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Protein
Submitted name:

Sodium-calcium exchanger isoform NCX1.3

Gene

NCX1

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Sodium-calcium exchanger isoform NCX1.3Imported
Gene namesi
Name:NCX1Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei75 – 9319HelicalSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Transmembranei163 – 18826HelicalSequence analysisAdd
BLAST
Transmembranei200 – 22324HelicalSequence analysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence analysisAdd
BLAST
Transmembranei759 – 78325HelicalSequence analysisAdd
BLAST
Transmembranei836 – 85621HelicalSequence analysisAdd
BLAST
Transmembranei868 – 88821HelicalSequence analysisAdd
BLAST
Transmembranei904 – 92219HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 934902Sequence analysisPRO_5004160747Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO97801.
SMRiO97801. Positions 403-688.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini302 – 36564JInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the sodium/potassium/calcium exchanger family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOGENOMiHOG000266971.
HOVERGENiHBG006441.
KOiK05849.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR001623. DnaJ_domain.
IPR004836. Na_Ca_Ex.
IPR032452. Na_Ca_Ex_C-exten.
IPR002987. NaCa_exhngr1.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
PF16494. Na_Ca_ex_C. 1 hit.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
PR01260. NACAEXCHNGR1.
SMARTiSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00845. caca. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O97801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLSLSPTF SMGFHLLVIV ALLFSHVDYV IAETEMEGEG NETGECTGSY
60 70 80 90 100
YCKKGVILPI WEPQDPSFGD KIARATVYFV AMVYMFLGVS IIADRFMSSI
110 120 130 140 150
EVITSQEKEI TIKKPNGETT KTTVRIWNET VSNLTLMALG SSAPEILLSV
160 170 180 190 200
IEVCGHNFTA GDLGPSTIVG SAAFNMFIII ALCVYVVPDG ETRKIKHLRV
210 220 230 240 250
FFVTAAWSIF AYTWLYIILS VISPGVVEVW EGLLTFFFFP ICVVFAWVAD
260 270 280 290 300
RRLLFYKYVY KRYRAGKQRG MIIEHEGDRP SSKTEIEMDG KVVNSHVENF
310 320 330 340 350
LDGALVLEVD ERDQDDEEAR REMARILKEL KQKHPEKEIE QLIELANYQV
360 370 380 390 400
LSQQQKSRAF YRIQATRLMT GAGNILKRHA ADQARKAVSM HEVNTEVTEN
410 420 430 440 450
DPVSKIFFEQ GTYQCLENCG TVALTIIRRG GDLTNTVFVD FRTEDGTANA
460 470 480 490 500
GSDYEFTEGT VVFKPGETQK EIRVGIIDDD IFEEDENFLV HLSNVKVSSE
510 520 530 540 550
ASEDGILEAN HVSTLACLGS PSTATVTIFD DDHAGIFTFE EPVTHVSESI
560 570 580 590 600
GIMEVKVLRT SGARGNVIVP YKTIEGTARG GGEDFEDTCG ELEFQNDEIV
610 620 630 640 650
KIITIRIFDR EEYEKECSFS LVLEEPKWIR RGMKGGFTIT DEYDDKQPLT
660 670 680 690 700
SKEEEERRIA EMGRPILGEH TKLEVIIEES YEFKSTVDKL IKKTNLALVV
710 720 730 740 750
GTNSWREQFI EAITVSAGED DDDDECGEEK LPSCFDYVMH FLTVFWKVLF
760 770 780 790 800
AFVPPTEYWN GWACFIVSIL MIGLLTAFIG DLASHFGCTI GLKDSVTAVV
810 820 830 840 850
FVALGTSVPD TFASKVAATQ DQYADASIGN VTGSNAVNVF LGIGVAWSIA
860 870 880 890 900
AIYHAANGEQ FKVSPGTLAF SVTLFTIFAF INVGVLLYRR RPEIGGELGG
910 920 930
PRTAKLLTSC LFVLLWLLYI FFSSLEAYCH IKGF
Length:934
Mass (Da):104,331
Last modified:May 1, 1999 - v1
Checksum:i2A228DA30254BBC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107593 mRNA. Translation: AAD04173.1.
RefSeqiNP_001028033.1. NM_001032861.1.
XP_014967690.1. XM_015112204.1.
XP_014967691.1. XM_015112205.1.
XP_014967698.1. XM_015112212.1.
UniGeneiMmu.3463.

Genome annotation databases

GeneIDi574193.
KEGGimcc:574193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107593 mRNA. Translation: AAD04173.1.
RefSeqiNP_001028033.1. NM_001032861.1.
XP_014967690.1. XM_015112204.1.
XP_014967691.1. XM_015112205.1.
XP_014967698.1. XM_015112212.1.
UniGeneiMmu.3463.

3D structure databases

ProteinModelPortaliO97801.
SMRiO97801. Positions 403-688.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574193.
KEGGimcc:574193.

Organism-specific databases

CTDi6546.

Phylogenomic databases

HOGENOMiHOG000266971.
HOVERGENiHBG006441.
KOiK05849.

Miscellaneous databases

NextBioi19964513.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR001623. DnaJ_domain.
IPR004836. Na_Ca_Ex.
IPR032452. Na_Ca_Ex_C-exten.
IPR002987. NaCa_exhngr1.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
PF16494. Na_Ca_ex_C. 1 hit.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
PR01260. NACAEXCHNGR1.
SMARTiSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00845. caca. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Li X.-F., Lytton J.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: KidneyImported.
  2. "A circularized sodium-calcium exchanger exon 2 transcript."
    Li X.F., Lytton J.
    J. Biol. Chem. 274:8153-8160(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: KidneyImported.

Entry informationi

Entry nameiO97801_MACMU
AccessioniPrimary (citable) accession number: O97801
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.