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O97951

- UDB18_MACFA

UniProt

O97951 - UDB18_MACFA

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Protein

UDP-glucuronosyltransferase 2B18

Gene
UGT2B18
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward 3-hydroxyandrogens. It is principally active on C19 steroids having a hydroxyl group at position 3-alpha of the steroid molecule and also active on planar phenols and bile acids.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

SABIO-RKO97951.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B18 (EC:2.4.1.17)
Short name:
UDPGT 2B18
Gene namesi
Name:UGT2B18
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei493 – 51321Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 529508UDP-glucuronosyltransferase 2B18PRO_0000036042Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi68 – 681N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Expressed in liver, prostate, kidney, testis, adrenal, bile duct, bladder, colon, small intestine, cerebellum and pancreas.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO97951.
SMRiO97951. Positions 285-451.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004033.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O97951-1 [UniParc]FASTAAdd to Basket

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MSVKWTSVIL LIQLSFYFSS GSCGKVLVWA AEYSHWMNMK TILEELVQRG    50
HEVTVLASSA SILFDPNNSS ALKIEVFPTS LTKTEFENII RQQIKRWSEL 100
PKDTFWLYFS QMQEIMWKFG DITRNFCKDV VSNKKLMKKL QKSRFDVVFA 150
DAIFPCSELL AELLNTPLVY SLRFTPGYNF EKHCGGFLFP PSYVPVVMSE 200
LSDHMTFMER VKNMIYMLYF DFCFQIYAMK KWDQFYSEVL GRPTTLSETM 250
GKADIWLIRN SWNFQFPHPL LPNVDFVGGL HCKPAKPLPK EMEEFVQSSG 300
ENGVVVFSLG SMVTNMKEER ANVIASALAQ IPQKVLWRFD GKKPDTLGLN 350
TRLYKWIPQN DLLGHPKTRA FITHGGSNGI YEAIYHGVPM VGIPLFADQP 400
DNIAHMKAKG AAVRLDFDTM SSTDLVNALK TVINDPLYKE NVMKLSRIQH 450
DQPVKPLDRA VFWIEFVMRH KGAKHLRPAA HDLTWFQYHS LDVIGFLLAC 500
VATVIFIIMK CCLFCFWKFA RKGKKGKSD 529
Length:529
Mass (Da):60,801
Last modified:May 1, 1999 - v1
Checksum:i3ECEB497B8C3601F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016310 mRNA. Translation: AAC98726.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016310 mRNA. Translation: AAC98726.1 .

3D structure databases

ProteinModelPortali O97951.
SMRi O97951. Positions 285-451.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004033.

Enzyme and pathway databases

SABIO-RK O97951.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of a simian UDP-glucuronosyltransferase UGT2B18 active on 3-hydroxyandrogens."
    Beaulieu M., Levesque E., Barbier O., Turgeon D., Belanger G., Hum D.W., Belanger A.
    J. Mol. Biol. 275:785-794(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
    Tissue: Prostate.

Entry informationi

Entry nameiUDB18_MACFA
AccessioniPrimary (citable) accession number: O97951
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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