Reviewed, UniProtKB/Swiss-Prot O97860 (PPA5_RABIT)

Names and origin

Protein names

Recommended name:
    Tartrate-resistant acid phosphatase type 5
      Short name=TR-AP
    EC=3.1.3.2
Alternative name(s):
    Tartrate-resistant acid ATPase
      Short name=TrATPase
    Type 5 acid phosphatase

Gene names

Name:

ACP5

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	A phosphate monoester + H2O = an alcohol + phosphate.
Cofactor	Binds 2 iron ions By similarity.
Subunit structure	Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s) By similarity.
Subcellular location	Lysosome By similarity.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Ligand	Iron
Molecular function	Hydrolase
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acid phosphatase activity Inferred from electronic annotation. Source: EC ferric iron binding Inferred from sequence or structural similarity. Source: UniProtKB ferrous iron binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 325	304	Tartrate-resistant acid phosphatase type 5		PRO_0000023983
Amino acid modifications
	Glycosylation	116	1	N-linked (GlcNAc...) Potential
	Glycosylation	147	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O97860-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 9AE28F2CDDCB5C7B	FASTA	325	36,624
	10 20 30 40 50 60 MDTWTLLLVL HTSLLLPWAE GATPTLRFVA VGDWGGVPNA PFHTAREMAN AKQIGKVVQM 70 80 90 100 110 120 LGAHFILSLG DNFYFSGVQS VSDKRFQETF EDVFSDRSLQ NVPWYVLAGN HDHIGNVSAQ 130 140 150 160 170 180 IAYSKVSKRW NFPSPFYRLR FRIPRTNVSV AIYMLDTVTL CGNSNDFLSQ QPERPRNLEL 190 200 210 220 230 240 ARTQLAWLKR HLADAKEDYV LVAGHYPVWS IAEHGPTHCL VKKLQPLLVK YGVTAYLCGH 250 260 270 280 290 300 DHNLQYLQDE NGVGYVLSGA GNFMDPSTQH QRSVPNGYLR FHYGAENSLG GFAYLEITPK 310 320 EMTVTYMEAS GKSLFKTRLP KRAKA

References

[1]

"Large scale isolation of osteoclast-specific genes by an improved method involving the preparation of a subtracted cDNA library." Kobori M., Ikeda Y., Nara H., Kato M., Kumegawa M., Nojima H., Kawashima H. Genes Cells 3:459-475(1998) [PubMed: 9753427] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Japanese white. Tissue: Bone.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB009340 mRNA. Translation: BAA75919.1.
RefSeq	NP_001075457.1.
UniGene	Ocu.1775
3D structure databases
SMR	O97860. Positions 19-324.
ModBase	Search...
Genome annotation databases
GeneID	100008599.
Phylogenomic databases
HOVERGEN	O97860.
Enzyme and pathway databases
BRENDA	3.1.3.2. 255.
Family and domain databases
InterPro	IPR004843. M-pesterase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPA5_RABIT

Accession

Primary (citable) accession number: O97860

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	May 1, 1999
Last modified:	February 9, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)