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Protein

Interleukin-10

Gene

IL10

Organism
Trichosurus vulpecula (Brush-tailed possum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.By similarity

GO - Biological processi

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10
Short name:
IL-10
Alternative name(s):
Cytokine synthesis inhibitory factor
Short name:
CSIF
Gene namesi
Name:IL10
OrganismiTrichosurus vulpecula (Brush-tailed possum)
Taxonomic identifieri9337 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDiprotodontiaPhalangeridaeTrichosurus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001537417 – 174Interleukin-10Add BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi17N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi26 ↔ 122By similarity
Disulfide bondi76 ↔ 128By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO97798.
SMRiO97798.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004110.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
PfamiView protein in Pfam
PF00726. IL10. 1 hit.
PRINTSiPR01294. INTRLEUKIN10.
SMARTiView protein in SMART
SM00188. IL10. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00520. INTERLEUKIN_10. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O97798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTWMLLFCL LCVTSSNLSS ALEDNCKTFS TTLPNMLREL RAAFSSVKTY
60 70 80 90 100
FQTRDKLETK LIDKSLLEEL KSYLGCQALS EMIKFYLEEV MPRAEENELD
110 120 130 140 150
VKEDVGSLGE KLKALRLRLK RCHRFLPCED NSRVVKQVRN TYKELQEQGV
160 170
YKAMGDFDIF IGYMEEYLTM HIGK
Length:174
Mass (Da):20,263
Last modified:May 1, 1999 - v1
Checksum:iDA838DBF74DF9C06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026277 mRNA. Translation: AAD01799.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026277 mRNA. Translation: AAD01799.1.

3D structure databases

ProteinModelPortaliO97798.
SMRiO97798.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004110.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
PfamiView protein in Pfam
PF00726. IL10. 1 hit.
PRINTSiPR01294. INTRLEUKIN10.
SMARTiView protein in SMART
SM00188. IL10. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00520. INTERLEUKIN_10. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIL10_TRIVU
AccessioniPrimary (citable) accession number: O97798
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 15, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.