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Protein

Integrin beta

Gene

GPIIIa

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotation
Biological processCell adhesionUniRule annotation

Enzyme and pathway databases

ReactomeiR-CFA-114608. Platelet degranulation.
R-CFA-1566948. Elastic fibre formation.
R-CFA-2129379. Molecules associated with elastic fibres.
R-CFA-216083. Integrin cell surface interactions.
R-CFA-3000170. Syndecan interactions.
R-CFA-3000178. ECM proteoglycans.
R-CFA-354192. Integrin alphaIIb beta3 signaling.
R-CFA-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-CFA-372708. p130Cas linkage to MAPK signaling for integrins.
R-CFA-4420097. VEGFA-VEGFR2 Pathway.
R-CFA-445144. Signal transduction by L1.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:GPIIIaImported
Synonyms:ITGB3Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei715 – 737HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501050345723 – 784Integrin betaSequence analysisAdd BLAST762

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 457UniRule annotation
Disulfide bondi35 ↔ 45UniRule annotation
Disulfide bondi38 ↔ 71UniRule annotation
Disulfide bondi48 ↔ 60UniRule annotation
Disulfide bondi199 ↔ 206UniRule annotation
Disulfide bondi254 ↔ 295UniRule annotation
Disulfide bondi396 ↔ 408UniRule annotation
Disulfide bondi428 ↔ 677UniRule annotation
Disulfide bondi455 ↔ 459UniRule annotation
Disulfide bondi470 ↔ 482UniRule annotation
Disulfide bondi479 ↔ 517UniRule annotation
Disulfide bondi484 ↔ 493UniRule annotation
Disulfide bondi495 ↔ 508UniRule annotation
Disulfide bondi523 ↔ 528UniRule annotation
Disulfide bondi525 ↔ 558UniRule annotation
Disulfide bondi530 ↔ 543UniRule annotation
Disulfide bondi545 ↔ 550UniRule annotation
Disulfide bondi564 ↔ 569UniRule annotation
Disulfide bondi566 ↔ 597UniRule annotation
Disulfide bondi571 ↔ 580UniRule annotation
Disulfide bondi582 ↔ 589UniRule annotation
Disulfide bondi603 ↔ 608UniRule annotation
Disulfide bondi605 ↔ 653UniRule annotation
Disulfide bondi610 ↔ 620UniRule annotation
Disulfide bondi623 ↔ 626UniRule annotation
Disulfide bondi630 ↔ 639UniRule annotation
Disulfide bondi636 ↔ 709UniRule annotation
Disulfide bondi657 ↔ 685UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSCAFG00000013735.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 72PSIInterPro annotationAdd BLAST47
Domaini34 – 457INBInterPro annotationAdd BLAST424
Domaini630 – 714Integrin_B_tailInterPro annotationAdd BLAST85
Domaini738 – 784Integrin_b_cytInterPro annotationAdd BLAST47

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
InterProiView protein in InterPro
IPR013111. EGF_extracell.
IPR027068. Integrin_beta-3.
IPR033760. Integrin_beta_N.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR012896. Integrin_bsu_tail.
IPR002369. Integrin_bsu_VWA.
IPR032695. Integrin_dom.
IPR016201. PSI.
IPR002035. VWF_A.
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF52. PTHR10082:SF52. 1 hit.
PfamiView protein in Pfam
PF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiView protein in SMART
SM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiView protein in PROSITE
PS00243. INTEGRIN_BETA. 1 hit.

Sequencei

Sequence statusi: Complete.

O97702-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRARPLWAAV LLLGALAGTG VGVSNICTTR GVHSCQQCLA VSPVCAWCSD
60 70 80 90 100
EALPLGSPRC NLKENLLKDN CALESIEFPI SEVRILEARP LSNKGSGDSS
110 120 130 140 150
QITQVSPQRI ALRLRPDDSK NFSIQVRQVE DYPVDIYYLM DLSYSMKDDL
160 170 180 190 200
SSIQNLGTKL ASQMHKLTSN LRIGFGAFVD KPVSPYMYIS PPEALKNPCY
210 220 230 240 250
DMKTTCLPMF GYKHVLTLTD QVTRFNEEVK KQSVSRNRDA PEGGFDAIMQ
260 270 280 290 300
ATVCDEKIGW RNDASHLLVF TTDAKTHIAL DGRLAGIVQP NDGQCHIGSD
310 320 330 340 350
NHYSASTTMD YPSLGLMTEK LSQKNINLIF AVTENVVNLY QNYSELIPGT
360 370 380 390 400
TVGILSTDSS NVLQLIVDAY GKIRSKVELE VRDLPEELSL SFNATCLNNE
410 420 430 440 450
VIPGLKSCVG LKIGDTVSFS IEAKVRGCPQ EKEKSFTIKP VGFKDSLTIQ
460 470 480 490 500
VTFDCDCACQ AQAEPSSHRC NNGNGTFECG VCLCGPGWLG SQCECSEEDY
510 520 530 540 550
HPSQQDECSP REGQPACSQR GECLCGQCVC HSSDFGKITG KYCECDDFSC
560 570 580 590 600
VRYKGEMCSG HGQCSCGDCL CDSDWTGYYC NCTTRTDTCM SSNGLLCGGR
610 620 630 640 650
GKCECGSCVC IQPGSYGDTC EKCPTCPDAC TFKKECVECK KFDRGTLHDD
660 670 680 690 700
NTCNRYCRDE IESVKELKDT GKDAVNCTYK NEDDCVVRFQ YYEDSSGKSI
710 720 730 740 750
LYVVEEPECP KGPDILVVLL SVMGAILLIG LATLLIWKLL ITIHDRKEFA
760 770 780
KFEEERARAK WDTANNPLYK EATSTFTNIT YRGT
Length:784
Mass (Da):86,389
Last modified:May 1, 1999 - v1
Checksum:i6B2A6D34916EA260
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03006340 Genomic DNA. No translation available.
AF116270 mRNA. Translation: AAD13680.1.
UniGeneiCfa.3641.

Genome annotation databases

EnsembliENSCAFT00000021789; ENSCAFP00000020239; ENSCAFG00000013735.

Similar proteinsi

Entry informationi

Entry nameiO97702_CANLF
AccessioniPrimary (citable) accession number: O97702
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: August 30, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported