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Reviewed, UniProtKB/Swiss-Prot O97959 (ADH1G_PAPHA)

Last modified June 16, 2009. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase 1C
    EC=1.1.1.1
Alternative name(s):
    Alcohol dehydrogenase subunit gamma
Gene names
Name: ADH1C
Synonyms: ADH3
OrganismPapio hamadryas (Hamadryas baboon)
Taxonomic identifier9557 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Papio

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Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subunit structure

Homodimer or heterodimer of closely related subunits By similarity.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Expressed in kidney.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

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Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   PTMAcetylation
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionalcohol dehydrogenase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 375374Alcohol dehydrogenase 1C
PRO_0000160665

Regions

Nucleotide binding200 – 2056NAD By similarity
Nucleotide binding293 – 2953NAD By similarity

Sites

Metal binding471Zinc 1; catalytic By similarity
Metal binding681Zinc 1; catalytic By similarity
Metal binding981Zinc 2 By similarity
Metal binding1011Zinc 2 By similarity
Metal binding1041Zinc 2 By similarity
Metal binding1121Zinc 2 By similarity
Metal binding1751Zinc 1; catalytic By similarity
Binding site2241NAD By similarity
Binding site2291NAD By similarity
Binding site3701NAD By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity

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Sequences

Sequence LengthMass (Da)Tools
O97959-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: BBB215BCD5FDB9EA

FASTA37539,841
        10         20         30         40         50         60 
MSTAGKVIKC KAAVLWEVKK PFSIEEVEVA PPKAHEVRIK MVAVGICRSD DHVVSGTLVT 

        70         80         90        100        110        120 
PLPAILGHEA AGIVEGVGEG VTTVKPGDKV IPLFTPQCGK CRVCKNPESN YCFKNDLSNP 

       130        140        150        160        170        180 
RGTMQDGTRR FTCGGKPIHH FLGISTFSQY TVVDENAVAK IDAASPLEKV CLIGCGFSTG 

       190        200        210        220        230        240 
YGPAVKVAKV TPGSTCAVFG LGGVGLSAVM GCKAAGAARI IAVDINKDKF AKAKELGATE 

       250        260        270        280        290        300 
CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTIMASL LCCHEACGTS VIVGVPPDSQ 

       310        320        330        340        350        360 
NLSINPVLLL TGRTWKGAIF GGFKSKESVP KLVSDFMAKK FSLDALITNV LPFEKINEGF 

       370 
DLLRSGKSIR TILMF

« Hide

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References

[1]"Evolution of class I alcohol dehydrogenase genes in catarrhine primates: gene conversion, substitution rates, and gene regulation."
Cheung B., Holmes R.S., Easteal S., Beacham I.R.
Mol. Biol. Evol. 16:23-36(1999) [PubMed: 10331249] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.

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Cross-references

Sequence databases

L30113 mRNA. Translation: AAD09950.1.

3D structure databases

HSSPHSSP built from PDB template 1HT0 based on UniProtKB P00326.
SMRO97959. Positions 1-374, 2-375.
ModBaseSearch...

Phylogenomic databases

HOVERGENO97959.

Enzyme and pathway databases

BRENDA1.1.1.1. 39388.

Family and domain databases

InterProIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn.
IPR013149. ADH_Zn-bd.
IPR002328. ADH_Zn_CS.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameADH1G_PAPHA
AccessionPrimary (citable) accession number: O97959
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: January 23, 2007
Last modified: June 16, 2009
This is version 51 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents