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O97919

- CCL5_BOVIN

UniProt

O97919 - CCL5_BOVIN

Protein

C-C motif chemokine 5

Gene

CCL5

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils By similarity.By similarity

    GO - Molecular functioni

    1. chemoattractant activity Source: Ensembl
    2. phosphatidylinositol phospholipase C activity Source: Ensembl
    3. phospholipase activator activity Source: Ensembl
    4. protein kinase activity Source: Ensembl
    5. receptor signaling protein tyrosine kinase activator activity Source: Ensembl

    GO - Biological processi

    1. activation of phospholipase D activity Source: Ensembl
    2. calcium ion transport Source: Ensembl
    3. cell-cell signaling Source: Ensembl
    4. cellular calcium ion homeostasis Source: Ensembl
    5. cellular protein complex assembly Source: Ensembl
    6. cellular response to fibroblast growth factor stimulus Source: Ensembl
    7. cellular response to interferon-gamma Source: Ensembl
    8. cellular response to interleukin-1 Source: Ensembl
    9. cellular response to organic cyclic compound Source: Ensembl
    10. cellular response to tumor necrosis factor Source: Ensembl
    11. eosinophil chemotaxis Source: Ensembl
    12. exocytosis Source: Ensembl
    13. inflammatory response Source: UniProtKB-KW
    14. leukocyte cell-cell adhesion Source: Ensembl
    15. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    16. MAPK cascade Source: Ensembl
    17. negative regulation by host of viral transcription Source: Ensembl
    18. negative regulation of chemokine-mediated signaling pathway Source: Ensembl
    19. negative regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
    20. negative regulation of macrophage apoptotic process Source: Ensembl
    21. negative regulation of T cell apoptotic process Source: Ensembl
    22. negative regulation of viral genome replication Source: Ensembl
    23. neutrophil activation Source: Ensembl
    24. positive regulation of calcium ion transport Source: Ensembl
    25. positive regulation of cell-cell adhesion mediated by integrin Source: Ensembl
    26. positive regulation of cellular biosynthetic process Source: Ensembl
    27. positive regulation of epithelial cell proliferation Source: Ensembl
    28. positive regulation of homotypic cell-cell adhesion Source: Ensembl
    29. positive regulation of macrophage chemotaxis Source: Ensembl
    30. positive regulation of monocyte chemotaxis Source: Ensembl
    31. positive regulation of natural killer cell chemotaxis Source: Ensembl
    32. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    33. positive regulation of smooth muscle cell migration Source: Ensembl
    34. positive regulation of smooth muscle cell proliferation Source: Ensembl
    35. positive regulation of T cell apoptotic process Source: Ensembl
    36. positive regulation of T cell chemotaxis Source: Ensembl
    37. positive regulation of T cell proliferation Source: Ensembl
    38. positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
    39. protein kinase B signaling Source: Ensembl
    40. protein tetramerization Source: Ensembl
    41. response to toxic substance Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_210568. G alpha (i) signalling events.
    REACT_212617. Chemokine receptors bind chemokines.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 5
    Alternative name(s):
    SIS-delta
    Small-inducible cytokine A5
    T-cell-specific protein RANTES
    Gene namesi
    Name:CCL5
    Synonyms:SCYA5
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 19

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 9168C-C motif chemokine 5PRO_0000005170Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 57By similarity
    Disulfide bondi34 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000009463.

    Structurei

    3D structure databases

    ProteinModelPortaliO97919.
    SMRiO97919. Positions 24-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG38896.
    GeneTreeiENSGT00730000110278.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiO97919.
    KOiK12499.
    OMAiCSIPAVV.
    OrthoDBiEOG7CVQ1F.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O97919-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSATAFAV LLMAAALCAP ASASPYASDT TPCCFAYISR PLPRTHVQEY   50
    FYTSSKCSMA AVVFITRKNR QVCANPEKKW VREYINALEL S 91
    Length:91
    Mass (Da):10,059
    Last modified:March 18, 2008 - v2
    Checksum:i930DD38E015B0183
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti69 – 691N → K in CAA07430. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007043 mRNA. Translation: CAA07430.1.
    EU276060 mRNA. Translation: ABX72058.1.
    BC102064 mRNA. Translation: AAI02065.1.
    RefSeqiNP_787021.1. NM_175827.2.
    UniGeneiBt.552.

    Genome annotation databases

    EnsembliENSBTAT00000009463; ENSBTAP00000009463; ENSBTAG00000007191.
    GeneIDi327712.
    KEGGibta:327712.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007043 mRNA. Translation: CAA07430.1 .
    EU276060 mRNA. Translation: ABX72058.1 .
    BC102064 mRNA. Translation: AAI02065.1 .
    RefSeqi NP_787021.1. NM_175827.2.
    UniGenei Bt.552.

    3D structure databases

    ProteinModelPortali O97919.
    SMRi O97919. Positions 24-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000009463.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000009463 ; ENSBTAP00000009463 ; ENSBTAG00000007191 .
    GeneIDi 327712.
    KEGGi bta:327712.

    Organism-specific databases

    CTDi 6352.

    Phylogenomic databases

    eggNOGi NOG38896.
    GeneTreei ENSGT00730000110278.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi O97919.
    KOi K12499.
    OMAi CSIPAVV.
    OrthoDBi EOG7CVQ1F.
    TreeFami TF334888.

    Enzyme and pathway databases

    Reactomei REACT_210568. G alpha (i) signalling events.
    REACT_212617. Chemokine receptors bind chemokines.

    Miscellaneous databases

    NextBioi 20810176.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of Bos taurus RANTES mRNA."
      Aust G., Thamm B., Rost A.K.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Intestine.
    2. "U.S. veterinary immune reagent network: expressed bovine gene sequences."
      U.S. Veterinary Immune Reagent Network
      Hudgens T., Tompkins D., Baldwin C.L.
      Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Belted Galloway.
      Tissue: Peripheral blood.
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiCCL5_BOVIN
    AccessioniPrimary (citable) accession number: O97919
    Secondary accession number(s): Q3T192
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3