O97797 (FXYD3_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FXYD domain-containing ion transport regulator 3

Alternative name(s):
Chloride conductance inducer protein Mat-8
Mammary tumor 8 kDa protein

Gene names

Name:	FXYD3
Synonyms:	MAT8

Organism

Sus scrofa (Pig) [Complete proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	88 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the FXYD family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	Chloride
Molecular function	Chloride channel Ionic channel
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	chloride channel complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chloride channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 88	71	FXYD domain-containing ion transport regulator 3		PRO_0000010364
Regions
	Topological domain	18 – 38	21	Extracellular Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Topological domain	60 – 88	29	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	O97797 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 6CC7810B90512E5A	FASTA	88	9,314
	10 20 30 40 50 60 MHEVALSVLI LLAGLSALDA NDPEDKNSPF YYDWHSLRVG GLICAGTPCA LGIIILLSGK 70 80 CKCKFSQKPS HRPGDAPPLI TPGSAHDC

References

[1]

"Structures of P-type transporting ATPases and chromosomal locations of their genes." Maeda M., Hamano K., Hirano Y., Suzuki M., Takahashi E., Terada T., Futai M., Sato R. Cell Struct. Funct. 23:315-323(1998) [PubMed: 10206733] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Gastric mucosa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB015759 mRNA. Translation: BAA35078.1.
RefSeq	NP_999373.1. NM_214208.1.
UniGene	Ssc.569.
3D structure databases
ProteinModelPortal	O97797.
SMR	O97797. Positions 21-85.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	397413.
KEGG	ssc:397413.
Organism-specific databases
CTD	5349.
Phylogenomic databases
HOVERGEN	HBG008212.
Family and domain databases
InterPro	IPR000272. Ion-transport_regulator_FXYD. [Graphical view]
KO	K13361.
Pfam	PF02038. ATP1G1_PLM_MAT8. 1 hit. [Graphical view]
ProDom	PD005989. PD005989. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01310. FXYD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FXYD3_PIG

Accession

Primary (citable) accession number: O97797

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	May 1, 1999
Last modified:	November 16, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program