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O97860

- PPA5_RABIT

UniProt

O97860 - PPA5_RABIT

Protein

Tartrate-resistant acid phosphatase type 5

Gene

ACP5

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Cofactori

    Binds 2 iron ions.By similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC
    2. ferric iron binding Source: UniProtKB
    3. ferrous iron binding Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Iron

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tartrate-resistant acid phosphatase type 5 (EC:3.1.3.2)
    Short name:
    TR-AP
    Alternative name(s):
    Tartrate-resistant acid ATPase
    Short name:
    TrATPase
    Type 5 acid phosphatase
    Gene namesi
    Name:ACP5
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 325304Tartrate-resistant acid phosphatase type 5PRO_0000023983Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).By similarity

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000024029.

    Structurei

    3D structure databases

    ProteinModelPortaliO97860.
    SMRiO97860. Positions 19-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG279261.
    HOVERGENiHBG000433.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR024927. Acid_Pase_5.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O97860-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTWTLLLVL HTSLLLPWAE GATPTLRFVA VGDWGGVPNA PFHTAREMAN    50
    AKQIGKVVQM LGAHFILSLG DNFYFSGVQS VSDKRFQETF EDVFSDRSLQ 100
    NVPWYVLAGN HDHIGNVSAQ IAYSKVSKRW NFPSPFYRLR FRIPRTNVSV 150
    AIYMLDTVTL CGNSNDFLSQ QPERPRNLEL ARTQLAWLKR HLADAKEDYV 200
    LVAGHYPVWS IAEHGPTHCL VKKLQPLLVK YGVTAYLCGH DHNLQYLQDE 250
    NGVGYVLSGA GNFMDPSTQH QRSVPNGYLR FHYGAENSLG GFAYLEITPK 300
    EMTVTYMEAS GKSLFKTRLP KRAKA 325
    Length:325
    Mass (Da):36,624
    Last modified:May 1, 1999 - v1
    Checksum:i9AE28F2CDDCB5C7B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009340 mRNA. Translation: BAA75919.1.
    RefSeqiNP_001075457.1. NM_001081988.1.
    UniGeneiOcu.1775.

    Genome annotation databases

    GeneIDi100008599.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009340 mRNA. Translation: BAA75919.1 .
    RefSeqi NP_001075457.1. NM_001081988.1.
    UniGenei Ocu.1775.

    3D structure databases

    ProteinModelPortali O97860.
    SMRi O97860. Positions 19-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000024029.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100008599.

    Organism-specific databases

    CTDi 54.

    Phylogenomic databases

    eggNOGi NOG279261.
    HOVERGENi HBG000433.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR024927. Acid_Pase_5.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000898. Acid_Ptase_5. 1 hit.
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Large scale isolation of osteoclast-specific genes by an improved method involving the preparation of a subtracted cDNA library."
      Kobori M., Ikeda Y., Nara H., Kato M., Kumegawa M., Nojima H., Kawashima H.
      Genes Cells 3:459-475(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Japanese white.
      Tissue: Bone.

    Entry informationi

    Entry nameiPPA5_RABIT
    AccessioniPrimary (citable) accession number: O97860
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3