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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Eulemur mongoz (Mongoose lemur)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.UniRule annotationSAAS annotation

Cofactori

Cu cationUniRule annotationNote: Binds a copper A center.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotationSAAS annotation, Transport

Keywords - Ligandi

CopperUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation
Gene namesi
Name:COIIImported
Synonyms:coIIImported
Encoded oniMitochondrionImported
OrganismiEulemur mongoz (Mongoose lemur)Imported
Taxonomic identifieri34828 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLemuriformesLemuridaeEulemur

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4620HelicalSequence analysisAdd
BLAST
Transmembranei66 – 8520HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Structurei

3D structure databases

SMRiO99794. Positions 1-227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9191COX2_TMInterPro annotationAdd
BLAST
Domaini92 – 225134COX2_CUAInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG012727.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O99794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYPVQLGFQ DAASPIMEEL LYFHDHTLMI MFLISSLVLY IISLMLTTEL
60 70 80 90 100
IHTSTMDAQE VETVWTILPA VILILIALPS LRILYMMDEI TTPSLTLKTM
110 120 130 140 150
GHQWYWSYEY TDYENLCFDS YMTPPSDLKP GELRLLEVDN RVVLPTELPI
160 170 180 190 200
RMLISSEDVL HSWTIPSLGV KTDAIPGRLN QATLMASRPG VYYGQCSEIC
210 220
GANHSFMPIV LELVPLKIFE EWLLSML
Length:227
Mass (Da):25,910
Last modified:May 1, 1999 - v1
Checksum:i15DB4A5616D86A09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081045 Genomic DNA. Translation: AAD13162.1.
AM905040 Genomic DNA. Translation: CAP18026.1.
RefSeqiYP_001661358.1. NC_010300.1.

Genome annotation databases

GeneIDi5867467.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081045 Genomic DNA. Translation: AAD13162.1.
AM905040 Genomic DNA. Translation: CAP18026.1.
RefSeqiYP_001661358.1. NC_010300.1.

3D structure databases

SMRiO99794. Positions 1-227.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5867467.

Organism-specific databases

CTDi4513.

Phylogenomic databases

HOVERGENiHBG012727.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Phylogeny of the Lemuridae: effects of character and taxon sampling on resolution of species relationships within Eulemur."
    Yoder A.D., Irwin J.A.
    Cladistics 15:351-361(1999)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SpleenImported.
  2. "Mitogenomic relationships of placental mammals and molecular estimates of their divergences."
    Arnason U., Adegoke J.A., Gullberg A., Harley E.H., Janke A., Kullberg M.
    Gene 421:37-51(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO99794_EULMO
AccessioniPrimary (citable) accession number: O99794
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.