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O97951 (UDB18_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2B18

Short name=UDPGT 2B18
EC=2.4.1.17
Gene names
Name:UGT2B18
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward 3-hydroxyandrogens. It is principally active on C19 steroids having a hydroxyl group at position 3-alpha of the steroid molecule and also active on planar phenols and bile acids.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein By similarity. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Tissue specificity

Expressed in liver, prostate, kidney, testis, adrenal, bile duct, bladder, colon, small intestine, cerebellum and pancreas. Ref.1

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 529508UDP-glucuronosyltransferase 2B18
PRO_0000036042

Regions

Transmembrane493 – 51321Helical; Potential

Amino acid modifications

Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation681N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O97951 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 3ECEB497B8C3601F

FASTA52960,801
        10         20         30         40         50         60 
MSVKWTSVIL LIQLSFYFSS GSCGKVLVWA AEYSHWMNMK TILEELVQRG HEVTVLASSA 

        70         80         90        100        110        120 
SILFDPNNSS ALKIEVFPTS LTKTEFENII RQQIKRWSEL PKDTFWLYFS QMQEIMWKFG 

       130        140        150        160        170        180 
DITRNFCKDV VSNKKLMKKL QKSRFDVVFA DAIFPCSELL AELLNTPLVY SLRFTPGYNF 

       190        200        210        220        230        240 
EKHCGGFLFP PSYVPVVMSE LSDHMTFMER VKNMIYMLYF DFCFQIYAMK KWDQFYSEVL 

       250        260        270        280        290        300 
GRPTTLSETM GKADIWLIRN SWNFQFPHPL LPNVDFVGGL HCKPAKPLPK EMEEFVQSSG 

       310        320        330        340        350        360 
ENGVVVFSLG SMVTNMKEER ANVIASALAQ IPQKVLWRFD GKKPDTLGLN TRLYKWIPQN 

       370        380        390        400        410        420 
DLLGHPKTRA FITHGGSNGI YEAIYHGVPM VGIPLFADQP DNIAHMKAKG AAVRLDFDTM 

       430        440        450        460        470        480 
SSTDLVNALK TVINDPLYKE NVMKLSRIQH DQPVKPLDRA VFWIEFVMRH KGAKHLRPAA 

       490        500        510        520 
HDLTWFQYHS LDVIGFLLAC VATVIFIIMK CCLFCFWKFA RKGKKGKSD 

« Hide

References

[1]"Isolation and characterization of a simian UDP-glucuronosyltransferase UGT2B18 active on 3-hydroxyandrogens."
Beaulieu M., Levesque E., Barbier O., Turgeon D., Belanger G., Hum D.W., Belanger A.
J. Mol. Biol. 275:785-794(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
Tissue: Prostate.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF016310 mRNA. Translation: AAC98726.1.

3D structure databases

ProteinModelPortalO97951.
SMRO97951. Positions 285-451.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG004033.

Enzyme and pathway databases

SABIO-RKO97951.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUDB18_MACFA
AccessionPrimary (citable) accession number: O97951
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families