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O97831

- LPHN1_BOVIN

UniProt

O97831 - LPHN1_BOVIN

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Protein
Latrophilin-1
Gene
LPHN1, LPH1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421Carbohydrate By similarity
Sitei837 – 8382Cleavage; by autocatalysis By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. carbohydrate binding Source: InterPro
  3. cell adhesion molecule binding Source: UniProtKB
  4. latrotoxin receptor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. calcium-mediated signaling using intracellular calcium source Source: UniProtKB
  2. heterophilic cell-cell adhesion Source: UniProtKB
  3. neuropeptide signaling pathway Source: InterPro
  4. positive regulation of synapse maturation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiS63.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Latrophilin-1
Alternative name(s):
Calcium-independent alpha-latrotoxin receptor 1
Short name:
CIRL-1
Gene namesi
Name:LPHN1
Synonyms:LPH1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 7

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Cell projectionaxon. Cell projectiongrowth cone. Cell junctionsynapse. Cell junctionsynapsepresynaptic cell membrane. Cell junctionsynapsesynaptosome
Note: Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 857833Extracellular Reviewed prediction
Add
BLAST
Transmembranei858 – 87821Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini879 – 89214Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei893 – 91321Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini914 – 9196Extracellular Reviewed prediction
Transmembranei920 – 94021Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini941 – 96323Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei964 – 98421Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini985 – 100117Extracellular Reviewed prediction
Add
BLAST
Transmembranei1002 – 102221Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini1023 – 104927Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1050 – 107021Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini1071 – 10744Extracellular Reviewed prediction
Transmembranei1075 – 109521Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini1096 – 1472377Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. cell junction Source: UniProtKB-KW
  3. growth cone Source: UniProtKB
  4. integral component of membrane Source: UniProtKB-KW
  5. neuron projection Source: UniProtKB
  6. plasma membrane Source: UniProtKB
  7. presynaptic membrane Source: UniProtKB
  8. synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 By similarity
Add
BLAST
Chaini25 – 14721448Latrophilin-1
PRO_0000012906Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 71 By similarity
Disulfide bondi50 ↔ 128 By similarity
Disulfide bondi83 ↔ 115 By similarity
Disulfide bondi96 ↔ 102 By similarity
Glycosylationi98 – 981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi140 ↔ 322 By similarity
Disulfide bondi480 ↔ 515 By similarity
Disulfide bondi503 ↔ 532 By similarity
Glycosylationi531 – 5311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi640 – 6401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi741 – 7411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi800 – 8001N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi801 ↔ 832 By similarity
Glycosylationi805 – 8051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi820 ↔ 834 By similarity
Glycosylationi826 – 8261N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Autoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO97831.

Expressioni

Tissue specificityi

Brain-specific expression but low levels are also detected in kidney, lung and spleen.1 Publication

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85). Interacts with syntaxin and with protein of the SHANK family via the PDZ domain By similarity.

Structurei

3D structure databases

ProteinModelPortaliO97831.
SMRiO97831. Positions 29-134.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 12990SUEL-type lectin
Add
BLAST
Domaini139 – 398260Olfactomedin-like
Add
BLAST
Domaini798 – 84952GPS
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni117 – 1204Carbohydrate binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi413 – 4164Poly-Thr
Compositional biasi1302 – 131312Poly-Pro
Add
BLAST
Compositional biasi1408 – 141811Poly-Pro
Add
BLAST

Domaini

The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin By similarity.

Sequence similaritiesi

Contains 1 GPS domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253931.
GeneTreeiENSGT00710000106375.
HOGENOMiHOG000049065.
HOVERGENiHBG052337.
InParanoidiO97831.
KOiK04592.

