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O99255 (COX1_PLACH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COI
Encoded onMitochondrion
OrganismPlasmodium chabaudi
Taxonomic identifier5825 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Vinckeia)

Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 476476Cytochrome c oxidase subunit 1
PRO_0000183394

Regions

Transmembrane19 – 3921Helical; Potential
Transmembrane61 – 8121Helical; Potential
Transmembrane105 – 12521Helical; Potential
Transmembrane144 – 16421Helical; Potential
Transmembrane194 – 21421Helical; Potential
Transmembrane240 – 26021Helical; Potential
Transmembrane278 – 29821Helical; Potential
Transmembrane309 – 32921Helical; Potential
Transmembrane345 – 36521Helical; Potential
Transmembrane379 – 39921Helical; Potential
Transmembrane415 – 43521Helical; Potential
Transmembrane455 – 47521Helical; Potential

Sites

Metal binding661Iron (heme A axial ligand) Probable
Metal binding2461Copper B Probable
Metal binding2501Copper B Probable
Metal binding2951Copper B Probable
Metal binding2961Copper B Probable
Metal binding3821Iron (heme A3 axial ligand) Probable
Metal binding3841Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link246 ↔ 2501'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
O99255 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 83DA0694884F33BA

FASTA47652,784
        10         20         30         40         50         60 
MVFNRYALIT NCNHKTLGLY YLWFSFLFGI YGFLLSVILR TELYSSSLRI IAQENVNLYN 

        70         80         90        100        110        120 
MIFTVHGIIM IFFNIMPGLF GGFGNYYLPI LCGSSELAYP RINSISLLLQ PIAFILVILS 

       130        140        150        160        170        180 
TAAEFGGGTG WTWYPPLSTS LMSLSPVAVD VIVIGLLVSG IASIMSSLNF LTTVMHLRAK 

       190        200        210        220        230        240 
GLTLGILSVS TWSLIITSIM LLLTLPVLTG GVLMLLSDLH FNTLFFDPTF AGDPILYQHL 

       250        260        270        280        290        300 
LWFFGHPEVY ILILPAFGII SHVISTNYSR SLFGNQSMIL AMGCIAVLGS VVWVHHMYTT 

       310        320        330        340        350        360 
GLEVDTRAFF TSTTILISIP TGTKVFNWLC TYMSTNFGIT HSSSLLSLLF ICTFTFGGTT 

       370        380        390        400        410        420 
GVILGNGAID VALHDTYYVI AHFHFVLSIG AIIALFTSVS FFQESFFGKT LRENTIIVLW 

       430        440        450        460        470 
SILFFVGVVL TFLPMHFLGF NVMPRRIPDY PDALNGWNMI CSIGSTMTLF GLLIFK 

« Hide

References

[1]Tan T.M.C., Noviyanti R., Syafruddi N., Marzuki S., Ting R.C.Y.
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF014116 Genomic DNA. Translation: AAD01528.1. Sequence problems.

3D structure databases

ProteinModelPortalO99255.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_PLACH
AccessionPrimary (citable) accession number: O99255
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: April 16, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways