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O97919

- CCL5_BOVIN

UniProt

O97919 - CCL5_BOVIN

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Protein

C-C motif chemokine 5

Gene
CCL5, SCYA5
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils By similarity.

GO - Molecular functioni

  1. chemoattractant activity Source: Ensembl
  2. phosphatidylinositol phospholipase C activity Source: Ensembl
  3. phospholipase activator activity Source: Ensembl
  4. protein kinase activity Source: Ensembl
  5. receptor signaling protein tyrosine kinase activator activity Source: Ensembl

GO - Biological processi

  1. activation of phospholipase D activity Source: Ensembl
  2. calcium ion transport Source: Ensembl
  3. cell-cell signaling Source: Ensembl
  4. cellular calcium ion homeostasis Source: Ensembl
  5. cellular protein complex assembly Source: Ensembl
  6. cellular response to fibroblast growth factor stimulus Source: Ensembl
  7. cellular response to interferon-gamma Source: Ensembl
  8. cellular response to interleukin-1 Source: Ensembl
  9. cellular response to organic cyclic compound Source: Ensembl
  10. cellular response to tumor necrosis factor Source: Ensembl
  11. eosinophil chemotaxis Source: Ensembl
  12. exocytosis Source: Ensembl
  13. inflammatory response Source: UniProtKB-KW
  14. leukocyte cell-cell adhesion Source: Ensembl
  15. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  16. MAPK cascade Source: Ensembl
  17. negative regulation by host of viral transcription Source: Ensembl
  18. negative regulation of chemokine-mediated signaling pathway Source: Ensembl
  19. negative regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
  20. negative regulation of macrophage apoptotic process Source: Ensembl
  21. negative regulation of T cell apoptotic process Source: Ensembl
  22. negative regulation of viral genome replication Source: Ensembl
  23. neutrophil activation Source: Ensembl
  24. positive regulation of calcium ion transport Source: Ensembl
  25. positive regulation of cell-cell adhesion mediated by integrin Source: Ensembl
  26. positive regulation of cellular biosynthetic process Source: Ensembl
  27. positive regulation of epithelial cell proliferation Source: Ensembl
  28. positive regulation of homotypic cell-cell adhesion Source: Ensembl
  29. positive regulation of macrophage chemotaxis Source: Ensembl
  30. positive regulation of monocyte chemotaxis Source: Ensembl
  31. positive regulation of natural killer cell chemotaxis Source: Ensembl
  32. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  33. positive regulation of smooth muscle cell migration Source: Ensembl
  34. positive regulation of smooth muscle cell proliferation Source: Ensembl
  35. positive regulation of T cell apoptotic process Source: Ensembl
  36. positive regulation of T cell chemotaxis Source: Ensembl
  37. positive regulation of T cell proliferation Source: Ensembl
  38. positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
  39. protein kinase B signaling Source: Ensembl
  40. protein tetramerization Source: Ensembl
  41. response to toxic substance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_210568. G alpha (i) signalling events.
REACT_212617. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 5
Alternative name(s):
SIS-delta
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene namesi
Name:CCL5
Synonyms:SCYA5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 19

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 9168C-C motif chemokine 5PRO_0000005170Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57 By similarity
Disulfide bondi34 ↔ 73 By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009463.

Structurei

3D structure databases

ProteinModelPortaliO97919.
SMRiO97919. Positions 24-91.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38896.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiO97919.
KOiK12499.
OMAiCSIPAVV.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O97919-1 [UniParc]FASTAAdd to Basket

« Hide

MKVSATAFAV LLMAAALCAP ASASPYASDT TPCCFAYISR PLPRTHVQEY   50
FYTSSKCSMA AVVFITRKNR QVCANPEKKW VREYINALEL S 91
Length:91
Mass (Da):10,059
Last modified:March 18, 2008 - v2
Checksum:i930DD38E015B0183
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691N → K in CAA07430. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ007043 mRNA. Translation: CAA07430.1.
EU276060 mRNA. Translation: ABX72058.1.
BC102064 mRNA. Translation: AAI02065.1.
RefSeqiNP_787021.1. NM_175827.2.
UniGeneiBt.552.

Genome annotation databases

EnsembliENSBTAT00000009463; ENSBTAP00000009463; ENSBTAG00000007191.
GeneIDi327712.
KEGGibta:327712.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ007043 mRNA. Translation: CAA07430.1 .
EU276060 mRNA. Translation: ABX72058.1 .
BC102064 mRNA. Translation: AAI02065.1 .
RefSeqi NP_787021.1. NM_175827.2.
UniGenei Bt.552.

3D structure databases

ProteinModelPortali O97919.
SMRi O97919. Positions 24-91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000009463.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000009463 ; ENSBTAP00000009463 ; ENSBTAG00000007191 .
GeneIDi 327712.
KEGGi bta:327712.

Organism-specific databases

CTDi 6352.

Phylogenomic databases

eggNOGi NOG38896.
GeneTreei ENSGT00730000110278.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi O97919.
KOi K12499.
OMAi CSIPAVV.
OrthoDBi EOG7CVQ1F.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_210568. G alpha (i) signalling events.
REACT_212617. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi 20810176.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of Bos taurus RANTES mRNA."
    Aust G., Thamm B., Rost A.K.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.
  2. "U.S. veterinary immune reagent network: expressed bovine gene sequences."
    U.S. Veterinary Immune Reagent Network
    Hudgens T., Tompkins D., Baldwin C.L.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Belted Galloway.
    Tissue: Peripheral blood.
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiCCL5_BOVIN
AccessioniPrimary (citable) accession number: O97919
Secondary accession number(s): Q3T192
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 18, 2008
Last modified: September 3, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi