Reviewed, UniProtKB/Swiss-Prot O97951 (UDB18_MACFA)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 2B18
      Short name=UDPGT 2B18
    EC=2.4.1.17

Gene names

Name:

UGT2B18

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward 3-hydroxyandrogens. It is principally active on C19 steroids having an hydroxyl group at position 3-alpha of the steroid molecule and also active on planar phenols and bile acids.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome membrane; Single-pass membrane protein By similarity. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Tissue specificity	Expressed in liver, prostate, kidney, testis, adrenal, bile duct, bladder, colon, small intestine, cerebellum and pancreas. Ref.1
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 529	508	UDP-glucuronosyltransferase 2B18		PRO_0000036042
Regions
	Transmembrane	493 – 513	21	Potential
Amino acid modifications
	Glycosylation	67	1	N-linked (GlcNAc...) Potential
	Glycosylation	68	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O97951-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 3ECEB497B8C3601F	FASTA	529	60,801
	10 20 30 40 50 60 MSVKWTSVIL LIQLSFYFSS GSCGKVLVWA AEYSHWMNMK TILEELVQRG HEVTVLASSA 70 80 90 100 110 120 SILFDPNNSS ALKIEVFPTS LTKTEFENII RQQIKRWSEL PKDTFWLYFS QMQEIMWKFG 130 140 150 160 170 180 DITRNFCKDV VSNKKLMKKL QKSRFDVVFA DAIFPCSELL AELLNTPLVY SLRFTPGYNF 190 200 210 220 230 240 EKHCGGFLFP PSYVPVVMSE LSDHMTFMER VKNMIYMLYF DFCFQIYAMK KWDQFYSEVL 250 260 270 280 290 300 GRPTTLSETM GKADIWLIRN SWNFQFPHPL LPNVDFVGGL HCKPAKPLPK EMEEFVQSSG 310 320 330 340 350 360 ENGVVVFSLG SMVTNMKEER ANVIASALAQ IPQKVLWRFD GKKPDTLGLN TRLYKWIPQN 370 380 390 400 410 420 DLLGHPKTRA FITHGGSNGI YEAIYHGVPM VGIPLFADQP DNIAHMKAKG AAVRLDFDTM 430 440 450 460 470 480 SSTDLVNALK TVINDPLYKE NVMKLSRIQH DQPVKPLDRA VFWIEFVMRH KGAKHLRPAA 490 500 510 520 HDLTWFQYHS LDVIGFLLAC VATVIFIIMK CCLFCFWKFA RKGKKGKSD

References

[1]

"Isolation and characterization of a simian UDP-glucuronosyltransferase UGT2B18 active on 3-hydroxyandrogens." Beaulieu M., Levesque E., Barbier O., Turgeon D., Belanger G., Hum D.W., Belanger A. J. Mol. Biol. 275:785-794(1998) [PubMed: 9480769] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY. Tissue: Prostate.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF016310 mRNA. Translation: AAC98726.1.
3D structure databases
SMR	O97951. Positions 285-451.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Phylogenomic databases
HOVERGEN	O97951.
Enzyme and pathway databases
BRENDA	2.4.1.17. 3438.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UDB18_MACFA

Accession

Primary (citable) accession number: O97951

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)