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Protein
Submitted name:

Cytotoxic T-lymphocyte-associated protein 4

Gene

CTLA-4

Organism
Ovis aries (Sheep)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cytotoxic T-lymphocyte-associated protein 4Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:CTLA-4Imported
Synonyms:CTLA4Imported
OrganismiOvis aries (Sheep)Imported
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei160 – 184HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_500877869336 – 221Sequence analysisAdd BLAST186

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 130Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST101

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00530000063873.
HOVERGENiHBG057978.
KOiK06538.
OMAiFSKGMHV.
OrthoDBiEOG091G0IGY.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR008096. CTLA4.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01720. CTLANTIGEN4.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O97631-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACSGFQSHG TWRTSRTWPC TALFFLLFIP VFSKGMNVTQ PPVVLASSRG
60 70 80 90 100
VASFTCEYES SGKADEVRVT VLRKAGIQVT EVCAGTYMVE DELTFLDDSS
110 120 130 140 150
CIGTSRGNKV NLTIQGLRAM DTGLYVCKVE LMYPPPYYMG EGNGTQIYVI
160 170 180 190 200
DPEPCPDSDF LLWILAAVSS GLFFYSFLIT AVSLSKMLKK RSPLTTGVYV
210 220
KMPPTEPECE KQFQPYFIPI N
Length:221
Mass (Da):24,490
Last modified:May 1, 1999 - v1
Checksum:iD317E9D5557BA6FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AMGL01055439 Genomic DNA. No translation available.
AF092740 mRNA. Translation: AAD04380.1.
RefSeqiNP_001009214.1. NM_001009214.1.
UniGeneiOar.703.

Genome annotation databases

EnsembliENSOART00000019938; ENSOARP00000019665; ENSOARG00000018321.
GeneIDi443040.
KEGGioas:443040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AMGL01055439 Genomic DNA. No translation available.
AF092740 mRNA. Translation: AAD04380.1.
RefSeqiNP_001009214.1. NM_001009214.1.
UniGeneiOar.703.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOART00000019938; ENSOARP00000019665; ENSOARG00000018321.
GeneIDi443040.
KEGGioas:443040.

Organism-specific databases

CTDi1493.

Phylogenomic databases

GeneTreeiENSGT00530000063873.
HOVERGENiHBG057978.
KOiK06538.
OMAiFSKGMHV.
OrthoDBiEOG091G0IGY.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR008096. CTLA4.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01720. CTLANTIGEN4.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO97631_SHEEP
AccessioniPrimary (citable) accession number: O97631
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.