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Protein

Tartrate-resistant acid phosphatase type 5

Gene

ACP5

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Tartrate-resistant acid phosphatase type 5 (EC:3.1.3.2)
Short name:
TR-AP
Alternative name(s):
Tartrate-resistant acid ATPase
Short name:
TrATPase
Type 5 acid phosphatase
Gene namesi
Name:ACP5
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 325304Tartrate-resistant acid phosphatase type 5PRO_0000023983Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).By similarity

Structurei

3D structure databases

ProteinModelPortaliO97860.
SMRiO97860. Positions 19-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG279261.
HOVERGENiHBG000433.
InParanoidiO97860.
KOiK14379.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O97860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTWTLLLVL HTSLLLPWAE GATPTLRFVA VGDWGGVPNA PFHTAREMAN
60 70 80 90 100
AKQIGKVVQM LGAHFILSLG DNFYFSGVQS VSDKRFQETF EDVFSDRSLQ
110 120 130 140 150
NVPWYVLAGN HDHIGNVSAQ IAYSKVSKRW NFPSPFYRLR FRIPRTNVSV
160 170 180 190 200
AIYMLDTVTL CGNSNDFLSQ QPERPRNLEL ARTQLAWLKR HLADAKEDYV
210 220 230 240 250
LVAGHYPVWS IAEHGPTHCL VKKLQPLLVK YGVTAYLCGH DHNLQYLQDE
260 270 280 290 300
NGVGYVLSGA GNFMDPSTQH QRSVPNGYLR FHYGAENSLG GFAYLEITPK
310 320
EMTVTYMEAS GKSLFKTRLP KRAKA
Length:325
Mass (Da):36,624
Last modified:May 1, 1999 - v1
Checksum:i9AE28F2CDDCB5C7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009340 mRNA. Translation: BAA75919.1.
RefSeqiNP_001075457.1. NM_001081988.1.
UniGeneiOcu.1775.

Genome annotation databases

GeneIDi100008599.
KEGGiocu:100008599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009340 mRNA. Translation: BAA75919.1.
RefSeqiNP_001075457.1. NM_001081988.1.
UniGeneiOcu.1775.

3D structure databases

ProteinModelPortaliO97860.
SMRiO97860. Positions 19-324.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008599.
KEGGiocu:100008599.

Organism-specific databases

CTDi54.

Phylogenomic databases

eggNOGiNOG279261.
HOVERGENiHBG000433.
InParanoidiO97860.
KOiK14379.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Large scale isolation of osteoclast-specific genes by an improved method involving the preparation of a subtracted cDNA library."
    Kobori M., Ikeda Y., Nara H., Kato M., Kumegawa M., Nojima H., Kawashima H.
    Genes Cells 3:459-475(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Japanese white.
    Tissue: Bone.

Entry informationi

Entry nameiPPA5_RABIT
AccessioniPrimary (citable) accession number: O97860
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: May 1, 1999
Last modified: June 24, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.