Family and domain databases

InterProiIPR022624. DUF3497.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O97831-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MARLAAVLWS LCVTAILVTS ATQGLSRAGL PFGLMRRELA CEGYPIELRC     50
PGSDVIMVEN ANYGRTDDKI CDADPFQMEN VQCYLPDAFK IMSQRCNNRT 100
QCVVVAGSDA FPDPCPGTYK YLEVQYDCVP YKVKQKVFVC PGTLQKVLEP 150
TSTHESEHQS GAWCKDPLQA GDRIYVMPWI PYRTDTLTEY ASWEDYVAAR 200
HTTTYRLPNR VDGTGFVVYD GAVFYNKERT RNIVKYDLRT RIKSGETVIN 250
TANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEGNNGRL VVSQLNPYTL 300
RFEGTWETGY DKRSASNAFM VCGVLYVLRS VYVDDDSEAA GNRVDYAFNT 350
NANREEPVSL AFPNPYQFVS SVDYNPRDNQ LYVWNNYFVV RYSLEFGPPD 400
PSAGPATSPP LSTTTTARPT PLTSTASPAA TTPLRRAPLT THPVGAINQL 450
GPDLPPATAP APSTRRPPAP NLHVSPELFC EPREVRRVQW PATQQGMLVE 500
RPCPKGTRGI ASFQCLPALG LWNPRGPDLS NCTSPWVNQV AQKIKSGENA 550
ANIASELARH TRGSIYAGDV SSSVKLMEQL LDILDAQLQA LRPIERESAG 600
KNYNKMHKRE RTCKDYIKAV VETVDNLLRP EALESWKDMN ATEQAHTATM 650
LLDVLEEGAF LLADNVREPA RFLAAKQNVV LEVTVLNTEG QVQELVFPQE 700
YPSENSIQLS ANTIKQNSRN GVVKVVFILY NNLGLFLSTE NATVKLAGEA 750
GSGGPGGASL VVNSQVIAAS INKESSRVFL MDPVIFTVAH LEAKNHFNAN 800
CSFWNYSERS MLGYWSTQGC RLVESNKTHT TCACSHLTNF AVLMAHREIY 850
QGRINELLLS VITWVGIVIS LVCLAICIST FCFLRGLQTD RNTIHKNLCI 900
NLFLAELLFL VGIDKTQYEI ACPIFAGLLH YFFLAAFSWL CLEGVHLYLL 950
LVEVFESEYS RTKYYYLGGY CFPALVVGIA AAIDYRSYGT EKACWLRVDN 1000
YFIWSFIGPV SFVIVVNLVF LMVTLHKMVR SSSVLKPDSS RLDNIKSWAL 1050
GAIALLFLLG LTWAFGLLFI NKESVVMAYL FTTFNAFQGV FIFVFHCALQ 1100
KKVHKEYSKC LRHSYCCIRS PPGGAHGSLK TSAMRSNARY YTGTQSRIRR 1150
MWNDTVRKQT ESSFMAGDIN STPTLNRGTM GNHLLTNPVL QPRGGTSPYN 1200
TLIAESVGFN PSSPPVFNSP GSYREPKHPL GGREACGMDT LPLNGNFNNS 1250
YSLRSGDFPP GDGAPEPPRG RNLADAAAFE KMIISELVHN NLRGGSSGAK 1300
GPPPPEPPVP PVPGGSGEEE AGGPGADRAE IELLYKALEE PLLLPRAQSV 1350
LYQSDLDESE SCTAEDGATS RPLSSPPGRD SLYASGANLR DSPSYPDSSP 1400
EGPSEALPPP PPAPPGPPEI YYTSRPPALV ARNPLQGYYQ VRRPSHEGYL 1450
AAPGLEGPGP DGDGQMQLVT SL 1472
Length:1,472
Mass (Da):162,205
Last modified:May 1, 1999 - v1
Checksum:i860D7C75AA0D2F24
GO
Isoform 2 (identifier: O97831-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-137: KVKQKV → I

Show »
Length:1,467
Mass (Da):161,608
Checksum:i0F8079CF9E8FC6DD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei132 – 1376KVKQKV → I in isoform 2.
VSP_022136

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF111097 mRNA. Translation: AAD09191.1.
AF111098 mRNA. Translation: AAD09192.1.
PIRiT18411.
T18413.
RefSeqiNP_001107200.1. NM_001113728.1. [O97831-1]
XP_005208683.1. XM_005208626.1. [O97831-2]
UniGeneiBt.27855.

Genome annotation databases

EnsembliENSBTAT00000004789; ENSBTAP00000004789; ENSBTAG00000003675. [O97831-2]
GeneIDi788252.
KEGGibta:788252.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF111097 mRNA. Translation: AAD09191.1 .
AF111098 mRNA. Translation: AAD09192.1 .
PIRi T18411.
T18413.
RefSeqi NP_001107200.1. NM_001113728.1. [O97831-1 ]
XP_005208683.1. XM_005208626.1. [O97831-2 ]
UniGenei Bt.27855.

3D structure databases

ProteinModelPortali O97831.
SMRi O97831. Positions 29-134.
ModBasei Search...

Protein family/group databases

MEROPSi S63.013.
GPCRDBi Search...

Proteomic databases

PRIDEi O97831.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000004789 ; ENSBTAP00000004789 ; ENSBTAG00000003675 . [O97831-2 ]
GeneIDi 788252.
KEGGi bta:788252.

Organism-specific databases

CTDi 22859.

Phylogenomic databases

eggNOGi NOG253931.
GeneTreei ENSGT00710000106375.
HOGENOMi HOG000049065.
HOVERGENi HBG052337.
InParanoidi O97831.
KOi K04592.

Miscellaneous databases

NextBioi 20928986.

Family and domain databases

InterProi IPR022624. DUF3497.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTi SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view ]
PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors."
    Lelianova V.G., Davletov B.A., Sterling A., Rahman M.A., Grishin E.V., Totty N.F., Ushkaryov Y.A.
    J. Biol. Chem. 272:21504-21508(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  2. "The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution."
    Matsushita H., Lelianova V.G., Ushkaryov Y.A.
    FEBS Lett. 443:348-352(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Tissue: Brain.

Entry informationi

Entry nameiLPHN1_BOVIN
AccessioniPrimary (citable) accession number: O97831
Secondary accession number(s): O97830
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi