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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

Gene

NDUFA12

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
Alternative name(s):
Complex I-B17.2
Short name:
CI-B17.2
Short name:
CIB17.2
NADH-ubiquinone oxidoreductase subunit B17.2
Gene namesi
Name:NDUFA12
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188441 – 145NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO97725.
PRIDEiO97725.

PTM databases

iPTMnetiO97725.

Expressioni

Gene expression databases

BgeeiENSBTAG00000014669.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

CORUMiO97725.
DIPiDIP-38802N.
IntActiO97725. 3 interactors.
STRINGi9913.ENSBTAP00000019529.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35q2-139[»]
5LDWelectron microscopy4.27q1-145[»]
5LDXelectron microscopy5.60q2-139[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA12 subunit family.Curated

Phylogenomic databases

eggNOGiKOG3382. Eukaryota.
ENOG4111XVR. LUCA.
GeneTreeiENSGT00390000005848.
HOGENOMiHOG000140337.
HOVERGENiHBG024390.
InParanoidiO97725.
KOiK11352.
OMAiWHGWIHH.
OrthoDBiEOG091G0XDC.
TreeFamiTF106106.

Family and domain databases

InterProiView protein in InterPro
IPR007763. NDUFA12.
PANTHERiPTHR12910. PTHR12910. 1 hit.
PfamiView protein in Pfam
PF05071. NDUFA12. 1 hit.

Sequencei

Sequence statusi: Complete.

O97725-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLQVLKRG LQQVSGHGGL RGYLRVLFRA NDVRVGTLVG EDKYGNKYYE
60 70 80 90 100
DNKQFFGRHR WVIYTTEMNG KNTFWDVDGS MVPPEWHRWL HCMTDDPPTV
110 120 130 140
KPPTARKFIW TNHKFNLSGT PQQYVPYSTT RKKIQEWVPP STPYK
Length:145
Mass (Da):17,090
Last modified:May 1, 1999 - v1
Checksum:i7471348CC3AD53C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011400 mRNA. Translation: CAA09608.1.
BC102502 mRNA. Translation: AAI02503.1.
RefSeqiNP_776731.1. NM_174306.3.
UniGeneiBt.103280.

Genome annotation databases

EnsembliENSBTAT00000019529; ENSBTAP00000019529; ENSBTAG00000014669.
GeneIDi281742.
KEGGibta:281742.

Similar proteinsi

Entry informationi

Entry nameiNDUAC_BOVIN
AccessioniPrimary (citable) accession number: O97725
Secondary accession number(s): Q3T092
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families