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O97860

- PPA5_RABIT

UniProt

O97860 - PPA5_RABIT

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Protein

Tartrate-resistant acid phosphatase type 5

Gene
ACP5
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Binds 2 iron ions By similarity.

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. ferric iron binding Source: UniProtKB
  3. ferrous iron binding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Tartrate-resistant acid phosphatase type 5 (EC:3.1.3.2)
Short name:
TR-AP
Alternative name(s):
Tartrate-resistant acid ATPase
Short name:
TrATPase
Type 5 acid phosphatase
Gene namesi
Name:ACP5
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 325304Tartrate-resistant acid phosphatase type 5PRO_0000023983Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi147 – 1471N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s) By similarity.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000024029.

Structurei

3D structure databases

ProteinModelPortaliO97860.
SMRiO97860. Positions 19-324.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG279261.
HOVERGENiHBG000433.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O97860-1 [UniParc]FASTAAdd to Basket

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MDTWTLLLVL HTSLLLPWAE GATPTLRFVA VGDWGGVPNA PFHTAREMAN    50
AKQIGKVVQM LGAHFILSLG DNFYFSGVQS VSDKRFQETF EDVFSDRSLQ 100
NVPWYVLAGN HDHIGNVSAQ IAYSKVSKRW NFPSPFYRLR FRIPRTNVSV 150
AIYMLDTVTL CGNSNDFLSQ QPERPRNLEL ARTQLAWLKR HLADAKEDYV 200
LVAGHYPVWS IAEHGPTHCL VKKLQPLLVK YGVTAYLCGH DHNLQYLQDE 250
NGVGYVLSGA GNFMDPSTQH QRSVPNGYLR FHYGAENSLG GFAYLEITPK 300
EMTVTYMEAS GKSLFKTRLP KRAKA 325
Length:325
Mass (Da):36,624
Last modified:May 1, 1999 - v1
Checksum:i9AE28F2CDDCB5C7B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009340 mRNA. Translation: BAA75919.1.
RefSeqiNP_001075457.1. NM_001081988.1.
UniGeneiOcu.1775.

Genome annotation databases

GeneIDi100008599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009340 mRNA. Translation: BAA75919.1 .
RefSeqi NP_001075457.1. NM_001081988.1.
UniGenei Ocu.1775.

3D structure databases

ProteinModelPortali O97860.
SMRi O97860. Positions 19-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000024029.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100008599.

Organism-specific databases

CTDi 54.

Phylogenomic databases

eggNOGi NOG279261.
HOVERGENi HBG000433.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PIRSFi PIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Large scale isolation of osteoclast-specific genes by an improved method involving the preparation of a subtracted cDNA library."
    Kobori M., Ikeda Y., Nara H., Kato M., Kumegawa M., Nojima H., Kawashima H.
    Genes Cells 3:459-475(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Japanese white.
    Tissue: Bone.

Entry informationi

Entry nameiPPA5_RABIT
AccessioniPrimary (citable) accession number: O97860
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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