53D6374C4DF11AB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081829 Genomic DNA. Translation: AAD05518.1.
PIRiT11154.
RefSeqiNP_008511.1. NC_002074.1.

Genome annotation databases

GeneIDi808364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081829 Genomic DNA. Translation: AAD05518.1 .
PIRi T11154.
RefSeqi NP_008511.1. NC_002074.1.

3D structure databases

ProteinModelPortali O99818.
SMRi O99818. Positions 4-506.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 808364.

Organism-specific databases

CTDi 4512.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mitochondrial gene order is not conserved in arthropods: prostriate and metastriate tick mitochondrial genomes."
    Black W.C. IV, Roehrdanz R.L.
    Mol. Biol. Evol. 15:1772-1785(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_RHISA
AccessioniPrimary (citable) accession number: O99818
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3