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O97859

- NEUR3_BOVIN

UniProt

O97859 - NEUR3_BOVIN

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Protein

Sialidase-3

Gene
NEU3
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates.1 Publication

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei25 – 251Substrate By similarity
Binding sitei45 – 451Substrate By similarity
Active sitei50 – 501Proton acceptor By similarity
Binding sitei179 – 1791Substrate By similarity
Binding sitei181 – 1811Substrate By similarity
Binding sitei225 – 2251Substrate By similarity
Binding sitei245 – 2451Substrate Reviewed prediction
Binding sitei341 – 3411Substrate By similarity
Active sitei371 – 3711Nucleophile By similarity
Active sitei388 – 3881 Reviewed prediction

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
  2. ganglioside catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Lipid degradation, Lipid metabolism

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase-3 (EC:3.2.1.18)
Alternative name(s):
Ganglioside sialidase
Membrane sialidase
N-acetyl-alpha-neuraminidase 3
Gene namesi
Name:NEU3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Cell membrane; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Sialidase-3PRO_0000208902Add
BLAST

Proteomic databases

PRIDEiO97859.

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000036593.

Structurei

3D structure databases

ProteinModelPortaliO97859.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati129 – 14012BNR 1Add
BLAST
Repeati203 – 21412BNR 2Add
BLAST
Repeati254 – 26512BNR 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi24 – 274FRIP motif

Sequence similaritiesi

Contains 3 BNR repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG84455.
HOGENOMiHOG000233778.
HOVERGENiHBG052608.
InParanoidiO97859.
KOiK12357.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026944. Sialidase-3.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF7. PTHR10628:SF7. 1 hit.
SUPFAMiSSF50939. SSF50939. 2 hits.

Sequencei

Sequence statusi: Complete.

O97859-1 [UniParc]FASTAAdd to Basket

« Hide

MEEVTSCSFS SPLFQQEDKR GVTYRIPALI YVPPAHTFLA FAEKRSSSKD    50
EDALHLVLRR GLRTGQSVQW EPLKSLMKAT LPGHRTMNPC PVWERKSGYV 100
YLFFICVQGH VTERQQIMSG RNPARLCFIC SQDAGYSWSD VRDLTEEVIG 150
PEVTHWATFA VGPGHGIQLQ SGRLIIPAYA YYIPFWFFCF RLPYRARPHS 200
LMIYSDDLGA TWHHGRLIKP MVTVECEVAE VIGKAGHPVL YCSARTPNRH 250
RAEALSIDHG ECFQKPVLSH QLCEPPHGCQ GSVVSFCPLE IPGGCQDLAG 300
EDAPAIQQSP LLCSSVRPEP EAGTLSESWL LYSHPTNKKR RVDLGIYLNQ 350
SPLEAACWSR PWILHCGPCG YSDLAALENE GLFGCLFECG TKQECEQIAF 400
RLFTDREILS HVQGDCSTPG MNSEPSKK 428
Length:428
Mass (Da):47,917
Last modified:May 1, 1999 - v1
Checksum:i418B34F3245A8F21
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB008184 mRNA. Translation: BAA75071.1.
RefSeqiNP_776547.2. NM_174122.3.
UniGeneiBt.477.

Genome annotation databases

GeneIDi281349.
KEGGibta:281349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB008184 mRNA. Translation: BAA75071.1 .
RefSeqi NP_776547.2. NM_174122.3.
UniGenei Bt.477.

3D structure databases

ProteinModelPortali O97859.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000036593.

Protein family/group databases

CAZyi GH33. Glycoside Hydrolase Family 33.

Proteomic databases

PRIDEi O97859.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 281349.
KEGGi bta:281349.

Organism-specific databases

CTDi 10825.

Phylogenomic databases

eggNOGi NOG84455.
HOGENOMi HOG000233778.
HOVERGENi HBG052608.
InParanoidi O97859.
KOi K12357.

Miscellaneous databases

NextBioi 20805357.

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR026944. Sialidase-3.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view ]
PANTHERi PTHR10628. PTHR10628. 1 hit.
PTHR10628:SF7. PTHR10628:SF7. 1 hit.
SUPFAMi SSF50939. SSF50939. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of a plasma membrane-associated sialidase specific for gangliosides."
    Miyagi T., Wada T., Iwamatsu A., Hata K., Yoshikawa Y., Tokuyama S., Sawada M.
    J. Biol. Chem. 274:5004-5011(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Brain.

Entry informationi

Entry nameiNEUR3_BOVIN
AccessioniPrimary (citable) accession number: O97859
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 1999
Last modified: March 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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