O97860 (PPA5_RABIT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tartrate-resistant acid phosphatase type 5
Short name=TR-AP
EC=3.1.3.2

Alternative name(s):
Tartrate-resistant acid ATPase
Short name=TrATPase
Type 5 acid phosphatase

Gene names

Name:

ACP5

Organism

Oryctolagus cuniculus (Rabbit) [Reference proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphate monoester + H2O = an alcohol + phosphate.
Cofactor	Binds 2 iron ions By similarity.
Subunit structure	Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s) By similarity.
Subcellular location	Lysosome By similarity.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Ligand	Iron
Molecular function	Hydrolase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acid phosphatase activity Inferred from electronic annotation. Source: EC ferric iron binding Inferred from sequence or structural similarity. Source: UniProtKB ferrous iron binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 325	304	Tartrate-resistant acid phosphatase type 5		PRO_0000023983
Amino acid modifications
	Glycosylation	116	1	N-linked (GlcNAc...) Potential
	Glycosylation	147	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O97860 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 9AE28F2CDDCB5C7B	FASTA	325	36,624
	10 20 30 40 50 60 MDTWTLLLVL HTSLLLPWAE GATPTLRFVA VGDWGGVPNA PFHTAREMAN AKQIGKVVQM 70 80 90 100 110 120 LGAHFILSLG DNFYFSGVQS VSDKRFQETF EDVFSDRSLQ NVPWYVLAGN HDHIGNVSAQ 130 140 150 160 170 180 IAYSKVSKRW NFPSPFYRLR FRIPRTNVSV AIYMLDTVTL CGNSNDFLSQ QPERPRNLEL 190 200 210 220 230 240 ARTQLAWLKR HLADAKEDYV LVAGHYPVWS IAEHGPTHCL VKKLQPLLVK YGVTAYLCGH 250 260 270 280 290 300 DHNLQYLQDE NGVGYVLSGA GNFMDPSTQH QRSVPNGYLR FHYGAENSLG GFAYLEITPK 310 320 EMTVTYMEAS GKSLFKTRLP KRAKA

References

[1]

"Large scale isolation of osteoclast-specific genes by an improved method involving the preparation of a subtracted cDNA library." Kobori M., Ikeda Y., Nara H., Kato M., Kumegawa M., Nojima H., Kawashima H. Genes Cells 3:459-475(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Japanese white. Tissue: Bone.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB009340 mRNA. Translation: BAA75919.1.
RefSeq	NP_001075457.1. NM_001081988.1.
UniGene	Ocu.1775.
3D structure databases
ProteinModelPortal	O97860.
SMR	O97860. Positions 19-324.
ModBase	Search...
Protein-protein interaction databases
STRING	9986.ENSOCUP00000024029.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100008599.
Organism-specific databases
CTD	54.
Phylogenomic databases
eggNOG	NOG279261.
HOVERGEN	HBG000433.
OrthoDB	EOG4Z36FB.
Family and domain databases
InterPro	IPR024927. Acid_Pase_5. IPR004843. Metallo_PEstase_dom. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000898. Acid_Ptase_5. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPA5_RABIT

Accession

Primary (citable) accession number: O97860

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program