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Protein

Adhesion G protein-coupled receptor L2

Gene

ADGRL2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiP02.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor L2
Alternative name(s):
Calcium-independent alpha-latrotoxin receptor 2
Short name:
CIRL-2
Latrophilin-2
Gene namesi
Name:ADGRL2
Synonyms:LPH2, LPHN2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 855830ExtracellularSequence analysisAdd
BLAST
Transmembranei856 – 87621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini877 – 8848CytoplasmicSequence analysis
Transmembranei885 – 90521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini906 – 9116ExtracellularSequence analysis
Transmembranei912 – 93221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini933 – 95523CytoplasmicSequence analysisAdd
BLAST
Transmembranei956 – 97621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini977 – 99418ExtracellularSequence analysisAdd
BLAST
Transmembranei995 – 101521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini1016 – 105641CytoplasmicSequence analysisAdd
BLAST
Transmembranei1057 – 107721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini1078 – 10814ExtracellularSequence analysis
Transmembranei1082 – 110221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini1103 – 1478376CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 14781453Adhesion G protein-coupled receptor L2PRO_0000012909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis
Disulfide bondi140 ↔ 322PROSITE-ProRule annotation
Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence analysis
Glycosylationi524 – 5241N-linked (GlcNAc...)Sequence analysis
Glycosylationi633 – 6331N-linked (GlcNAc...)Sequence analysis
Glycosylationi735 – 7351N-linked (GlcNAc...)Sequence analysis
Glycosylationi748 – 7481N-linked (GlcNAc...)Sequence analysis
Glycosylationi791 – 7911N-linked (GlcNAc...)Sequence analysis
Glycosylationi796 – 7961N-linked (GlcNAc...)Sequence analysis
Glycosylationi817 – 8171N-linked (GlcNAc...)Sequence analysis
Modified residuei1393 – 13931PhosphoserineBy similarity
Modified residuei1428 – 14281PhosphoserineBy similarity
Modified residuei1449 – 14491PhosphoserineBy similarity

Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei828 – 8292CleavageBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO97817.
PRIDEiO97817.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016334.

Structurei

3D structure databases

ProteinModelPortaliO97817.
SMRiO97817. Positions 30-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 13090SUEL-type lectinPROSITE-ProRule annotationAdd
BLAST
Domaini139 – 398260Olfactomedin-likePROSITE-ProRule annotationAdd
BLAST
Domaini789 – 84052GPSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 olfactomedin-like domain.PROSITE-ProRule annotation
Contains 1 SUEL-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3545. Eukaryota.
KOG4193. Eukaryota.
KOG4729. Eukaryota.
ENOG410XSD2. LUCA.
HOVERGENiHBG052337.
InParanoidiO97817.
KOiK04593.

Family and domain databases

InterProiIPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR031240. Latrophilin-2.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like_dom.
[Graphical view]
PANTHERiPTHR12011:SF61. PTHR12011:SF61. 3 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF16489. GAIN. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view]

Sequences (11)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O97817-1) [UniParc]FASTAAdd to basket

