ID   PPA5_RABIT              Reviewed;         325 AA.
AC   O97860;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   16-JUN-2009, entry version 46.
DE   RecName: Full=Tartrate-resistant acid phosphatase type 5;
DE            Short=TR-AP;
DE            EC=3.1.3.2;
DE   AltName: Full=Tartrate-resistant acid ATPase;
DE            Short=TrATPase;
DE   AltName: Full=Acid phosphatase 5, tartrate resistant;
DE   Flags: Precursor;
GN   Name=ACP5;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Japanese white; TISSUE=Bone;
RX   MEDLINE=98424349; PubMed=9753427;
RX   DOI=10.1046/j.1365-2443.1998.00202.x;
RA   Kobori M., Ikeda Y., Nara H., Kato M., Kumegawa M., Nojima H.,
RA   Kawashima H.;
RT   "Large scale isolation of osteoclast-specific genes by an improved
RT   method involving the preparation of a subtracted cDNA library.";
RL   Genes Cells 3:459-475(1998).
CC   -!- CATALYTIC ACTIVITY: A phosphate monoester + H(2)O = an alcohol +
CC       phosphate.
CC   -!- COFACTOR: Binds 2 iron ions (By similarity).
CC   -!- SUBUNIT: Exists either as monomer or, after proteolytic
CC       processing, as a dimer of two chains linked by disulfide bond(s)
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Lysosome (By similarity).
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AB009340; BAA75919.1; -; mRNA.
DR   RefSeq; NP_001075457.1; -.
DR   UniGene; Ocu.1775; -.
DR   HSSP; P09889; 1UTE.
DR   SMR; O97860; 19-324.
DR   GeneID; 100008599; -.
DR   HOVERGEN; O97860; -.
DR   BRENDA; 3.1.3.2; 255.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0003993; F:acid phosphatase activity; IEA:EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004843; M-pesterase.
DR   Pfam; PF00149; Metallophos; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hydrolase; Iron; Lysosome; Signal.
FT   SIGNAL        1     21       Potential.
FT   CHAIN        22    325       Tartrate-resistant acid phosphatase type
FT                                5.
FT                                /FTId=PRO_0000023983.
FT   CARBOHYD    116    116       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    147    147       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   325 AA;  36624 MW;  9AE28F2CDDCB5C7B CRC64;
     MDTWTLLLVL HTSLLLPWAE GATPTLRFVA VGDWGGVPNA PFHTAREMAN AKQIGKVVQM
     LGAHFILSLG DNFYFSGVQS VSDKRFQETF EDVFSDRSLQ NVPWYVLAGN HDHIGNVSAQ
     IAYSKVSKRW NFPSPFYRLR FRIPRTNVSV AIYMLDTVTL CGNSNDFLSQ QPERPRNLEL
     ARTQLAWLKR HLADAKEDYV LVAGHYPVWS IAEHGPTHCL VKKLQPLLVK YGVTAYLCGH
     DHNLQYLQDE NGVGYVLSGA GNFMDPSTQH QRSVPNGYLR FHYGAENSLG GFAYLEITPK
     EMTVTYMEAS GKSLFKTRLP KRAKA
//