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O97860 (PPA5_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Tartrate-resistant acid phosphatase type 5

Short name=TR-AP
EC=3.1.3.2
Alternative name(s):
Tartrate-resistant acid ATPase
Short name=TrATPase
Type 5 acid phosphatase
Gene names
Name:ACP5
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactor

Binds 2 iron ions By similarity.

Subunit structure

Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s) By similarity.

Subcellular location

Lysosome By similarity.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   LigandIron
   Molecular functionHydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionacid phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

ferric iron binding

Inferred from sequence or structural similarity. Source: UniProtKB

ferrous iron binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 325304Tartrate-resistant acid phosphatase type 5
PRO_0000023983

Amino acid modifications

Glycosylation1161N-linked (GlcNAc...) Potential
Glycosylation1471N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O97860 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 9AE28F2CDDCB5C7B

FASTA32536,624
        10         20         30         40         50         60 
MDTWTLLLVL HTSLLLPWAE GATPTLRFVA VGDWGGVPNA PFHTAREMAN AKQIGKVVQM 

        70         80         90        100        110        120 
LGAHFILSLG DNFYFSGVQS VSDKRFQETF EDVFSDRSLQ NVPWYVLAGN HDHIGNVSAQ 

       130        140        150        160        170        180 
IAYSKVSKRW NFPSPFYRLR FRIPRTNVSV AIYMLDTVTL CGNSNDFLSQ QPERPRNLEL 

       190        200        210        220        230        240 
ARTQLAWLKR HLADAKEDYV LVAGHYPVWS IAEHGPTHCL VKKLQPLLVK YGVTAYLCGH 

       250        260        270        280        290        300 
DHNLQYLQDE NGVGYVLSGA GNFMDPSTQH QRSVPNGYLR FHYGAENSLG GFAYLEITPK 

       310        320 
EMTVTYMEAS GKSLFKTRLP KRAKA 

« Hide

References

[1]"Large scale isolation of osteoclast-specific genes by an improved method involving the preparation of a subtracted cDNA library."
Kobori M., Ikeda Y., Nara H., Kato M., Kumegawa M., Nojima H., Kawashima H.
Genes Cells 3:459-475(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Japanese white.
Tissue: Bone.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB009340 mRNA. Translation: BAA75919.1.
RefSeqNP_001075457.1. NM_001081988.1.
UniGeneOcu.1775.

3D structure databases

ProteinModelPortalO97860.
SMRO97860. Positions 19-324.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000024029.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100008599.

Organism-specific databases

CTD54.

Phylogenomic databases

eggNOGNOG279261.
HOVERGENHBG000433.

Family and domain databases

InterProIPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_apaH.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFPIRSF000898. Acid_Ptase_5. 1 hit.
ProtoNetSearch...

Entry information

Entry namePPA5_RABIT
AccessionPrimary (citable) accession number: O97860
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program