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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Sarcophyton glaucum (Toadstool umbrella leather coral)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.UniRule annotation

GO - Molecular functioni

Keywordsi

Biological processElectron transport, Respiratory chainUniRule annotationSAAS annotation, Transport
LigandCopperUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotationSAAS annotation
Gene namesi
Name:COIIImported
Encoded oniMitochondrionImported
OrganismiSarcophyton glaucum (Toadstool umbrella leather coral)Imported
Taxonomic identifieri70919 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaOctocoralliaAlcyonaceaAlcyoniinaAlcyoniidaeSarcophyton

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei71 – 94HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliO99619
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 107COX2_TMInterPro annotationAdd BLAST91
Domaini108 – 248COX2_CUAInterPro annotationAdd BLAST141

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

O99619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTPINALLE ASLLRDAAEP FQLSFQDAAS PVMEEILLLH NQIMFILIII
60 70 80 90 100
ITTVLWLIIR GLTGQAYHRY LIEGVTIEIV WTIIPAIILV FIAFPSLKLL
110 120 130 140 150
YLMDEVVEPG VTVKAIGHQW YWSYEYSDYQ TTLGEDSTLE FDSYMIPTSD
160 170 180 190 200
LQPGDLRLLE VDNRMVVPID TYVRVLVTGA DVLHSFAVPS LAIKMDAVPG
210 220 230 240 250
RLNQTGFLAK RPGLFYGQCS ELCGANHSFM PIVIEAVSMD KYISWLSSLC

ADL
Length:253
Mass (Da):28,391
Last modified:May 1, 1999 - v1
Checksum:iF8B37D4C08939D0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064823 Genomic DNA Translation: AAC99650.1
PIRiT12405

Similar proteinsi

Entry informationi

Entry nameiO99619_SARGL
AccessioniPrimary (citable) accession number: O99619
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health