ID CCL5_BOVIN Reviewed; 91 AA. AC O97919; Q3T192; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 18-MAR-2008, sequence version 2. DT 24-JAN-2024, entry version 138. DE RecName: Full=C-C motif chemokine 5; DE AltName: Full=SIS-delta; DE AltName: Full=Small-inducible cytokine A5; DE AltName: Full=T-cell-specific protein RANTES; DE Flags: Precursor; GN Name=CCL5; Synonyms=SCYA5; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Intestine; RA Aust G., Thamm B., Rost A.K.; RT "Cloning of Bos taurus RANTES mRNA."; RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Belted Galloway; TISSUE=Peripheral blood; RG U.S. Veterinary Immune Reagent Network; RA Hudgens T., Tompkins D., Baldwin C.L.; RT "U.S. veterinary immune reagent network: expressed bovine gene sequences."; RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Crossbred X Angus; TISSUE=Ileum; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Chemoattractant for blood monocytes, memory T-helper cells CC and eosinophils. Causes the release of histamine from basophils and CC activates eosinophils. May activate several chemokine receptors CC including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G CC protein-coupled receptor GPR75. Together with GPR75, may play a role in CC neuron survival through activation of a downstream signaling pathway CC involving the PI3, Akt and MAP kinases. By activating GPR75 may also CC play a role in insulin secretion by islet cells. CC {ECO:0000250|UniProtKB:P13501}. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ007043; CAA07430.1; -; mRNA. DR EMBL; EU276060; ABX72058.1; -; mRNA. DR EMBL; BC102064; AAI02065.1; -; mRNA. DR RefSeq; NP_787021.1; NM_175827.2. DR AlphaFoldDB; O97919; -. DR SMR; O97919; -. DR STRING; 9913.ENSBTAP00000057122; -. DR PaxDb; 9913-ENSBTAP00000009463; -. DR Ensembl; ENSBTAT00000082438.1; ENSBTAP00000057122.1; ENSBTAG00000053649.1. DR GeneID; 327712; -. DR KEGG; bta:327712; -. DR CTD; 6352; -. DR VEuPathDB; HostDB:ENSBTAG00000053649; -. DR eggNOG; ENOG502S8D1; Eukaryota. DR GeneTree; ENSGT01100000263482; -. DR HOGENOM; CLU_141716_4_2_1; -. DR InParanoid; O97919; -. DR OMA; HIQEYFY; -. DR OrthoDB; 4265193at2759; -. DR TreeFam; TF334888; -. DR Reactome; R-BTA-380108; Chemokine receptors bind chemokines. DR Reactome; R-BTA-418594; G alpha (i) signalling events. DR Proteomes; UP000009136; Chromosome 19. DR Bgee; ENSBTAG00000053649; Expressed in ileocecal valve and 96 other cell types or tissues. DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central. DR GO; GO:0031726; F:CCR1 chemokine receptor binding; IEA:Ensembl. DR GO; GO:0031730; F:CCR5 chemokine receptor binding; IEA:Ensembl. DR GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl. DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central. DR GO; GO:0046817; F:chemokine receptor antagonist activity; IEA:Ensembl. DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:Ensembl. DR GO; GO:0016004; F:phospholipase activator activity; IEA:Ensembl. DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl. DR GO; GO:0004672; F:protein kinase activity; IEA:Ensembl. DR GO; GO:0043621; F:protein self-association; IEA:Ensembl. DR GO; GO:0030298; F:receptor signaling protein tyrosine kinase activator activity; IEA:Ensembl. DR GO; GO:0006816; P:calcium ion transport; IEA:Ensembl. DR GO; GO:0007267; P:cell-cell signaling; IEA:Ensembl. DR GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl. DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central. DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central. DR GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central. DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl. DR GO; GO:0070098; P:chemokine-mediated signaling pathway; ISS:UniProtKB. DR GO; GO:0048245; P:eosinophil chemotaxis; IEA:Ensembl. DR GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl. DR GO; GO:0006887; P:exocytosis; IEA:Ensembl. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB. DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central. DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl. DR GO; GO:0007159; P:leukocyte cell-cell adhesion; IEA:Ensembl. DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central. DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central. DR GO; GO:0043922; P:negative regulation by host of viral transcription; IEA:Ensembl. DR GO; GO:0045744; P:negative regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl. DR GO; GO:2000110; P:negative regulation of macrophage apoptotic process; IEA:Ensembl. DR GO; GO:0070233; P:negative regulation of T cell apoptotic process; IEA:Ensembl. DR GO; GO:0045071; P:negative regulation of viral genome replication; IEA:Ensembl. DR GO; GO:0042119; P:neutrophil activation; IEA:Ensembl. DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central. DR GO; GO:0051928; P:positive regulation of calcium ion transport; IEA:Ensembl. DR GO; GO:0033634; P:positive regulation of cell-cell adhesion mediated by integrin; IEA:Ensembl. DR GO; GO:0031328; P:positive regulation of cellular biosynthetic process; IEA:Ensembl. DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central. DR GO; GO:0034112; P:positive regulation of homotypic cell-cell adhesion; IEA:Ensembl. DR GO; GO:0010759; P:positive regulation of macrophage chemotaxis; IEA:Ensembl. DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IEA:Ensembl. DR GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; IEA:Ensembl. DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl. DR GO; GO:0014911; P:positive regulation of smooth muscle cell migration; IEA:Ensembl. DR GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl. DR GO; GO:0070234; P:positive regulation of T cell apoptotic process; IEA:Ensembl. DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; IBA:GO_Central. DR GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl. DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl. DR GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB. DR GO; GO:0009636; P:response to toxic substance; IEA:Ensembl. DR CDD; cd00272; Chemokine_CC; 1. DR Gene3D; 2.40.50.40; -; 1. DR InterPro; IPR039809; Chemokine_b/g/d. DR InterPro; IPR000827; Chemokine_CC_CS. DR InterPro; IPR001811; Chemokine_IL8-like_dom. DR InterPro; IPR036048; Interleukin_8-like_sf. DR PANTHER; PTHR12015:SF170; C-C MOTIF CHEMOKINE 5; 1. DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1. DR Pfam; PF00048; IL8; 1. DR SMART; SM00199; SCY; 1. DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1. DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1. PE 3: Inferred from homology; KW Chemotaxis; Cytokine; Disulfide bond; Inflammatory response; KW Reference proteome; Secreted; Signal. FT SIGNAL 1..23 FT /evidence="ECO:0000255" FT CHAIN 24..91 FT /note="C-C motif chemokine 5" FT /id="PRO_0000005170" FT DISULFID 33..57 FT /evidence="ECO:0000250" FT DISULFID 34..73 FT /evidence="ECO:0000250" FT CONFLICT 69 FT /note="N -> K (in Ref. 1; CAA07430)" FT /evidence="ECO:0000305" SQ SEQUENCE 91 AA; 10059 MW; 930DD38E015B0183 CRC64; MKVSATAFAV LLMAAALCAP ASASPYASDT TPCCFAYISR PLPRTHVQEY FYTSSKCSMA AVVFITRKNR QVCANPEKKW VREYINALEL S //