Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot O97860 (PPA5_RABIT)

Last modified February 9, 2010. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Names and origin

Protein namesRecommended name:
    Tartrate-resistant acid phosphatase type 5
      Short name=TR-AP
    EC=3.1.3.2
Alternative name(s):
    Tartrate-resistant acid ATPase
      Short name=TrATPase
    Type 5 acid phosphatase
Gene names
Name: ACP5
OrganismOryctolagus cuniculus (Rabbit)
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactor

Binds 2 iron ions By similarity.

Subunit structure

Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s) By similarity.

Subcellular location

Lysosome By similarity.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   LigandIron
   Molecular functionHydrolase
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Cellular componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionacid phosphatase activity

Inferred from electronic annotation. Source: EC

ferric iron binding

Inferred from sequence or structural similarity. Source: UniProtKB

ferrous iron binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 325304Tartrate-resistant acid phosphatase type 5
PRO_0000023983

Amino acid modifications

Glycosylation1161N-linked (GlcNAc...) Potential
Glycosylation1471N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O97860-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 9AE28F2CDDCB5C7B

FASTA32536,624
        10         20         30         40         50         60 
MDTWTLLLVL HTSLLLPWAE GATPTLRFVA VGDWGGVPNA PFHTAREMAN AKQIGKVVQM 

        70         80         90        100        110        120 
LGAHFILSLG DNFYFSGVQS VSDKRFQETF EDVFSDRSLQ NVPWYVLAGN HDHIGNVSAQ 

       130        140        150        160        170        180 
IAYSKVSKRW NFPSPFYRLR FRIPRTNVSV AIYMLDTVTL CGNSNDFLSQ QPERPRNLEL 

       190        200        210        220        230        240 
ARTQLAWLKR HLADAKEDYV LVAGHYPVWS IAEHGPTHCL VKKLQPLLVK YGVTAYLCGH 

       250        260        270        280        290        300 
DHNLQYLQDE NGVGYVLSGA GNFMDPSTQH QRSVPNGYLR FHYGAENSLG GFAYLEITPK 

       310        320 
EMTVTYMEAS GKSLFKTRLP KRAKA 

« Hide

References

[1]"Large scale isolation of osteoclast-specific genes by an improved method involving the preparation of a subtracted cDNA library."
Kobori M., Ikeda Y., Nara H., Kato M., Kumegawa M., Nojima H., Kawashima H.
Genes Cells 3:459-475(1998) [PubMed: 9753427] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Japanese white.
Tissue: Bone.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB009340 mRNA. Translation: BAA75919.1.
RefSeqNP_001075457.1.
UniGeneOcu.1775

3D structure databases

SMRO97860. Positions 19-324.
ModBaseSearch...

Genome annotation databases

GeneID100008599.

Phylogenomic databases

HOVERGENO97860.

Enzyme and pathway databases

BRENDA3.1.3.2. 255.

Family and domain databases

InterProIPR004843. M-pesterase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePPA5_RABIT
AccessionPrimary (citable) accession number: O97860
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: May 1, 1999
Last modified: February 9, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information