Also known as: bbbbf

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSSGCRMRS LWFIIIISFL PNTEGFSRAA LPFGLVRREL SCEGYSIDLR
60 70 80 90 100
CPGSDVIMIE SANYGRTDDK ICDADPFQME NTDCYLPDAF KIMTQRCNNR
110 120 130 140 150
TQCIVVTGSD VFPDPCPGTY KYLEVQYECV PYMEQKVFVC PGTLKAIVDS
160 170 180 190 200
PCIYEAEQKA GAWCKDPLQA ADKIYFMPWT PYRTDTLIEY ASLEDFQNSR
210 220 230 240 250
QTTTYKLPNR VDGTGFVVYD GAVFFNKERT RNIVKYDLRT RIKSGEAIIN
260 270 280 290 300
YANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEQNNGMI VISQLNPYTL
310 320 330 340 350
RFEATWETVY DKRAASNAFM ICGVLYVVRS VYQDNESETG KNAIDYIYNT
360 370 380 390 400
RLNRGEYVDV PFPNQYQYIA AVDYNPRDNQ LYVWNNNFIL RYSLEFGPPD
410 420 430 440 450
PAQVPTTAVT ITSSAEMFKT TVSTTSTTSQ KGPMSTTVAG SQEGSKGTKA
460 470 480 490 500
PPAVSTTKIP PVTNIFPLPE RFCEALDARG IRWPQTQRGM MVERPCPKGT
510 520 530 540 550
RGTASYLCVL STGTWNPKGP DLSNCTSHWV NQLAQKIRSG ENAASLANEL
560 570 580 590 600
AKHTKGPVFA GDVSSSVRLM EQLVDILDAQ LQELKPSEKD SAGRSYNKLQ
610 620 630 640 650
KREKTCRAYL KAIVDTVDNL LRPEALESWK HMNSSEQAHT ATMLLDTLEE
660 670 680 690 700
GAFVLADNLV EPTRVSMPTE NIVLEVAVLS TEGQVQDFKF PLGIKGAGSS
710 720 730 740 750
IQLSANTVKQ NSRNGLAKLV FIIYRSLGQF LSTENATIKL GADFIGRNST
760 770 780 790 800
IAVNSHVISV SINKESSRVY LTDPVLFTLP HIDPDNYFNA NCSFWNYSER
810 820 830 840 850
TMMGYWSTQG CKLVDTNKTR TTCACSHLTN FAILMAHREI AYKDGVHELL
860 870 880 890 900
LTVITWVGIV ISLVCLAICI FTFCFFRGLQ SDRNTIHKNL CINLFIAEFI
910 920 930 940 950
FLIGIDKTKY MIACPIFAGL LHFFFLAAFA WMCLEGVQLY LMLVEVFESE
960 970 980 990 1000
YSRKKYYYVA GYLFPATVVG VSAAIDYKSY GTEKACWLHV DNYFIWSFIG
1010 1020 1030 1040 1050
PVTFIILLNI IFLVITLCKM VKHSNTLKPD SSRLENINNY RVCDGYYNTD
1060 1070 1080 1090 1100
LPGSWVLGAF ALLCLLGLTW SFGLLFINEE TIVMAYLFTI FNAFQGVFIF
1110 1120 1130 1140 1150
IFHCALQKKV RKEYGKCFRH SYCCGGLPTE SPHSSVKAST TRTSARYSSG
1160 1170 1180 1190 1200
TQSRIRRMWN DTVRKQSESS FISGDINSTS TLNQGMTGNY LLTNPLLRPH
1210 1220 1230 1240 1250
GTNNPYNTLL AETVVCNAPS APVFNSPGHS LNNARDTSAM DTLPLNGNFN
1260 1270 1280 1290 1300
NSYSLRKGDY NDSVQVVDCG LSLNDTAFEK MIISELVHNN LRGSSKAHNL
1310 1320 1330 1340 1350
ELTLPVKPVI GGSSSEDDAI VADASSLMHG DNPGLELHHK ELEAPLIPQR
1360 1370 1380 1390 1400
THSLLYQPQK KAKPEGTDSY VSQLTAEAED HLQSPNRDSL YTSMPNLRDS
1410 1420 1430 1440 1450
PYQESSPDME EDLSPSRRSE NEDIYYKSMP NLGAGHQLQM CYQISRGNSD
1460 1470
GYIIPINKEG CIPEGDVREG QMQLVTSL
Length:1,478
Mass (Da):165,547
Last modified:May 1, 1999 - v1
Checksum:i643722171D6D413E
GO
Isoform 2 (identifier: O97817-2) [UniParc]FASTAAdd to basket

Also known as: babbf

The sequence of this isoform differs from the canonical sequence as follows:
     404-469: Missing.

Show »
Length:1,412
Mass (Da):158,912
Checksum:iB50CAD23EF6E0BB8
GO
Isoform 3 (identifier: O97817-3) [UniParc]FASTAAdd to basket

Also known as: baabf

The sequence of this isoform differs from the canonical sequence as follows:
     404-469: Missing.
     598-610: Missing.

Show »
Length:1,399
Mass (Da):157,293
Checksum:i307D6C7914739332
GO
Isoform 4 (identifier: O97817-4) [UniParc]FASTAAdd to basket

Also known as: babaf

The sequence of this isoform differs from the canonical sequence as follows:
     404-469: Missing.
     1038-1053: NNYRVCDGYYNTDLPG → K

Show »
Length:1,397
Mass (Da):157,194
Checksum:iEDE97F31AFBEC251
GO
Isoform 5 (identifier: O97817-5) [UniParc]FASTAAdd to basket

Also known as: bbabf

The sequence of this isoform differs from the canonical sequence as follows:
     598-610: Missing.

Show »
Length:1,465
Mass (Da):163,928
Checksum:i4B6C4C917C211C9B
GO
Isoform 6 (identifier: O97817-6) [UniParc]FASTAAdd to basket

Also known as: bbbaf

The sequence of this isoform differs from the canonical sequence as follows:
     1038-1053: NNYRVCDGYYNTDLPG → K

Show »
Length:1,463
Mass (Da):163,829
Checksum:iFD01176320179B68
GO
Isoform 7 (identifier: O97817-7) [UniParc]FASTAAdd to basket

Also known as: bbaaf

The sequence of this isoform differs from the canonical sequence as follows:
     598-610: Missing.
     1038-1053: NNYRVCDGYYNTDLPG → K

Show »
Length:1,450
Mass (Da):162,211
Checksum:iC87238521C9B582B
GO
Isoform 8 (identifier: O97817-8) [UniParc]FASTAAdd to basket

Also known as: bbbbe

The sequence of this isoform differs from the canonical sequence as follows:
     1185-1227: Missing.

