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Protein

Integrin beta

Gene

GPIIIa

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotationSAAS annotation

Keywords - Biological processi

Cell adhesionUniRule annotation

Enzyme and pathway databases

ReactomeiR-CFA-114608. Platelet degranulation.
R-CFA-1566948. Elastic fibre formation.
R-CFA-2129379. Molecules associated with elastic fibres.
R-CFA-216083. Integrin cell surface interactions.
R-CFA-3000170. Syndecan interactions.
R-CFA-3000178. ECM proteoglycans.
R-CFA-354192. Integrin alphaIIb beta3 signaling.
R-CFA-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-CFA-372708. p130Cas linkage to MAPK signaling for integrins.
R-CFA-4420097. VEGFA-VEGFR2 Pathway.
R-CFA-445144. Signal transduction by L1.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:GPIIIaImported
Synonyms:ITGB3Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei715 – 73723HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 784762Integrin betaSequence analysisPRO_5007697290Add
BLAST

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000032511.

Structurei

3D structure databases

SMRiO97702. Positions 25-784.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 457424INBInterPro annotationAdd
BLAST
Domaini630 – 71485Integrin_B_tailInterPro annotationAdd
BLAST
Domaini738 – 78447Integrin_b_cytInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation
Contains VWFA domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR027068. Integrin_beta-3.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR032695. Integrin_dom.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF25. PTHR10082:SF25. 1 hit.
PfamiPF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O97702-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRARPLWAAV LLLGALAGTG VGVSNICTTR GVHSCQQCLA VSPVCAWCSD
60 70 80 90 100
EALPLGSPRC NLKENLLKDN CALESIEFPI SEVRILEARP LSNKGSGDSS
110 120 130 140 150
QITQVSPQRI ALRLRPDDSK NFSIQVRQVE DYPVDIYYLM DLSYSMKDDL
160 170 180 190 200
SSIQNLGTKL ASQMHKLTSN LRIGFGAFVD KPVSPYMYIS PPEALKNPCY
210 220 230 240 250
DMKTTCLPMF GYKHVLTLTD QVTRFNEEVK KQSVSRNRDA PEGGFDAIMQ
260 270 280 290 300
ATVCDEKIGW RNDASHLLVF TTDAKTHIAL DGRLAGIVQP NDGQCHIGSD
310 320 330 340 350
NHYSASTTMD YPSLGLMTEK LSQKNINLIF AVTENVVNLY QNYSELIPGT
360 370 380 390 400
TVGILSTDSS NVLQLIVDAY GKIRSKVELE VRDLPEELSL SFNATCLNNE
410 420 430 440 450
VIPGLKSCVG LKIGDTVSFS IEAKVRGCPQ EKEKSFTIKP VGFKDSLTIQ
460 470 480 490 500
VTFDCDCACQ AQAEPSSHRC NNGNGTFECG VCLCGPGWLG SQCECSEEDY
510 520 530 540 550
HPSQQDECSP REGQPACSQR GECLCGQCVC HSSDFGKITG KYCECDDFSC
560 570 580 590 600
VRYKGEMCSG HGQCSCGDCL CDSDWTGYYC NCTTRTDTCM SSNGLLCGGR
610 620 630 640 650
GKCECGSCVC IQPGSYGDTC EKCPTCPDAC TFKKECVECK KFDRGTLHDD
660 670 680 690 700
NTCNRYCRDE IESVKELKDT GKDAVNCTYK NEDDCVVRFQ YYEDSSGKSI
710 720 730 740 750
LYVVEEPECP KGPDILVVLL SVMGAILLIG LATLLIWKLL ITIHDRKEFA
760 770 780
KFEEERARAK WDTANNPLYK EATSTFTNIT YRGT
Length:784
Mass (Da):86,389
Last modified:May 1, 1999 - v1
Checksum:i6B2A6D34916EA260
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03006340 Genomic DNA. No translation available.
AF116270 mRNA. Translation: AAD13680.1.
UniGeneiCfa.3641.

Genome annotation databases

EnsembliENSCAFT00000021789; ENSCAFP00000020239; ENSCAFG00000013735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03006340 Genomic DNA. No translation available.
AF116270 mRNA. Translation: AAD13680.1.
UniGeneiCfa.3641.

3D structure databases

SMRiO97702. Positions 25-784.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000032511.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000021789; ENSCAFP00000020239; ENSCAFG00000013735.

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.

Enzyme and pathway databases

ReactomeiR-CFA-114608. Platelet degranulation.
R-CFA-1566948. Elastic fibre formation.
R-CFA-2129379. Molecules associated with elastic fibres.
R-CFA-216083. Integrin cell surface interactions.
R-CFA-3000170. Syndecan interactions.
R-CFA-3000178. ECM proteoglycans.
R-CFA-354192. Integrin alphaIIb beta3 signaling.
R-CFA-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-CFA-372708. p130Cas linkage to MAPK signaling for integrins.
R-CFA-4420097. VEGFA-VEGFR2 Pathway.
R-CFA-445144. Signal transduction by L1.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR027068. Integrin_beta-3.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR032695. Integrin_dom.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF25. PTHR10082:SF25. 1 hit.
PfamiPF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO97702_CANLF
AccessioniPrimary (citable) accession number: O97702
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.