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Protein

Mitochondrial uncoupling protein 3

Gene

UCP3

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 3
Short name:
UCP 3
Alternative name(s):
Solute carrier family 25 member 9
Gene namesi
Name:UCP3
Synonyms:SLC25A9
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 32Helical; Name=1Sequence analysisAdd BLAST22
Transmembranei74 – 96Helical; Name=2Sequence analysisAdd BLAST23
Transmembranei117 – 133Helical; Name=3Sequence analysisAdd BLAST17
Transmembranei180 – 196Helical; Name=4Sequence analysisAdd BLAST17
Transmembranei214 – 233Helical; Name=5Sequence analysisAdd BLAST20
Transmembranei268 – 290Helical; Name=6Sequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906741 – 308Mitochondrial uncoupling protein 3Add BLAST308

Proteomic databases

PaxDbiO97649.
PRIDEiO97649.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000015753.

Structurei

3D structure databases

ProteinModelPortaliO97649.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 102Solcar 1Add BLAST92
Repeati111 – 202Solcar 2Add BLAST92
Repeati211 – 296Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni275 – 297Purine nucleotide bindingBy similarityAdd BLAST23

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiO97649.
KOiK15103.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002030. Mit_uncoupling_UCP-like.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

O97649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGLKPPEVP PTTAVKLLGA GTAACFADLL TFPLDTAKVR LQIQGENQAA
60 70 80 90 100
RSAQYRGVLG TILTMVRNEG PRSPYNGLVA GLQRQMSFAS IRIGLYDSVK
110 120 130 140 150
QLYTPKGSDH SSITTRILAG CTTGAMAVTC AQPTDVVKVR FQASIHAGPR
160 170 180 190 200
SNRKYSGTMD AYRTIAREEG VRGLWKGILP NITRNAIVNC AEMVTYDVIK
210 220 230 240 250
EKVLDYHLLT DNLPCHFVSA FGAGFCATVV ASPVDVVKTR YMNSPPGQYQ
260 270 280 290 300
NPLDCMLKMV TQEGPTAFYK GFTPSFLRLG SWNVVMFVSY EQLKRALMKV

QMLRESPF
Length:308
Mass (Da):33,772
Last modified:May 1, 1999 - v1
Checksum:iFDF1F2BC28FDE997
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7 – 8PE → SD in AAD33396 (Ref. 2) Curated2
Sequence conflicti13T → M in AAD33396 (Ref. 2) Curated1
Sequence conflicti17L → F in AAD33396 (Ref. 2) Curated1
Sequence conflicti49A → AVQT in AAD33396 (Ref. 2) Curated1
Sequence conflicti150R → G in AAD33396 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095744 mRNA. Translation: AAD08811.1.
AF128837 mRNA. Translation: AAD33396.1.
DQ530368 mRNA. Translation: ABF74760.1.
RefSeqiNP_999214.1. NM_214049.1.
UniGeneiSsc.82448.

Genome annotation databases

GeneIDi397116.
KEGGissc:397116.

Similar proteinsi

Entry informationi

Entry nameiUCP3_PIG
AccessioniPrimary (citable) accession number: O97649
Secondary accession number(s): Q19B00, Q9XSE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 5, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families