Show »
Length:1,435
Mass (Da):160,995
Checksum:i0E544DFC14AF7233
GO
Isoform 9 (identifier: O97817-9) [UniParc]FASTAAdd to basket

Also known as: bbabe

The sequence of this isoform differs from the canonical sequence as follows:
     598-610: Missing.
     1185-1227: Missing.

Show »
Length:1,422
Mass (Da):159,376
Checksum:i3504BA64F199843B
GO
Isoform 10 (identifier: O97817-10) [UniParc]FASTAAdd to basket

Also known as: bbbae

The sequence of this isoform differs from the canonical sequence as follows:
     1038-1053: NNYRVCDGYYNTDLPG → K
     1185-1227: Missing.

Show »
Length:1,420
Mass (Da):159,277
Checksum:i9B338D9DD6A77DC9
GO
Isoform 11 (identifier: O97817-11) [UniParc]FASTAAdd to basket

Also known as: bbaae

The sequence of this isoform differs from the canonical sequence as follows:
     598-610: Missing.
     1038-1053: NNYRVCDGYYNTDLPG → K
     1185-1227: Missing.

Show »
Length:1,407
Mass (Da):157,658
Checksum:i01AF1591513D2C48
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei404 – 46966Missing in isoform 2, isoform 3 and isoform 4. 1 PublicationVSP_010100Add
BLAST
Alternative sequencei598 – 61013Missing in isoform 3, isoform 5, isoform 7, isoform 9 and isoform 11. 1 PublicationVSP_010101Add
BLAST
Alternative sequencei1038 – 105316NNYRV…TDLPG → K in isoform 4, isoform 6, isoform 7, isoform 10 and isoform 11. 1 PublicationVSP_010102Add
BLAST
Alternative sequencei1185 – 122743Missing in isoform 8, isoform 9, isoform 10 and isoform 11. 1 PublicationVSP_010103Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111072 mRNA. Translation: AAD05308.1.
AF111074 mRNA. Translation: AAD05310.1.
AF111076 mRNA. Translation: AAD05312.1.
AF111077 mRNA. Translation: AAD05313.1.
AF111078 mRNA. Translation: AAD05314.1.
AF111079 mRNA. Translation: AAD05315.1.
AF111080 mRNA. Translation: AAD05316.1.
AF111081 mRNA. Translation: AAD05317.1.
AF111082 mRNA. Translation: AAD05318.1.
AF111083 mRNA. Translation: AAD05319.1.
AF111084 mRNA. Translation: AAD05320.1.
PIRiT18370.
T18377.
T18380.
T18381.
T18382.
T18383.
T18384.
T18385.
T18386.
T18387.
T18388.
RefSeqiNP_851356.1. NM_181013.1. [O97817-1]
UniGeneiBt.23209.

Genome annotation databases

GeneIDi281278.
KEGGibta:281278.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111072 mRNA. Translation: AAD05308.1.
AF111074 mRNA. Translation: AAD05310.1.
AF111076 mRNA. Translation: AAD05312.1.
AF111077 mRNA. Translation: AAD05313.1.
AF111078 mRNA. Translation: AAD05314.1.
AF111079 mRNA. Translation: AAD05315.1.
AF111080 mRNA. Translation: AAD05316.1.
AF111081 mRNA. Translation: AAD05317.1.
AF111082 mRNA. Translation: AAD05318.1.
AF111083 mRNA. Translation: AAD05319.1.
AF111084 mRNA. Translation: AAD05320.1.
PIRiT18370.
T18377.
T18380.
T18381.
T18382.
T18383.
T18384.
T18385.
T18386.
T18387.
T18388.
RefSeqiNP_851356.1. NM_181013.1. [O97817-1]
UniGeneiBt.23209.

3D structure databases

ProteinModelPortaliO97817.
SMRiO97817. Positions 30-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016334.

Protein family/group databases

MEROPSiP02.009.
GPCRDBiSearch...

Proteomic databases

PaxDbiO97817.
PRIDEiO97817.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281278.
KEGGibta:281278.

Organism-specific databases

CTDi23266.

Phylogenomic databases

eggNOGiKOG3545. Eukaryota.
KOG4193. Eukaryota.
KOG4729. Eukaryota.
ENOG410XSD2. LUCA.
HOVERGENiHBG052337.
InParanoidiO97817.
KOiK04593.

Family and domain databases

InterProiIPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR031240. Latrophilin-2.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like_dom.
[Graphical view]
PANTHERiPTHR12011:SF61. PTHR12011:SF61. 3 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF16489. GAIN. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution."
    Matsushita H., Lelianova V.G., Ushkaryov Y.A.
    FEBS Lett. 443:348-352(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10 AND 11).

Entry informationi

Entry nameiAGRL2_BOVIN
AccessioniPrimary (citable) accession number: O97817
Secondary accession number(s): O97805
, O97807, O97809, O97810, O97811, O97812, O97813, O97814, O97815, O97816
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.