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O97919

- CCL5_BOVIN

UniProt

O97919 - CCL5_BOVIN

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Protein

C-C motif chemokine 5

Gene

CCL5

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. chemokine-mediated signaling pathway Source: UniProtKB
  3. G-protein coupled receptor signaling pathway Source: UniProtKB
  4. immune response Source: InterPro
  5. inflammatory response Source: UniProtKB-KW
  6. negative regulation of macrophage apoptotic process Source: Ensembl
  7. positive regulation of epithelial cell proliferation Source: Ensembl
  8. positive regulation of monocyte chemotaxis Source: Ensembl
  9. regulation of insulin secretion Source: UniProtKB
  10. regulation of neuron death Source: UniProtKB
  11. response to tumor necrosis factor Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_210568. G alpha (i) signalling events.
REACT_212617. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 5
Alternative name(s):
SIS-delta
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene namesi
Name:CCL5
Synonyms:SCYA5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 19

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9168C-C motif chemokine 5PRO_0000005170Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009463.

Structurei

3D structure databases

ProteinModelPortaliO97919.
SMRiO97919. Positions 24-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38896.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiO97919.
KOiK12499.
OMAiCSIPAVV.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O97919-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVSATAFAV LLMAAALCAP ASASPYASDT TPCCFAYISR PLPRTHVQEY
60 70 80 90
FYTSSKCSMA AVVFITRKNR QVCANPEKKW VREYINALEL S
Length:91
Mass (Da):10,059
Last modified:March 18, 2008 - v2
Checksum:i930DD38E015B0183
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691N → K in CAA07430. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007043 mRNA. Translation: CAA07430.1.
EU276060 mRNA. Translation: ABX72058.1.
BC102064 mRNA. Translation: AAI02065.1.
RefSeqiNP_787021.1. NM_175827.2.
UniGeneiBt.552.

Genome annotation databases

EnsembliENSBTAT00000009463; ENSBTAP00000009463; ENSBTAG00000007191.
GeneIDi327712.
KEGGibta:327712.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007043 mRNA. Translation: CAA07430.1 .
EU276060 mRNA. Translation: ABX72058.1 .
BC102064 mRNA. Translation: AAI02065.1 .
RefSeqi NP_787021.1. NM_175827.2.
UniGenei Bt.552.

3D structure databases

ProteinModelPortali O97919.
SMRi O97919. Positions 24-91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000009463.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000009463 ; ENSBTAP00000009463 ; ENSBTAG00000007191 .
GeneIDi 327712.
KEGGi bta:327712.

Organism-specific databases

CTDi 6352.

Phylogenomic databases

eggNOGi NOG38896.
GeneTreei ENSGT00730000110278.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi O97919.
KOi K12499.
OMAi CSIPAVV.
OrthoDBi EOG7CVQ1F.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_210568. G alpha (i) signalling events.
REACT_212617. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi 20810176.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of Bos taurus RANTES mRNA."
    Aust G., Thamm B., Rost A.K.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.
  2. "U.S. veterinary immune reagent network: expressed bovine gene sequences."
    U.S. Veterinary Immune Reagent Network
    Hudgens T., Tompkins D., Baldwin C.L.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Belted Galloway.
    Tissue: Peripheral blood.
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiCCL5_BOVIN
AccessioniPrimary (citable) accession number: O97919
Secondary accession number(s): Q3T192
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 18, 2008
Last modified: October 29, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3