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Protein

Apelin receptor

Gene

APLNR

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for SIV infection (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Gastrulation

Names & Taxonomyi

Protein namesi
Recommended name:
Apelin receptor
Alternative name(s):
Angiotensin receptor-like 1
G-protein coupled receptor APJ
Gene namesi
Name:APLNR
Synonyms:AGTRL1, APJ
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 14

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence analysisAdd
BLAST
Transmembranei27 – 5125Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini52 – 6615CytoplasmicSequence analysisAdd
BLAST
Transmembranei67 – 9125Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini92 – 1009ExtracellularSequence analysis
Transmembranei101 – 12525Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini126 – 14419CytoplasmicSequence analysisAdd
BLAST
Transmembranei145 – 16622Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini167 – 20034ExtracellularSequence analysisAdd
BLAST
Transmembranei201 – 22121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini222 – 24423CytoplasmicSequence analysisAdd
BLAST
Transmembranei245 – 27127Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini272 – 28413ExtracellularSequence analysisAdd
BLAST
Transmembranei285 – 30824Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini309 – 38072CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Apelin receptorPRO_0000069174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence analysis
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

BgeeiENSMMUG00000010627.
ExpressionAtlasiO97666. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000013928.

Structurei

3D structure databases

ProteinModelPortaliO97666.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiO97666.
KOiK04174.
OMAiVMVFRST.
OrthoDBiEOG091G0BIX.
TreeFamiTF330024.

Family and domain databases

InterProiIPR020279. Apelin_receptor_C.
IPR003904. APJ_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01416. APJRECEPTOR.
PR00237. GPCRRHODOPSN.
ProDomiPD061381. Apelin_receptor_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O97666-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL
60 70 80 90 100
WTVFRSSREK RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF
110 120 130 140 150
SCKLSSYLIF VNMYASVFCL TGLSFDRYLA IVRPVANARL RLRVSGAVAT
160 170 180 190 200
AVLWVLAALL AMPVMVFRTT GDLENTTKVQ CYMDYSMVAT VSSDWAWEVG
210 220 230 240 250
LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL RKRRRLLSII
260 270 280 290 300
VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNV FPYCTCISYV
310 320 330 340 350
NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH
360 370 380
SQGPGPNMGK GGEQMHEKSI PYSQETLVVD
Length:380
Mass (Da):42,606
Last modified:May 1, 1999 - v1
Checksum:iE84F03E31FABF7ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100206 Genomic DNA. Translation: AAC72404.1.
RefSeqiNP_001040591.1. NM_001047126.1.
UniGeneiMmu.10854.

Genome annotation databases

EnsembliENSMMUT00000014866; ENSMMUP00000013928; ENSMMUG00000010627.
GeneIDi706823.
KEGGimcc:706823.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100206 Genomic DNA. Translation: AAC72404.1.
RefSeqiNP_001040591.1. NM_001047126.1.
UniGeneiMmu.10854.

3D structure databases

ProteinModelPortaliO97666.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000013928.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000014866; ENSMMUP00000013928; ENSMMUG00000010627.
GeneIDi706823.
KEGGimcc:706823.

Organism-specific databases

CTDi187.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiO97666.
KOiK04174.
OMAiVMVFRST.
OrthoDBiEOG091G0BIX.
TreeFamiTF330024.

Gene expression databases

BgeeiENSMMUG00000010627.
ExpressionAtlasiO97666. baseline.

Family and domain databases

InterProiIPR020279. Apelin_receptor_C.
IPR003904. APJ_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01416. APJRECEPTOR.
PR00237. GPCRRHODOPSN.
ProDomiPD061381. Apelin_receptor_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPJ_MACMU
AccessioniPrimary (citable) accession number: O97666
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.