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Protein

Interleukin-33

Gene

IL33

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (By similarity).By similarity
In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-33
Short name:
IL-33
Alternative name(s):
Protein DVS27
Gene namesi
Name:IL33
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasmic vesicle, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000967891 – 263Interleukin-33Add BLAST263
PropeptideiPRO_00004300821 – ?

Post-translational modificationi

The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However, proteolytic processing by CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full-length protein. May also be proteolytically processed by calpains. Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation. In vitro proteolytic cleavage by CASP1 was reported but could not be confirmed in vivo suggesting that IL33 is probably not a direct substrate for that caspase (By similarity).By similarity

Proteomic databases

PRIDEiO97863.

Expressioni

Tissue specificityi

Expressed in cultured umbilical artery smooth muscle cells after stimulation with IL1A and IL1B, and to a lesser extent with IFNG. Expressed in vasospastic cerebral arteries after subarachnoid hemorrhage.1 Publication

Interactioni

Subunit structurei

Forms a 1:1:1 heterotrimeric complex with its primary high-affinity receptor IL1RL1 and the coreceptor IL1RAP.By similarity

GO - Molecular functioni

Structurei

3D structure databases

SMRiO97863.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 65Homeodomain-like HTH domainBy similarityAdd BLAST65
Regioni66 – 109Interaction with RELABy similarityAdd BLAST44

Domaini

The homeodomain-like HTH domain mediates nuclear localization and heterochromatin association.By similarity

Sequence similaritiesi

Belongs to the IL-1 family. Highly divergent.Curated

Phylogenomic databases

HOVERGENiHBG081791.
InParanoidiO97863.
KOiK12967.

Family and domain databases

InterProiView protein in InterPro
IPR026145. IL-33.
PANTHERiPTHR21114. PTHR21114. 1 hit.
PfamiView protein in Pfam
PF15095. IL33. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O97863-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYSTTKIPP AKMNSSADKA LVKSPKLRKS QQKPEGVCQM YFMQLRSGLI
60 70 80 90 100
IEKTSCYFRK EITKRYSPRT AEKCRKQCLV FTACHQQLNK DFTSDVPMLQ
110 120 130 140 150
KCFGRANVPS IQEYSASLST YNDQSITFVF EDGSYEIYVE DLRKGQEKDK
160 170 180 190 200
VLFRYYDSQS PSHETGDDVD GQTLLVNLSP TKDKDFLLHA NNEEHSVELQ
210 220 230 240 250
KCENQLPDQA FFLLHRKSSE CVSFECKNNP GVFIGVKDNH LALIKVGDQT
260
KDSYIEKTIF KLS
Length:263
Mass (Da):30,179
Last modified:May 1, 1999 - v1
Checksum:i25647EC7E50824F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024517 mRNA. Translation: BAA75891.1.
RefSeqiNP_001003180.1. NM_001003180.1.
UniGeneiCfa.3672.

Genome annotation databases

GeneIDi403810.
KEGGicfa:403810.

Similar proteinsi

Entry informationi

Entry nameiIL33_CANLF
AccessioniPrimary (citable) accession number: O97863
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 1, 1999
Last modified: September 27, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families