Reviewed,
UniProtKB/Swiss-Prot O97756 (SNAT_MACMU)
Last modified
January 19, 2010.
Version 62.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Serotonin N-acetyltransferase Short name=Serotonin acetylase EC=2.3.1.87 Alternative name(s): Aralkylamine N-acetyltransferase Short name=AA-NAT | ||||
| Gene names |
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| Organism | Macaca mulatta (Rhesus macaque) | ||||
| Taxonomic identifier | 9544 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Protein attributes
| Sequence length | 204 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the N-acetylation of serotonin into N-acetylserotonin. |
| Catalytic activity | Acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine. |
| Pathway | Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2. |
| Subunit structure | Monomer By similarity. Interacts with YWHAZ; the interaction requires phosphorylation on Thr-28, and modulates the enzymatic activity of AANAT through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT can bind, via the phosphorylated Ser-202 site, the other YWHAZ monomer with similar effect By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Tissue specificity | Highly expressed in pineal gland and retina. |
| Post-translational modification | Phosphorylated; cAMP-dependent phosphorylation on both N-terminal and C-terminal sites regulates AANAT activity through allowing interaction with 14-3-3 proteins and protecting the enzyme against proteasomal degradation By similarity. |
| Sequence similarities | Belongs to the acetyltransferase family. AANAT subfamily. Contains 1 N-acetyltransferase domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Biological rhythms Melatonin biosynthesis |
| Cellular component | Cytoplasm |
| Molecular function | Acyltransferase Transferase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | melatonin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW rhythmic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | aralkylamine N-acetyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 204 | 204 | Serotonin N-acetyltransferase | PRO_0000074581 | |||||
Regions | |||||||||
| Domain | 32 – 193 | 162 | N-acetyltransferase | ||||||
| Region | 121 – 123 | 3 | Acetyl-CoA binding By similarity | ||||||
| Region | 129 – 134 | 6 | Acetyl-CoA binding By similarity | ||||||
| Region | 165 – 167 | 3 | Acetyl-CoA binding By similarity | ||||||
Sites | |||||||||
| Binding site | 121 | 1 | Substrate; via carbonyl oxygen By similarity | ||||||
| Site | 118 | 1 | Important for the catalytic mechanism; involved in substrate deprotonation By similarity | ||||||
| Site | 120 | 1 | Important for the catalytic mechanism; involved in substrate deprotonation By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 28 | 1 | Phosphothreonine; by PKA By similarity | ||||||
| Modified residue | 202 | 1 | Phosphoserine By similarity | ||||||
Sequences
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References
| [1] | Coon S.L. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pineal gland. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U46661 mRNA. Translation: AAD00061.2. |
| RefSeq | NP_001040592.1. |
| UniGene | Mmu.3603 |
3D structure databases | |
| SMR | O97756. Positions 18-193. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O97756. |
Genome annotation databases | |
| Ensembl | ENSMMUT00000026668; ENSMMUP00000024958; ENSMMUG00000018970; Macaca mulatta. [Genome view] ENSMMUT00000040995; ENSMMUP00000034025; ENSMMUG00000018970; Macaca mulatta. [Genome view] |
| GeneID | 706924. |
| KEGG | mcc:706924. |
Organism-specific databases | |
| CTD | 706924. |
Phylogenomic databases | |
| eggNOG | prNOG15095. |
| HOVERGEN | O97756. |
| InParanoid | O97756. |
| OMA | VPFYERF. |
| OrthoDB | EOG9GF60Z. |
| PhylomeDB | O97756. |
Enzyme and pathway databases | |
| BRENDA | 2.3.1.87. 1774. |
Family and domain databases | |
| InterPro | IPR016181. Acyl_CoA_acyltransferase. IPR000182. GCN5-rel_AcTrfase. [Graphical view] |
| Gene3D | G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit. |
| Pfam | PF00583. Acetyltransf_1. 1 hit. [Graphical view] |
| PROSITE | PS51186. GNAT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SNAT_MACMU | ||||||||
| Accession | Primary (citable) accession number: O97756 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


